🌟 -- Liquid-Liquid Extraction (separation) and drying agent OFFICIAL

Liquid-liquid extraction (or #separation)
Shows how to go about performing a liquid-liquid extraction using a separating #funnel.
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“Ever tried. Ever failed. No Matter. Try again. Fail again. Fail better.”
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LIGHT-HEARTED CHEMISTRY LECTURE SERIES - FUN MAN FLIPPED CLASSROOM
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[@alyssalynursal3869]

Thank you for the video. Because of COVID we are only going in labs for 3 hrs, 4 times the entire semester. So we have to be very prepared before attending. Your video helped clear up the procedure immensely.

[@chemfunman]

You are very welcome! all the best :D

[@mamaymay8259]

I felt attacked when he went "patience, guys, patience..."'. Gravity is just too slow. Thank you so much for the video, totally soothed my anxiety about my organic chem lab.

[@thidarateksittikul3453]

Thanks, Very useful in teaching liquid-liquid extraction experiment !

[@patientsaint8913]

What is being extracted? I thought the sodium bicarbonate was being used to do the extraction from the methylene chloride...why does the methylene chloride need to be evaporated at the end?

[@jhyland87]

Very useful. Thank you for sharing!!

[@moparthykamalakaruna4695]

it is very helpful for learners,thank u for your simple and clear explanation.

[@elomon21]

Thank you for this video.

[@hadealabdalhameead2483]

Very good ,Thank you

[@aasifapeer9569]

It is a very useful video...Brilliant job...

[@devikasrivastava3245]

indeed it was very helpful

[@RajeshKumar-bf7wd]

So much thankful for serving humanity. Hope for all god bless you sir.

[@chemfunman]

bless you too!

[@myhanhta8918]

Very useful. Thank you so much

[@chemfunman]

You are most welcome! please share and like it.

[@rharishkmr]

patience guys patience.... that sounds good :)

[@WaverlyRose]

Beautifully done!

[@chemfunman]

thank you, what other videos would be good to film?

[@damilolaobayomi6228]

Your videos have been very helpful I am really grateful!!! Keep up the good work and please help us become good scientists!!!

[@chemfunman]

Thank you so much for your comment! I am glad you enjoyed, do share with your friends. You are most welcome :D

[@typhainesharon7383]

Thank you 🙏

[@chemfunman]

You’re welcome 😊

[@olgakaldou1606]

Hello!! It's the first video I have watched from you so far, so I don't really know all the videos you have made. My suggestions are: precipitation of proteins, enzyme kinetics, particle Barr or blood groups! Your videos are very helpful!! I am really grateful!!! Keep up the good work and please help us to become good scientists!!!

[@chemfunman]

keep watching the rest, thanks for your support ! hope they are beneficial and share the good news. Yes all the way! rock science.

[@shivanandwagh7949]

Really nice video....best explanation...👍👍

[@chemfunman]

thanks!

[@dragendorf2000]

Subscribed. Thank you, the videos are very helpful ❤❤

[@chemfunman]

Thanks for subbing!

[@aroopgoswami6539]

Thank you so much Sir it really helped a lot and cleared my doubts .. 😄😄

[@chemfunman]

Most welcome 😊

[@421ameysingh6]

great vid broo

[@chemfunman]

Glad you enjoyed

[@alexanderg8466]

If I want to keep going, I can use a filter flask , and a vaccum pump.. Can you explain me how?

[@micahkkipruto5336]

Thank you

[@chemfunman]

You're welcome

[@chemfunman]

SUBSCRIBE NOW to this channel now to receive more great videos! Connect with me on Facebook | facebook.com/chemfunman/ Twitter @chemfunman (twitter.com/chemfunman) Introduction music: I will let you know when this video gets 150,000 views! Stay safe! “Ever tried. Ever failed. No Matter. Try again. Fail again. Fail better.” - Samuel Beckett

[@kiteoma]

hey man! Love the video and the way you present it. I have a problem though... I'm doing this liquid liquid extraction of a carboxy benzo crown ether out of a ethanol-water solution after a reflux. The extraction is done with chloroform. The problem is, normally the carboxy benzo compound should be in the chloroform phase after extraction and evaporating the chloroform doesn't allow my crystals to form. Protocol used is this one: ''Cation Binding Properties of Crown Ether-Modified Polyet hylenimines'' on page 856. Any suggestions on how to get my crystals? This is for my thesis paper in University and time is ticking! Thanks so much

[@priyaPriya-cr8fh]

Sir what you explain is very good but sometimes video is not clear to see sir please it once

[@RoflJoker1994]

thank you so muchhhhhhhhhh !!!

[@chemfunman]

RoflJoker1994 You are most welcome, Joker.

[@chemfunman]

what other videos would be good to film?

[@RoflJoker1994]

Fun Man FUNG science/chemistry related or anything?

[@chemfunman]

chemistry techniques, science related :D For now, other suggestions (also let me know)

[@dunn6357]

Oh tnx u sooooo much Yesterday i watched this 2hours before my lab xm,which i totally forgot, i Done my extraction experiment well, thank u so much but better if u teach how to recognize layers correctly,, using a ☺☺☺☺☺☺

[@chemfunman]

glad it helped!

[@joenabarro4842]

spot on video.

[@chemfunman]

+Joe Nabarro thank you.

[@joenabarro4842]

really helped in my preparation for synthesis and extraction of 3-methylbutylacetate. I managed to attain full marks; no trace of any H2O on the IR spectrum. So its me who should be doing the thanking.

[@chemfunman]

Joe Nabarro You are most welcome! Glad to be of help.

[@chemfunman]

thank you Joe, what other videos would be good to film?

[@joenabarro4842]

I find you tube an excellent resource when preparing for chemistry undergraduate practicals. One is able to obtain a feel for the techniques when they author explains in detail their actions and techniques. In my limited experience as a chemist I've found that little adjustments to the way procedures are carried out cumulatively make a big difference. Have you done a flash column chromatography one?and nitrophenylate ester hydrolysis?

[@denizbalkanl1927]

thank you

[@chemfunman]

Most welcome, Deniz.

[@chemfunman]

what other videos would be good to make?

[@valeclarinet9618]

Thank you very much for the video, I have a question, what filter paper do you use to filter sodium sulfate?????, if I need it to not retain oils and fats, the cellulose one would not work for me, what would you advise me?

[@chemfunman]

WhatMan filter paper is good. Try decanting

[@blackirish781]

I have definitely lost compounds due to not making sure that the stopcock on my sep funnel was closed. I think everyone who does chemistry had done that st least once.

[@chemfunman]

Thanks for your support!

[@niighaag]

Can i use this method for drying leaf materials, / Steam Products from tree/plant into powder

[@chemfunman]

+Prenumerera Mig fattar du? FATTARU??BACKARÅÅ Yes please give it a try! maybe you can look into this for better instructions. kzbin.info/www/bejne/gnLOoKiqftmdd5Y on how to grind solid sample

[@purbashasaha3613]

hi..i am working on bioremediation. My bacteria has degraded a xenobiotic compound and i need to extract the degraded unknown compounds. In order to extract the unknown degraded metabolites from the broth, how do i choose the appropriate solvent for extraction?

[@chemfunman]

check polarity

[@roxannemulaudzi4296]

Hi, can I use this method to extract salicylic acid from bacteria in nutrient broth? Thank you.

[@chemfunman]

unlikely, this extraction is good for solution. However, we know that Westphal et al. applies this exact same liq-liq extraction using phenol-hot water to extract endotoxins from bacteria culture.

[@johnmichaelruiz9862]

can i use this method for isolation of lectin from legumes?

[@chemfunman]

Lectin is a big protein, I presume it might precipitate in the solvent, possibly other methods could work.

[@mishmash6991]

OK I NEED TO KNOW HOW TO TAKE OUT PHENYLEPHRINE OUT FROM NON-DROUSY ALC FREE DAYTIME COLD & FLU ORANGE FLAVOR DRINK ? ANYONE SOMEONE CAN YOU HELP ME ?

[@kuyamog372]

How to extract or ferment dry product to get the oil?

[@chemfunman]

+Genar Gundan This is an extraction protocol, we can grind the dry product using mortar and pestle, and use an organic solvent to dissolve the extract, after which, conduct the extraction procedures as shown in the video above.

[@mantiger11]

Hey so I have an unknown compound. I want to do an acid base extraction on it. I think the compound is basic because of the solubility tests I did. Do I use HCl instead of NaHCO3 when adding to separatory funnel? thank you

[@chemfunman]

+Samuel Lee if the organic compound you wish to extract is basic, first, add HCl to form a salt, so it goes into the aqueous phase. we get rid of the organic phase to eliminate organic impurities/ side-products. then, take the aqueous phase and add NaHCO3 to convert your desired compound back in to the neutral form (no charge) so that it goes into the organic phase, then collect the organic phase (so your aqueous impurities remains in the aq phase) --> rotovap solvent and TADA! see kzbin.info/www/bejne/foS9e5asbcuaa8U

[@mantiger11]

+FunMan Fung hey thanks so much for answering! Is it possible for me to use dimethyl chloride as the first step? Also instead rotovap is there another way to evaporate?

[@timecode37]

@@mantiger11 this is late, but you could vacuum distill the solvent if you don't have a rotovap or with low boiling solvents you could also just use atmospheric distillation

[@mantiger11]

@@timecode37 Haha thank you. I haven't done these experiments since I was in undergrad. Good times!

[@amirsuasana]

Hi Fun, I'm doing research on extracting peptides from fish fillet for antimicrobial study, one of the procedure require me to do acidic extraction,which I need to remove acid from the organic solvent,can I use this method? What's your opinion?

[@chemfunman]

Sounds ok to me, give it a try. Acid remove the amines in the fish. ensure that the temperature is not too high, if not it might cleave the peptide bonds.

[@amirsuasana]

I see,good info bro..thanks fun

[@cintiaduartedefreitasmilag3912]

Hi, thanks for this video. I love it, quite clear and didactic. I am an assistant professor at the Institute of Chemistry - UNESP (Brazil) and I'm intending to use it in my remote practical organic chemistry course. As there is this watermark saying that its usage is subjected to permission, I'd like to know how to get this permission. Thanks

[@chemfunman]

Hi Cintia, thank you for your interest, do you wish to provide a transcript in Portuguese while students listen in english? Do you students comprehend this video if they are being directed here? Stay well

[@cintiaduartedefreitasmilag3912]

@@chemfunman Hi! My students do not comprehend English enough to follow this video. I took a look at the automatic transcription and it is bizarre! So, I definitely wish to provide a transcript in Portuguese since the automatic one is awful. If it is ok for you I will work on it up the end of this week. Cheers

[@chemfunman]

@@cintiaduartedefreitasmilag3912 would you drop me an email? think this can be easily done! I hope you are well

[@cintiaduartedefreitasmilag3912]

@@chemfunman [e-mail]. thanks! Take care...

[@jhyland87]

Where is that opening song from!! I cant remember, driving me crazy

[@chemfunman]

sweeeetest music around! house-music , from the piano :D

[@chemfunman]

BTW you have solid taste

[@niam4768]

Sir i have a question, When can we say that the lower surface is Organic layer? because the Water Density is higher than organic solvent. Because some reference said that Organic layer is the upper part. Thank you

[@chemfunman]

use density. denser layer will be at the bottom. most organic solvents are less dense than water. a few, e.g. dichloromethane, trichloromethane are denser. so be clear!

[@niam4768]

@@chemfunman thank you very much Sir. 😊🙏

[@Crevin777]

When I try, it allways clump. Even when snowstorm effect happens, some parte of magnesium sulfate clump. Why? Is it normal or it does means that drying wasn't efective? Thanks if someboddy help me

[@chemfunman]

If they clumped together, this is an irreversible process. no matter how much more you are going to add, these remain as clumps.

[@Crevin777]

So does that mean it went wrong? Thanks for the atention!

[@Crevin777]

Or if snowstorm effect hapens It does means that It is already done, even if I add more?

[@chemfunman]

exactly! snowstorm means OK, no need to add further, proceed to filtration

[@Crevin777]

Thanks very much!

[@jomarmijares1151]

Can I ask what chemicals are used in this experiment?

[@chemfunman]

dichloromethane , water, magnesium sulfate /

[@muhammadrizkyfauzi5003]

Can we regenerate sodium sulphate to become anhydrate again? How's procedure? Thanks a lot..

[@chemfunman]

Drying over the hot plate?

[@muhammadrizkyfauzi5003]

@@chemfunman i don't know, can you explain how to make sodium sulphate anhydrate again? 🙏

[@chemfunman]

@@muhammadrizkyfauzi5003 filtration, have the damped solid, put it under the red IR lamp. Did you check out my other video on suction filtration? it is there, have a look!

[@muhammadrizkyfauzi5003]

Oke, thanks a lot..

[@saakshisaini4920]

Can't I separate these liquids with the help of pipette?

[@chemfunman]

Can’t do that because They May be miscible

[@saakshisaini4920]

@@chemfunman oh.. I don't have separating funnel since mine is biology lab but wanted to perform this experiment

[@Kamiifusen]

whats the name of the song that was playing in the beginning?

[@chemfunman]

Darude - Sandstorm

[@Kamiifusen]

Fun Man FUNG Im refering to the paino solo at the beginning. I was pretty sure it was a chinese song.

[@waltersobchak7275]

Fun Man FUNG So good to see a scientific professional with a sense of humor. You seem like great professor. Your students are lucky.

[@jhyland87]

Im wondering the same thing.. No answers though?

[@chemfunman]

house music

[@marciamarquene5753]

Du ND e amanhã às três dias quando estiver chegando no centro de um pedido de uma pergunta se ele pode ir embora e

[@CaptainBaseball]

Can you make a video how to extract ricin from castor bean ?

[@chemfunman]

CaptainBaseball hi, we would only make it if this is pertinent to our pedagogical aim. :) By the way, why do you need ricin for? It is very toxic to humans! almost untraceable poision.

[@MaverickStrokerstein]

CaptainBaseball gg wp, let's attempt to murder Obama again WOOOhoo! third time lucky!

[@RoflJoker1994]

CaptainBaseball ROOOOFL!. Breaking bad for the win!

[@sydneyhunt6681]

You keep breathing on it at end air getting in so no dry

[@chemfunman]

sharp ears

[@neobikes]

wear gloves and use funnel for solids when adding drying agent

[@chemfunman]

thank you! absolutely!

[@dannyesliger710]

Can you do a synthesis video on acetic anhydride please and thank you. Even a private video will pay for your work if works for me. NEED HELP lol

[@chemfunman]

I am sorry this is for the education in general and we may only work on the videos if this pertains the pedagogy values of our students :)

[@dannyesliger710]

I have a question since your clearly a professor. what would you recommend for safety precaution's for various alkane nitriles such as acetonitrile etc. I know of course a good fume hood but with a good fume hood would doing reactions with such alkane nitriles be enough to prevent the worse case scenario (cyanide poisoning) What else would you recommend for safety. Any tips or what you would do would be great!

[@chemfunman]

Danny Esliger Hi Danny, I am extremely regretful I just saw your reply, I hope this will still serve you good.The list is quite long (safety precaution for the chemicals aforementioned). What we normally do is to find the MSDS from the internet (many chemicals companies offer updated details) and sieve out those safety information that are pertinent to your students/ projects/ experiments. cyanide poisoning would be avoided as this is a controlled item. : safety data sheet :

[@MaverickStrokerstein]

Danny Esliger gg wp, let's make some heroin.

[@marciamarquene5753]

R viu se fala alguma coisa ER no centro de casa da tia Maria e o cafezinho da tarde para todos os dias para todos nós vamos ter fé e fé e o almoço está falando sério e amanhã às noite toda e o cafezinho tava precisando de um pedido para mim

[@marciamarquene5753]

DJ Henrique e amanhã vou ter um compromisso e amanhã vou lá pegar ET e o cafezinho tava precisando x

[@marciamarquene5753]

X brasil copa da casa e o cafezinho tava no médico amanhã vou lá pegar um pedido para mim ir lá buscar as coisas ai sim entendi agora da escola e amanhã

[@chemfunman]

Great! Glad you like it :-)

[@nagarajankuppusamy3147]

Ñ

[@alkemaoy]

how is the organic layer in the bottom and aqueous in the top ?! since, organic layer is the lighter ! it should be the upper layer !

[@chemfunman]

The organic layer for this video is Dichloromethane (specific gravity = 1.3266 g/cm3) vs water (1.00g/cm3) so the organic layer is denser and stay at the bottom. In other extraction, using solvents such as diethyl ether (0.7314g/cm3), the organic would be at the top. We should always check the density before doing extractions to prevent losses.

[@fatimahusna]

@@chemfunman if I used toluene solution and also diethyl ether, is it means that diethyl ether would be at the top??

[@chemfunman]

@@fatimahusna yes!

[@marciamarquene5753]

F da vida da casa e o almoço amanhã às três d ER hoje né se fala alguma coisa ER hoje e amanhã às noite toda vez por favor se fala alguma coisa e amanhã vou lá no r viu amor da nossa vida

[@chickletsushi2761]

You're not wearing gloves? -5 points.

[@chemfunman]

we earn it back by collaborating with students on videos. damage of 5 pts is OK. (we had a note saying we should have worn gloves, sorry!)

[@roirat04]

Tell that to the 5 technicians that I worked along in my career and their families. They all had some form of cancer and died FROM working with chlorinated solvents, one GC- MS Chemist died from brain cancer . Put on the viton gloves or don't do the organic extractions.

[@jhyland87]

Whats the music/song playing in the beginning?

[@chemfunman]

justin hyland it’s classified! Secret recipe- home made music

[@jhyland87]

@@chemfunman really? It sounds wayyy too familiar...

[@chemfunman]

@@jhyland87 haha - my apologies sorry not for disclosure :p