Pentose Phosphate Pathway - Regulation, Purpose and Importance in Human Health

[@ZahdShah]

Brief summary: PPP drives the formation of reducing agent, NADPH (used in fatty acid synthesis), and pentose sugars which are used for glycolysis and nucleic acid synthesis. Glucose-6-phosphate, catalysed by enzyme glucose-6-phosphate dehydrogenase, reduces NADP+ into NADPH. The final net result of this oxidative branch pathway is ribulose-5-phosphate and 2 NADPH molecules. Ribulose-5-phosphate can get converted into xylulose-5-phosphate which is further converted into fructose-6-phosphate. Fructose-6-phosphate is utilised in glycolysis where glucose is broken down into pyruvate to generate ATP. Ribose-5-phosphate is also used for the production of PRPP which determines pyramidine and purine nucleotide synthesis. This process mainly occurs in the liver and adipose tissues where NADPH can be utilised to donate electrons required for fatty acid synthesis. PPP is regulated by the activity of glucose-6-phosphate dehydrogenase where NADPH can allosterically inhibit its activity at high concentrations.

[@vincel.a5034]

not a medicine student but a biotechnology student and wow bro you always save me in the last minute. you're heavenly sent 👌

[@phsal5182]

I think it would be much easier to follow along if you also presented the chemical structures of the starting materials, intermediates and products. I think this would help with understanding, vs just cramming. Thank you for your videos.

[@fwiomb]

thanks! relating the mechanism to its purpose in the bigger picture is really helpful.

[@jonen9494]

This makes biochem so much more bearable. Thanks!

[@ivanarepic6057]

hopefully ill feel the same one day

[@marthabenson7629]

This makes biochemistry much easier to understand.

[@suza.5306]

Amazing video. Clear, concise, and easy to understand. Thank you!

[@brycekworth]

Beautifully concise and informative.

[@tamemomar5724]

You're a legend man. Thanks a lot

[@lindav1189]

I have Mediterranean variant; I have almost no g6pd. Every time I have surgery, I go into hemolytic anemia. It is X recessive, but due to lyonization, someone like I, can be very fragile and react with the slightest oxidative stressor. I was just in the hospital requiring transfusions because I pet a dog that had just gotten the flea and tick ointment administered on their neck.

[@chiadchiadi4733]

You're the best. Thank you, very easy to understand.

[@ssanvee8340]

Absolutely love your way of teaching!!❤❤

[@kennedyotieno9440]

Thanks so Much ...you saved My day sir

[@yasirmohammedali]

Thank you ... Have a great day

[@playerfromwest1561]

Saved my night god bless... it was soooo helpfull

[@anuoluwapojojo7306]

You did justice to this video. Thank you so much!

[@mapa9512]

Very interesting and understanding. Thank you!

[@suvidhijain8219]

This really helped me with my class 11th finale exams thank u 😁

[@anastasjam5561]

Thanks so much for your videos! It's really helpful to have as an extra resource.

[@Kay-wk6lt]

Thank you for this ❤️🤍

[@JasonLeon-baybeeee]

Thank you bro. Very helpful!

[@salauddinaiube1810]

thanks you.very informative class.

[@pankajkalita3725]

Nice explaination.Can you tell me by which enzyme Glucono -1,5- lactone 6P was converted into 6- phosphogluconate ?

[@JackeelG]

Lactonase

[@GpCyc1]

@@JackeelG more precisely 6-Phosphogluconolactonase

[@wallmethod]

Hahaha From G-6-PO4 (g6pd) - 6phophogluconolactone (GLUCONOLACTONE HYDROLASE) - 6phosphogluconate (6phosphogluconate dehydrogenase) - Ribulose-5-PO4........

[@ryandiaz2096]

Thank you JJ for all your amazing videos!! It would be great if you could do a lesson on the areas of the brain that lack a blood-brain barrier (I think circumventricular organs.. hypothalamus, etc.). A lot of people I ask at my university do not know much about the areas of the brain that lack a BBB and their physiological functions. I would love to learn more myself on this topic and it would be much appreciated if you were able to make a video. Thank you either way!

[@lindav1189]

Babies with high and prolonged jaundice do not have the BBB and within the first week of their lives, they can go from being born perfectly healthy to severely brain damaged. Kernicterus, sadly destroys a child. The mothers of these children say they can't even look at their baby's first days, and most have PTSD from the disaster. Women go home and THEN the jaundice hits, some doctors even downplay it. This is not part of newborn testing in most of United States.

[@35Bassell06]

Great video. Super helpful for my Biochem class, cheers and keep up the good work

[@yogayantra]

thank you so much. It is so clear.

[@d8457]

Great lecture!

[@panayiotisantoniou5095]

a question; is the reaction at which Fructose-6-Phosphate , erythrose-4-phosphte and xylulose-5-phosphate part of the cycle or it ends where you finished it?

[@panayiotisantoniou5095]

btw amazing video! You helped me alot sir

[@proteinengineering007]

all 3 pentose sugars are converted back to hexoses after non oxidative phase. 6 molecules of pentose are converted to 5 molecules of hexoses.

[@edward_finn]

thank you jj

[@deevynpeace2519]

ppp occurs in the cytosol of the cell

[@wallmethod]

Gluc-G-6-PO4-(g6pd)-6phosphogluconolactone (gluconolactone hydrolase) - 6phosphogluconate (6phosphogluconate dh) - Ribulose5PO4 (ribulose-5-PO4-3-epimerase) - xylulose-5-PO4 (transketolase) - ribose-5-PO4 Where did you got your source?

[@priyasharma-qk7hv]

Explanation is 2 good❤️

[@nisanilyagz6991]

it was helpful, thank you so much

[@thabelomaginya248]

Love the video.brief and helpful thnx

[@dikecharles9078]

Excellent

[@drswetaruparel]

Very helpful !!! Thanks a lot... 👍

[@suadomer9349]

Thank you for your effort it’s really helpful & simple✨ but why don’t you involve the remaining of the non oxidative part of the pathway Thank you for reading, and giving me the chance to comment 😊

[@zizo853]

thanks a lot

[@waterbottler8782]

Thanks!

[@katarinala]

Very helpful! Thank you.

[@vidasarbah873]

You are the best

[@lindav1189]

Those in Africa have the A- variant, which is very mild.

[@ericmakakantare3523]

helpfull for usmle

[@theclassroomdoc]

Thanks very interesting. I'm just wondering if you can explain why the supplement d-ribose which works on the PPP pathway is used to increase ATP as apposed to just glycolysis.

[@marcalanbarcinas7813]

thank you sir!

[@drgoldhealthcare]

Clinically so relevant... Thank you

[@fawwazali8169]

Are you sure that xylulose 5 phosphate can be converted to fructose 6 phosphate? i think its incorrect

[@Ashk4n.01]

U rock! thanks for the video

[@Chloejessy]

Nice but how does it prevent oxidative stress

[@rajmukhopadhyay4837]

by making glutathione that converts h202 into h2o

[@mihirpant8474]

Why is it called anabolic rather than catabolic 6 carbon glucose is converting into 5 carbon

[@ejch8456]

fantastic video, that ad in the middle killed my flow though :-/

[@dusprinter2]

If you pay for Premium you wont have ads...best investment ever ;)

[@ameerhyder3168]

Kia bt hai bhai

[@emmanuellaallotey3616]

It’s not really clear I mean the picture quality

[@GodfreyMann]

8:23: Glutathione = GLU-TA-THIONE

[@mariahlouiserelator4871]

💗💗💗

[@vishnubudda3482]

Hjk

[@krienbergproductions8844]

you are so confused on teaching- guys go to NINJA NERD instead

[@marthabenson7629]

This makes biochemistry much easier to understand.