How to Avoid Insulin Resistance and Why it's Important | Dr. Robert Lustig & Dr. Dom D'Agostino

Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Robert Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.
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00:00 - Intro
01:44 - What is insulin?
04:43 - What is insulin resistance?
15:50 - There are three types of insulin resistance
36:03 - Weight management is not about calories in and calories out
44:00 - Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer
49:31 - Insulin is a crucial biomarker to measure for metabolic health
52:11 - Insulin resistance is a hinderance to weight management
54:42 - The intake of too much leucine can lead to insulin resistance
1:00:22 - Fiber feeds the gut microbiome and is crucial for metabolic health
1:11:27 - Is intermittent fasting necessary?
👋 WHO WE ARE:
Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life.
🔗 LINKS:
Transcripts & Show notes: www.levelshealth.com/podcasts...
Subscribe here on KZbin: kzbin.info?sub_...
Connect with Robert Lustig, MD, on Instagram: / robertlustigmd
Connect with Robert Lustig, MD, on Twitter: / robertlustigmd
Connect with Dominic D’Agostino, PhD, on Instagram: / dominic.dagostino.kt
Connect with Dominic D’Agostino, PhD on Twitter: / dominicdagosti2

[@barrysmith8193]

I’m 75 years old and have a 25 year plan. Dr Lustig is the most important trusted advisor in my support plan.

[@armikmuson5191]

👍👍👍

[@calibby85]

Power to you buddy!💪🏽🙌🏻👏🏼

[@ddee203]

I'm 44 and have a 25 year plan too. Dropped sugar around 6 years ago.. life changer

[@raymondchan4757]

​@calibby85 Noooo.koooooo

[@Acts-1322]

You might find Dr Chatterjee and Dr Jamnadas videos to also help you on your health journey. 1) nutritious diet with limited poisons (sugars and fake sugars, alcohol, smoking, omega 6 veg seed oils). 2) lots of strength training AND faster movement that strengthens heart/lungs. 3) LOW TECH to get good sleep 7-8 hours every night, no screens an hour before bed. 4) low stress, good relationships

[@LashusJourney]

My insulin was at a 8 last year, I reversed it to 3 in a year just by lifestyle changes. Thanks for all you do.

[@dx398]

Do you still eat fruits

[@yumicrisostomo3094]

What is your diet like?

[@lisaa8795]

Great slogan: "You cannot outrun a bad diet". Until I was about 50 I believed I would always bounce back from sugar binges by exercising.

[@Alex-hd6ek]

You are right, we should try swimming...

[@kenadams5504]

That was "pre-Lustig "...once you know about the affects of excess sugar , you can never unsee them.

[@BhagwatiPrasadJoshie]

Golden words man

[@hokeywolf3416]

Same here. Now that I avoid most sugar, my exercise consists of projects around the house.

[@AquaSunny]

​@@kenadams5504the most funny thing is that word LUSTIG in German language means ,,funny,, so it really was preLustig 😂

[@lilytea3]

0:54: 🔑 Insulin resistance is a phenomenon where the receptors for insulin on the cells are downregulated and signaling beyond the receptor is dysfunctional, leading to various chronic diseases. 11:21: 💡 The liver is the primary site of insulin resistance and fatty liver disease affects a large portion of the population. 19:54: 📚 The discussion involves the relationship between diabetic nephropathy, insulin, and glucose levels, as well as the impact of exercise and diet on metabolic conditions. 28:05: 🍎 The liver plays a crucial role in metabolic health, and fixing the liver is important for preventing and treating chronic metabolic diseases. 36:58: 📚 Type 2 diabetes is eminently reversible by fixing the diet, but the American Diabetes Association does not emphasize the importance of insulin and does not recommend measuring it. 46:15: 📉 Fasting insulin is an important measure of metabolic health and should ideally be less than 10 Microunits per milliliter, with insulin resistance occurring above 15 Microunits per milliliter. 55:35: 👨‍⚕ Fiber is essential for maintaining a healthy intestinal barrier and preventing inflammation in the body. 1:05:08: 🔬 There is currently no strong evidence to support the use of supplements in improving insulin resistance. 1:14:00: ✅ The discussion explores the use of GLP-1 analogs for insulin resistance and weight loss, highlighting the need for further research. Recap by Tammy AI

[@garzascreek]

Thanks for the quick links.

[@PromeoRoy]

Tell me in simple language how to reverse Type 2 diabetes. I had very recently been a Type 2 diabetic as l drank bottles of alphanso mango juices, icecreams and large amount of sweets,chocolares,cakes etc. After being on Insulin ( 2 types ) and regulated diet for 45 days , my fasting sugar is between 89 io 108 and PP readings are 113 to less than 200. I am now being on Insulin Glargine Injection I P 100 IU/ml ( r-DNA - origin ) , 10 units, only, once in the morning. Also l am taking 1 Tab of 2 mg GLIMEPRIDE.

[@emmwhite3945]

@@PromeoRoy hello from Canada, Simple advice … just take one day at the time…. really, stop eating anything made from white / even whole grain flour, any pasta, rice, potatoes, tacos…and similar…. No fruit juices, beer, alcohol, ice cream, donuts and cookies - nothing from flour and sugar….🛎 Any veggie’s, salads, any lean meat, water to drink-5-6 glasses/day minimum, eggs/ omelette, cheese - not too much, nuts are good.., All this information is very important

[@elizabethsamuel2219]

very useful discussion

[@user-ru4dr4zg5x]

K​@@PromeoRoy

[@SurenderKVats]

Dr Lustig, you are doing a favor to citizens of the world. Your advice is simple, straight and so valuable. Thanks for making it available on the net.

[@debrobinson857]

Now we just need to get people to pay attention.

[@evasquez8977]

⁠@@debrobinson857😮🎉

[@christinabengtsson8346]

About processing food, like juicing. If you destroy all fiber in juicing, your teeth process all food - likewise - by chewing like a grainer - all food - down to puré berörd swolloing. Everything enda up puré.

[@christinabengtsson8346]

What about your teeth and chewing? ...which grinds everything down before swollowing anyway. That is total processing! Puré

[@lynlawley8903]

Chewing gets things to process from mouth,to gut to mirobs

[@marionalbergo1146]

Dr Lustig is a genius he just knows more then anyone else - dr or otherwise! !! Probably because he has been doing this for decades. He is dedicated and really is the only one I follow - period. I bought his book and cut out sugar and processed food. I lost 20 pounds 150 to 130. And ALL my belly fat !!I have more energy and my lungs take in deep breaths better and my oxygen levels went from 93 to 98. My ha1c was 5.6 - I’m going back (6 months later) for another test which I expect to be much lower. I have said this before but I believe Dr Lustig deserves a Nobel Prize for his work and dedication to educating the human race AND the health establishments and doctors all over the world.

[@juliettailor1616]

I agree re: Dr Lustig. Did you cut out bread? I find that to be the main culprit in my diet. I've cut out most sugar and try to go without bread and am thinking of consuming only real sourdough bread if I can find any. Apparently sourdough is the only bread which is good for insulin resistance.

[@vogeljennifer6318]

agree

[@franzpink2403]

What is the name of Dr Rob Lustig's book?

[@RealityCheck1]

​@@juliettailor1616remove ALL highy processed foods

[@niranjanpaul2176]

Too noble for the nobel folks

[@tonystonebraker]

Down 122lbs. The difference is amazing. Once I learned about insulin and it’s effect. Game changer. Don’t understand why doctors never mentioned it before.

[@jamesdean7756]

Isn’t it obvious dummy

[@JWB671]

You created an energy deficit and lost weight. Your body was still producing plenty of insulin, otherwise you would be dead.

[@lorellgingrich1334]

I've referred to this joke in other places but it bears repeating once again: From the show "Frasier" Niles Crane to Frasier Crane : "He's such a good patient. He always pays his bill and never gets well." Pharma stocks...?

[@tonystonebraker]

@@lorellgingrich1334 lol. I think you are exactly right

[@Mr-hn2bp]

These are new findings not incorporated into medical curriculum yet.

[@mpoharper]

If I ever have a health problem, I want Dr. Lustig on my case!!

[@salvadorissa7770]

What an amazing, comprehensive and enlightening discussion..! I was diagnosed with Syndrome X, hyperinsulinemia, reactive hypoglycemia about 35+ years ago. Never knew what to do about it until recently, when I decided to actively measure my fasting insulin and find ways to lower it from 17.5 units to 4.7, per the latest test. In my case, understanding how to reduce cortisol was the key. Once I controlled cortisol, my blood pressure and blood sugar normalized. I was able to add 3-day water only fasts to my time restricted eating protocol. Unfortunately, this wasn't anything my medical care providers taught me. IMO it took too long for me to acquire the knowledge and then the resolve to act. Thanks to scientists like Dr Lustig and others that care to tell it like it is and teach others....

[@ethioamericann]

Thank you 🙏that is really a helpful feedback. Yes Dr. Robert Lustig is the best advocate for people with metabolic syndrome especially kids with fructose overconsumption. I personally have been practicing OMAD diet for almost a year now, and I was able to bring down my HGB A1C from 10.5 to 5.7 primarily due to a time restricted meal time coupled with a regular aerobic exercise ( walking & hiking). I really think if I also incorporate a 3 days of water fasting on weekly bases, I can overcome the weight-loos plateau and rich my eventual goal sooner 🤞🏾

[@scottfrench9267]

​@Tam Bekele My very humble, non-medical opinion: fasting is one of the most powerful health tools we have. I do a minimum of 16 hours / day, 36 hour fasts regularly, and longer (72+ hour) fasts multiple times a year. It can be overdone, though. A weekly 72 hour fast would be very taxing on your body and maybe too much of a good thing? It took us years and decades to get in the ill health we were in. Let's take the time, slow and steady, to heal from the poor nutritional habits of our past.

[@kenadams5504]

How did you reduce your cortisol levels ?

[@salvadorissa7770]

@@kenadams5504 Long story short....What worked for me was to perform exercises that activate the parasympathetic nervous system (links to videos below.) The longer narrative: Around the 52nd hour of fasting my blood pressure increased to the likes of 180 Systolic/100 Diastolic 100 heart rate. ...It would fast normalize if I ate something. Also, during fasting, my blood glucose never went below 90+, even while in ketosis!. And If I went for a walk or worked in the backyard w/o eating my glucose would go up into the 110s. My son and I, both not MDs but technically inclined, theorized that both reactions pointed to cortisol and stress. Only recently I heard someone mention that gluconeogenesis is triggered by cortisol. These are the exercises that helped me: kzbin.info5XXxFrITiEM?feature=share By breathing in a manner like this short video recommends, my blood pressure went into the 90/60 82 range within minutes.... I have made it a habit to breathe like this. BTW I quit taking my ACE2 inhibitor about 6 months ago. These two exercises have also been very helpful, especially in high-stress situations: kzbin.info/www/bejne/gp-5ZIRora6VZ7c kzbin.info/www/bejne/sIbbZp6Ce96rY68

[@Mr-hn2bp]

​@@kenadams5504 Don't get upset, never rush to do anything, stop worrying unnecessarily.

[@lisaa8795]

Jaw-dropping explanation about the effect of stress on the body. I wondered why my fat is so stubborn....now I have another explanation besides age.

[@jeffreycash1572]

As someone who is thin and has developed pre-diabetes,gout, and slight atherosclerosis. I thank God ive come across Dr Lustig. He has helped me understand the process of metabolic disease. I had A1C of 6.3 1 year ago, now 5.4, with Keto carnivore diet and time restricted eating. I mentioned some of the concepts to my Dr's and its like im taking in a foreign language. 😢

[@jespestana]

I particularly appreciate the discussion on the origin of insulin resistance in the liver vs. in the muscles. Robert Lustig is great explaining why fructose (for instance, in refined sugar) is so detrimental to health. D'Agostino being a researcher on the same field makes for a great interview discussion so far. Thanks for hosting these important discussions. 😊

[@-DailyInspiration]

Wishing everyone who is watching this video to always have strength of heart and peace in soul: Amid life's tumultuous sea, a toolkit for the soul we seek, To mend the heart, find peace, and joy in times so bleak. In this video's embrace, a treasure trove, a hopeful start, Bolstering the mind, kindling hope, soothing every wounded heart 💗

[@jovoorheescollinsmphbsnbch6245]

I love how you get all frustrated Dr. L. 😅😂 I get angry too. In my diabetes support group, when we started in 2018 we had 150 people. By Feb 2020, we had about 5,000 members. Since the pandemic, we have increased to 10,000 members. No one is talking about this in the legacy media or major medical associations.

[@SuperLammens]

They rather force face masks on people ❤

[@micheleshively8557]

No money in it. They'll never talk about it

[@T-aka-T]

So valuable for everyone who has been thrown onto their own resources to research their own health in the absence of a trustworthy general "standard of care" medical model and with hopelessly ignorant dieticians. Unlike the unqualified social media "influencers" pushing their products and copying each other's content, this is pure expertise shared with altruism by busy people. Thank you both. 👍❤️

[@sarahrose1665]

Such ACCURATE OBSERVATIONS... If you don't research solutions for your own health... no other person genuinely and "altruistically" gives a fig...Present company(Dr. Lustig) excluded... I concur with everything you've said... It's a blessing to find a port in the storm because this health business (medical propensity to medicate medicate medicate) can become overwhelming... I'm 75 and never took a pill in my life and I don't intend to start now for "convenience" sake to soothe a doctor's ego...I'll do the work...without being drugged...and refuse to be shamed in the process . SO GLAD YOU SHARED.🙋🌹👍

[@kevinbrannan8347]

Dr sten Eckberg is a valuable form of metabolic health info fits this discussion

[@T-aka-T]

@@kevinbrannan8347 that guy is not a doctor. He is a clever packagers of others' ideas. He's a chiropractor who sells supplements. He does a nice little whiteboard routine of presenting stuff he's cherry picked from actual practitioners and researchers and he NEVER acknowledges where he got it from or names other experts. (compare that with others who often discuss ideas with colleagues). There may be a place for that kind of packaging, but don't think he's a doctor.

[@T-aka-T]

funnily enough, I had him in mind when I made the original comment. 😏

[@kevinbrannan8347]

@@T-aka-T I see your point if it’s beneficial tho I am not a doctor but I can learn things About the body, I could not write a book I try to follow the silence and get the picture my own doctor probably does not take time to read , probably waits for guidelines that are set by government that suit them more than our health

[@elpompo5166]

This content is just amazing and I realize why we have all these issues in the US: we are being led by merchants and not scientists. Appreciate this work!

[@suzanneemerson2625]

We have been led astray by many scientists. Ever heard of Ancel Keys? He’s the one who convinced the American Medical Association that cholesterol causes heart disease, and caused the medical professionals to promote the deadly low fat diet, and statin drugs, which have caused irreparable harm. It turned out that he faked the data in his “scientific study.”

[@pameti.dragoblago]

not quite. it's the government that provides 'recommendations' (such as food pyramid), based on the 'scientific' findings. they are all in it together. media included.

[@lymphomasurvive]

The government is a merchant too. ​@@pameti.dragoblago

[@yolandacuevas751]

Dr. Lusting, 9 years ago I was diagnosed diabetic type 2, I have lost 100 lbs. in 9 years I was over weight “ very” but unable to take control over my glucose problem. Unable to find a solution and dedicated to find something I have found you. And Oh my goodness am I happy. You have changed my lift and gave me hope. Thank you

[@BerhaneKirosEmbaye-fn4sb]

If doctors could not cure you how can you give them much respect like this. For me I am very hopeless by doctors because they do not want to tell you what their test imply them,they like to hide them so that you can not treat or cure yourself. Thanks for advance! We do not need much explanation but a final cure for diabetes especially type2 and type 1 too.

[@lindajones4849]

Yolanda - congrats on your success

[@aprilek6003]

Love the Levels team and never get tired of hearing Dr. Lustig. Thanks for putting this old interview up

[@methods3110]

The trouble with Keto is that it is a major threat to the medical and drug ‘industry’ because it is too simple, too effective, and too safe. It just needs one person - YOU.

[@jumpercable20]

It worked for me, at the age of 70 I had high blood pressure for over 25 years, taking blood pressure meds, I went on a keto diet with intermittent fasting and went from 230lbs down to 146 lbs. in 18 months. NO MORE HIGH BLOOD PRESSURE. The easy way to fast is a small supper before 6:00 pm and nothing until after 12:00 or 1:00 pm, the next day. An empty stomach is a healthy stomach, I feel better and have more energy. My resting blood pressure is 120/70, you know the Doctors aren't happy because I don't need them or the dangerous meds from big pharma.

[@linz716]

@@jumpercable20 That's fantastic results! I was worried that at 66, I was too old to make a difference, so you have given me hope. My BP is fine, but triglycerides 3.5 and suffer from aches and pains in my hips.

[@jaimeu1463]

@@jumpercable20ppppppppppppppppppppppppppp

[@jaimeu1463]

@@jumpercable20p

[@graememudie7921]

@@linz716 I have been doing Keto for 2 years and started Carnivore on March 17th 2023. I am feeling amazing. My joint pains are gone, and I no longer need to go to the chiropractor. Indigestion is gone as well. I started doing press-ups, and in the first week, I did 35 per day, which was 5 more than I usually do. I have steadily increased the number every day and did 70 a few days ago! I can't believe it! What I added was boron, which was suggested by, Dr. Suresh Khidwadker, one of the many doctors I follow on KZbin. That took it to another level. I am 67 years young and will never eat vegetables again. No carbs, absolutely no carbs. I have not put sugar in my coffee or tea for at least 40 years. Another effect of this diet is that the plaque on my teeth has completely gone. After about a week, I could feel it coming off, a very strange sensation. Additionally, I no longer have bleeding gums. I only take thyroxine for my underactive thyroid. I hope to get off of it over the next year on this diet.

[@KevinSzabow]

Just last year was 310Lb at 20 years old Pre Diabetic. Today weighing in at 210Lb in 10 months about to turn 21 with a body fat Percentage of 17%. Diabetes risk free and seeing Dr lustwigs Ted Talk is what introduced me to the “real food” diet, I have never felt better and I have started a boxing career.

[@lindajones4849]

Congratulations on reversing prediabetes and basically saving your own life.

[@jaymehatfield9540]

Congratulations for dialing in your best self with discipline and knowledge at 21. I wish every young man with your abilities would apply themselves to useful job skills that require creativity and originality. Playing childrens ball games competitively or beating the crap out of someone is a poor use of proven aptitudes.

[@MyCleverHandle]

I'm sure there's a reason this popped into my feed today; I have a cardiology appt. today during which my doc will no doubt start banging his drum again about the need for me to be on a statin. He always overlooks my 30 year history of PCOS pre-menopause. And he never answers me when I ask why he's never ordered tests for fasting insulin levels or for old-fashioned glucose tolerance over a period of hours. Or why he or my primary care twit have never referred me for a nutrionist's diet evaluation. All he's ever concerned with is cholesterol levels. Like sugar doesn't matter at all. I honestly believe that I've developed Metformin resistance by now, and probably a good case of white coat-induced deafness. We simply aren't listening to each other anymore - a bad marriage! Thanks for this! And I'm a subscriber now!

[@CashMoneyMoore]

This is incredible content. Thank you levels for hosting these two, hearing them discuss these issues as a fly on the wall is illuminating

[@carloscoward2674]

😢and all s64😢😊have a

[@annefischer1433]

​@@carloscoward2674????

[@kevindunagan9822]

Quest doesn't even offer a fasting insulin test now. I had to go to the local hospital I use to get my blood insulin level, and I had to ask my PCP to order it. My fasting insulin turned out to be 17.5, but a month of intermittent fasting, keto, and exercise brought it down to 10.6.

[@user-ms5yl2gb5o]

So very grateful you are talking about all this on the internet and not just in meetings.... :)

[@edwardbernard9198]

This guy is brilliant! Making so much sense.

[@greenbroke6923]

Sooo helpful. Appreciate your knowledge and time!

[@suzikirby1973]

Thank you for this offering. Two wonderful minds in this space.

[@iainneilson1453]

Thank you both for a fascinating discussion. The section on different types of diabetes was particularly enlightening. Fortuitously, the question in my mind, for the past two days, has been, "why is insulin not a standard measurement?" Having heard and read several articles about elite athletes with type 2 diabetes, it is clear that the association with obesity is irrelevant. The association with metabolic health, however, is crucial.

[@Mr-hn2bp]

Insulin secreted into the blood is carried to the liver through the intestinal hepatic vein where it works and a majority of it is metabolized before entering the general circulation. The blood levels of insulin fluctuate fast and in a temporal manner apart from low level and insensitive/nonspecific tests. A better way may be measuring C-peptide level as a serogate .

[@jr.6199]

Lustig says 80% of obese patients have insulin resistance...that is most relevant!

[@radiogreenblue]

Dr Lustig, I am so facinated by your interviews and lectures online. I am inn the process of getting my A1C down by not eating fructose and severely limiting carbs.

[@SantiagoPerez-np4ep]

You know I was diagnosed with pre diabetes and completely changed my diet . I went back six months later and had my a1c checked and it dropped out of the pre diabetes range . So on my recent visit I asked my doctor if we could check my fasting insulin as he was typing up documenting our visit and he turns around and asked me “ why do you want that, that won’t tell us anything “ the other thing is when I looked at his notes I didn’t see the documentation of me asking or requesting that test hmm. I was disappointed coming from a ucla medical center but driven by the pharmaceutical industry . I am now looking for another doctor but they are so hard to find !

[@AnneAlready]

I feel your frustration. I'm in NZ and I just ordered a fasting insulin test myself. One day docs might catch up but I'm not holding my breath! Great work on the a1c by the way.

[@NadeemAhmed-nv2br]

I mean he is kind of right, blood sugar levels and insulin tell you the exact same story but if you asked him for an insulin sensitivity test, that would make more sense for him to do

[@annettesilva2120]

Very interesting and suspicious right? Doctors don't document anything.

[@annettesilva2120]

​@@NadeemAhmed-nv2brwhat is an insulin sensitivity test called? Is that a blood test?

[@2brntb]

Always love to listen to Dr. Lustig.

[@daveeeed]

It's amazing how much we know now about all the different types of dysfunction now. How they're able to work out the specific problem

[@qaisermajid]

What a wonderful dialogue, the information provided here is the most important information for Human kind for the next 100 years. I listened it once will do it several times & will read books written by both of you.

[@irynaskorobogach7483]

Amazing... Thanks for letting us learn crucial things!

[@HappyHabits]

Dr. Lustig....a pleasure to listen to.

[@hans-jurgenwiegand7465]

It’s like listening to my Dad, knowing he actually cares about us! Being 77 years old, I wished I could have learned more, years earlier! It can be weird, to be younger than your son, but nice if you’re appreciative & respectful! I do look up to him! More like an older brother. 👍🏻👍🏻👍🏻

[@monikakress3867]

Dr. Lustig makes me wish I had gotten my PhD in nutritional biochemistry.

[@kenadams5504]

He certainly highlights how interesting it is.

[@pameti.dragoblago]

you would have to remember all these chemicals and bio-chemicals, how they work on their own and in relation to other chemicals and bio-chemicals and for that matter, biome as well 🙂 it's a complex system.

[@ygillham]

Brilliant, Thank you. Love listening to Robert Lustig, he has the most brilliant mind!

[@stanislawpalka9015]

The best video on Insulin Resistance in the net. Congratulation to Robert Lustig.

[@WatchingPlanesnbirds]

Love the way he explains things

[@DieKellerei]

I simply love your content! This is one of the most reliable sources for people who are interested in nutrition and are tired of being lied to. What always confuses me though, is that some of the video covers look a lot like AG1 advertising. In my eyes AG1 is the exact opposite of Levels: a massive advertising with dubious statements (there are no 79 vitamins, for instance) to market a bad product that can even harm people.

[@chadpritchard1905]

You sir with your information has totally changed my life / mind and body . Thanks for saving me

[@paigeharmon6354]

I worked for a health insurance company in 1987 and as part of my job, I read a lot of Underwriting journals. I remember reading an article that said the rate of T2D was rising so fast, the researchers expected half of all Americans to have it by 2025. 1987 was 5 years or so after the food industry started pushing the lowfat narrative. People were developing T2D just 5 years after adopting high carb/low fat diets. And look where we are now - where the researcher predicted we'd be. Even as a very young underwriter, I told my coworkers that T2D would bankrupt our country.

[@kiutpi]

This podcast is wisdom! Thank you 🙏

[@jimpowers9553]

Certainly one of the best videos of medicine ever done by this brilliant endocrinologist.

[@colinchappell4973]

Dr. Lustig is LEGEND his call out on the link between processed sugars and MDS is blueprint for acting upon integrity regardless of popularity and conventional wisdom. Thank you for the excellent conversation. I salute you gentleman. Science, truth and doing the right thing for the right reasons. Word!

[@CarnivoreAnesthetist]

Did I just hear Robert Lustig he’s just a mere mortal! Hahahaha he’s let’s say he’s very confident! I will say this about the man! He is super smart and a wealth of information! Great interview!

[@rbalschun9624]

Excellent discussion! Thank you gentlemen!

[@deanjericevic8912]

An insightful & interesting video, Dr Robert Lustig ; extremely well explained, cogent, I leant a lot. "To ask the right question is already half of the solution of the problem", thank you Dr Dom D'Agostino. I not only obtained a better understanding of Insulin Resistance & all its ramifications but also came away with an understanding of "leaky gut", fascinating.

[@philipsheard624]

Thank you Dr. Rob Lustig & Dr. Dominic D’Agostino for this very insightful and important video. Very grateful x

[@lucia_cossu_voiceteacher]

Dom D’Agostino, you are facilitating and promoter of great quality science/clinic application. And thanks of course to Dr Lustig and his work.

[@debbieconrad6616]

As a medical professional who follows a keto and IF lifestyle to heal my metabolic issues, I'm so glad to have found these two docs. I geeked out big time over this fantastic interview!

[@robertoingenitoiseppato6177]

thank you so much for this info, this channell and all the knowlegde you share

[@le832]

This is genuinely fascinating. 😮

[@loutes66]

Prof. Robert Lustig is Nickola Tesla of the Century In Medicine , THANK YOU

[@user-ob5nk3ss1p]

Nickola Tesla is a fraud!!!! He is a trickster!

[@Kachiusa1180]

Everytime I watch Dr. Rob Lustig discussion. I got something new to bring home. Great scientist and great person too, as he stands for what's right, not just for health but also others that affect our living quality.

[@lkuty]

Great to see another video from Dr Lustig. I watched the old ones with great interest. Thank you for the content and the discussion. Quite technical and not always easy to follow but interesting nonetheless

[@pip5461]

This was a gold mine of information...

[@3mcanter]

This is the best explanation I have heard about insulin resistance. When I asked my doctor during my annual wellness visit to check my fasting insulin he said I didn’t need it. I m going back to have him draw it after hearing this. It was drawn a year ago by a different doctor. So I do have something to compare. I’m definitely insulin resistant. Now that I’m on a ketogenic diet I want to know if my levels are going down. I’ll suggest he look at this information. I hope he will.

[@mathewmathew08]

Thank you both. It is very helpful.

[@pregapillay5326]

Many many Thanks Drs.Lustig & D^Agostino for a Wonderful Dissertation on the metabolic syndrome. from a long-retired physician.

[@azammirza8188]

Great idea and thanks .

[@janetg1691]

Thank you for all the information.

[@kommsofort6977]

This is fantastic information. I could listen to these guys talk for hours. Thank you!

[@wadepatton2433]

You're in for a treat. There are hours upon hours of pretty good interviews with him now. Fresh stuff about the same old thing--that folks need to know.

[@cynthiasivak5689]

I've learned so much from following Dr. Lustig.

[@williamdennis1256]

That was great, Doc’s. Well worth the price of admission.

[@tuppercareyd]

This is a very important video that really does give a tremendous insight into metabolic health. Thank you so much

[@TheFarmersWife1]

This is beyond incredible! I wish there was a program for Senior citizens or make Medicare pay for this! Please! It would save millions in the long run!

[@samaa4622]

Thank you so much for such detailed content. Really sheds light on how body works with insulin and deep dives into it's function.

[@jovoorheescollinsmphbsnbch6245]

Beautiful discussion Gentlemen!!! I am a diabetes management coach and i belong to 2 support groups on Facebook. I will be sharing this content with them. My husband appears to be LADA probably post Hep A infection. Both of my identical twin girls have epilepsy and were both generically positive for predisposition to hyperinsulinemic hypoglycemia and Schindlers Type 3 🙄

[@wjack4728]

Dr. Lustig is legendary and heroic.

[@theobonaparte94]

Absolutely brilliant!

[@vaivavaliene942]

Excellent interview! :) Thank you!

[@maryswanson7146]

At 60 years I started a low carb diet now 2.5 years later I have dropped close to 80 lbs today I talked to my Dr at my annual visit and asked her if she follows any of the low carb USA or Low Carb down under podcasts and she said to me.” I don’t think carbohydrates diet plays any roll in fat gain or loss” I told her I lost 80 lbs myself on low carb, but she just brushed it aside. 😳 But she is really one of the good Drs who really cars for her patients.But low carb really is not yet that popular concept among Drs who are older than 50 years old

[@michaelberman3648]

I wish that I can find a knowledgeable physician like you who understands so much about the metabolic processes that go on where so many other physicians would completely over look! And that’s a real pity for most of our population who may not know what to look for in a great physician! I just think the bar must never be watered down especially in the case for physicians where so many lives hang in the balance and are so dependent upon total accuracy!

[@barrysmith8193]

I put together a narrative that demonstrates my health intention, my dietary plan, and my life’s philosophy. I then made appointments with 5 different doctors, met with each of them, and explained that I was looking for a trusted advisor for my life’s plan. I took a copy of Dr lustigs book Medabolical for each. Of the five I them I then selected the one that I was sure would be supportive in spirit and technical skills. I then wrote a letter of thanks and hand carried it to his office and asked him to share the letter with his staff. There are doctors that you can trust to practice to the benefit of you and his office both. Being proactive is not difficult you just have to do it. Don’t wait for someone to magically do it for you. It won’t happen.

[@Jana-pm3nj]

​@@barrysmith8193Bravo!! I must try this!

[@jonthomas9708]

Enjoyed this excellent and informative conversation around the nebulous term "insulin resistance". To learn that it can originate in different tissues and environments, that the types have specificity and are linked with different health problems I found very helpful. As someone who practiced time restricted feeding and was careful around carbs for 5 years before finding out I was on the first rung of pre-diabetes in spite of looking and feeling healthy this is a mystifying issue for me. As someone who took the information serously, immediately went from carb cautious to keto, bought a CGM and found 6 months later that my A1C was one degree WORSE this information helps me with the feelings of disempowerment and apathy in the face of this health challenge. As someone exasperated by being unable to get insulin tested it is encouraging to know that there are people more interested in these issues than my GP

[@afdave7]

I just found Dr Lustig and I have to admit, I love his FIRE!! He's super knowledgeable, and he fully understands the holistic view of the issue. Gives me hope we could ebb and fight the diabetic scourge with which the world is faced.

[@CelineNoyce]

I have a theory that insulin resistance / sugar also damages some organs in small ways that no one knows about. I had a large amount of sugar at a birthday party and happened to have a CMP taken the next day. My Liver enzymes were through the roof. They went down over the week back to normal. So, if I didn't have those tests, I never would have known. What does a large sugar or insulin spike do to your liver, kidneys, heart, brain... does each one of these do a tiny amount of damage that builds over time? Until one day you wake up with kidney, liver damage, heart failure and you have no idea why.

[@carolinashort7334]

Wow what a knowledge you’ve shared thank you so much.

[@sb9442]

ABSOLUTELY FANTASTIC INTERVIEW… stands alone apart from all others …THANK YOU BOTH SO MUCH for asking all the right questions of the absolute BEST resource of information available… DR LUSTIG IS ONE OF A KIND …. With all the qualities of a true humanitarian..not afraid to STAND TALL & PROUD OF the knowledge he is sharing with us & actually breaking the glass …THIS MAN ALONE WILL CHANGE THIS WORLD 🌎….IF …WE ALL… LISTEN 👂….THANK YOU

[@mikeycbd]

I'm not a medical doctor but I've been watching Dr Robert Lustig for many years. Recently I started viewing again because I wanted to understand how a marathon runner (me) in my very early 50s, 14 marathons, ends up having a 'heart attack'. Sugar was clearly the answer. I may have only been 72kg thinking I could eat whatever I want because I was burning off the sugar. Wrong. I now have been Keto since 2018 and now run in a Keto state. Note easy. I did my triglyceride to HDL ratio and it was 0.62, I'm thinking this year it will be even lower. Thanks for these very informative videos helping us to stay alive. ...oh... my heart attack may have actually just been a raise in troponin due to running and 4 hours in SR Tachycardia but they found a 99% blockage 4 days later when they just 'checked' before sending me home.

[@stephengreen9720]

MRNA

[@intothenight9256]

I can listen to dr lustig all day…thank you doctor!

[@wadepatton2433]

I go in spells. I watched everything he had up a few years ago--now he's everywhere. I've been binging since Saturday. and Metabolic is on the way to my mailbox. I broke with sugar 8 years ago but am trying to help others.

[@danadams6477]

I enjoy listening to and watching Dr. Lustigs numerous lectures, KZbin discussions, and occasional cameos on health documentaries. I would love for my son and I to meet him someday. Perhaps Dr. Lustig would consider making a lecture tour around the CSU campuses in California. Is that possible?

[@stevestevenss5193]

Yes let’s have him do an entire tour just for you lol smh

[@joec1212]

Great show gentlemen. Thanks so much!

[@ScienceAppliedForGood]

It was a very informative and important talk. I liked it a lot. A kind of must watch for good understanding of what Insulin Resistance is and what to do about it.

[@alessianala]

Interviewer is all over the place. The doc, is incredible

[@monicagordon602]

I wish you were in NYC and could be my doctor. Thank you for making these videos. I have learned so much from them.

[@SC-bd4ou]

Great conversation! A great deal of valuable info, and finally someone addresses the lack of routine insulin testing. I have been asking myself why it’s not included in standard testing! Bravo. Thanks for making these conversations public and available!

[@sharicreamer4514]

I asked my doc for a fasting insulin test once. She told me she wouldn't do it because she wouldn't know what to do with the results. We need to do better.

[@SC-bd4ou]

@@sharicreamer4514 Absolutely! Ignorance is not so much the issue as I can understand science and medicine evolve. It’s the lack of interest and essentially humility many doctors show that bothers me most. We need to be our own health advocates (and find the right doctors).

[@danadams6477]

@@SC-bd4ou No doubt.

[@Mr-hn2bp]

​@@sharicreamer4514 If the fasting insulin is normal, a high postprandial blood glucose level means you are eating too much to keep it high for too long. If it is high, you have insulin resistance. Do OMAD and keto to clear the liver of fat. This should also lower A1C and insulin.

[@kenadams5504]

@@Mr-hn2bp keto /carnivore also eliminate sugar/carbs ; that increase triglycerides. With lower trigs , you get less small dense ldl cholesterol that may cause plaque/heart disease,( depending on how much hdl you have).The carnivore diet of nutrient dense beef can also repair gut permeability, (caused by processed food). This restores the barrier between digesting food and the bloodstream .This polluted blood can also pass a permeable blood brain barrier ,(eventually resulting in neurological/psychiatric conditions.).This is thought to be driving skyrocketing cases of mental health disorders in countries with processed food .

[@ruthfrye9181]

although some of the scientific details hurts my brain a little, THIS INFO FROM THE DOC HAS GIVEN ME HOPE!...Thank u!!!

[@livincincy4498]

I really liked this presentation

[@250txc]

Mr. Lustig knows his stuff and Dom was all ears taking it all in .. Same as me ...

[@cinder176]

Dr. Dom, you cut off Dr Robert at a very crucial time. He started to explain the 4 ways to reduce insulin resistance and started with changing the diet. He didn’t finish explaining about the diet nor did he get to the other 3 methods when you interrupted and asked about Lucine in body builders. How many of the public listening are body builders? Let him finish how to heal insulin resistance before worrying about body builders because that’s what the vast majority of the public has.

[@monicahwilliams]

You both are amazing!

[@jacklineadong8324]

I love the level of in depth knowledge and explanation dr Lustig provides. I always grateful to listen to you.

[@winegoddess55]

This is all so fascinating and useful. I'd like to know what your take is on microplastics Dr. Lustig?

[@madonnaadell7465]

THANKS 😊😊

[@nolifemowlifelawnmaintenan4347]

Just "THANK YOU"!!

[@leadimentoobrien1221]

Fantastic. Thank you!

[@brigittefregault6411]

He’s brilliant! I love dr. Lustig!

[@osvaldovillarreal8750]

Excellent! Great info. What is normal fasting insulin levels in kids? What about in kids going through puberty?

[@DM_Slider]

I was an athlete 20 years ago and I didn’t eat well and had HTN and dyslipidemia back then. After cutting out UPF and sugar, I reversed all my chronic diseases. Dr. Lustig is the way, but you gotta know the biochemistry and medicine to know what to do. 21:07