Glomerular Filtration: Role of Afferent and Efferent Resistance on GFR

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Really enjoying theses videos Dr. Miller

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Thank you for this amazing video!

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[@ArjunKelaiya]

This was a great explanation! Thank you!

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[@rajasami1756]

i came here for afferent and efferent artrioles and i understood it [thanks]

[@salam7905]

it was so helpful.. thank you ^-^

[@denniswiltfong5326]

What happens if the afferent and the efferent arterioles constrict? There is no change to PGC, but there is a rise in RPF. Does that mean that GFR will also rise?

[@ahmadfarran-9845]

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[@daigb749]

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[@nataliomorales722]

Vídeo de alta calidad, pero me gustaría que estuviera en español

[@p.1127]

hello sir thanks for your great explanation. i have one question for this excellent video. what is the relationship between the efferent vasocontriction and reduced renal blood flow. why are we talking about reduced plasma flow in efferent arterol topic? thanks for the answer.

[@LanceMillerPhD]

That’s a good question. I decided to include renal plasma flow because the role of the efferent and afferent arterioles on glomerular filtration rate and renal blood flow are clinically relevant. As you read more about it you’ll gain an appreciation.

[@MK-cf1rm]

you explained what my teacher couldn't explain in 2 hours, thank you so much!

[@LanceMillerPhD]

Thanks.

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[@dibagabbary2066]

Perfect!

[@CarlosPires-du3ps]

If RPF is the sum of GFR + plasma in efferent capillary, won't efferent arteriole constriction cause a increase in GFR that offsets the decrease in plasma flow in efferent capillary so that RPF would be the same?

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[@md.alamgirhossain6435]

Nice...

[@marianorgr]

Resistance is the same as contraction?

[@booloob]

For all intents and purposes, yes. The vessel constricts, smaller hole = more resistance to flow

[@user-sq3ls6sj7i]

How comes that vasoconstriction and increased resistance caused reduced blood pressure?!?!?!

[@mustafasalihinci355]

masterpiece

[@mytvsayedirshadyousaf4674]

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[@arumugamkathatharan1995]

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[@amadeocelio1061]

Thank you for these amazing videos. They are very pedagogical. URGENT QUESTION: In your video, you mention that a slight increase in efferent arteriole resistance results in a decrease in RPF and an increase in GFR. If this statement is correct, why does this observation not seem to be reflected on the graph representing GFR as a function of RPF (at 4:30)? In other words, why does this graph (at 4:30) imply that a decrease in RPF must results in a decrease in GFR although a slight increase in efferent arteriole resistance has the opposite effect? Kind regards, Amadeo Celio.

[@LanceMillerPhD]

Hi Amadeo, That is a great question and observation. Renal hemodynamics can be bit tricky and confusing because of the effects of afferent arteriolar and efferent arteriolar resistance. The graph you refer to assumes that a decrease of blood pressure lead to the decrease in renal plasma flow, which would lead to a decrease in GFR and the subsequent increase in the filtration fraction. However, if blood pressure (i.e., input) were to remain normal, while there was an increase in efferent arteriolar resistance, then GFR would increase while renal plasma flow decreased. I think I will need to make a new video explaining these subtle differences. Thanks again for the comment, it was helpful. Kind regards, Dr. Miller

[@benyaminderakhshanzadeh1949]

Physiology 246