Dr. Benjamin Bikman - 'Insulin vs. Ketones - The Battle for Brown Fat'

[@rosemaryfreitas7656]

As a health professional I find myself angry at the ignorance of our current dietary teachings. These have not helped anyone. I am so grateful that teachers such as Dr. Bikman are proving them wrong.

[@IvySnowFillyVideos]

Me too. I started reading Dr.Atkins books 25 years ago. Its frustrating not many Dr's talk about nutrition. I'm happy to find this content.

[@DebraRN1195]

As an ICU RN, dealing with so many Diabetic patients, I find it difficult to administer high Dextrose TPN and chasing their Blood Sugars with insulin every six hours!!

[@michaelspencer2559]

Lots of simple minded people.

[@annwestcott3752]

I agree with you so much. I have long Covid, which translates into I have cognitive challenges. But I am not stupid. So I know I have to change my diet, but from the starting point of not being able to think properly and having very little energy. I’m also autistic and find change challenging. Mainstream medicine has been unhelpful. Basically all about managing energy, and assuming I don’t know how to breathe. I’ve humored them, to make sure I wasn’t missing anything. But meanwhile, back at my body, back at the evidence, evidence is starting to mount that I, along with my fellow sufferers are more likely to end up with dementia. And I’m 61 so I don’t want to play Russian roulette with this. But even discussing a basic, evidence based change, intermittent fasting, my health supporters have become anxious, and fearful that I am being silly, getting involved in faddish diets. But they haven’t been able to help. They’ve probably spent a small fortune on painkillers, and are happy to carry on managing my symptoms in this way. Whilst sitting there saying they don’t really know what is going on in my body. So here, I am, cognitively challenged trying to work out how to get well. And I will get well. But there is enough knowledge out there for medics to be able to support patients in improving their health at relatively low cost. For someone like me this would be wonderful. But I shy away from any possible medical intervention with my diet, because I’m pretty sure they would give me the wrong information. And if I don’t sort this myself, then I’m going to cost an awful lot more in terms of drugs to maintain me as an ill person. Basically modern medicine is a broken paradigm. Hypocrites knew this, but today medics don’t.

[@sixtysense]

Me too.

[@TheKetoSurvivor]

WoW! Love this talk. My son did the "keto" diet about a year ago and turned me on to watching Dr Berg keto talks on KZbin. I started my keto journey on Dec. 8th, at 477 lbs. As of Feb. 27th (2.5 months), I'm down 50# (427) and couldn't be more ecstatic. My cravings for food are minimal and mostly psychological at this point. I've reduced intake to about 2 meals a day with little interest for more. I do one meal a day "OMAD" at least once a week. I came off my insulin (was taking U-500) within days and am now starting to wean off my blood pressure meds. I really appreciate this deeper dive you've done into the science and that you're making it public. I hope you'll be able to do a collaborative video with Dr Berg soon because I think more people would appreciate the additional evidence. This is life changing affects the person doing it and all around them. Best of luck to you as you continue your work and thank you!

[@Loribyn]

Congratulations! (and well done).

[@pamir2593]

wow , keep up the good work ,the outcome is so much sweeter than any junk food ,refined carb ,dont get emotionally attached to your food and get it out of your memories and fill in the blank slots with the social experiences you have had with your family ,friends etc instead of the food you ate or ate with them which should mean little to nothing to you.

[@StygianStyle]

Happy to hear another success story. I hope this catches on in the mainstream media and the health industry. I discovered the insulin-based approach years ago, but I wish I had known about the power of less frequent eating coupled with keto. I'm finally doing it now and I'm making progress again.

[@nancyarchibald9095]

Fantastic results! Keep going!! I'm 63, disabled, but down 46 lbs since starting 10/22/18. Doing 20/3 I.F. btw **Dr. Ken Berry M D. would likely work better with Dr. Bikmen. Dr. Berg thrives within his "king of the hill" M.O. He was a chiropractor when working in a practice.

[@MsDestinedtoReign]

Joseph Bates Dr Berg is an Awesome Doctor, Congratulations on your journey and losing so much weight, keep up the great work. It’s easier to lose weight doing Keto (LCHF) than it is on High Carb Low Fat. How’s the mental clarity, have you noticed any difference in your outlook on and attitudes? You’re making amazing progress Joseph, don’t listen to the Naysayers or the Vegan Trolls that are landing on the Keto/Carnivore videos, ignore them. As you’re doing OMAD you might be interested in Carnivore OMAD. Check it out, you’re halfway there.

[@rufussweeneymd]

Dr. Bikman was my teacher for pathophysiology at BYU. He's a wonderful lecturer; his class was life-altering. Now, I'm doing research with the professor with whom he did his post-doc. I've become a champion of this message. In fact, I've started a podcast aimed at distilling a clear picture of what the current literature has to say about nutrition for the layman. If anyone is interested in talks like this, they'll enjoy the podcast. It's called Peer-Refined Health, and the first episode will be coming out later this month.

[@kingly71]

@Willy Driscoll just watched that.. I mean I suppose its possible. But come on man, that video is a joke. At least if you require even a shred of evidence to support a claim. Its nothing but testimonials - can't take it seriously unless they bring a bit more.

[@vtshadow314]

@Willy Driscoll I may have an answer for you. It has to do with what happens to vegans who stay on that WOE for extended periods of time. One case in particular should stand out. A KZbin content provider named Freely the Banana girl(kzbin.info) LINKED ONLY FOR REFERENCE. Has gone from a healthy young woman to almost skeleton. What I believe is happening is that are surviving off of pure glucose all the while being in a state of malnutrition. I don't know the exact mechanisms. But you can see it for your self. MANY of these Vegans are eating well over 5000 calories a day, yet they are shrinking into nothing. As well as the SERIOUS deficiencies they are having. Bone breaking and rotten teeth are two that stand out. As well as serious metabolic disorders leading to Vegans always feeling like they are freezing cold. I believe the problem with fruitarians and vegans is that no matter how much fibrous plant matter they consume, they just can not get enough calories into their bodies. And they start to burn off their body fat. Hence losing masses of Fat. But what happens when the body fat is gone and you get nothing but sugar? Eventually? Multiple Organ Failure syndrome. In the short run, pancreatic failure, Diabetes, and heart disease if prolonged.And in the end? Death.

[@micahgourley7984]

awesome, thanks :)

[@kam0406]

@@vtshadow314 I think Steve Jobs was on a fruit only diet before his diagnosis of pancreatic cancer. Some theorize that was the driving force....or at least a contributing factor.

[@2367J]

film the podcast and upload it to KZbin, I don't do podcasts unless there's video

[@rstores1]

DR Bikman is an amazing presenter, objective, articulate. Not the least bit offensive or obnoxious like some. It is a pleasure to watch and listen.

[@Jchathe]

I am overweight. I’ve been on high fat, almost zero carb carnivore for the past eleven weeks and haven’t counted calories at all. I haven’t lost much weight, just a few pounds, but I’ve lost over 20 inches off bust/waist/hips/thighs. It’s weird but amazing! 😁

[@mikafoxx2717]

All that protein must be triggering muscle growth!

[@lindamcneil711]

I have watched this several times... and this lecture is one of the best lectures that describes the rudimentary mechanisms of the metabolic effect of food. Thank you for al, your heard work.

[@davidmciver9483]

The last sentence has a typo, “heard”. That is ironic because we are heard animals that this advice helps a lot.

[@-astrangerontheinternet6687]

@@davidmciver9483 And more ironic- it’s “herd” animals 😂 But your point stands. Happy day, sir

[@KatariaGujjar]

If anybody wants this in more scientific and historic detail, please watch _The Aetiology of Obesity_ by Dr. Fung. It is a 6-8 hour lecture on the same topic.

[@fabioarruda3184]

An interesting thing that crossed my mind while watching is that when we are getting fat in nature is when we hunt, and to hunt we need to run a lot, and to run a lot we cannot be heavy.

[@lucvandermeeren]

BB is a superstar. I've watched many of his presentations and he hits it out of the park each time. He is always clear and concise, witty and humble. I now understand the biochemical pathways that underlie the health benefits of a low carb diet, intermittent fasting and exercise. I have ordered his book, "Why we get sick" and can't wait for it to arrive.

[@DanSuolo]

They're making synthetic meat in Laboratories. At the same time they're killing livestock it's all part of the bill back better reset plan!

[@nancyarchibald9095]

Not sure, I may have already posted. But this KWOE has changed my life. Today, I am down a whopping -99 lbs. BP 118/68. Fasting morning BS 94. This thumbnail was me at 305lbs. Today 206...still a way to go, but I'm so grateful for the truthful science Dr. Bikmen shares with us. LCHF is practically effortless in month #10. My body prefers fat for fuel. Thank you, Thank you, Thank you!!!

[@mobiustrip1400]

Brilliant presentation, way, way ahead of its time...

[@robertchew8167]

Dr. Bikman knows this stuff so well. Love it. No notes or anything !!

[@G03t-l7n]

This explains a lot about hunter gatherers. There are two modes for human. Hunters eat meat, sleep without proper shelter, and can’t store too much fat to the point of slowing down, so it breaks up fat and waste it while making heat to provide cold resistance, and the hunts are normally more than a day’s meal, making wasting not a big problem. For gatherers who eat grains and fruit, the opposite happens so they store fat due to not always having enough food to go around and lower metabolism, until we are able to produce more than enough calories from fruits and grains.

[@drewpamon]

We've been living off carbs for so long that we think of the emergency energy source (glucose) is the normal source and the normal sources (fat and protein) are the backups. Glucose is a quick and dirty way to supply energy and to store up fat in times that fat and protein are scarce

[@lindawick455]

Exactly. Glucose from gathering when fat/protein was scarce. Body knows that we would only eat it when times are hard, so make storage fat for later use.

[@incorectulpolitic]

so why does the body spend valuable energy to convert fat ad protein into glucose, if glucose is not important?

[@mannylongoria7633]

@@incorectulpolitic I believe based on my understanding is we evolved both due to the need for Fight/Flight Mechanisms we use Glucose because its fast so we are always prepared for rapid get away or defense. The Ketones is for everyday maintenance and function. We should be always in the maintenance mode as western society especially. I can see this science working in me. I have lost over 50 lbs by following a ketogenic way of life. I started at 350 and want to get down to 230. The wasting is interesting due to the need to drink lots of water 2-3 liters per day and now thanks to this video i understand why it works.

[@axeman6560]

So when are we short of protein and fats? Most supermarkets are just sugar delivery factories.

[@tommy605]

@@incorectulpolitic It's not important to eat. The body will convert the amount it needs from protein and the body will use what it converts. But too much protein will have a negative effect.

[@biomonkeywpaullauener4813]

This is one of the best explanations for the difference between glucose and ketone sources of energy. Brilliant!

[@matthewjfreeman75]

Completely brilliant and fascinating! I've been so incredibly impressed with the humble and enthusiastic way you present your research. After watching this I'm so grateful to have a better understanding of why and how Keto works and how it relates to my own issues with diabetes and insulin resistance. Thank you!

[@Cloppa2000]

I have never believed the 'calories don't matter for fat loss' brigade.. but this has totally enlightened me!!! Absolutely brilliantly explained! 👍👍👍👍

[@justtakealook1226]

The Video that cleared up why some people cant lose weight, Thanks BB

[@burritosburritos]

For the year and a half, I've done 20-24 hr dry fasts 3-4 times a week. Also I've only taken daily cold showers. Now, I haven't totally stopped my carb in take, but I suspect the dry fasts have upregulated my mitochondrial activity and increased my brown fat. In the past when I would sleep (especially in the winter), I would curl up in my blanket all night long, especially during the winter. This has been since I was a kid. Now I find myself waking up in the night having to remove the blanket cause I feel hot. If I haven't thrown off my blanket, I'm a lot more sweaty as compared to before. The last time I did this regularly was when I was a kid. This was probably a time when I had more brown fat and wasn't the product of decades of carb intake.

[@mayracasarez9354]

This makes so much sense. It's been happening to me and I couldn't understand why, now I know because of the work Ive been putting in in my lifestyle I'm creating more of that brown fat which is helping me lose fat. 🎉

[@DorindaD]

I would love to see a video where he goes more in depth like he was saying he'd like to

Great...it helped me a lot to understand relation between keto nutrition and ice swimming...I was swimming second winter in ice waters and it improves my termoregulation by changing white fat cells to brown fat cells. But nobody could explain it like this!! (thanks to this video!!) It feels great. And this winter I also started with keto nutrition...it should help us even more with better thermoregulation which is connected with better immunity too. 👍

[@CalebO1996]

Fascinating! Very, VERY enlightening. I had a sense of sheer amazement throughout Dr. Bikman's lecture. Imagine a scenario: Spring comes in the paleolithic era and Grog the Caveman comes across a patch of delicious berries. He and his tribe gorge on them to excess, storing an abundance of white adipose tissue on their body. Autumn comes, leaves fall and the sweet fruits of nature dry up and wither away. Grog has to figure something else out. Luckily some animals are migrating south for the winter. He and his tribe snag a few to bring along as pack animals until they arrive at their new home... Little did they know they'd be some winter chow soon. Winter brings terribly cold weather. We have not used slavery and pollution to create a huge clothing industry yet so the only options to stay warm are fire (if we know how to make it) or relying on body chemistry to help. Since we haven't seen any berries in a while, our insulin sensitivity is high and ketogenesis begins. That fatty caribou didn't taste too bad either. That WAT is converted slowly to BAT as discussed and out come ketones. Not sweet smelling urine mind you (like those with major insulin insensitivity and glucose in the blood), but pee rich in ketones. Caloric waste. Some nice warmth is gained from the thermogenesis resulting from the BAT and Grog lives to see Santa Clause and ring in the New Year once more. Congrats Grog, you really know how to use your body to your advantage! Now that we have clothing, air conditioning, a strange lack of ice ages, year-round fruit and grains, among other modern comforts people couldn't live without, the body does not need to use all of its facilities to keep us comfortable and healthy..... but that's exactly what it has evolved to do.

[@k14michael]

Caleb - best explanation EVER!

[@loubob21]

A very good explanation. The elephant in the room is always that if most humans (6 billion +) started eating like this, the planet would be void of all animal life. Keep this secret to ourselves?

[@OperatorJon]

@@loubob21 There's enough fat to go around, the issue is protein. We could easily get that from insects though. But no one really wants to, I wonder why 😂

[@y.g.1313]

good tale, Caleb. One correction on clothing, though. Buying hundreds of clothing items for pure consumerism is certainly fairly modern phenomena (produced by cheap labor, yes), but the caveman Grog was smart enough to use animal skins and fur for clothing !! This should have been obvious to you. Since I was like ~9 years old, I remember from school, the posters of 'cavemen' wearing that and holding big stones and bats in their hands.

[@adamamoroso7943]

But what's missing from both your Grog the Caveman scenario and the talk is the evolutionary and/or the physiological rational for the energy waste involved in ketosis. Is the waste a feature or a bug? From an evolutionary perspective it is understood that energy must be conserved to the greatest extent possible - our survival depended on it. The entire insulin system as I understand it is based on that idea in that it directs our bodies to store the energy that is not needed in any given moment. When carbs become scarce in the winter, as you mention, or in times of food scarcity generally the body can switch into an alternative energy system where it can now use the energy that it has stored in times of plenty. It wouldn't want to waste that energy. Presumably it even takes energy to break lipids down into the various components as Dr. Bikman covered. This seems to be an inefficiency that I'd like to be able to reconcile. Does it have to do with the starvation metabolism vs ketogenic diet? In other words is the body just not able to well-regulate the available energy against what it needs to function in any given moment, given that the lipid energy is being consumed rather than harvested from the body itself? I feel like I might be answering my own question to some degree here, but it would still be nice to hear the experts address it. And in addition it still seems like a surprising inefficiency that the body did not adapt a way to store excess energy in this alternative, ketogenic energy system. Though perhaps the explanation is revealed in the fact that it is a starvation energy system. If that is the case though I'm still curious how that explanation interplays with the other aspects of this system like the brown fat Dr. Bikman is studying. Does brown fat play any role in starvation metabolism? If indeed ketosis can be thought of as 'starvation metabolism', at least evolutionarily speaking, and it explains the energy waste involved, why wouldn't the body have adapted a way to store the excess energy during those lean times, as it would have been so much more vital for survival?

[@Journeyman-Fixit]

Brilliant explanation of what I have been doing wrong all my life and how to fix it, it really hits home for me at 11:00 in this video. Thanks for the education would be an understatement - thumbs up!

[@demonazgrael]

Journeyman I

[@alphacause]

What a wonderful presentation. This is definitely one I will keep in m video playlist, and reference when someone speaks about caloric consumption being the sole determinant of weight loss and maintenance. Thank you for this.

[@barbaragonzales5944]

The concept of uncoupling is new to me and I'm a practicing physician. I knew about white vs brown fat but had no idea they can change based on the metabolic milieu.

[@FLJD427]

OUTSTANDING presentation. Just awesome.

[@craigmcintier5488]

This answered so many of my questions. Awesome talk!

[@brianchandler3346]

Thanks for putting this up. You've provided some of the best information I've found on how insulin comes into play. I now no longer need my Metformin from maintaining a strict Ketogenic lifestyle, but now I understand more about why that is.

[@kimmiller3899]

How does Metformin play into this?

[@JJMalvarez]

Excellent talk...Good for those on Keto and also for those in Intermittent fasting. A must watch for Diabetics to understand more about what's going on in their bodies.

[@drshyamvaidya]

love it.. so good to hear him, it solves many of my questions, thank you for doing this.

[@peterfaber9316]

What people are completely unaware of, (and in my opinion the scientists don't emphasize this enough), is that metabolic rate varies depending on what you eat and how often you eat. It doesn't vary a little bit, but enormous. Metabolic rate between 2 people with equal health, same weight and bodyfat percentage, on different diets of the same amount of calories, can be different as much as 50%. Fifty percent!!!!! Reducing calories just drops your metabolic rate by about the same amount of calories. Nobody seems to be aware of this. The problem is that this effect is somewhat hidden because it's not instant. At first you burn through glycogen. Glycogen stores are about 2 to 3 kg of glucose and water and they are in the muscle and liver. That's the first week of dieting. After that first week, the metabolic rate starts to drop to match the caloric intake. And it's when the real suffering starts: Feeling cold, constantly thinking about eating, living from meal to meal, grumpiness, etc. If people could only really understand these shifts in metabolic rates, they wouldn't even try to just simply cut calories. It is weird as hell. I've explained this to people and even if they say they understand, the only possible effect is that they start a low calory diet because they became aware (again) they need to lose some weight. It's like trying to convince mormons that god doesn't exist. A total waste of time.

[@spaceghost8995]

EXACTLY. That's why my days of calorie counting were nearly useless.

[@erastvandoren]

BS, metabolic rate is quite stable, variations are not greater than 10-15%.

[@jakesnowake1]

@Odd Fish funny you say we reject the bible as we are currently studying the sermon on the mount in my gospel doctrine Sunday school class and have been going through Christ's ministry all year... Also if you were unaware the speaker Benjamin Bikman is a very active member of the Church of Jesus Christ of latter day saints.

[@karinlogtenberg]

@Odd Fish Clearly you don't know anything about Mormonism, so sad....

[@TheRealMonnie]

@@jakesnowake1 actually the Bible that Mormons use is not the Bible. There are several places where words are changed. There are several ministries online to look into showing Mormonism is a cult. Jesus Christ is part of the Godhead, the Trinity, the three in one, and that's the major doctrine Mormons reject. Compare the watchtowers Bible with the KJV. Ephesians 2:8-9: "For by grace are ye saved through faith; and that not of yourselves: it is the gift of God: Not of works, lest any man should boast.". Works based salvations like Mormonism's are heretical towards the Bible. You cannot earn your way, and saying you can is prideful. Jesus paid it all. We only need to trust in him. That's what the Bible teaches.

[@nickopetra]

how long does it take to develop Brown fat in the presence of ketosis.

[@paulylah]

How long is a piece of string ?

[@jumpjet777]

@@paulylah I'm buggered if I am going to study string theory :P

[@IvySnowFillyVideos]

Are u stringing me along : - D

[@mikesmith4053]

As a new type two diabetic, and spending my career in the medical field, I couldn’t figure out why they were not testing insulin level or output. If I’m insulin resistant can you don’t know the insulin output of the pancreas how in the world would giving More insulin solve the problem.

[@Julia_Berrrlin]

because the old treatment focuses on glucose. It's also not widely known that diabetes type 2 is reversible

[@Heretical_Theology]

This is fantastic. Love LCHF diet but never heard the science behind it explained like this. Thank you!

[@ramkumar-lc1st]

Pls read his book " Why we get sick" free pdf available online!! Real eye opener about insulin resistance,, after reading it you will really make conscious choice about carbs and sugar!!

[@nikkiguerlain]

What a great lecture! Thank you!

[@jimcameron9848]

Very good video and very timely. It is concerning to me that similar video topics without any substance garner 1000s of views, while the complex and substantive videos like this one are not readily viewed. It suggest to me that there is a large role for policy on this and education generally.

[@spaceghost8995]

Because lazy people just want a quick sound bite. Most are far too stupid and/or lazy to actually dig into some numbers.

[@dannybasquez7631]

Very interesting, I would love to see a video of the Q & A portion as well.

[@armadillotoe]

I have been very strictly to pretty much keto for about 18 months. I devour information on keto, health, and weight loss. This is the 1st time I have seen an actual reason why eating so much fat is a good thing when inducing ketosis. I hate blindly following instructions, and love knowing why I should do things. More dietary fat means less insulin. This also explains when I began the keto diet, I was so hot, and minimal exertion would cause me to sweat uncontrollably. I could take a long cold shower, and before I could dry off, I was sweating again. When fat is "burned" it actually is turned into carbon dioxide, and water. If you are more rapidly burning fat than can be expelled as water and carbon dioxide, breathing and whizzing out ketones (converted fat) makes perfect sense. This is the best explanation of the ketogenic diet I have ever seen.

[@kicknadeadcat]

The insulin roller coaster is what finally messes with your pancreas. That’s why doctors have it backwards they try to control glucose when they should be to controlling insulin for type 2.

[@DorindaD]

No wonder so many people who start a keto diet feel like they are having hot flashes.

[@loubob21]

In truth he did say the heat was mostly imperceptible.

[@spaceghost8995]

I know that I typically fast for 24 hours, and then I eat about 2 pounds of meat. After that, I feel hot for about two hours.

[@cbpuzzle]

@@spaceghost8995 That much meat and it could be bacterial inflammation. Meat rotting in your gut, not digesting. Add 2 tbsp of ACV to that meal to help digest all that meat and see it the heat goes away.

[@IvySnowFillyVideos]

Geez...here I thought I've had menopause for 20 years : - D

[@mpy1234567]

thx, keep those videos coming

[@robertlaslo8951]

Ketogenic wasting probably includes perspiration as well as the other two means because my body odor changes during ketosis indicating that sweat may be another way to waste.

[@ubuu7]

Do you smell worse on keto sweat?

[@helmutgottschalk7983]

Thank you so much for sharing this information. Keto diet has changed my life for the better after 50 years of being overweight. Now I know more about what's going on in my body and can pay even more attention to what I put in it.

[@RobinJacobi]

I am thankful that you have given us the science behind the keto diet. Im finally losing the fats. I didnt count calories, however, now I do because eating proteins and maybe a little to much fat (which was measured in tablespoons) causes me to retain fat. I can only assume im extremely insulin resistant. So very thankful for this research!

[@harikrishnanchandramohan4209]

Can anyone pls tell me how to use this diet on a diabetic patient on medication. My mom has to take medication three times a day on how can she possibly fast.

[@regular-joe]

From what I understand, look into going Keto first. As her insulin resistance improves, she'll start being able to reduce her medications (under doctor's supervision!). Intermittent fasting can follow after that!

[@maiaallman4635]

Hi, I'm also diabetic. I would suggest getting a continuous glucose monitor so your mom will know her BG every 5 minutes, less chance of going into hypoglycemia. Then she has to make sure that the long acting insulin is prescribed separately to the fast acting insulin, so she can inject them separately. Initially start keeping the long acting insulin at the same level as the doctor prescribed. Inject the quick acting insulin as required in response to the BG readings you see from your 5 minute readings. The body does produce some glucose in the blood by itself from other sources. Also, before you start, buy some ketone urine strips and make sure that your mom's ketones don't go over the safe level, as that is dangerous and will require hospitalisation for Diabetic Keto Acidosis, which is very dangerous.

[@yamaha69x]

the study at 27:30 also indicates that after 3-6 months there were no significant changes between the 2 groups.

[@LTPottenger]

They lost more weight, they are talking about bloodwork

[@okritsky]

18:03 wrong reference to the original study? misprint? I can't find the original study by number given.

[@jbfitness3056]

I frigging love this presentation. Thank you Dr. Ben Bickman

[@John03140]

Another brilliant Low Carb Down Under post!

[@makalasipes9339]

John Strain wanna try it

[@TheZGALa]

Thank you for sharing this fascinating and valuable research!!

[@betterlifebroadcasting7547]

YAy! Thermo geekiness! Also.. as regards the restricted calorie vs. ad libidum groups, one group also wasn't feeling angry, controlled by outside forces and resentful. That makes a HUGE difference in whether a person is going to keep the weight off after the diet.

[@Jefferdaughter]

Interesting thought. But does that really apply to people who voluntarily signed up for a study? And were most likely compensated for their participation?

[@betterlifebroadcasting7547]

I appreciate the question! But I think it probably does. I mean, we all sign up for work and are compensated for it too, but that doesn't stop us from resenting it on occasion. And then, having been "told what to do" there's an almost inevitable bit of rebellion once a person is "free" of the restriction.

[@ArinaThomsen]

Brilliant and absolutely necessary research. Thank you, Dr. Bikman! I hope your ideas will become very widely spread in the modern medical field and among the general population.

[@frankfromupstateny3796]

Look....our ancestors ate meat when they could...and ate really anything that they could...when they weren't being eaten too. Today....we eat crap and watch TV for 8 hours a day...or sit on our asses... If we cut our carbs now...and increase our good fats...and slightly decrease our protein or nitrogen levels...we lose weight due to "wasting; pissing out ketone bodies,...and burning more "fat"...as a consequence of eating more fat. If we now know that "brown fat" can upregulate with more fat eaten...it's a "given" that we need more fat... Time to change the pyramid...again...

[@HammerheadGuitar]

Humans are the greatest predator to ever live, we chase the lions and wolves away and eat their food. Humans ate mostly animal products and plants when the hunt went wrong. You would die if you didn't eat enough animal proteins and fats in the past. Non of the grains, vegetables or fruits you eat are found in nature. Stop believing that humans were as pathetic and weak as modern humans who have sugar and plant based diets, we are the apex predator and have the bodies of carnivores.

[@loubob21]

If you were dropped into the woods to survive, the first thing you would consider for food would be animals. (Birds, Fish, small mammals etc.) Why? because you know that you could cook them and survive from the nutrients they provide. You wouldn't start eating leaves, or berries or root vegetables. You wouldn't even know if they were safe. Eating animals is safe.

[@justanothernoobe]

What an amazing presentation. For me, as a non-academic (certainly non-scientific or medical), this made complete sense and was easy to understand - the use of the slides to support / explain the findings was great (ok - I DID have to pause a few of the slides to make sure I understood the graphical correlations). I hear some recent concerns about keto diet effects on the kidneys for diabetics. I'm Type 2 - although moderating my diet so comfortably at pre-diabetic levels. Would be keen to hear if there has there been any new information since this presentation that might be relevant to diabetics.

[@Marqusdavis]

Absolutely fascinating. Thank you for the presentation.

[@paoladellabilancia5965]

I noticed that so many "carnivores" sniff very frequently while speaking - this one, Berry, Chaffee... it's very annoying. Who knows why - maybe they are just nervous.

[@michaeldillon3113]

This ties up with something I heard on a Dr Fung talk where he mentioned that nearly a hundred years ago it was discovered that diabetics ( insulin deficient !) expend about 30O kcalories a day . Incidentally I saw a documentary about brown adipose tissue on TV at least 30 years ago , so like a lot of this knowledge it has been around for years . Thank goodness these brilliant people are putting all this knowledge together and applying it in the clinical setting ( goodness knows we desperately need it ) . Great talk doctor 👍

[@iant419]

I've been listening to keto advocates for years and I've never heard about white vs brown fat! Somebody tell Thomas Delauer.

[@tonyspaniol1966]

Rusty Shackleford TD already has videos talking about brown fat.

[@myjourney3229]

This is a fantastic video. I've been getting into a ketogenic diet lately as well as doing the Wim Hof method which advises cold showers that build brown fat.

[@Unexcelled]

Wim Hof is the real deal. The science Dr. Bikman is presenting coorelates with the cold exposure. Dr. Bikman explains it extremely well. The Wim Hof method helps the body develop brown fat. The brown fat also has a positive effect on the immune system. That's just one part of what the Wim Hof method does. Concentrating on the cold while breathing similar to what a free-diver would can cause the brain to develop new pathways that can literally control automatic body functions. It's essentially a way to become a monk. I myself can now release adrenaline, or dopomine- not unlimited amounts but enough to make me twice as strong in the gym with a burst of adrenaline, or calm down from a stressful situation with a few breaths and a release of dopomine. I've barely scratched the surface having done the method for a couple of months.

[@sidmichael1158]

Link?

[@IvySnowFillyVideos]

Interesting about ur workouts. I sleep with my room temp@50f & swim in cold water from mountain snow. Im always hot.

[@liutasx]

Insulin is hormone showing, that is energy level in body. High insulin is showing that body is in energy excess and body cells don't want accept more energy e.g. carbs, fats or protein. Data shows that reducing insulin by ketogenic diet doesn't accelerate weight lose. Best way to lose weight is supervised prolonged fasting. You can try time restricting feeding.

[@ms.crystal8280]

But how do levels of ketones affect the liver?

[@cbpuzzle]

Liver creates the ketone level. It converts fat acids to ketones and puts them in the bloodstream for energy.

[@musclesmouse]

wow, this is happening in my body. I feel hotter and my wife feels the heat also. so the ketones she smells is my fat burning. this really helps me understand what is happening.

[@anewlifestirring]

Thank you for yet another clear and informative presentation. One question that remains is to understand to what point ketones themselves have an effect on the metabolic pathways and cellular inflammation and to what extent they are merely an index of the glucose shortage and the opening of the decarboxylation pathway. Do ketones have an anti-inflammatory effect or does the glucose shortage starve intracellular germs and viruses that produce inflammation? In so many ways, the valiant band of metabolic explorers you represent remind me of the feats of Livingston and Stanley discovering Africa.

[@YeshuaKingMessiah]

Its pretty well proven that ketones themselves are the key, having the effect. Dr Boz has some vids on this. Shes very much in brain healing n healed her mom of cancer.

[@g4training]

For the record babies don’t shiver because they have brown fat. They have brown fat because they don’t have muscle which is required to shiver. In other words he has it the wrong way around. Babies lose their fat as they develop muscle.

[@ИвоВасилев-щ3к]

It make sense. The organism is always trying to adapt and survive in the environment, so all carbs/sugar foods are grown in the summer time (wheat, fruits, grains, honey... etc) so the organism is trying to store more fat by consuming those type of foods to prepare for the winter time -when the food supplies are limited. In the winter when is common to not have that type of foods around, the ketones are produced. Those ketones also turn the white fat cells into brown, which produce more energy and warming the body in the cold months. We are part of the mother nature !

[@DarinHibbs1]

Looking for a video by this Dr. On thyroid issues

[@ryanjones4042]

Ketosis slows your thyroid. Ketosis mimics a permanent fasting, so you are in constant survival mode.

[@PamelaStClair-lu1fj]

@@ryanjones4042 i know you posted this a year ago but I saw this just now. That may explain why I developed hypothyroidism after doing a strict Atkins diet for a year!

[@guskale9085]

Gotta love science.

[@VegasCyclingFreak]

Wasting some energy makes sense to me... it's a byproduct of being warm blooded.

[@Tmanaz480]

Contrast that with glucose, which we have a hard time eliminating. Our kidneys try their best to get rid of excess glucose, but it's damaging to them.

[@cbpuzzle]

Navy Seals and Olympic swimmers in training burn 8000+ calories a day in cold water compared to a track athlete burning 2500+. The heat production is very calorie intensive.

[@jschultzf3]

Interesting how the endocrine theory engulfs the caloric theory - you explained this really well! I also never realized that that there are two different kinds of fat tissue: white and brown...fascinating!

[@amywilde8892]

DR. Bickman mentions pairing up with a bariatric clinic to test the patients - has that testing/study/ findings been published yet?

[@dralasays]

What a fantastic lecture.

[@IvySnowFillyVideos]

Why am I worried that they're gonna now tax the ketones we breathe out?

[@joeamrine7450]

I'm suggesting this out of ignorance, But isn't gluconeogensis very energetically inefficient? Due to the higher concentrations of glucose, glucose-6-p, glucose-1,6-bp and early substrates of glycolysis, wouldn't this make the non-standard state delta G of the steps involved in gluconeogensis very energetically costly requiring a lot of atp? So if you were to decrease carbohydrates intake, wouldn't your body need to go through a very energetically inefficient gluconeogensis to restore blood glucose concentrations, using a lot of ATP? And also the low glucose effects on hormones (insulin) that would upregulate fat burning enzymes in order to make the atp needed to fuel gluconeogensis?

[@Biohackthefat]

So Interesting and wonderful data! I love this! ❤️

[@Tienganhmrtuan]

Th presentation was quite complicated to me. Any way, Thanks for sharing your idea!

[@pavement66]

brilliant stuff. thanks for posting

[@KenZShadower]

How do you explain stalls some people experience even though in keto diet?

[@seal9454]

As you lose weight, your body's energy requirements and expenditure decreases since your fat mass is shrinking. This means that you have to gradually lower the amount of calories you are consuming. For example, an obese individual might see fast weight loss eating at 2,500 calories, rather than the 6,000 calories he/she could have been consuming on a daily basis. However, this person would eventually need to lower the calories to continue the weight loss. Weight loss stalls happen when your body burns the same amount of calories you are consuming.

[@Kurtrussell_]

Cold exposure, like having cold showers, dramatically increases the activation of brown fat in the body.

[@trejosworld]

33:02 “Eat when you’re full.” That’s all I got from this talk and I’m doing it now!

[@IvySnowFillyVideos]

Lol

[@555Trout]

Does anyone know what causes the color change in the fat?

[@TheFogskum]

Absolutely fantastic presentation!

[@pureffm]

I have 3 important questions: (1) will the body enter ketosis when food intake has less than 20g carbs and moderate protein more easily if there is an important fat intake, or will the body need to be kickstarted with important amounts of fat? (2) If the body enters ketosis just as easily without fat intake, can the body and the brain in particular use those ketones for fuel without that fat intake or does it need to be trained with actual fat consumption? (3) Are ketones produced out of own body fat excreted through urine more easily than ketones produced through fat intake? My thinking is that since people who are fasting for more than a few days have good mental clarity and energy, high fat intake is not necessary to a ketogenic diet - as long as own fat reserves are sufficient and the typical fat transported vitamins are not lacking. Is this assumption correct?

[@carrollhoagland1053]

Laurent, good analysis. The trigger is in the liver when it senses "Low Glucose" or glycogon stores in the liver - it either uses available carbs to make glucose or stores it as fat. If the carbs are not present, it then signals adipose tissue to release fats. Dr. Bikman and Mike from High Intensity Health have a "New" discussion on Hormones and metabolic feed back systems. He goes more into science in this discussion ... LOL www.70GoingOn100.com the Centenarian Diet, or maybe 128, the Hayflick limit, or if a Ray Kurzweil fan then this is a Moot Point …

[@michaelcariello6233]

Laurent Grimal here is my thinking on your question. Fasting long enough will bring on ketosis. However, at some point we will have to eat. To stay in ketosis and take in nutrition on an everyday basis it must be a higher fat diet. Fat is the only macronutrient when ingested does not provoke an insulin response. So eating a high fat diet allows you to eat everyday without the body ever coming out of ketosis. So if you plan on eating everyday and want to remain in ketosis a majority of your calories must come from fat.

[@victoribiyemi4488]

Fat does produce an insulin response when ingested, any food does , however the insulin response from fat is not of the same magnitude of that from carbs and from some extent protein

[@rogerbird5665]

I love this guy. His thinking is so clear and easy to understand. I think I'm going to subscribe to his channel, if he has one.

[@danielstapler4315]

25:12 I once did some calculations based on the mmols on a ketostix for piddling on and worked out that not many ketones in absolute terms ended up in my urine. Was I wrong? how many Kcals actually end up in your urine? Ok Here are the calculations 3 mmol/L = 17.5mg/dL = 175 mg/L = 1gram per 5.7 litres of Urine. 1 gram Ketones = 9 Kcal I guess, so nearly 6 litres of urine (over 1.5 gals) = 9 Kcal Are these calculations right or wrong?

[@elenbokhari1040]

A very informative talk! However, as a next step would be interesting to understand wider physiological effects of the ketogenetic diet, I.e. cardiovascular health, dementia and cancer. As well, if this type of diet can be used during the whole human life span or only at certain pre-diabetic states. Again, well done!

[@VaughnMalecki]

Perhaps my access body fat I'm still hanging on to isn't as unhealthy as I thought. Maybe my body doesn't want to "waste energy" so it hangs onto it and stores it quite easily. 🤔 It kinda makes sense now why people say "just stick with it" and six months later they suddenly begin to see results of more muscle tone happening.

[@testinginstruments7785]

Wonderful presentation. Very useful. Thank you.

[@Laionel76]

Does anybody research the effect of triggering glucagon release (or not releasing)?

[@rickhdee]

Fascinating! I would conjecture that the body is not just "wasting" the energy but in fact senses the surplus of stored fat in the body and is purposely burning off that excess. It is only the constant supply of glucose that inhibits this action with our Standard American Diet. I would be interested in hearing what others think, since the body does not seem to do things without rhyme or reason.

[@ilegor365]

Great talk! What I found fascinating was the graph from the David Ludwig study starting at 26:30, where the metabolic rate for the low carb high fat diet continues to rise and stay high for 4-6 hours after the meal. Are there any other studies that have built on this study by looking at meal frequency and IF over a longer time span 24-72 hours?

[@pacojavo2978]

Just watched the video and I was exactly thinking the same regarding HFLC meal metabolic reaction, and if it keeps improving if next meals are also HFLC 👍

[@benzei2003]

Really good lecture, easy to understand. Great career choice as a professor

[@lindael2]

I am going to watch this for the second time. Sent a link to my Dr. Great information.

[@elisafrye2115]

Thank you, Professor Bikman! You have explained the complex metabolic reaction of our bodies to carbohydrates, protein, and fat so clearly that I think even a fairly uninformed person can understand the role of carbohydrates and insulin in fat deposition. I am going to point out your presentation to several type 2 diabetics who think I’m nuts for controlling my type 2 Diabetes strictly through diet-a diet greatly made up of-OH HORRORS-FAT!

[@mabelheinzle2275]

Thank you Sir - this knowledge will save lives

[@cojanti]

The science is clear and intriguing - thank you. However, the term 'metabolic advantage' is highly subjective: for the vast majority of human history calories have been in short supply, so to store and not to waste energy would have been advantageous. Could it be the case that from an evolutionary perspective, ketosis was signalling a lack of calories, and the higher metabolism was pushing us to go find calories? Of course, it has it's uses today in our bubble of excess calories, but part of me really wonders if this is optimal or just a survival mechanism.

[@scotchfillet]

Ketosis is a function of low insulin, not low energy. You can have an excess of calories and still be in ketosis.

[@richsellskc]

good stuff. makes sense. working for me. eat till you are full. low carb. good fat. good, modest protein....easy as pie.

[@mthoodstyle]

I watched it once. Then sat down and watched it again this time taking NOTES. I needed to participate in order to fully absorb what he was teaching. Great stuff! Information like this helps people like me say no to carbs with a sense of purpose. No insulin thank you. I'll be eating ketones for the win. Go Chiefs!

[@vjr6939]

amazing vid, i recently read Dr Volek's research on high level endurance athletes, high carb vs low carb, and i think this accounting discrepancy came up, was actually wondering about how that worked out, guess this sort of answers it!

[@julievalentine5375]

I know there are strips to measure Ketones in the urine. How are Ketones in the breathe measured or detected?

[@PokeyMeansBusiness]

I don't think there's any easy, direct method to detecting ketones in the breath that would give you a number, but a lot of people report "keto breath" and their breath smelling bad or fruity.

[@conceptualelegance]

breathalizers , i wouldnt recommend neither of them. not even the blood tests, because ketones can be consumed or wasted. and its hard to account for where they are going. eg. you might be fueling on ketones and not excreting any, yet still in ketosis .

[@curtisbowman6199]

I know they have breath tests for measuring blood glucose levels, but they're not nearly as accurate as a blood test is. I'd assume it basically condenses your breath down into water vapor and tests that like you would urine.

[@Rodnas4]

www.ketonix.com

[@BenyaminMentchale]

Hi, I have a question regarding Keaton. Are Ketons used, as an input, to create energy, in the cell? Or Are Ketons, the output, of the energy creating process, in the cell?