Loss of function and gain of function mutation | oncogenes and tumor suppressor genes

This lecture on gene mutation explains about the loss of function and the gain of function mutation. This lecture explains the process of loss of function mutation and gain of function mutation separately and it also explains the effects of gain of function and gain of function mutation in details.
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[@Harry-mf6rq]

Decent video but not clear if this is for germline mutations or somatic mutations?

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Thanks man. Using this for exam review

[@Julia-ws3ne]

Such a great explanation! Thank you very much!

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[@LayneSadler]

Pretty sure LoF/GoF is **not** about the production level, but rather producing altogether different proteins e.g. missense variants and alternative splicing

[@olatunjizion9292]

Yeah LoF produces non enzymatic protein GoF produces inactive abnormal proteins

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[@joydevmondal7954]

Pls sir give me example of loss of function and gain of function mutation..

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Got clarity on the over expression and poor expression of cells that leading to Cancer!

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sooo helpful！you make it so clear！

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[@akritisharma9541]

sir please provide one video on suppressor mutation and it types..

[@stasiahowell4720]

please help clarify so “gain of function” in cancer studies means the cancer cells grow, replicate and take over right? and when “gain of function” used when those people spoke of it refererence to 🎉irus studies it means the lab is in fact creating stronger viruses by fertilizing them with “growth mediums” of sorts? to eventually study how to kill them, the virus which they or another lab has created? do they create cancers like that? does GOF mean same thing for both? so confusing on a side note ya think the eugenists out there are using bioengineers’ studies to get to people? guess i’ve read one too many King novels never seen so much illness ever!

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[@ishvichatterjee3454]

Sir, What are the types of gain of function mutation?? Kindly reply soon..

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Do you have a video about suppressor tRNAs?

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