LARGEST Study of Psilocybin TO DATE!

[@Woopass90]

Started macro doses last year. It helped me stop drinking. I have not had a drink for nearly 8 months. My life has changed.

[@fenristhewolfslair3993]

Congrats!!

[@fumarate1]

Psilocybin mushrooms got rid of my continual angry thoughts and feelings that where constanly going around in head all the time.

[@RyanHellyer]

Psilocybin therapy was the most deeply positive experience of my existence. My initial dose was meant to be 10 mg, but I overshot and had 14 mg (I didn't get the test results back from my mushrooms until after the therapy session took place). I'm surprised the results they're seeing in these studies are not higher than they are, but I guess I'm biased by my own deeply positive experiences with psilocybin.

[@AK-GER]

You must be mistaken Gramms for other measurement units?

[@ObeyDeFi]

​@@AK-GERa microdose is under 1 gram... I can take .10 of a gram and can still feel it working on my brain 🧠 😅 so ye it doesn't require much man

[@ObeyDeFi]

And if your actually treating a brain trauma etc it's unfortunately not recreational 😂 You'll feel the brain being tickled by the mushrooms right? Like that tingling sensation... but there's also mental work happening, you get the feeling of mental fatigue after awhile. But that means it's working and the mushrooms are exciting new neural pathways.

[@solsticemagik]

I have partook in psilocybin, Ayahuasca and peyote. I am so glad these substances are making a "come-back". These are such a healing medicine given to us by Pachamama.

[@Neko_Shufflin]

I wonder in what kind of environments these people took the substance in. I know setting, and your own initial thoughts play a HUGE role in the experience. Psilocybin has single-handedly cured my depression personally, and now i am I much more active and ambitious person

[@NoNo-gt2bo]

What was the amount of your usual dose?

[@Neko_Shufflin]

@@NoNo-gt2bo 1 gram about every 3 weeks. Unless I feel i don't need it

[@psilocyborg4775]

If they say psilocybin had adverse effects I would be interested to see them up against traditional antidepressants. I guarantee those drugs get approved and pushed through having the same or worse adverse effects. I've suffered from depression my whole life and medication that was prescribed by my doctor had extremely bad side effects. psilocybin changed my life. Everybody within reason should have at least one experience. There is a reason it has been used for thousands of years, there is a reason it is illegal and the latter is not because its bad. It expands consciousness and certain groups do not want the public knowing this.

[@duncanelliff3903]

I would have thought the effects would have been more sustained at 10 mg. I could see psilocybin as a really great tool for people that are approaching treatment resistant depression (with anorexia or self harm), but are not at say 4+ years where TRD is robust. Like shuffling someone's deck a little bit before their pattern is even more integrated into their life. A bit more thinking around the negative, like how do we make someone's TRD less worse over a longer amount of time. My thought at least lol

[@robertbooth3699]

Clinicians need to look more closely at the setting in which these trials are held. Being in a room often strange to the "patient", surrounded by people who regard you with a medical eye... these are not optimal conditions right from the outset. That the mushrooms could have as positive affect under such circumstances says a lot by itself. Take the subject to a safe, comfortable, outdoor spot of some natural beauty. Bring along a trusted friend, as well as the therapist. Pack a picnic lunch. Spend the day. Setting is key.

[@Neuropharmacist]

A valid point. Fortunately most studies already focus on these aspects.

[@wingofafly]

It's important to have a good mindset before tripping, otherwise the trip could become very challenging.

[@pauldead7882]

Thank you for everything you do Dr. NP :)

[@Neuropharmacist]

Thank you!

[@PersonalBlob]

Dude you're videos are amazing, another guy I'd recommend is a Professor named David Nutt, who also studies the mental health effects of psilocybin, if you ever want do a collab video I'd recommend him!

[@Neuropharmacist]

Haha, indeed David is big player! I've been to his lecture a couple of times.

[@websmink]

Psilocybin helped but the effects didn’t last more than a month. And I did have psychotic episodes that required ER visits with higher does or during a tough or depressed periods, which are the norm for someone with depression. Psychedelics can be very dangerous and it is wishful thinking and dangerous ignorance to treat them as the panacea for treat,ent resistant depression. Also, what would they do for people with personality disorders and other mental disorders that can’t be treated with psychedelics?

[@slowfudgeballs9517]

Was there a therapist there for when the effects initially wear off?

[@horuslupercal9936]

Started macro-dosing twice a month for Bipolar 2. I stopped taking 2 out of 3 of my psych meds when I started taking Psilocybin. I've been going for 6 months so far. I get a boost in mood for about 5-6 days after each dose. But it hasn't affected some mania, like over spending. Overall it's been a very enjoyable experience.

[@finn7383]

I am one of those who believe in the mirical effect of mushrooms. The thing is that those are natures medicin and although we need clinical studies, those therapies are not ment to be executed in a clinical or sterile enviorment, i would love this study to include succesd rates of retreat centers. I am pretty sure the effects would be more positiv.

[@aeon--]

Thank you for this video -- very well laid out. Helped me understand the subject and the context better.

[@Neuropharmacist]

My pleasure, thank you!

[@ThatTieDyeGuy]

have you read about the study that mixed Lion's Mane Mushroom with Psilopsybin? Maybe by mixing lion's mane, which stimulates dendrite activity, with Psilocybin would lock the effect longer. In my personal studies and readings over the years, it seems the anti-depressant effect of a just subperceptual dose of LSD seems to last longer than a similar just subperceptional dose of psilopsybin Mushrooms. Another option are a specialized type of counselor that acts as a Guide through a 3.5 - 5 gram experience. Interesting stuff, I did a paper on psychedelics for my Biopsychology course in school. I have always been interest in the good that they can do for the world. Thanks for the info :D

[@happytrails699]

my son recently did some of this in Denver and has had horrible insomnia ever since. is there a link between this drug and difficulty sleeping?

[@Neuropharmacist]

Not really. Acutely most psychedelics will promote wakefulness, and may make it difficult to sleep on the day of ingestion, but I've not heard of any lasting insomnia being associated with psilocybin. There are some reports of mania or hypomania caused by these drugs, which can cause insomnia. Chronic insomnia can be a serious condition and I would seek help from medical professionals if it is disturbing daily life.

[@happytrails699]

@@Neuropharmacist one followup question. i saw that drugs like ecstasy and mdma can cause damage to serotonin in the brain, does psilocybin cause similar effects?

[@julius-sumner-miller]

@@happytrails699 how is your son doing?

[@MasculinityMindset]

Watch at 1.5x speed. Thank you for the info.

[@KittyComoMeow]

The company didn’t use fresh mushrooms, did they? They’re using a synthetic product. Right?

[@Neuropharmacist]

Correct.

[@KittyComoMeow]

@@Neuropharmacist Thank you for this channel. I learn a lot.

[@eballin45]

Fail

[@domitron]

It was 10mg versus 25mg, not 1mg versus 25mg. 1mg is well below threshold effects.

[@isolatedbutjacked7036]

Im confused because he said a “high dose” was 25 mg. To put in perspective a gram is 1000mg. How is this a high dose.

[@Neuropharmacist]

Pure psilocybin.

[@isolatedbutjacked7036]

@@Neuropharmacist …?

[@c0dy1287]

​@@isolatedbutjacked7036I think they mean 25mg of pure psilocybin not a gram of mushrooms that contain psilocybin

[@angiebear8727]

I’m for anything that could potentially help people but am really sad that this is being turned into a cure all fad. Everyone is different and people whom think this is a magic bullet without also speaking to a trained mental health professional is more than likely going to be disappointed with the long term results. Ty for the non judgmental ways you explain these topics. Very helpful

[@tenorei]

it helped me with so many issues beyond depression, i think the healing potential is much more than what is being explored right now

[@angiebear8727]

@@tenorei so glad it has helped you!❤️

[@chrisramage5581]

Yeah iv done the 🍄s all I got out of them was a better understanding of the way our planet needs our best, and how A,I, doesn't need a healthy ecology, but be sure we do ,your fight back ,eat no fish,

[@Tethysmeer]

Interesting results. Psylocibin induces complex brain reactions, therefore mixed results. It will never be a medication for everyone, but maybe administered with care can help some.

[@LouiesLog]

I feel Psilocybin is very hit and miss. I have had experiences on it that have helped with my treatment resistant depression and some made it worse.

[@jolyvincent]

Set & setting

[@candy_helpsoninstagram3878]

Get stuffs here👆look up 🔝..

[@traceykays433]

How do I get in one of these trails for mushrooms and depression.

[@edesquire1912]

Does psylosiben help with symptoms of cte? Confusion, disorientation, memory etc.. thank you

[@XOPOIIIO]

Is it safe for those who are immune to suicidal thoughts?

[@Neuropharmacist]

How do you identify people with such "immunity"?

[@XOPOIIIO]

@@Neuropharmacist Ask them.

[@Rene-uz3eb]

Well then it’s mostly placebo effect from enjoying the trip I guess, the more hype the better. Otoh shouldn’t neglect the neurogenesis growth potential, but a lot of other things and foods have that too.

[@Luca_Munz]

So is 233 people the highest study so far?

[@rhazelwood6461]

please start doing a summary in these vids please, thks!

[@Neuropharmacist]

Thanks, that's a good tip!

[@samadam-z]

Are there any studies of the psyclobin that is present before drying, and the effect of both present at administration?

[@Neuropharmacist]

Psilocybin is not an endogenously occurring chemical in the human body.

[@jindrichmatous927]

Mushrooms are magic and science is exact. I think we should keep that for magical moments. And if somebody get healed, thatt's very great. If somebody extends its wisdom, that's also very good! And lot of us gets healed exactly during "adverse events" :-) Enjoy the science :-)

[@jeremias93m]

there is so much side effects from "normal" psychiatric medicine. Compared to psylocibin it is'nt as harmful to the body than say abilify. That I can say because I have had years long treatment with abilify. And I was forced to take it and see what the side effects were from abilify. And it was the worst side effect like overheat from the sun .

[@Neuropharmacist]

I have to agree, but then again I find it difficult to compare the potential uses of psilocybin with atypical antipsychotic drug.

[@MamaZShaman]

Thank you - I was in a conference re Psilocybin and the young men related about using this and hooking people up to Ai, I said "no way!" Keep it organic (Microdose)

[@eballin45]

Regardless of if one wants to do microdosing or heroic doses, organic/natural no doubt..not pharma produced psilocybin as with THC as they tried in 90s. The natural (organic) plant/fungi is the way they're meant to be...entourage effect is real.. set and setting and knowledge can't be understated.

[@Neuropharmacist]

Thanks!

[@pg-hd9nu]

@@eballin45 I believe that in these states of altered conscience, there needs to be a connection to the passing of time and nature, like being outside to look at trees and clouds. I believe that there should be some blocking in the future to compare outdoor settings (with the freedom to return indoors) and indoors. The outdoors can keep someone tethered to reality and give someone a calm field of view compared to daunting artifical structures (in my opinion). What do you think?

[@eballin45]

@@pg-hd9nu we need the connection to nature in general no question. Beautiful amazing as is music art etc but as Terence McKenna says they are beautiful and amazing on their own. High dose in silent darkness..no outside stimuli..not smart for beginners but that is a completely different thing from microdosing to 'get through the days'. All depends on one's choice. Many if not all need the full experience(s) of it's true nature...the Ego needs. Doesn't want it but..THEY WILL GIVE YOU WHAT YOU NEED. NOT WHAT "YOU" WANT. Keep on learning more and more and in different areas. All have "pieces of the Puzzle". There is no one truth.

[@Neuropharmacist]

@@pg-hd9nu That's an interesting perspective. There's a fair bit of research on the beneficial properties of spending outdoors and looking at nature and how that changes perceived stress etc.

[@MrSchweppes]

25mg and 10mg sounds like microdosing.

[@Neuropharmacist]

It's not. Psilocybin is active at around 3-4 mg and 25 mg is a relatively high dose.

[@baarth8305]

We are speaking about psilocybin (4-PO-DMT) not psilocybin mushrooms

[@Luca_Munz]

Yeah it’s only 2.5g and 1g roughly I believe.

[@ThatTieDyeGuy]

This is the one I was talking about kzbin.info/www/bejne/paCQnpKKmMiiitU

[@Neuropharmacist]

There's no evidence for psilocybin having synergy with Lion's mane, and very little evidence for Lion's mane having any effects on dendrite function or therapeutic benefit. I don't find it impossible, but to me this looks more like a cash grab based on hype than a scientifically justified mix.

[@charlesloukas1946]

Has anyone researched rhizo secretions from them ?

[@Neuropharmacist]

Not that I'm aware, but I don't really know the field of mycology.

[@charlesloukas1946]

@@Neuropharmacist thanks for replying

[@Algoritmik]

May I ask why your face is so dull? Is this a strategy to show you are not biased about the subject or its just you?

[@Neuropharmacist]

Mostly just me, and bad presenting skills. Innate Finnish melancholia.

[@steeroth93]

You have no use for these tools if you don't know how to utilize them

[@inphinitezero5499]

poor placebo group haha

[@Neuropharmacist]

True :)

[@ekatasatya2995]

poor test animals for egoistic human research.

[@waynecsmith5145]

$TRYP

[@charlypetra191]

Run this at 1.5 speed. What about the legacy left over from years of other medications.