Liver Function Tests (LFTs) Explained Clearly by MedCram.com

Understand liver function tests (LFT) with clear illustrations from Dr. Roger Seheult of www.medcram.co...
Includes a discussion of direct (conjugated) and indirect (unconjugated) bilirubin, cholestasis, alkaline phosphatase, GGT, Gilbert's syndrome, jaundice, and more. This video on liver function tests is lecture 2 of 4 on the liver.
Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram: Medical topics explained clearly including: Asthma, COPD, Acute Renal Failure, Mechanical Ventilation, Oxygen Hemoglobin Dissociation Curve, Hypertension, Shock, Diabetic Ketoacidosis (DKA), Medical Acid Base, VQ Mismatch, Hyponatremia, Liver Function Tests, Pulmonary Function Tests (PFTs), Adrenal Gland, Hepatitis B, Liver Cancer, Pneumonia Treatment, and many others. New topics are often added weekly- please subscribe to help support MedCram and become notified when new videos have been uploaded.
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Recommended Audience: Health care professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NDBE, RN, RT, MD, DO, PA, NP school and board examinations.
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Produced by Kyle Allred PA-C
Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your health care provider.

[@Medcram]

See the whole series at www.medcram.com along with other top quality videos including reviews in pulmonary, cardiology, infectious disease, and hematology!

[@infoshortsforyou]

Which is best test to confirm gilbert?

[@gomezwl]

Winner of a video, I've been looking for "foods to eat to reverse fatty liver" for a while now, and I think this has helped. Have you heard people talk about - Jeyebastian Venlena Blaster - (do a search on google ) ? Ive heard some super things about it and my colleague got great results with it.

[@Mediforce]

Best lecture I have ever seen on liver tests. I now show it to all my health care students when we study the liver. Outstanding job sir!

[@chickenmanfan4977]

As an emergency medicine PA-C, with plans to go into academia later in my career, I appreciate your videos for review of general medical knowledge. The videos are engaging and the material is very well explained. I've directed PA students of mine to your videos to help them in their studies and to help understand laboratory and physical exam findings while on their clinical rotations with me. Keep up the great work! Your videos are invaluable to me.

[@Medcram]

ChickenManFan Thank you for the great feedback- so glad to hear that you and your PA students have been helpful. We'll get some new videos up soon, and thanks again for your support

[@antoniodmack]

these are ... we must donate if we can to keep them going. ninja nerds channel is worth it too.

[@sheilabradley6530]

New NP working in hepatology and liver transplant - YOU are life saver!!!!!

[@cu99460]

You by far the best lecturer on KZbin for pathology. I love your work. Clear and accurate information. Keep it up!

[@bobbanana13]

Thanks for the video, its great and i have a clear concept on LFT now. just wanted to make some corrections. If i am wrong let me know: -gilbert syndrome is autosomal recessive (not dominant) -Extravascular hemolysis causes an increase in Indirect bilirubin. (not intravascular. intravascular causes hemoglobinemia and hemoglobinuria. extravascular hemolysis results in breakdown of the heme into unconjugated bilirubin)

[@Medcram]

+bobbanana13 You are correct that Gilbert's is autosomal recessive- thanks for catching this and an annotation has been made in the video

[@nahedomar4933]

Faisal Tamimi ج

[@arnelrodriguez6346]

+Faisal Tamimi Nice video content! Forgive me for chiming in, I am interested in your opinion. Have you heard the talk about - Millawdon Future Ticket Trick (do a search on google)? It is an awesome one off guide for teaching children to read minus the hard work. Ive heard some awesome things about it and my work buddy got great success with it.

[@Mizzdre_]

Thank you sooooo much for doing these lectures. I referred to your lectures while I was working on my NP degree. Now I am working in Gastroenterology and your lectures are really helping me to pull all of this info together! I really reallllly appreciate you for sharing your knowledge and making the subject matter understandable in a very unique way. I don't know if you will read this but thanks for all you do!

[@Medcram]

Thanks for the great feedback Andrea. Glad to hear the lectures were helpful for your NP degree and now on the job!

[@kwyatttime]

You make it so easy to understand. 11 minutes of listening and watching this video was better than an hour and a half of an egotistical lecture. I will look for more to reinforce other lectures.

[@yankydoodle10]

I totally agree with you. We had a whole semester of clinical lab medicine course. The lectures were no where near Dr. Seheult's explanation. The classes were a waste of time and left us with confusion. Only with Dr. Seheult's lecture I am able to understand the concept better.

[@CleoandCoco]

These are very helpful for me as a PA student. Videos help me understand much more than books do, so this is perfect. Nice and clear.

[@Medcram]

+Aaron Powell Glad the videos are helpful with your studies

[@harvest3070]

Outstanding! As a practicing PA, I always appreciate good review. These are wonderful. Please keep them coming!!

[@MarieCarlton]

This education is without comparison, so important. Keep going, this knowledge is key for us. Thank you

[@osamahmousa]

I have PHD of biochemistry , but ur explanation is awesome , thank u so much

[@praneethspjain1082]

biochemistry lol

[@osamahmousa]

@@praneethspjain1082 whats funny in that?

[@Onlinehelpteamdotcom]

You are a very, very good speaker. Thank you very much because, thanks to you, this has finally clicked!

[@Medcram]

HelpingU.info thanks for the feedback- glad the lecture helped things click

[@holidayharden8032]

Thanks for your dedication to the explanation of LFTs, super clear and very easy to understand!!!

[@entessarh2022]

i always find a difficulty in understanding these stuff BUT you made it easy for meee thank you so much 🙏 .. Keep it up 💪

thank you !!!! i´ve seen many medical videos but yours are the best!.Saludos desde Mexico!

[@cardician2008]

you are a hero in online medical education! thank you :D

[@jacquihocking5773]

How to heal bilirubin

[@brittanyberry7351]

Thank you so much for offering these to the public!!! I am in nursing school and if it weren't for these videos, I'd never pass my tests! I do have one request, for you to add neuro content to your channel. Specifically seizures, stroke, traumatic brain injury, spinal cord injury as well as multiple sclerosis, Huntington's disease, amytrophic lateral sclerosis, myasthenia gravis, Guillain-Barre, Bell's Palsy

[@ratboyzen]

I am a visual learner and this was perfect. Thank you.

[@Medcram]

Good to hear, thank you for the feedback

[@edelquinn3619]

Me too

[@Riverbuny]

wow I wish I'd found you earlier, what a relief, thank you so much, finally things are making sense

[@bingutiful]

Thank you so much! I am working towards FNP and you helped me a lot with clear outlined explanation!

[@Medcram]

Bing Xiao Good to hear- Thanks for the feedback

[@taxik007]

Thanks, now i understand my medical documentation from doctor :)

[@renakim7163]

thank you for making this video.. it helps me a lot on my exam tomorrow.. may I ask if you could make a lecture about the bilirubin metabolism?? please.. thank you!! more powers!

[@desleyhatfield7053]

very clear and comprehensive explanation, thank you!!

[@marissavillas7856]

thank you so much for sharing your knowledge with us !!! GOD BLESS you sir !!!

[@inculoasorata]

Great Video. Thanks. I have a question if I may. What if ALK Phos is low. What might that indicate?

[@shermsl]

I really benefited alot on liver and kidney. Please share about jaudice and lipoproteins.

[@rebeccanickerson6921]

Thanks for these lectures! Can you do one explaining the A-a gradient, especially with patients who aren't on room air. Thanks!

[@operasinger2126]

❤️ God can help. This helps. No cost. Speak quietly out loud or in normal voice "God, please make health perfect and have perfect liver. Thank you ." This prayer must be repeated throughout the day to help. www.howtocallongodforhelp.com Please share. Thank you ❤

[@shannonclark6973]

Thanks! I'm a nurse. Very helpful. My attention is not the easiest to keep, but you did! Very clear.

[@drsuessl]

Thank you so much. You make it easy to understand. I love your drawings and your voice. My GI doc does not draw as well. He explains well and is on my side. I'm at the top of the list for a new liver. 3points on Monday towards my MELD score!!!!!

[@Mrashi1975]

You made d things so easy... Thx

[@gwynethle6782]

great lecture again! please do more lecture on cardiovascular diseases such as Acute Decompensated Heart failure, systolic heart failure vs Diastolic heart failure, how the kidney works, asthma Vs COPD. Thank you very much.

[@katiefischer5474]

Isn’t Gilbert’s disease autosomal recessive?

[@hotfoot214]

Dr you are God's gift to students...thank you Sir.........

[@waleedmorsi5521]

Amazing...simple and attractive...thank you so much

[@drkaysalami]

you are a hero.. this material is didactic .. thumbs up

[@asifkhanrahime445]

Amazing Keep it up about test of biochemistry Thank you.

[@dhyannehohepa5777]

Great video, studying NP so this is completely useful

[@concienciayenergia]

Thank you for this video, I am worry becouse I have "cyst" in the liver; I have a test in the emergency room when they are looking for some apendicitis; when I when to my family dr. she said is not important. Can you explain me why I have this ( what I am eating o medicine take it to cause it) and how to fix it without surgery? I really apreciate it. thank you

[@entisarsaleh6]

it is great , thank you very much Doc for your effort.it helps too much .

[@jasonfowler2854]

What apps/devices used for the animation/presentation? I would like to know how to do this.

[@cbarthnurse]

Very good explanation!

[@itfiguresjkt]

Thanks for explaining LFT test. I am doing reserch on Liver detox, Which test can make me clear that my liver detox is working or no? Can you or anyone please help me.

[@kelseyrhae8023]

My bilirubin is high at a 2.0 they want me to come and re test in 2 weeks. Should I be worried??

[@user609]

What was the outcome of the followup? Best wishes to you.

[@geochafg]

waiting for the 2nd part! thank you!

[@_emmaxx9]

Thanks for this video I’ve just had two blood test results and it said both times I had low results but I don’t know what that means

[@Habib-um2oc]

Hello, i thought that the urine got its concentrated yellow colour from some bilirubin that passed through. Wouldn't that make urine bilirubin levels a bit high?

[@tatopiano]

Hello! is there any possible way to heal Gylbert's syndrom, will it gone if one transplant the liver...?

[@mariaanderson8823]

ANOTHER great lecture. Thank you VERY much.

[@Medcram]

Maria Anderson thank you for the feedback, glad you've found the lectures helpful

[@richarrower1]

thanks so much for your explanations extremely helpful for exams

[@yarachamaa6373]

thank you for the amazing videos, i think gilbert is recessive if I'm not mistaken just thought i'd point that out :)

[@thesheikhfurqan]

I had jaundice almost 2 years from now i went for a proper medical checkup and did every thing to cure it . I avoided oily and fatty foods. I only ate salads. I took every medicine until the tests showed Normal. But then when I repeated the test a month after it again showed bilirubin out of the normal range.This hapenned many times that year and in the end Doc. said that" you have Gilberts Syndrome...and all of this is normal for people wth GS." For now I am assuming that I have Gilberts synd. Moreover, what i realize is that the bilirubin level in my blood increases whenever i have an illness like fever or headache ,stress(during exams),during fasting (in the month of ramadhan).Now i want to know if I really have GS or not and i will be so glad if You help me in this.

[@laurentiu244]

Like your schematic explanation . Very good . Thank you

[@tototato2190]

your videos are great! please make more..

[@koizumialison]

I'd like to hear a lecture specific to PT/INR and PTT tests and function

[@vijayasenareddydendi5271]

That is the way to teach, medicine looks simple now. Thank you.

[@singanamalaharish5482]

superb sir. plz make a video of " CT head plain" interpretation

[@jamesmueller4943]

Hello, I know you can't diagnose anything, but I would really respect your opinion. My ALT is 113 (normal is 10-63) AST and ALP normal. Had an ultrasound done, came back showing a mildly enlarged spleen at 13.47cm, and my liver is showing fatty liver. It also showed bile ducts were normal. All my CBC is normal. My Total bilirubin is 3.2 (normal is 1.5), and direct being 0.3 (normal). So that means my indirect is causing my high bilirubin. LDH was actually a little low at 100 (normal was 120-250). Since hemolysis is pretty much ruled out, do you think this is a case of Gilbert's Sydrome?

[@apj171]

Do I need to fast before a liver function test? I fasted for 12 hours before a liver function test 3 weeks ago and my ALT was 57. Today I didn't fast and my ALT was 114! Is this because I didn't fast? I haven't had any alcohol, and am eating a very clean diet for the last 3 weeks.

[@umama5531]

please I want to ask my Left AST value is 19 range is 10- 50 U/L and the ALT 9(L) 10- 50 U/L what is that suppose to mean I'm Chronicaly effected which HBv and takin medication thank you

[@ducayaaneyare5240]

thanks lecture teacher lam understand and l wish next lecture

[@neknson]

Hi, Thank you very much :) Gilbert's disease is autosomal dominant >> according to devidson's

[@captainfrost1899]

my sgpt is 90 i dont drink alcohol or smoke can u please help me with this

[@adamjacob7763]

Always awaiting your great lectures =)

[@izakekelia9668]

Thank you, great lecture....

[@MedicinePearl]

Great learning videos ❤

[@doctordanbailey]

Fantastic, thanks so much!

[@anasaravanan1954]

could you please do more on CXR's? I am by myself on ICU and Some nursing homes, still having difficulties in reading. If you please do for chest CT's and abdominal CT's.

[@jonathanstriedinger9685]

I just found I got low liver function but the Dr wasn't to clear im confused can some body explained. Not the Dr on the video but the Dr who read my blood results

[@HafizahHoshni]

Thanks again for well explained video! I appreciate it. 1/9/2018 😊

[@12NFLtitles]

Medcram, I had my liver function test done last week with my annual physical. Everything came back normal except my bilirubin, total bilitubin was 1.2 (normal is up to 1.0) and direct bilirubin was 0.20(normal is up to 0.18) what would be the cause?

[@majidahmad5945]

Great lecture, thank you sir :)

[@Medcram]

majid ahmad you are welcome- thanks for the comment

[@kaylaguse5232]

thank you thank you thank you!

[@paramvaidya]

Excellent

[@livingkennedy]

Not really understanding this - if there is a blockage of the ability to excrete, why is it that the direct bili goes up? It just seems like intuitively it should be the opposite. If the liver cannot conjugate and/or excrete, then why does it go up? Seems like the unconjugated would go up.

[@richardrosales4291]

Cool 😎. Very interesting 🤔 love learning

[@firstnamelastname-xt5kn]

why am i paying for school when i have you and youtube

[@Medcram]

first name last name Thanks for the comment- glad the videos help

[@fibckf]

If there is a blockage in the intra and extra hepatic ducts, and the conjugated bilirubin is excreted through these, wouldn't there be less conjugated bilirubin floating around the bloodstream and not more? Thank you :) Also if you would ever consider getting someone (or perhaps yourself) to transcribe your lectures for subtitles, myself and the whole deaf medical community would greatly appreciate it! Thank you :)

[@sandyboodram3910]

clearly explained

[@ka5878]

love the screen colorful

[@jimyalexmerino5992]

That´s great!!! Thank you°!!

[@vcb4vcb]

all my liver enzymes are 4 times elevated than normal , i have done most of the tests under the planet -ct abdo ,fibroscan , ultrasound, gastroscopy and colonoscopy they are normal, all blood tests are normal including cholestrol ,serum studies and antibibodies test any idea whats the cause for it , i rarely drink alcohol

[@suroor7609]

vishnu babu so stop itb

[@vegeta9411]

vishnu babu stop drinking alcohol for a while dude and also junk food. You need to cleanse your liver completely. I suggest milk thistle, NAC, Green vegetables, Green tea, and drink a glass of water with Limon in the morning.

[@vijaykumarborude512]

Very helpful

[@sonalibanerjee5196]

THANK YOU

[@hanaasakr85]

عالمى :) :) كنتو فين من زمان

[@lambofgaurdian]

To day i stretched and something cracked now something in my lower chest area hurts i put some ice on it but it still hurts

[@kylehallas2011]

albert navarro go see your doctor, the internet isn't the right place to get health advice

[@Annayu2011]

Hello , what if only the bilirubin increased but not the alkaline phosphatase, its level is normal

[@dcasanova26]

It could be Gilbert's syndrome since there is no obstruction or cholestasis causing an elevated alk phos

[@saintz2k7]

Roger Seheult you are a life saver, much better than my shitty teachers!!!

[@markjuliusmalpaya5123]

Ref. range of my AST is 38 , ALT is 55 and AFP is 15. Based on the lab. test - I'm Hepatitis B e Antigen Reactive By March 28, 2015, I was scheduled for my blood test enterpretation with my doctor. Anyone can help me to understand these? really needs your help. (sorry for my bad english)

[@jorgecarrejo7562]

My ALT is 32 and my AST is 24.. But my ALP is 137.. Apparently they didn't test my GGT.. Should I be concerned about the ALP being elevated?

[@jorgecarrejo7562]

@Adrian Bailey according to lab Corp their normal ranges are 39 to 117... But I'm going to try to get my endo to order a whole new panel tomorrow when I see her... It's been 2 months and I fasted for 16 days straight.. Since the last blood work.. So I am hoping it's back down to normal..

[@NatusyaKim]

Thanks) it is clear and short)

[@TekMoliGy]

my ALT and AST came back about 3 times the upper limits but all the rest of my liver enzymes came back normal.

[@Medcram]

+nate Get that checked out with your physician ASAP.

[@cheeseman0]

thats gold

[@josephwiard6695]

My bilirubin is slightly elevated. I have early alcoholic cirrhosis its currently 1.9 can my liver heal and can i lower it?

[@user609]

How have things been over the last 10 months? Best wishes.

[@escesc14]

GOD please make more people like this :)

[@ad03dh]

Dont you mean increase in conjugated in urine.

[@shamakuma1967]

Vandenberg test hays test

[@me048]

Thank you... Amazing

[@dhananjaymishra4931]

great video thx

[@me048]

Thank you...

[@jeanettemassey8742]

Quite interesting