Fluoroquinolones | 2nd vs 3rd vs 4th Generation | Targets, Mechanism of Action

[@jjmedicine]

Hey everyone - JJ, here once again! Thanks for all the views and comments on this video! If you haven't already please like this video if you liked it! And if you haven't already, please subscribe to this channel for more lessons like this one and to help support this channel. I really appreciate all of your support :) Check out more pharmacology lessons in the pharmacology playlist: kzbin.info/aero/PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR If you want to learn Medical Terminology (very helpful for science & medicine), please check out my lessons on that topic (my most popular lesson series): kzbin.info/www/bejne/ZmW6mWV7btSBq8k I know I haven't been the best at responding in the past, but I'm trying my best to respond to most comments now, so if you have any please leave your comment below. Take care, and keep in touch! JJ

[@westfield90]

Dad has pneumonia and they put him on 5 days of amoxicillin and azitromycin but that didn’t fully stop the fever and the infection came raging back. Now they started 10 day of levofloxacin and I’m praying this works. It’s really knocked him hard.

[@westfield90]

Update: The Levofloxacin seems to have worked well. The fever has stopped on day 4/10 and hasn't been there for 5 days since he finished the course.

[@westfield90]

@@rainycloud111 Thats quite a while ago now but I do remember it. It was a particularly stressful time in my life but I started getting vitiligo on the back my neck and the side of the temples. Small discolored patched that seemed to be growing in size. I actually took a Tyrosine supplement (My Dad had a health food store and I think I might have read Tyrosine was required to form Melanin) and I remember sitting under a bulb lamp for about 15 minutes close to those areas, for perhaps two weeks and sure enough the patches went back to normal. Of course I can't definitively say that is what cured it but I was very happy that it went away and hasn't been back since.

[@orenoyume9849]

I like how this channel makes a video that lists out important key points without making me feels jammed. it really helps!

[@mandyleepie12]

Don't use these drugs they are poison and ruining people's lives. 💔 Look through the comments.

[@acceptinglife6491]

your videos are amazing, too bad I only discovered them the day before my pharmacology exam

[@antoninotroisi6585]

never take it and give it search us Floxie in facebook

[@CherryDolce93]

Adverse reactions are at 7:50 - please do not ever take these drugs, I’m speaking from personal experience

[@peacefinder9557]

Enz Di Cristofaro what happened to you ??

[@bartwilson2513]

All drugs have side effects and prescribing physicians assess risk vs. harm for every patient. This is bad advice. You are telling someone with an infection that only this class of drug works (or is the only one available) not to take it? Even though the side effect of not taking it is death? I know someone who almost died because they took a baby aspirin (80mg).....should everyone never take aspirin because of my friend’s experience?

[@jintygm]

@@bartwilson2513 You really need to look into this class of drugs. Around 8 Black Box warnings from FDA !!! Only to be used in life or death situations when all others have been tried. Cipro is a failed Chemo drug. Highly toxic. Have a look on You tube at Rx PillD or on Facebook groups for Fluoroquinolone Toxicity/damage and tell the millions worldwide whose lives have been shattered that they should still have taken them. Oh that includes Doctors. Check out Dr Ghalili.

[@jerelee5809]

This is bad advice!! All drugs have adverse reactions. If their risks always outweigh the benefits, then they would be completely banned, however all physicians assess this and would give the drug if the benefits outweigh the risk Keep in mind that microbes resist antibiotics which is why there are different kinds and some are reserved.

[@hopeiilv3690]

وننزل من القرءان ماهو شفاء ورحمة للمؤمنين ولا يزيد الظالمين إلا خسارا

[@Erenmir]

Awesome video. Only one add on. Isn't the reason why we don't use moxifloxacin in UTIs the fact that it simply doesn't work? Because the elimination through kidneys is not enough? That's why it is not recommended usually.

[@bruttosporcoecattivo]

Taking fluoroquinolones it's like playing Russian roulette. Never take these kind of drugs unless it's a life or death situation.

[@qmi404]

I took them because of kidney infections. I recovered completely. My infection might come from my crown because I don't have other diseases.

[@alexisaac1554]

Yes exactly. Very dangerous

[@bruttosporcoecattivo]

@@alexisaac1554 Go try explain that to the doctors...

[@alexisaac1554]

@@bruttosporcoecattivo yeah good luck what makes me sick is that it was neglagance on there half I had a spinal injury and they suspected it to be discitis but this is where Nhs got it twisted 4 blood culture studies no cultures. One biopsy no cultures. But still sent me home with cipro and floxed me. No black box warning no telling me these are dangerous is crazy.

[@bruttosporcoecattivo]

@@alexisaac1554 Take my case : "suspected UTI". All the tests came out negative. He was sure I had no infection whatsoever, but he prescribed me a FQ, "just in case", to be sure...floxed at 30 years old, and in the best physical shape of my life.

[@anthonygreenfield123]

I also had tendonitis in my back, after just 3 pills 400 mg moxifloxacin. For an UTI

[@SW-oo2jw]

Causes ruptured tendons. Look it up!

[@ilaydamahmutoglu5942]

you arre the best, I DON'T REALLY UNDERSTAND İN CLASS BUT YOU MADE ME LEARN IT WİTH FUN!!!! thank you!!!!!

[@regevnava]

What liver issues can this meds create. Can you please specify? Thanks

[@Columbariusify]

very useful and clearly explained

[@angelrose4320]

Why ciproflaxin eye drops used in redness eye issues sometimes caused by allergy, what is the mechanism there...

[@bartwilson2513]

Ciprofloxacin is often paired with a corticosteroid to reduce the immune response. So the drops may contain both drugs and could be prescribed in the case of allergy, though there are better ways to treat allergies affecting the eyes.

[@jintygm]

Never ever take a Fluoroquinolone will a steroid or NSAID. It is a horrendous combination.

[@zachhamm3610]

@@jintygm How kind of them to combine a fluoroquinolone with a steroid, feels like both my achilles are going to rupture for the past 5 weeks. And severe peripheral neuropathy, but at least 600mg gabapentin a day stops it.

[@Phantastic_pharmacist]

Thanks for the video. M.catarrhalis is a gram positive diploccocus though

[@sarahward5974]

Really helpful thank you

[@1Bettina10]

Thank you so much for these! Helping me immensely with my pharmacology module!

[@bellesky7377]

thanks a lot for brief explanation

[@BilalAhmadkhan48]

I watch every single clip of your channel but i m sad to know that you haven't made any video for "Nitrofurans" and i missed that topic and tomorrow will be my paper 😑 BTW it's like side effect of being silent viewer 🙂

[@svenforstmann9608]

I am disabled by Fluoroquinolones (3 pills only !) since three years, sitting in a Wheelchair and unable to tolerate most medications. I am socially isolated and almost have no life thanks to fluoroquinolones.

[@gdjdvydus2269]

Sven Forstmann what happened?

[@Weesa4]

Omg that sucks, hope get better soon. But if it's possible can you elaborate?

[@karimsanda8901]

Which of them did you take ?

[@docjnsn73a]

I'm also suffering greatly from Fluoroquinolone Toxicity for the last 15 years. This is supposedly rare but the tens of thousands of people who suffer from these side effects would disagree. This doesn't include the potential link these drugs have to many different "autoimmune " diseases such as fibromyalgia, chronic fatigue syndrome, gulf war syndrome, ibs, crohn's and many others. Even worse is that most of us were prescribed these for minor infections where a safer drug would have worked

[@recusa6519]

Jeff Camsell I developed severe, sensory motor polyneuropathy after taking ciprofloxacin for a mild UTI. I now wear braces to walk and am likely going to be in a wheelchair before long. First symptom was stiffness in ankles and my reflexes disappeared. I was a runner and was very fit. This drug ruined my life. Please stop with the "science" and look at the results of prescribing a risky drug that literally kills an ant with a sledgehammer. And "some" nervous system reactions?!? You must be kidding.

[@informing_]

I have Enterococcus Faecalis prostatitis, I was given Cipro and after 7 days of it I took one dosage of Moxifloxacine, although cipro didn’t do anything when Moxi kicked in after 1-2 hours of taking I had nausea, then I stood up and I was fainting until I couldn’t see anything and very loud ringing to my ears and from then my nervous system acts weird I nervous all the time! What did I broke I think my mood is messed up from them

[@informing_]

@@yakushimasu6316 Extremely dangerous

[@alexisaac1554]

I hate these compounds. Ruined my life adverse reaction is rough as heck but I had discitis I only wish I had used a different antibiotic very naive around these antibiotics. And what makes it worse I was prescribed it with out having a culture via bloods, and biopsy, I'm so angrey with the neglagance of the HNS in uk.

[@lydiafridah2629]

Amazing video. Thank you!

[@prabeshkarmacharya9755]

Thanks

[@akibferdaus2001]

Can I shift from 2nd generation to 4th generation? As my infection not going away

[@kovacsmagdolnajulia]

Rokkanttá fog tenni : Polineuropatia

[@antonela478]

Very good , joyita

[@mkshorts_75p]

Mdr tb mei levofloxacin resistant ho to moxifloxacin de sakte hai???

[@mkshorts_75p]

If levofloxacin resistant in mdr tb. Then can we use moxifloxacin????

[@tahasaeed299]

What type of BSC drug is ciprofloxacin??

[@ormikadubey4273]

Referred three books , none helped me this much

[@maamulahayoutube-wr65]

Very good ❤😊

[@markanthony2massaro692]

Great video like away. Thanks you very much .!!!

[@dimmacommunication]

Perfect for prostatitis with E.faecalis

[@rebbekandahuma2173]

wow, thank you so much.

[@dimmacommunication]

what if my bacteria is resistant to Levo and Cipro could Moxi be useful ?

[@acksonmunshya2696]

Thank you

[@eyeYT]

thanks very much!

[@sandywhat2429]

People with Ehlers Danlos Syndrome and connective tissue disorder CANNOT take fq's.

[@farzandalikhan5933]

Yall it caused me tendonitis in my hip and shoulder and it also caused me to have eye floaters. And it also gave me stripes marks

[@moonoom764]

dont take these!!

[@zachhamm3610]

Yup, never been so fucked up, pray I heal everybody

[@zachhamm3610]

Also the EAR DROPS DID THIS TO ME! The stupid white coats will gaslight you saying you're crazy because the FDA hasn't blackboxed ear drops (yet). They will refuse gabapentin and make you literally insane with neuropathy so severe that it feels like your hands and feet are on fire. I had to go to the street for GABAPENTIN!

[@moonoom764]

@@zachhamm3610 So sorry to hear that! is Gabapentin helping you?

[@zachhamm3610]

@@moonoom764 It stops the neuropathy, but the tendonitis is bad too unfortunately.

[@Lover9420]

If levofloxacin is resistance in mdr tb. Can i use moxifloxacin

[@SAIFALI-br3qc]

Very much helpful.....

[@Eire4life]

Here’s a bit of good info, these quinolone (if given to anyone withdrawing from benzodiazepines)antibiotics, will make the withdrawal worse as it effects the same receptors)

[@afnanm9564]

Perfeect!

[@dhanvantarihealthcare6084]

Best scientific and very useful infimetion for medical practionars

[@hopeiilv3690]

أعوذ بالله السميع العليم من الشيطان الرجيم

[@eppystein2953]

Death-medicine

[@hemmel777]

He's canadian

[@salvatore.M77]

Helpful, thank you ❤️

[@odjdksljsktaywhsjak9253]

بسم الله الرحمان الرحيم

[@lucid212]

you are great!

[@ተፈጥሮ]

Ciprofloxacin is safe for less than one year?

[@kovacsmagdolnajulia]

Egy szemtől meghalhatsz

[@adelnajjar1779]

It's not safe at all, even one pill can make you disabled for the rest of your life

[@KEire1916]

12 pills 💊 and I'm ruined

[@pizza40421]

How do you structurally distinguish a second generation from a third generation from a fourth generation quinolone?

[@C-130-Hercules]

Moxifloxacin gave me small fiber neuropathy. ☠️

[@venkybly]

Tq

[@Malath98]

😭😭😭😭😭

[@shwetadubey1546]

Sir please suject me,my urien culture report,puscell 5-6/hpf, ecoli 37*c,,I tack docter According, Moxifloxacin an surup alkasol but not efacted me,please suject me a Moxifloxacin combination to me ,my report according an my 13 year old girl child, ecolie infaction ,please🙏

[@Imanfareed1234]

Couple if mistakes in ur presentation