Malate-Aspartate Shuttle

Lesson on the malate-aspartate shuttle explaining the purpose and mechanism of the shuttle. The malate aspartate shuttle is important for transporting NADH, produced from glycolysis, into the mitochondria for ATP production from the electron transport chain. The mitochondrial inner membrane is impermeable to NADH, so the cell needs to "transport" the energy within the NADH in another form (malate). Malate is then transported into the mitochondria, where the "energy" stored within malate is reprocessed into NADH, and this NADH can then be processed in the electron transport chain.
Hey everyone. In this lesson you will be introduced to the malate aspartate shuttle, why we need the shuttle, what types of cells use this shuttle, and how this shuttle functions. You will also learn about how gluconeogenesis utilizes this shuttle to produce glucose.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one. :)
JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@KarunyaSai-rt5ry]

The most comprehensive explanation that i've ever seen !!! I actually came here as, I had a doubt on , why the malate aspartate shuttle is described in reverse direction in gluconeogenesis and in ETC. Now my doubt has been cleared . Thank you !!!!

[@abcdefgabcdefg4502]

Thank you for making this great video. I love the comprehensible way you explain, you've helped me a lot!

[@mariyahahmad5387]

Thank you veryyyyy much, I watched a lot of videos to understand this process but no one was like your explanation, thank you🙏🏽

[@ShahsawarM]

Thank you for the gluconeogensis part, I was in need of that and was searching for a video on this

[@desiderata6997]

Honestly it is quite amazing that all because cells can't transport NADH this whole cycle of enzymes and antiporters is required.

[@harold1009]

Thank you Sir, this was very helpful

[@zixuanwang6480]

makes so much sense. thank you so much

[@Godfearing489]

Wow this was the best explanation!!😍🤩

[@edward_finn]

i love this, thank you so much

[@SP-eg3rn]

great explanation . thank you !

[@janhabipatra9177]

Thanks for this video

[@saakshikole2737]

Wow thank you

[@_jessie__]

Thank you💜

[@gracefulgaze714]

thankyou a ton😍😍

[@daltonnguyen855]

Thank you!!!

[@leavinoneday]

Thank you

[@dadada8464]

Great video, thanks so much!

[@ndukanwankwo8393]

God bless you

[@e.k.5145]

I think malate aspartate shuttle also utilizes nadh transpass in kidneys along with heart and liver

[@ellora5535]

Thanks 😊

[@Joeythegoats]

wouldn't it be reductase enzyme instead of dehydrogenase when we adding H to the Rx and forming NAD from NADH+H

[@mala9917]

Thank

[@PranavKumar-sh2fg]

thanks buddy

[@arthurvinck1179]

Ist the shuttle across the inner membrane of the mitochondria, so from the inner membrane space to the matrix (instead of from the cytosol)?

[@goahead3654]

in ur other video on gluconeogenesis u said that oxaloacetate can be formed only in the mitochondria. In THIS video, y did u start with oxaloacetate on the cytosol side? isn't it supposed to be produced or made in the mitochondria?

[@jjmedicine]

Hi there! Glad you're finding the videos helpful! Oxaloacetate can be formed in either the mitochondria or the cytosol by malate dehydrogenase since it is a reversible enzyme. In the gluconeogenesis lesson, malate was converted to oxaloacetate in the cytosol by malate dehydrogenase because in that particular cellular energy state, there was more NAD+ in the cytosol to push that reaction toward cytosolic oxaloacetate formation. However, in the malate-aspartate shuttle lesson, the cell wasn't producing glucose through gluconeogenesis, it was breaking it down through glycolysis. NADH is produced in glycolysis, and that NADH could push that malate dehydrogenase reaction toward formation of malate (from oxaloacetate). It's a back and forth mechanism depending on what the cell is doing and depending on the nutrient and energy status of the cell. Hope that helps :)

[@FatimaBoud99]

@@jjmedicine Nice to this point, the question is from where is the initial source of OXA that is being converted to malate in a well-fed state (where NADH is produced by glycolysis), if this make sense!??

[@NguyenAnh-el6wi]

Only 6 years late 😭😭😭

[@desiderata6997]

Honestly it is quite amazing that all because cells can't transport NADH this whole cycle of enzymes and antiporters is required.

[@fannyalbi9040]

to reduce wastage?