Krebs Cylcle Trick How to remember krebs cycle FOREVER!!

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KREBS CYCLE (called after Hans Krebs) is a part of cellular respiration. Its other names are the citric acid cycle, and the tricarboxylic acid cycle (TCA cycle).
It is the series of chemical reactions used by all aerobic organisms to generate energy. It is important to many biochemical pathways. This suggests that it was one of the earliest parts of cellular metabolism to evolve.
The Krebs cycle comes after the link reaction and provides the hydrogen and electrons needed for the electron transport chain. It takes place inside mitochondria.
The TCA cycle plays a central role in the breakdown, or catabolism, of organic fuel molecules-i.e., glucose and some other sugars, fatty acids, and some amino acids. Before these rather large molecules can enter the TCA cycle they must be degraded into a two-carbon compound called acetyl coenzyme A (acetyl CoA). Once fed into the TCA cycle, acetyl CoA is converted into carbon dioxide and energy.
The TCA cycle consists of eight steps catalyzed by eight different enzymes (see Figure). The cycle is initiated when acetyl CoA reacts with the compound oxaloacetate to form citrate and to release coenzyme A (CoA-SH). Then, in a succession of reactions, (2) citrate is rearranged to form isocitrate; isocitrate loses a molecule of carbon dioxide and then undergoes oxidation to form alpha-ketoglutarate; alpha-ketoglutarate loses a molecule of carbon dioxide and is oxidized to form succinyl CoA; succinyl CoA is enzymatically converted to succinate; succinate is oxidized to fumarate; fumarate is hydrated to produce malate; and, to end the cycle, malate is oxidized to oxaloacetate. Each complete turn of the cycle results in the regeneration of oxaloacetate and the formation of two molecules of carbon dioxide.
Energy is produced in a number of steps in this cycle of reactions. In step 5, one molecule of adenosine triphosphate (ATP), the molecule that powers most cellular functions, is produced. Most of the energy obtained from the TCA cycle, however, is captured by the compounds nicotinamide adenine dinucleotide (NAD+) and flavin adenine dinucleotide (FAD) and converted later to ATP. Energy transfers occur through the relay of electrons from one substance to another, a process carried out through the chemical reactions known as oxidation and reduction, or redox reactions. (Oxidation involves the loss of electrons from a substance and reduction the addition of electrons.) For each turn of the TCA cycle, three molecules of NAD+ are reduced to NADH and one molecule of FAD is reduced to FADH2. These molecules then transfer their energy to the electron transport chain, a pathway that is part of the third stage of cellular respiration. The electron transport chain in turn releases energy so that it can be converted to ATP through the process of oxidative phosphorylation.
The German-born British biochemist Sir Hans Adolf Krebs proposed this cycle, which he called the citric acid cycle, in 1937. For his work he received the 1953 Nobel Prize in Physiology or Medicine. Although Krebs elucidated most of the reactions in this pathway, there were some gaps in his design. The discovery of coenzyme A in 1945 by Fritz Lipmann and Nathan Kaplan allowed researchers to work out the cycle of reactions as it is known today.

[@AstroDeeptej]

i missed my lectures and everybody said that i will never understand krebs cycle and then i found this video and now i know more than them...

[@ananyaghosh3339]

This same thing happened with me and my teacher refused to explain it to me 😢

[@k2c3po01]

​@@ananyaghosh3339what a useless teacher

[@dohahassan3501]

Ikr? Lol

[@Medicosicknowledge]

Acha Batana zra phir citrate into isocitrate Sirf arrangements change huyi toh CO2 kahan sa bni NAD kahan sa aya ????????

[@laibakhan4102]

​@@MedicosicknowledgeIs step ma CO2 release ni hogi Next step ma jab isocitrate a-ketoglutarate ma change hoga tab C02 release hogi or NADH b Is step ma 6C compound (isocotrate) 5C compond ma change huva ha is liya 1 carbon as CO2 release ho gi or jo electrons release ho gay unhay NAD+ accept kar lay ga or NADH ma chnage ho jay ga Hope this helps

[@heatherstone333]

I've ditched all my lecture notes as they make no sense, my tutors at University do not know how to teach things in a way I can understand. This KZbin channel is an absolute Godsend, whoever creates the content for this channel is a genius!! Thankyou so much for helping me through my Biomed degree!!

[@MEDSimplified]

Thank you for ur kind words. Glad u liked the channel 😍😍

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Same to you. I don't understand anything from my University class lecture. We call our teacher "Robot Sir", because nobody understand his lesson.

[@ladydee245]

This was me for months!! I even hated the fact that I spent money on my textbook coz I rarely used it

[@kajendrannone2437]

Really

[@michaeladenning2706]

7 minutes of your video explained this better than a textbook, a PowerPoint, and a 90 min lecture on the subject. Thank you SO much!

[@samuelleingang9121]

good stuff! Also note: if you compare the two mnemonics side-by-side and skip Aconitase, every enzyme lines up with the intermediate it is named for. C | S : Citrate Synthase _ | A : Aconitase I | D, : Isocitrate Dehydrogenase K | D : alpha-Ketoglutarate Dehydrogenase S | S : Succinyl CoA Synthase S | D : Succinate Dehydrogenase F | F : Fumarase M, | D! : Malate Dehydrogenase O? | _ :

[@magedgeorge8406]

I changed the second one to "SAD Devil Sipping Down Five Drinks" made more sense to combine first 3 letters together. Thanks for the video !!

[@bettinalasavio4627]

I've spent the last 2 hours watching lectures trying to understand what you just said in 5 minutes. Thank you for your videos!!

[@ashleycruz1126]

I was struggling for the longest time to understand the Krebs cycle and this video just made it all crystal clear. Thank you!!

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“Can I Keep Selling Substances For Money Officer” helped me totally answer a question on a test today! 👍🏻 thanks!

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Wtf

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I have a test this morning, Krebs cycle has been a big thing to me but you made it easy You saved me, thank you🙏

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People think am a genius since i started watching this channel videos...wait am a genius thanks to medsimlified . i no longer have to read big books to grasp one point all it takes is five minutes. to become a genius. thanks a lot

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[@MEDSimplified]

Thankkkk u so much for appreciating 😉😉😉😉❤️

[@tremeramcbean3719]

I have an exam in 6 days and so far nothing has helped me. Thank you so much for making this vid, you are a life saver!

[@sherylmccoy8884]

The use of mnemonic aids is very helpful. Dr. Krebs has always been one of my Science heroes. I'll recommend your video to students. Thanks.

[@CianiaKim]

I'm learning this right now to prepare for my PCAT and it looked terrifying at first but because of you MEDSimplified I feel like I can memorize it. Thank you and God bless please continue to help future students ♥

[@veronaodhiambo6336]

watched this video for my IB exams 2 years ago now I'm back from my biochem lectures and you just never seem to fail in explaining this so simply!!!!

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Thaaank youu soooooo much Sir... Yesterday was my exam and I was so stressed but for you I have written my exam well 😄.. I am fully satisfied.. thaaank youu

[@salonisaini1577]

Hey! you are really amazing at teaching . I've watched your videos and I know it is really difficult to edit the videos in such a way that people understand . I've tried to make education​ videos but they are not up to the mark . you are my inspiration and I watch your videos to get an idea how to make people understand . just wanted to tell you . thank you so much ❤️

[@MEDSimplified]

Thankk you. Your words nd appreciation means so much to me😁

[@SummyCinTa]

The enzyme that converts succinyl-CoA to succinate is succinyl-CoA synthetase, not succinyl-CoA synthase. Synthetase means that ATP is generated

[@SumitKumar-df6po]

Being a medico I can say its the best video on yt for this topic but only for +2 students.....for higher studies....even this cycle is not complete ( cis-aconitate and succinate thiokinase absent)

[@surajmukhia9824]

Right

[@user-yp8xi1mn1f]

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brother i cant thankyou in word. you are literally god for me

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I have an exam tomorrow and you're saving my life here

[@aroob7793]

its really amazing....I have learnt it only within 15 min..God bless u..😊

[@TenzinDhesel]

Amazing! I memorized the whole thing by just watching the video once!!

[@fidelineim463]

This is so far the best video on krebs cycle, thank you very muchhh

[@MEDSimplified]

Thankk you so much for Appreciating 😅😅

[@emmankhan4711]

I've an exam this weekend and i hate biochemistry but this just saved my exam. thank you so much!!

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Thank u so much.... I was beating my head against the wall to remember it bt all in vain. Finally your video helped me to remember it in a min.... Loved it.... 😇😇😇

[@saibylapudi5817]

Sir ur explanation was awesome I'm able to understand the Krebs cycle now

[@dianamukonchimanyika2781]

Have managed to write a citric cycle today, thankyou so much for your simple teaching

[@Bioscanknowledge]

thanks for the video man did help a lot. i have my final exam tomorrow i hope i remember this

[@MEDSimplified]

You are very welcome man!

[@cheyannepatterson2210]

This video is unvelievably helpful. Thank you so much!

[@cloud8157]

OMMMGGGGGG I had metabolic biochemistry exams 2 days ago and was struggling with this cycle why this appear now in my recommendation while i needed it 2 days ago .... TALK ABOUT BAD LUCK

[@sonhalirickeelal7700]

thank you, I have a biochemistry test this Friday which I am ABSOLUTELY dreading. This video explains the Krebs cycle so well, Thank you!!!

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Saved my life. THANKYOOOOOU! 😭😭💕💕💕

[@cowieebb6638]

The tips for memorization was so helpful!

[@vetkainat]

never in my life thought kerb cycle can be easy you made it. thanks bro

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Brilliant and amazing, It enabled me to memorize them ASAP.

[@MEDSimplified]

You are most welcome. And thanks for your feedback

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I didn't understand at the time of lecture but u r awesome thank u

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[@MEDSimplified]

You are welcome 🙃🙃Thanks a lot for Appreciating 😄

[@arabmuhammad9971]

I've got a final this weekend.. Came just in time 😄

[@MEDSimplified]

I am glad i was able to help!

[@obengfamily2213]

A million thanks to you! I feel I know something about the kreb-cycle

[@mariekit6560]

Yesss hopefully it'll help me on my biochem oral exams!

[@kimnwife]

Oh my goodness! You are amazing! This was the BEST way to remember~ and study for my exam! Thank you so much!! I have watched so many- why couldn't I have watched this first!! Thank you!!

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The best video to understand Krebs cycle Everrrr...Thankyou

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Brilliant! Thank you so much for taking the time to create this useful content!

[@cynthiaholland262]

OMG, learning the Kreb's cycle was so easi with this video and the one before. Thank you!!!

[@matthburdett]

I just started my MSc and we're first covering the basic principles of biology, I saw the Krebs cycle and immediately came here for a recap. Text books always complicate key concepts!

[@maryshula1398]

wow I have never watched any video which is this good .. big ups to you guys🎉🤗

[@kavithamuthukumar8540]

thank you so much for the video...now im able to remember krebs cycle easily........life saver video

[@geraldeen]

Very helpful. Very well explained. I just realised that I can actually learn Kreb's cycle. I had already given up Thank you so much 🥰

[@thenqrty_]

DUDE THANK YOU!!! I had a graded recitaiton nad this made it alot easier

[@pg_chavan]

Today i came to know that ki tallent kis kis roop me nazar aati hain.apka talent is video ne batadiya insallah what a explaination

[@devvyness2235]

You saved me in my Biochem exam. Thankies !!

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Your effort is very commendable, i loved the way you explained it. I am sorry that I am not able to support you right now but I will try to find a way for supporting you and donate as much as I can.

[@krishnapranami4983]

I have test in tomorrow thak uh so much sir agar apka video nai dekhti toh mai toh yeh que skip krne wali thi pr aab ache se ata he ✨💯🤟

[@tta7773]

This just saved me so much time. Thank you!!!

[@souravghosh7551]

Bro this is a pure hack thank you so much for this.. ❤️

[@nidashoaib4968]

Life saving lecture ❤️❤️❤️

[@AnkitKumar-fl9oi]

Kai Dino se Mai ese padh raha tha pr yaad nahi ho raha tha, ab Sala poora samajh mein aa gaya, very very thanks sir ji

[@asmashah8244]

loved the methodology nd great concepts.....keep it up😁.....I m being helped by this channel💞Thanks

[@drmohamedisak1419]

Thank u very much may Allah bless u i was worry for my presentation that about krebcycle but when i watch this video everything become well nd i understand well Thnk u Dr #Al-hayat medical university for Somalia - Mogadishu

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This is very very very helpful for me to cram for my exams in one night

[@mokoiasavage4507]

Frrrr XDD

[@cuzuvmcvoy]

I just discovered the CURE for my INSOMNIA! THANKS!

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Thank u sir🤝🤝 very useful video nd helpful my studies God bless u 🙌🙌🙌

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I wish all the best things for you all your videos are so helpful

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I can’t thank you enough for this video You are so smart and your video has delivered the information easily! Thanks a lot

[@katarinamurtin4504]

i wish i searched this video before it was one day before my biochemistry exam, but this an excellent lesson!

[@samyadam2586]

Thank You from the deep of my heart ..❤

[@shantinisureshkhanna2448]

Bestest video for Krebs cycle ever🎉

[@MEDSimplified]

Glad you think so!

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very helpful, u helped a med student from moi university

[@aliciacrism5345]

This video is about to help me pass a final. So thank you

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Wow, it's an atrocity that I'm only finding this now. Thank you so much!

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this video was extremely helpful ....thank you

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WHOAAAAAH. This made things simpler for me 😳. Amazing!

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you are the ultimate saviour thank you the video is so helpful ♥

[@MEDSimplified]

Awesome, I'm so glad you found it helpful! Thanks for watching!

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well explained and great teaching

[@gayatriwankhede6098]

Very well explained it & simplified properly.. Thanks😊keep it up👍

[@payalchoudhary4863]

Its very hard for me But u made very easy this cycle So thank u so much sir

[@yelnik-gn7xd]

Woahhh... Wonderful explanation❤😊

[@anickanel6051]

You literally saved my life!!

[@abhisheka4379]

Most awaited video , thanks

[@MEDSimplified]

Hey. Thanks man. Glad u liked it

[@abhisheka4379]

MEDSimplified I'm a med student , I have to say I follow ur videos for biochem cycles

[@ابتهالالترهوني-ج3ت]

That was amazing, thank you

[@pyarelal435]

Your channel is best you make us learn the actual biology! I just wish you god blesses you with all the happiness😀😉😉😉

[@syedyasmeen7802]

Thank u so much sir i have learned in just 10 mins after seeing this video this video make me a very helpful i confused a lot but now watching this video it makes me a very helpful thank u so much sir for explaining a typical answer in a easy manner tq

[@MEDSimplified]

Thanks a lot for Appreciating 😄

[@mahakhanswal]

Everything is superrr good ...the only thing that I suggest is that u should tell the structure too😅 ..right now I have to learn the structurces separately . Other then that u are doing a great job 😉😊

[@MEDSimplified]

Point noted. Thankk you for the advice 🙃

[@mike60061]

I was trying to make my own up and couldnt. This is a fantastic way, already able to draw it by memory.

[@MEDSimplified]

Glad I could help!

[@utkarshanayak1710]

Really thankful to this channel for such an innovative way to help us remember such a complicated and critical thing.😄😄😄

[@srividyaraja1454]

This video is really helpful!! Thank u 🤗

[@zebebahusan-ex6ot]

Thanks you you save my time

[@nehaamitjoshi1230]

Thank you sir u make this cycle very easy to understand 😊

[@sachinchoudhary6168]

Good work sir ji 👍👍

[@ateffayed1]

Quick Catch, the enzyme used to convert Succinyl-CoA to Succinate is not Succinyl-CoA synthase, it is technically Succinyl-CoA Synthetase. The difference being that Synthase does NOT require the use of ENERGY. Whereas, synTHEtase does which is the conversion of GDP to GTP as mentioned. Other than that dope video.

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Subscribing immediately after watching this video.. Thanks a lot sir ❤️🇧🇩

[@FlauntNardine]

Thanks a bunch, your video was really helpful ☺️.