Loop Diuretics Made Simple!

[@hashank5595]

how do we excrete magnesium and calcium? you just said they would reabsorbed between the cells so when they do that they are no longer in the lumen?

[@fullnelsondnb]

Yes, they are no longer in the lumen of the thick ascending limb. At first, they are in the lumen, then the positive charge of the lumen from the Mg2+, Ca2+ and K+ drives passive paracellular (between cells) transport back into the blood. If there is Mg2+ left in the lumen. If there is excess Mg2+ in the lumen, it moves moves through the kidney to the distal convoluted tubule where it can be reabsorbed va an active transcellular route via the TRPM6 channel. About 10% of filtered magnesium is reabsorbed in the distal convoluted tubule by transcellular active transport.

[@Dr_Signo]

+Theodore Nelson forgot about that difference in gradient, thanks :)

[@grenkespet]

I still don't get it. if the positive lumen drive Ca back into the blood why does it cause hypocalcemia?

[@kiararae4908]

yabuda It does not cause hypocalcemia as the Calcium gets reabsorbed in the distal tubule. :)

[@arslanarslanahmed8333]

@@grenkespet loop diuretics also lose ca

[@calajoieful]

I love your videos-I learn more in 10 mins from these than in 2 hrs listening to my professor in lecture! Can you please make some about cardiac arrhythmias and the drugs for it!

[@charlesuci]

I understand that the decreased amount of K+ being released into the lumen creates a less positive environment, reducing the amount of paracellular absorption of divalent ions. However, the only source of reduced Potassium absorption we cited was through NKCC inhibition. Doesn't that mean the Potassium discrepancy is accounted for by the ions that were never absorbed through the NKCC symporter?

[@ayishaibrahim9211]

So simple. Thank you so much

[@herstory4768]

That was fantastic

[@dylanpointon8131]

Love your videos :) I just finished watching your Thiazaides made simple and it was a great video :) Thankyou for making something sound so simple P.S I have subscribed :D

[@nadege9691]

I think at 8:01 you meant to say there is an inherent excretion of Calcium...inherent reabsorption would not cause excretion of Ca leading to hypocalcemia as seen in loop diuretics.

[@hannizam7108]

Nadege Barbe yes!! there is sth wrong at 8.01 to my lecture note, mine says mg and ca2+'s transport to interstitial space is blocked via loop diuretics

[@afarmboy76]

+han nizam this took me a minute to figure out, the way he explained it. By blocking the NKCC pump, there is a relative neutralization of the charge in the lumen ***d/t the Cl not being reabsorbed***. Less positive charge, ie: a lower gradient, in the lumen decreases "push" of Ca and Mg back into the interstitium, thus causing loss of these cations along with K and Na. I think he has it correct, but correct me if I'm wrong here.

[@dinareda2177]

this kind of videos helps me alot ....... thank you

[@thelawfulsophist3539]

Thank you for the informative video. As you asked for comments: I had no problem in determining the final conclusion that the water will follow its osmotic gradient and be carried out with the lumen, but I will admit that my kids missed that conclusion as it was not "vocally highlighted". Perhaps a slight pause, ... Nevertheless, A+.

[@굴리-v1v]

One of side effects of loop diuretics is the accumulation of Na K Cl. If Na K Cl is accumulated, there will be more positive potentials in lumen compared to interstitium. Why can;t Mg and Ca get out of cells? I thought without K absorption, there will be enough positive potential in lumen.. Why there are more positive potential in interestitum as side effects of loop diuretics? I really appreciate if you could answer this question

[@terrilanet5966]

loop diuretics cause metabolic alkalosis . How does this occur? Where would increase HCO3- come from ?

[@bangsmatter4394]

I was looking for the same answer, I wasn't able to find any tutorial about Metabolic alkalosis anywhere here in this channel. I can only CONCLUDE that since Loop Diuretics only blocks the Thick Ascending Limb, it lets concentrated urine pass through the distal parts where functions are not blocked by any type of diuretics, thus, unused electrolytes needed for production of Bicarbonate concentrates on the distal areas. Please correct me if you found the answer.

[@uncle_nurse]

Thanks! I really got it now !

[@هاجرعبدالكريمقاسم-ر7ج]

Thanks so much

[@hannizam7108]

is there is sth wrong at 8.00? to my lecture note, mg and ca2+'s transport to interstitial space is blocked via loop diuretics, what doest it work for? what's the reason of toxicity?

[@ssugu2010]

han nizam Reabsorption of mg2+ and ca 2+ is decreased b/c the positive potential created by the K+ leaky channel becomes less positive. So you will get increased excretion of ca2+ and mg2+

[@hannizam7108]

thanks, passed the exam, time to forget all those now :p

[@Souloutstanding]

+han nizam hahaha i knowwww

[@nellyhoffman6194]

amazing i love youman ! :)

[@نون-ر8ط]

thank you very much < it is so informative god bless you bashar -russia

[@pettmarkranis2509]

thank you

[@penguinrobot3811]

thanks!! this really helped!

[@mohammedafif2817]

thx so much ❤

[@monaabdulaziz8431]

thanx a lot , it was helpful

[@honeydarling3563]

thnq so much

[@hebasaad8673]

Helpful

[@mohammadnaseemkhan597]

Thanks...

[@wajeehaiftkhar2306]

thnk u sooooooooooooo much.......

[@CV-tc5uq]

you are so awesome!!!!!!!!!!

[@ALIMAX20072]

+Colleen Valdez he is not said khoulod

[@nellyhoffman6194]

did i say i love you man ?

[@chelseytyler88]

Like a cleanse? Why cannot food do this?

[@shz4478]

Dude your video is full of errors. Half of your statement don't make sense. Your diagram is wrong. 1- The K+ channel is on the basolateral side not on he luminal side. 2- The Na/K ATPase doesn't play any role in this. 3- The symporter you drew on basolateral side is supposed to be Na/Cl symporter not a K/Cl transporter. 4- The Mg and Ca diffusion is blocked by the increased positive charged ions lined on the Luminal membrane - due to a block Na/K/Cl symporter - that push away double positive charged Mg and Ca. That's what Kaplan says.