Making a Dangerous Energy Drink With a Powerful Caffeine Analog

[@The_Foolish_Fool]

Home chemist nearly kills himself, he considers this a success.

[@MenkoDany]

*Curb your enthusiasm theme plays*

[@nsevv]

Yes.

[@SuperUltimateLP]

I mean.. kinda... Since there was no irregular heartbeat or similar effect, considering this was a overdose... Seems reasonably safe... Bad way to test lethal dose, I admit 😂 But now with such a result,I would happily try it my self (I'm not a chemist tho, someone with the qualifications would need to offer it 😅)

[@TopOfAllWorlds]

Just because the heart beat wasn't irregular doesn't mean there arenXt any other leathal side effects ​@@SuperUltimateLP

[@LabCoatz_Science]

@@TopOfAllWorlds True, there is always a chance that this compound is carcinogenic or produces some other form of lasting damage. Fortunately, I filmed this about six months ago, and no evidence of lasting effects have been noticed (of course, that doesn't mean it's safe). This compound is apparently found in small amounts in cocoa, so at least our bodies have some experience dealing with it!

[@fabillo522]

Great candidate episode for a collab with Chubbyemu: "A man mistakenly drank 200mg of a homemade chemical. This is what happened to his body"

[@statinskill]

I think CE is actually a licensed MD and therefore could get into major difficulties with his licensing board. It's called unethical human experimentation. There could be criminal consequences and civil liability on top of everything. Just even for how half-assed this entire experiment was built. He took 10x the intended dose FFS! If this kid called, people should simply tell him "Leave me out of this and don't ever call me about shit like this again. You absolutely should not be doing this, it could kill you or have long-term consequences". And then hangup and block the number.

[@delphicdescant]

Except it doesn't work unless he can say "☝🤓 Presenting to the emergency room"

[@TwiztedHarlequin]

@@delphicdescant Not a problem, just add yet another zero and you're sorted.

[@thog7653]

​@TwiztedHarlequin he'd be presenting to the morgue not the emergency room 💀

[@shikutoai]

@@delphicdescant Homie got an EKG administered during the peak activity - I have a sneaking suspicion he went to the emergency room.

[@zapdog_]

bro made a real life stamina potion

[@joejones9520]

please stop with the b word

[@soejrd24978]

@@joejones9520 BABABOOEY

[@zapdog_]

@@joejones9520 bazinga

[@zapdog_]

@@joejones9520 bazinga

[@Hexane630]

@@joejones9520 “Bro”?

[@Wolfgal16]

Chemist: I synthesized this edible product from completely different chemicals Chemist: *juicing lime upside down* how do I make it not spray everywhere

[@nicolashentschel847]

Yeah the upside down juicing hurt to look at

[@threestans9096]

have you seen Nilered? that kid has never had a real life. The mistakes he makes or questions he asks, or his poor cooking ability for his age is crazy. he needs to take a year break and just live as a normal human and hell be way smarter. hes the epitome of all book smarts and not a lick of street smarts/common sense.

[@joshuamiller8235]

yeah I was laughing at his cooking skills. especially when he was going over the ingredients.

[@Rockzilla1122]

​@@threestans9096I love when trogs out themselves with the whole street/book shit lol

[@p6v665]

@@threestans9096 huge projection

[@racreational]

We got caffeine 2 before GTA 6

[@Flesh_Wizard]

55 hour energy

[@KCM25NJL]

Only cuz we'll need an upgrade before GTA 6

[@nuclearmantis666]

Lol

[@Randomyoutubecommenter]

We got so many of these before GTA 6 comments before GTA 6

[@xostler]

@@Flesh_Wizardhidden gem comment

[@B_O_N_E]

As a non-chemist I can finally contribute by mentioning that you want to flip your lime so the cut part is pointing down into the lower half of the press!

[@LabCoatz_Science]

You have changed my outlook on life and cooking.

[@shnilikmw]

Blew this mans mind lol 😂

[@LokiScarletWasHere]

Damn, beat me to it by like 3 hours. Well, I'd might as well help by giving LabCoatz the reason why this is the case. The meat of the fruit is supposed to face downward, the press then inverts the fruit in the process of pressing it. This causes the press to extract almost all the juice from the fruit.

[@anticlickbait]

Oh that's why. Thank you very much. Fr.

[@aellipsis]

I had felt an irrational reaction of disgust when I saw that.

[@ckrickie]

Cant believe they made Caffeine 2

[@LabCoatz_Science]

Hope my sequel is better than Disney's...

[@JanoschNr1]

@@LabCoatz_Science Well maybe if you create a energy drink that makes you sleepy on a instant ... then you might be up to par with Disney

[@BsedMan-if6tb]

We got a caffeine sequel before GTA 6

[@McGreenBean]

@@BsedMan-if6tbat this rate we will have Caffeine 3 before GTA 6

[@harold_bryant]

Caffeine²

[@desmond-hawkins]

This feels like a video version of an Erowid trip report.

[@adeadlyfart13]

These kids nowadays have no idea how valuable Erowid was back then!

[@Mitutumuch]

good oll erowid + bluelight

[@thefarklenator4518]

Erowid is probably the reason I’m still alive today my teen years where a fucking mess

[@franciasii2435]

Erowid is the greatest preventative method of drug abuse.

[@PsychoSk8r4bg]

I used erowid as a decisive factor throughout my years of experimentation.

[@nekomakhea9440]

An energy drink that mentally stimulates without the heart palpitations, anxiety, or jitters, of normal caffeine would be a huge hit if it actually worked right. Though the fact that you didn't die doing home-made drugs is a pretty huge success in itself.

[@Zickzii]

Give green tea a try, make a lot of it or make it strong. it's quite bitter when it's strong, I wouldnt rely on sugar as a pick me up so I just drink it bitter or make a lot. 1-2 lipton bags for 1 liter of water

[@Zickzii]

Oh and don't burn it by using too hot water cus then it's really bitter heh

[@jttech44]

add 200-400mg of L-theanine to your coffee. Problem solved.

[@maestro9765]

People who get heart palpitations from caffeine probably have heart problems. And same for anxiety. I can be anxious person but caffeine doesn't change anything. People are overreacting.

[@saxomophony]

You gotta try some Yerba Mate. It’s exactly that.

[@waynebimmel6784]

Make a caffine analogue with a halflife of one hour. For when you need a boost of energy at 8 PM but still be able to sleep at 11.

[@bAc0nBoY755]

YES

[@jttech44]

Pretty sure that's just cocaine

[@lordgasman9099]

@@jttech44 can confirm, OP just needs a bag and a key.

[@wolfetteplays8894]

@@lordgasman9099 Trueeee

[@ttttttttttt2582]

what you're looking for is nicotine

[@TvshkaHumma]

Man I have been sober for 15+ years but when you took that torch to the test tube and melted the theobromine tweaker thoughts came flooding in!, thanks for keeping me on my toes!.

[@cursedaudio984]

Congratulations on over 15 years. That's true peak performance x

[@hammondj82]

Keep on keeping on man! Congrats on the 15 yr mark!

[@TvshkaHumma]

@@hammondj82 Right on thanks!

[@MessierM66]

Same here, especially seeing that sublimation! Congrats on your sobriety man. 16 years sobriety here!

[@alexsetterington3142]

I been sober for nearly 30 minutes, so I'm getting there.

[@smatthewson2613]

"Don't self experiment, especially with chemicals that don't have an established dose" Dr. Shulgin be like "Hold my mushroom tea"

[@thestr0m548]

Shulgin took great care with establishing a personal appropriate dose, usually starting at less than 1/1000 of an expected dose and slowly working his way up

[@fss1704]

OOOOOOOOOOOOOOOOOOOOOOOHHHHHHHHHHHHHHHHHHHHHH boy.......

[@fss1704]

Like he's expecting to find anything remaining after he left the cup with me lol

[@fukpoeslaw3613]

I always experimented first on a few friends with datura tea. One of them is still alive!!

[@fukpoeslaw3613]

Waar de fuk is mijn comment gebleven? Godverdomme KZbin!!

[@GLUBSCHI]

"Powerful caffeine analog" well this is it, he's finally snapped and decided to make cocaine

[@XceptionalBro]

Nah, that's the next video!

[@mesiroy1234]

Coulumbian?

[@BsedMan-if6tb]

​@@mesiroy1234No, Peruvian rocket fuel.

[@wolfy9005]

Substituted xanthines first, substituted tropanes next

[@dinadaughtry8993]

​@@BsedMan-if6tboff white, but the chunks break up to look like tiny fish scales kinda,heart attack with a smile

[@Chasedtuna9]

13:30 it helps if you face the fruit in the juicer the correct way. You put the cut side down to basically squeeze the fruit inside out. The shape of the juicer is a bit counterintuitive, but that is the way it is actually supposed to be put in there. No idea if this comment is actually going to be seen, but it is a lot cleaner and you get more of the juice that way.

[@andrewmalcolm79]

Seconded.

[@Stat1onary]

Huge advice

[@heret1c385]

I was really not sure if he was making a joke there. This seems like a mistake that can happen, but at the same time hes smart and the issue is rather obvious.

[@andrewmalcolm79]

@@Stat1onary life changing.

[@EverythingFades]

I'm going to be real, the second you added 10x the dosage you were meant to, I was fully invested in the video.

[@fredrikcarlen3212]

Yeah! I subscribed just so I could be first to see which stimulant dosage he would 10x on himself next time! Better not disappoint!

[@trueman7888]

The fact that it is already 10x the A2 receptor, puts 100x the strength of caffeine…. Let’s be real, he felt like Hulk lol

[@joedirt3563]

​​@@trueman7888Felt like the hulk until it wore off then felt like Joe Biden. A vegetable.

[@EbolaBearr]

Hes lucky it was a relatively safe chemical, he could have easily self deleted if it was something else. Hes probably always gunna triple check scales from now on haha

[@dieSpinnt]

Sure. Now we are back on the watchlist!

[@M3dicayne]

First half: Chemistry. Second half, 1st part: How to make limonade - kinda. Second half, 2nd part: Major scale screw-up by the power of 10 and turning into a Duracell Rabbit.

[@irgendwieanders2121]

What is a factor of 10 inbetween friends...

[@jhallo1851]

@@irgendwieanders2121basically off by times 10. If he needed 20mg and he scaled 200mg that would be off by a factor of 10. Same if he needed 20mg and he scaled 2mg.

[@irgendwieanders2121]

@@jhallo1851 r/woooosh

[@eldunari6676]

Correct me if I’m wrong, but a power of 10 is WAY bigger than a magnitude of 10, which makes this comment way funnier imo

[@anglaismoyen]

​@@eldunari6676 People use "power of" ambiguously. It can mean x^10 or 10^x

[@frdcda1453]

LC, is a 20-ish years old man, presenting☝️ to the emergency room with sweating, headache.

[@Prussian_Blue]

Don't worry bro, every home chemist almost got a random seizure, it's actually the amateur chemistry gold standard ❤

[@Psychx_]

This and escaping the accidental liberation of Chlorine, H2S, NH3, NOx or other obnoxious gases is part of the unofficial graduation ceremony.

[@Octahedran]

It is indeed, pretty much a rite of passage lmao

[@Dragonbyte]

Can confirm

[@abolfdilter416]

@@Psychx_ gaslighted friends into making chlorine in class, teacher had to open up all windows cuz everyone was getting red eyes

[@alexrogers777]

@@abolfdilter416 accurate username

[@hgbugalou]

Funny but good suggestion when ingesting potentially dangerous things - write exactly what, when, and how much you took with a sharpie across your chest. The doctors will see it in the ER if you end up there and aren't awake.

[@imikla]

And in this case, it would have 20mg crossed out, and 200mg written next to it.

[@melody3741]

I always did this when doing stupid shit with drugs

[@fss1704]

@@imikla That is not the point, they know when and what you took.

[@imikla]

@@fss1704 That is exactly the point. Did you not watch the video?

[@sgjuxta]

Either that or make sure you have a buddy with you who can relay all that information to a medical team in case of emergency

[@jort93z]

Its so ironic how you took great care to make sure its all pure and stuff, and then just misread the scale and chug 10 times the amount lmao.

[@GigsTaggart]

I just don't see how this happened. When I saw that pile I thought there's no way that's 20mg, maybe he'll dissolve it and use part of the volume for precision. How does someone who does chemistry not know what 20mg looks like?

[@MrYrodz]

@@GigsTaggart 20 milligrams is literally a pinch, I also don’t understand how he missed so much

[@LabCoatz_Science]

​@@GigsTaggart Honestly, I saw the scale say 0.20g, and my brain took some kind of shortcut to say "oh, 0.20g is 20 milligrams"...I totally didn't even think twice about it, since it looked like a fairly small, safe amount. In the end, I'm glad it was a fairly safe drug, because if it had been something else, I would almost certainly be dead. As far as I'm concerned, that was the last time I'll ever test anything beyond just smell on myself...heck, I shouldn't have even tried it in the first place!

[@SADWETNESS]

Classic chemist shit

[@thetaintpainter5443]

@@LabCoatz_Scienceyeah, I once did this with 4-AcO-DMT by accident. Meant to weigh out 25mg, and I read .25g as 25mg. Let's just say that was a very interesting experience

[@_Borko]

The only part of this video I remotely understood was the list at 12:12, but even then Tarragon took me for a ride. What a cool experiment, and as someone heart sensitive to caffeine this was extra awesome.

[@KingBongHogger]

Every chemist has an "oh sh*t" moment that forces them to double check every scale. Thankfully yours didn't end with burns or scars!

[@garicrewsen1128]

Or a myocardial infarct!

[@meanman6992]

“Hello, 5-hour energy, can I speak to someone who has authority over the formula you utilize?”

[@patheddles4004]

For real though.

[@BsedMan-if6tb]

I'm thinking of using this recipe to make 26 hour energy, and sell it to servicemen.

[@negative6442]

@@BsedMan-if6tb Sell it to college students lmao

[@AkiUwUx3]

@@BsedMan-if6tb the two forbidden hours of the day, no longer do we need to drink 5 five hour energies, we only drink one 26 hour energy and get double the amount of forbidden time

[@Flesh_Wizard]

55 hour energy

[@Hairspraygoblin]

The bitterness comes from the pith (white peel) from the citrus. When zesting; only use the most outer layer. Source; am cook.

[@KeeganAWhite]

Caffeine is too boring, today we will be replacing the caffeine in my homemade energy drink with meth.

[@robloggia]

Time was you could by them over the counter.

[@alexrogers777]

based.

[@venivinivinci]

Dmaa

[@JayAshborne]

Teeth gone in 30 minutes or less guaranteed.

[@joejones9520]

@@JayAshborne that's a myth, no proof m causes tooth decay, more likely poor dental care, dry mouth and sugar is culprit

[@aneb2002]

You're using that juicer upside down, put the juicy side of the fruit down, not up, it's supposed to invert the fruit as it juices

[@wamlartmuse17]

Came to comment the same thing.

[@knobjob2839]

Thank God someone said it

[@dksmith605]

Yep, juicy side down.

[@LabCoatz_Science]

Two mistakes in one video, and counting...now I just feel dumb, lol

[@dksmith605]

@@LabCoatz_Science but you learned something and that makes you smarter than you were before, which is kind of the point of science 👍🏻 Mistake or not, you were 1000% committed to dosing yourself with your new energy drink and we now have some human test data 🤣

[@Lolsesbibi]

Explaining to people in the ER that you tested a home synthetised mollecule on yourself would have been wonderful

[@averyalexander2528]

As someone who had a worsening high-dose caffeine dependency, having very bad days including one memorable one after taking nearly one entire gram, (1,000 mg) the moment you said it was equivalent to 2 grams of caffeine, i was hit with a wave of sadness as i waited to see how it affected you. Glad to see you got through the other end of it okay though.

[@jameswilkes451]

Glad you got better. I love coffee but I can easily see how it could spiral out of control if I didn't exercise any semblance of self-control. Especially since I feel quite foggy a lot of the time.

[@rhombus673]

I feel you dude, i accidentially overdosed on 1.2 grams and my heart's been weak ever since. That had been my daily dose for over a week leading up to that point, and I ended up drinking it faster than i could handle. Stay away fron energy drinks, they are dangerous and addictive. After all my illicit and recreational drug use, it was caffiene that nearly took my life at 18 years old.

[@Zaque-TV]

Yeah i took too much caffeine once and i felt like a zombie its hell lol

[@godofthunder6046]

Is there something wrong with me? I've taken over 3000mg in the span of a few hours. 1000mg is a normal dose for me. I mean, yes adhd makes stimulants work differently, but is that really a crazy amount?

[@rhombus673]

@@godofthunder6046 yes your heart will quit on you

[@Litepaw]

Now that this blew up, you have a channel that only synthesizes obscure caffeine analogues while using yourself as the test dummy. Congrats!

[@jttech44]

He should probably get some rats to test this stuff on.

[@joedirt3563]

​@@jttech44Like a real lab chemist would do.

[@DaVizzle_Bro]

I don't know why but I always feel like I learn better when I'm not worried that I have to memorize this for some kind of college exam. If only we were allowed to learn like this throughout life

[@jhbange]

I saw the scale you were using and immediately thought, "oh, you shouldn't use that scale, I have that exact model and it's way too easy to forget it measures 10's of milligrams rather than milligrams". I was experimenting with concentrated energy drink formulations and using anhydrous caffeine and very nearly dosed myself with a 10x dose once the exact same way.

[@toseltreps1101]

that's an idiot's mistake and not the fault of the scale.

[@SianaGearz]

@@toseltreps1101 Sometimes being smart means choosing more suitable tools, because most of the smartest people tend to be pretty dumb for a few minutes a day, so you want all the possible guard rails to prevent it from getting dangerous.

[@Alex-ck4in]

​@@toseltreps1101people like you have a hard time admitting, but even the smartest humans are like Swiss cheese. Catch as many details as you can, but eventually, something will slip through a hole.

[@rileysimmons9886]

​@SianaGearz yeah, agreed. That's really not an adequate scale for weighing anything at that low of a level, anyway - it doesn't even have adequate readability for the task, let alone actual resolution. Those things are for jewelery and weed, not single doses of substances which are notated in mg.

[@gonelucid]

​@toseltreps1101 facts.. dosing should always be thought out. And not only that but I first timer should always use a much smaller, tester dose. The difference between a smart drug user and a chemist.

[@whatevernamegoeshere3644]

Sounds like an energy drink containing Dmax and caffeine would be an interesting fast start + long term combo Also glad you are alright

[@aodhstormeyes]

Sounds like a lot of trial testing because one wrong move and while yes dmax takes longer to take effect, than caffeine, you still need enough of each to get the right "buzz" going and if there's any overlap in the time they are in your system, you could be having a really bad day.

[@thog7653]

ah yes, legal meth

[@Flesh_Wizard]

Call it "double barrel" or something

[@galliumgames3962]

Call it “earthquake” where the caffeine is like the P waves and the DMAX is the S wave.

[@aodhstormeyes]

@@Flesh_Wizard Very ominous for something I'm putting in my mouth.

[@tonymonxana992]

“Don’t talk to me until I had my morning heart palpitation”🤣

[@Nuovoswiss]

The greatly delayed onset indicates an active metabolite being responsible for most of the effects. Allyl groups are metabolized along a couple pathways, but the predominant one being epoxidation of the double bond, followed by hydrolysis to the corresponding diol. The other pathway results in a sulfoxy metabolite. Both are often mutagenic and carcinogenic. See the paper "From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment"

[@EbolaBearr]

Hmmm hmm, yes quite, hmm very intriguing indeed. I have no clue what you just said :D

[@WastedElephant]

But how mutagenic and carcinogenic are they? We talking a lifetime of exposure for a 50% risk of cancer increase? Or single exposure, you got cancer next month?

[@czechgop7631]

Are you a student in pharmacology or something? Because this is pretty interesting analysis

[@orchdork775]

Wait, are you saying that the metabolite is cancerous? I'm confused haha

[@Nuovoswiss]

@@WastedElephant No way to tell without testing. Some will innocently react with RNA, or even DNA but in such a way that the mutation is detected by the cell and not tumor forming.

[@luke_fabis]

You put your citrus halves into your citrus juicer backwards. These juicers are designed to turn the fruit inside out. So, you need to put the flat cut side facing the cupped part of thr juicer. It's counterintuitive, but it's a lot more efficient and a lot less messy that way.

[@redacted3610]

oh good someone mentioned this lol

[@rocketamadeus3730]

Residual effects from the last research chemical.

[@BloodWolfXZ]

Devices meant to squish things are in the shape you want it to end in, not start in. Or, maybe more helpfully, put it in juice side down. Idk why people expect it to work when the rind is blocking the holes.

[@Sorrow000]

19:32 elevated R wave, your heart was beating stronger on the DMAX. your ECG is measuring your ventricular activity totaling around 4.3 mV (the normal limit is 2.5 mv). - For those less medically knowledgeable, I'm looking at Lead 2 or II in the ECG. His ECG shows a MASSIVE spike up; that spike up is called the R wave, it represents the positive electrical movement (at least in regards to lead 2) going down towards the positive electrode of the ECG. in his situation, it seems that after the electricity goes down his "bundle of his" (google it for an illustration) it really ramps up and makes his ventricles squeeze stronger. I bet his blood pressure went a little higher too. careful gamers XD

[@paulkirjonen1226]

I suppose this alteration is not very healthy with theoretical regular use, if we let ourselves speculate. Is it worse compared to typical effects of a lot of caffeine?

[@eli_777]

You're an absolute legend for showing the mistakes too.

[@ErgoBytes]

18:00 As someone who has consumed various different doses of "substances". Higher doses of things tend to take longer to peak, I beleive this is simply due to your body's ability to process the material. For example, when consumed THC is processed in the liver, it breaks down into 11-OH-THC which is actually what makes you feel high. Your body can only process so much THC a minute/hour, so if you consume a TON it simply takes longer to peak and lasts longer. It's the same story with Psilocybin and likley the same situation with your caffeine analog.

[@restlessmind268]

goated information. keep up with the good work

[@RyeCA]

That's just wrong For some substances, you will feel the effects much faster

[@bootnoot8696]

@@RyeCAyeah “some”

[@theKashConnoisseur]

@@RyeCA If it's going to pass through the mucosa or the stomach lining directly into the bloodstream (alcohol, cocaine, etc), you won't be waiting on liver metabolism to deliver actives to your brain. But if it's needing to pass through the liver first (edible THC, psilocybin, etc), you will be limited by the rate the liver can process at, and so you will see a delayed "peak" and a longer overall duration.

[@user255]

@@theKashConnoisseur Why delayed peak? As you said it is limited by the rate liver process it. It is continuous process, so liver does not absorb all in and release only after everything is processed.

[@danpina17]

Thanks for the recipe, my workouts are gonna go insane with my new pre-workout

[@plarnston]

I appreciate the effort put into these subtitles! They really do reflect the audio experience, whereas some other KZbinr's subtitles don't seem to have as much care put into them. Thank you!

[@nrbeast6000]

r u def?

[@YouTubeSupportSucks]

​@@nrbeast6000can you spell?

[@locurset]

I really appreciate it too when I see subtitles on a video, and it's not just KZbin's automatic captions.

[@ShakerCheeseIsRite]

Congrats on not dying, bro 👍

[@GrimTactics]

As someone who has panic disorder and anxiety, I would have ended up in the ER lol. You are a brave person doing that and great video.

[@haydennorris2913]

There are some molecules that dont perfectly fit into their receptor but bend them in such a way that they cannot easily leave the receptor. LSD is only a partial agonist of the serotonin receptor, but its effects last 12 hrs. This isnt due to its solubility. Its the way it fits into the receptor. DMT is much closer to a full agonist, but doesnt last as long.

[@scthomas1982]

12 hours my ass. 6-8 if lucky.

[@MichaelGottloib]

@@scthomas1982 12 hours of you consider afterglow

[@jacobm2625]

​@@scthomas1982 6-8 hours of perceived effects, maybe, but that doesn't mean that there isn't still binding at the receptor for longer.

[@RyeCA]

Not LSD if it's only 6hrs for you. Or tolerance​@@scthomas1982

[@shnilikmw]

LSD doesn’t even get its psychedelic effects from the serotonin receptor, its from the dopaminergic D2 receptor. And LSD has high affinity for serotonin receptors. What youre speaking to is called affinity, its not because they can’t leave the receptor due to shape, the molecules form bonds with the receptor, but just because a molecule fits doesn’t mean it’ll have a physiological effect. The molecule has to have a specific chemistry that allows it to interact with the protein in a way that it results in a physiological response. Your theory would be plausible, if these molecules weren’t non-selective agonists. They bind to at least 10 different receptor families, not just individual receptors, but whole family’s from SERTs, DATs, and so many others. And the affinities for all of these receptors differ.

[@jammin023]

Quite apart from the scales mixup, it's a mistake to go straight to the full expected dose. The king of the self-experimenters is Alexander Shulgin - learn from him. I recall reading either in the intro to Pihkal or Tihkal or in an interview, he always started with the tiniest dose, like a tenth or a hundredth of the expected active dose, and titrate upwards from there on subsequent bioassays. This helps to guard against (a) the active dose turning out to be way lower than expected, (b) errors in synthesis or measurement, (c) unexpected side-effects or allergic reactions from the compound itself or any remaining byproducts. Chugging the whole bottle like you did was reckless in the extreme. I'm glad you lived to tell the tale.

[@Remyy_10k]

I was across the room for a sec and thought he said fentanyl when he said “fennel” I had to go back and make sure I was trippin 😂😭😭

[@turtled361]

homemade alternative stimulants are fine, but I draw the line at red 40. Thank you for leaving it out.

[@variouselite]

Thank you for sharing this especially the mistake and effects. Mad respect. Glad youre alright.

[@SamSamSandwichman]

Love you're video. Kinda wished you had uploaded this at 2x speed though LOL. Glad you're OK.

[@stazeII]

We need a doctor Nick “20.0 means 200?! What a country!”

[@SianaGearz]

More like 0.20g means 200mg not 20mg.

[@tPu0]

This was the first video I watched from your channel. And my god, it was so entertaining, so interesting. Thank you LabCoatz, I'm now going to watch your channel from time to time :)

[@bigmacc882]

I found it hilarious that I got a sleep ad right as you started experiencing extreme jitters and shakes. My first thought was “I know one person who wont be falling asleep in the next 6 minutes”

[@DangerousLab]

0:26 Extracted it once? Nah, I extracted it multiple times daily! On a side note, it is extra dangerous to drink chemicals despite the fact you might have read the MSDS and calculated the proper dosage for DMAX, as the product is so impure and unverified that there might be a substantial amount of deadly side products present in it.

[@madmattdigs9518]

Then, I shouldn’t be alive. I’ve been consuming said chemicals for 35 years. I’m not worried about it.

[@Pyxis10]

Today I drink yummy yummy poison cancer/caffine Mmmmmm.....blegh ☠️

[@hunterm9]

Your non-improved results do not surprise me. Even with caffeine, its main effect is on the human perception of tiredness and focus. It's actual ability to improve performance is quite small and shows mixed results on an individual level, depending on the task. So it may help you get through your day or let you do more stuff since you feel more focused, but it's not going to make you superhuman. Unsurprising that dmax works the same way. I've taken 1.6g of caffeine before (over a couple hours) and I can relate to some of your symptoms. I had lethargy, shakiness, anxiety, some feelings of focus (largely overwhelmed by feeling like shit), but also my heart felt like it was strained to the maximum and I was experiencing palpitations. I still felt like shit 8-10 hours later and my heart still felt strained, but if I recall correctly I actually fell asleep pretty quickly because of how exhausted I was. I don't know how at risk I was of actual health issues but it was generally a pretty good wakeup call to not fuck around and find out. Glad you're okay.

[@elvinfp]

When juicing citrus, they're supposed to go in cut side down. The hand-juicer essentially turns the half of a citrus inside-out as you squeeze. That's why you got so much spray, because your lime halves were upside-down.

[@redcrow1836]

Common thing is "e"s in the tea, coffee and chemists 0:07

[@jaimeortega4940]

Good job! And you are correct there are no illegal caffeine analogues.

[@MrZyphose]

Nile is just entertaining, and to me, that outweighs most of these chemistry programs. Nile enjoys pushing the envelope (tasting, smelling, eating, etc)when he can. He smiles and is personable. 😊

[@jansenart0]

10:55 Oh come on, we all know how saccharine was discovered. We should get back to randomly licking things in the lab, we made such amazing discoveries back then and nothing you're handling and nothing it produced is going to be worse for you than ethylene glycol.

[@petitkus4408]

Another point, is that while in war times too we usually get thoses test data...

[@arran4285]

@@petitkus4408 I mean there are wars going on so

[@taiiiz3969]

​@@petitkus4408 war experiments were mostly horribly unscientific, barely any good information came out of experiment 731 or the yologhost other than how much of X does it take to end someone

[@snapdragon6601]

Another example of licking things in the lab (accidentally) that led to a serendipitous scientific discovery happened on April 19, 1943, in Basel, Switzerland. It continues to be celebrated every April 19th around the world, affectionately known as "Bicycle Day". 🚲😃

[@mikeandre7364]

I am by absolutely no means a chemist, but I just absolutely love chemtubers 😂 started with nilered, with bro playing whilst I fall asleep, then explosions and fire, then other science KZbinrs, and found your channel, and I'm just so happy that I've found content like this instead of internet brain rot 😂 your content is just so flipping good!

[@janthran]

you should check out the video by fraser builds on alchemy, it lends a perspective to chem that makes all of the other ones a lot more fun

[@searsbear7965]

Check out @chemdelic

[@TheMusicPoint]

"Caffeine 2, gives you wings... but you can never land."

[@mamaharumi]

As a big fan of both theacrine and methylliberine, this is very cool. I've always been interested in caffeine analogs.

[@frikghorgan]

if you don't mind my asking, how do those compare/contrast to just caffeine itself? also, recommendation on taking them together (with and without caffeine)?

[@onikin]

​@@frikghorganthere's little difference between them. Most of it is marketing hype so you buy the unregulated Supplement Industry's next super-new super-cool thing for more 💰 You'll get less jitteriness and a little lower blood pressure/heart rate. Longer lasting effects but at weaker strength per milligram. Adding L-theanine is probably just as good. But the FDA banned selling pure caffeine powder a bit ago (caffeine citrate😭), so maybe there's a loophole there to exploit.

[@mamaharumi]

@@frikghorgan Usually, synergy alongside caffeine. Gives it a bump without the negatives that come along with just increasing caffeine dosage. Theacrine lasts longer but is mild, dynamine is stronger but has a shorter duration. They're both interesting in their own right.

[@mamaharumi]

@@frikghorgan highly recommended n**tropics depot if you're interested

[@frikghorgan]

@@mamaharumi thank you, friend

[@kayayay9791]

20:07 cooking WHAT 😂😂😂

[@oresteiaanetik]

Bro I was just about to comment 'Should have checked your pulse that would be interesting" and then you casually pull out EKG strip lmaoo. Glad you're ok.

[@delphinusphokaena]

As soon as I saw how much was on that paper, I knew it couldn't be only 20mg...

[@stefanobonaiuti8243]

I guess he's used to using imperial units.

[@GarrettBlackmon]

How a chemist who measures things for a living misses this is baffling.

[@tissuepaper9962]

​@@GarrettBlackmonthat model of scale measures tens of milligrams, it's actually a very easy mistake to make.

[@iralee68]

Yea. Now that you mention it.

[@NuclearAnNoahlation]

The fitness industry is gon eat this tf up

[@walterbunn280]

So... on seperating the dmax from the allyl bromide and potassium bicarbonate, add it to isopropyl alcohol. The isopropyl alcohol will 'salt out', and the more ionic compounds will stay in the aqueous layer.

[@javon510]

3:00 NEVER TRY THIS AT HOME!! But if you wanted to here at the measurements and where to get everything 💀

[@bytefu]

As soon as I saw you measuring the sketchy compound, I immediately thought that it looks way more than 20 mg. I know because I am used to measuring roughly 1/3 of a 60 mg of atomoxetine, my ADHD medication (it's expensive, I'm poor, and the pill price doesn't depend on dosage), which is 20 mg. And basically 20 mg of anything is not much anyway, so it looked very suspicious.

[@meloney]

Not being able to pay for medicine is just sad..that this is even a thing :(

[@bytefu]

@@meloney Yes. However, I am able to pay, it's just I have to be creative about it.

[@bytefu]

@@meloney I mean, I need about 30 mg for best results, but at that dosage previously barely noticeable nausea starts being uncomfortable. And since 20 mg pills and 60 mg pills cost the same amount, why pay for the former? Of course, it would be much better to just buy 20 mg pills for a reasonable price. Monthly supply would cost roughly 10% of my income if I were buying them as is. What can you do? Capitalism works in mysterious ways.

[@AgentAsteriski]

Felt that on the price of atomoxetine... is your doc at least getting you the manufacturer's discount?

[@meloney]

@bytefu but that isn't solely a capitalist thing. I am from germany and get ADHD medication as well. In my case Elvanse/Vyvanse or whatever it is called elsewhere. Its lisdexamphetamine, 30mg for me. I pay about 5 euros per pack of 30. I could get the max dosage of 70mg for the same price. But painstakingly measuring half of each cap for about 2.5 euros (around 2.75 usd) saving really isn't worth it for that... Noone should pay 10% of their income when they need medication. I know how important ADHD medication can be. Lisdexamfetamine for the first time allowed me to go outside in public and just be myself without overthinking everything which causes me to panic. That would even be worth 20 euros for me per month. But rn per year its about 60-65. I could get even that completly without the 5 euro cost too, if i did the paperwork at the social healthcare insurance. (which isnt a lot at all, i did that for many years and got all meds without the 5 euro minimum self pay) In the US however, this isn't capitalism, this is terrible greed and really sad. Capitalism can work in other ways, such as it does with meds here. The meds still are getting paid for of course. Just not by the one who needs it. I hope that one day things change and you wont have to pay for them that much anymore!

[@Volnas97]

Fun fact, oranges contain compound, which blocks liver enzymes, that degrade chemical compounds, so by including orange juice, you also ensured, that the DMAX will remain in your body longer. Also much higher concentration of this thing can be found in grapefruits, which is why I used to drink grapefruit juice on caffeine pills during exam period.

[@TW0man4RMY]

Weird I thought oranges did the opposite. I used to drink orange juice when I wanted to come down off of LSD and it would always reliably work.

[@Volnas97]

@@TW0man4RMY Could be placebo, or the effect of oranges wasn't as severe

[@TW0man4RMY]

@@Volnas97 I actually ended up googling it and the vitamin C in oranges essentially speeds up LSD trips. So, when I was drinking OJ to end my LSD trips, I was really just speeding up the trip into and past the comedown stage. 🙂 I suggest others double check that tho as im just some random idiot on the internet. 🙂🙂

[@samuraijackson241]

Citrus fruit, particularly grapefruit, contains a compound that inhibits liver enzyme cytochrome P450, which is responsible for the breakdown of most, if not all, chemical drugs.

[@kortkunig2291]

So 150mg is the sweet spot. Got you.

[@jupa7166]

😂😂😂

[@nathanguyon7620]

Well, that made me giggle. Reminded me of the time I drank fifty shots of espresso on a dare. I tuned into a hummingbird (a 6'4 220lb hummingbird) and hallucinated a bit. Also think I peed out like half the water in my body. Made the Type-O Negative concert I was at a truly interesting experience. Also, don't drink fifty shots of espresso. Seriously. I'm glad I threw up at one point, probably would have had a heart attack if I hadn't.

[@RiehlScience]

Fifty shots of espresso contains 3000-4000 mg of caffeine. That’s enough to kill a smaller person.

[@TurtleMountain]

ehhh the average amount of caffeine in an espresso is 64mg so had you not thrown up, you would've had a stronger reaction than what this guy experienced but still well under the the lethal dosage which is 10g so you'd PROBABLY be fine.

[@RussellBeattie]

Time didn't slow down for you on the 50th cup? kzbin.info/www/bejne/eaLHXpKcfcmHr6Msi=PXo0JOPn9B8LMVA9

[@lrmackmcbride7498]

​@@TurtleMountain the maximum safe dose is 2g. That was over 3g so yeah good thing he threw up.

[@pjtruslow]

Wow. I’ve had 8 in about an hour and it was pretty undesirable especially having heart conditions and being pretty sensitive to stimulants. 50 shots is somewhere in the 3.5 gram range of caffeine.

[@JS-tm1gq]

I salute your contributions to science my dude. Absolute champion

[@3zzzTyle]

This could've been a curious ChubbyEmu episode.

[@a.c.2659]

A chemist makes his own energy drink, this is what happened to his nervous system.

[@RossRadford]

@@a.c.2659 Chemist presents 👆 to the emergency room WIDE AWAKE...

[@dancoroian1]

A lot of the people you're so adamantly warning about the dangers of ingesting homemade chemicals with unknown safety profiles were kids taking a WILD variety of RCs back in the aughts and 2010s 😜

[@shiva_hardly_sarcastic]

the whole RC mania continues til now actually. im not in the game anymore, when i quit 2 years ago there was still dozens of compounds easily accessible

[@dancoroian1]

@@shiva_hardly_sarcastic huh...figured everything had moved off the clear web now? Already when I got out about ~8 years ago that's the way it was headed

[@shiva_hardly_sarcastic]

@@dancoroian1 in germany where i am located its all still on the clear web

[@dancoroian1]

@@shiva_hardly_sarcastic well lucky you! Lol no such luck in the US

[@shiva_hardly_sarcastic]

@@dancoroian1 eh, wouldn't call it luck necessarily since it did fuel my addiction quite a bit

[@WiloPolis03]

This is the exact moment his organs became Heisenberg in the last scene of Breaking Bad.

[@joergmaass]

I once isolated some caffeine from tea and ended up with a few crystallised needles of a white substance on a glass plate. Not seeing that as being dangerous, I licked them off. Big mistake! I ended up on the couch for four hours, shaking, sweating, with a racing heart and the fear of collapsing. Not a pleasant experience and a potent reminder to exercise caution when doing stuff like that.

[@logical_mania]

When I was a kid I found my step-dads pre workout stacker 3 caffeine pills. I took 3 thinking I'd get some energy. Ensue 6 hours of me feeling sicker than I ever have in my life. Learned not to mess with caffeine that day.

[@NikomaGrob]

Lol that must've been scary. I had a similar experience but with 2c-e. I thought I was doing a small bump of amphetamines just to stay a little awake but it ended up being an 18 hour long psychedelic hell.

[@PsyTechnical]

I am so glad you are ok.

[@roots4x]

This level of commitment deserves a like and subscribe.

[@mo323dim]

Truly, you are wonderful. Thank you very, very much for your effort and wonderful work

[@machiii7394]

“Hey I made this 5 hour energy alternative! I call it 3 day energy.” “What’s in it?” “Medical grade methamphetamine.”

[@uuproverlord8324]

Desoxyn

[@thewolfstu]

13:35 So I believeee if you rupture the fruit by massaging it, face it so it's basically flipped with how you had it, and use a funnel it should help with that.

[@Methylene.]

Lab made his own home-made Jet xD good lord dude you're the best

[@Bludgeoned2DEATH2]

Can you even imagine coming back to see how LabCoatz is doing to find he hasn’t uploaded in years and then find out he accidentally off’d himself by taking 2grams of fucking caffeine to the face?! I’m just…you are so lucky dawg I am so glad you’re alive.

[@ResearchForMyself]

Shoot man so sorry that happened! Seriously bad luck, brilliant video really enjoyed it! Keep it up man love your work and mind

[@jaimeortega4940]

Added my, "mélange of spices."🤣😆

[@LabCoatz_Science]

I was seriously debating flashing a Dune meme there...not sure why I had to pick that exact phrasing, but melange does mean "mixture", haha

[@emilyrln]

If you had waited longer you could have made a spice syrup that would actually flow! (Looking up that oleo-saccharide thing to experiment with lol)

[@beskamir5977]

Next time, maybe have some onsite medical supervision... Please befriend a doctor if none of your friends are in medicine since I'm legit concerned you'll accidentally self delete.

[@Cpt_John_Price]

Well we all chug some caffeine or alcohol every now and then, might as well chug all at once. You want caffeine? There, have a caffeine.

[@beskamir5977]

@@Cpt_John_Price Not everyone does. I certainly don't. Besides even chugging those drugs is in much smaller quantities and you're more likely to vomit it back up before you get too poisoned.

[@beskamir5977]

@@Cpt_John_Price Usually those are a lot more diluted and thus consuming large enough quantities to cause harm would likely also induce vomiting. Besides, I don't consume any caffeine or alcohol ever so the "all" doesn't really apply to me :)

[@lil.kbbl.radio.]

The way it looked like you made your energy drink on the bathroom floor made me question everything you did in the lab beforehand.

[@Phapchamp]

I remember two years ago i drunk 5 whole cups (big ones) of dark coffee because i HAD TO stay up 3 days consecutively while studying to pass. I could feel my chest beating so fast and my head was getting so dizzy. But worst of all is i could not study properly because i was just constantly pissing 😭😭

[@TopOfAllWorlds]

Yeah that was dumb as fuck ngl. Sleeping is actually important to retaining what you study. So instead you should have slept at least a little (few hours or maybe a little more) in between. It would have been more efficient and less detrimental to your health.

[@Phapchamp]

​@@TopOfAllWorlds It was a microbiology med chem and pharmacognosy exam back to back. Dire situations require dire things.

[@ikarus1111a]

Localdrugseller presented to the emergency room, where we are now.

[@theKashConnoisseur]

5 cups of coffee is what I used to call "getting up in the morning" lmao. When I was a teen I took energy drinks recreationally, and as a result I have a massive caffeine tolerance. I've cut back to reasonable doses these days but I was a pot-a-day coffee drinker for YEARS. Also, fun fact: light roast coffee will tend to have the highest caffeine concentrations, and the darker the roast the lower the caffeine will tend to be. Reason being that dark roasted beans are roasted a lot longer, and caffeine sublimates out of the beans at roasting temperatures.

[@oldkingcrow777]

I drank 1200mg+ of caffeine daily for a few months. Didn't realize how bad it was until the first Saturday I didn't work (so no caffeine) I thought I was dying with some flu type thing. Felt my inner voice rationalize that I noticed today was the first day I've skipped caffeine. Drank 2 cups of tea and it all went away. That single moment ironically opened my eyes to the realities of chemical dependency and Gabe me a weird sympathy for folks with more serious withdrawals like benzos or opi@tes

[@cragonaut]

The EKG says Emergency so I'm guessing the anxiety didn't exactly pass...

[@LabCoatz_Science]

Nah, my Dad is a mobile x-ray tech and he just happened to have an EKG machine on hand! And my mom is an ER nurse, so she took my blood pressure, pulse, and blood oxygen. Never set foot in the hospital...that happened a few weeks later for an unrelated reason I'll explain in an upcoming video, lol!

[@cragonaut]

@@LabCoatz_Science Hey, I wouldn't criticize even if you did! I can appreciate first-hand how concerning those symptoms can be - even more so knowing you'd just ingested a homemade chemical. Just thought it an interesting thing to spot. Glad everything worked out well. Thanks the video.

[@64fanatic]

​@@LabCoatz_Sciencehomemade not-meth had a little drama eh? 😅

[@thewolfstu]

"It's unknown to how addictive this is and it is not meth.... but also, next week, we're gunna make a legal analog to meth." XD this is funny

[@robloggia]

A CNS stimulant with less chance of cardiovascular side effects? Seems like something that would have been studied as an ADHD treatment.

[@CDCI3]

Caffeine apparently doesn't activate the right receptors to help with ADHD. Caffeine isn't really very good at releasing monoamines, but rather seems to work as an antagonist for adenosine receptors that tell your body you're tired. A cardio-safe analog of one of the monoamine releasing stimulants would be nice, though.

[@bytefu]

@@CDCI3 Right, caffeine doesn't do much for my ADHD, no matter the dosage. Atomoxetine, an SNRI, definitely does.

[@bytefu]

@@CDCI3 By the way, atomoxetine is cardio-safe, as far as I know. But, of course, it's not nearly as effective as amphetamine derivatives. Not addictive at all, though.

[@robloggia]

@@bytefu Interesting I knew SNRIs were used for treating depression and compulsive disorders, I had no idea it was used in ADHD. Does it help with just focus, or does it work with hyperactivity as well?

[@bytefu]

@@robloggia I don't have much hyperactivity to start with, so can't say for sure. But it definitely helps to focus and reduces impulsive behaviour, like cravings (alcohol and nicotine included) and buying unnecessary crap at grocery stores. Atomoxetine also reduces appetite, that's a plus for me.

[@JoshuaBarrio]

Fennel and Tarragon is where you messed up. When it comes to flavors.

[@LabCoatz_Science]

THE NAME SOUNDED COOL!

[@vilhjalmurhalldorson2970]

I've done this type of chemistry one time in 2007. I made a strong pot of coffee from grains.i then boiled it a bit to make a strong solution. I used copper II chloride as my reducing agent. I then from there did my additions/reductions with chromium trioxide as well as other Regent's I made myself. I got the chromium from VHS tapes and dissolving it out with HCl. I oxydized it with h2o2 and used the acid distillate O=Cl-H to break the ligand to boil out cuprous chloride as a real raunchy smelling stuff,really stunk my room up

[@supermaster2012]

Well, time to build a not-meth lab and get rich. Thanks unknown KZbinr!

[@doctorpurple5173]

Did you struggle to sleep that night?

[@tristandaries1129]

“I next added my millage of spices to the zesty sugar jar” is one of the best sentences ever said

[@virescenticious]

Funny that you were actually far better off than if it was actual caffeine LOL.

[@WarlordEnthusiast]

Yea unfortunately those cheap scales are never accurate. I've made the exact same mistake with DMXE, it was completely stupid.

[@gutsfiend6678]

lol, that had to be quite the time

[@WarlordEnthusiast]

@@gutsfiend6678 Surprisingly it wasn't a khole, just insane dissociation for about 7 hours. At one point apparently I was acting like a black Baptist priest. That was 100mg (probably more) intranasal

[@odinata]

Thanks dude this is so valuable to humanity.

[@No1hyp0cr1te]

Lol idk about that, but it was entertaining…

[@wamlartmuse17]

I used to drink a bunch of caffeine. I'd be so jacked up, all the meth heads at my job were looking at me like, where he get his chit!? 😂. But the first time I had energy drinks... I used to work out a lot. I would do calisthenics first then go to weights. I figured I'd try an energy drink. So I road my bike to the store about a mile away. Going as fast & hard as I could. I ended up buying 2 energy drinks. One red bull & one sobe. The sobe was an actual energy drink they had in a can. Not the regular sobe drink marked energy.. so anyhoo.. I chugged one of the drinks before I left the parking lot. I drank the second one on the way home while riding swiftly, keeping my heart rate up. When I got home, I sat down, grabbed my dumbbells & was watching TV. I made it a few sets in & out of nowhere, my eyes spring open, my heart starts racing & I'm shaking. It hit really quick. I thought I was going to die 😂. I was rocking back and forth, my vision kept going white. I couldn't get up or call for help 😂. It finally started chilling out & going away. 15min. of hell lol. I cant remember if it was that or breaking my foot, that ended my workout routine. Definitely be very careful with chemicals, even legal ones.

[@LabCoatz_Science]

I had 160mg in a Monster once, and I had a panic attack driving home, lol. I apparently have a lower caffeine tolerance, so I usually stay below 100mg...an 8oz Red Bull or half a Monster works well for me if I'm trying to study or work out, but my resting heart does kick up to roughly 100 BPM, so I'm not a huge fan of the stuff. I do love the taste of an energy drink though, lol!

[@Reddotzebra]

@@LabCoatz_Science The reason I prefer Monster to other energy drinks is that (at least over here) they seem to contain the same amount of caffeine as many other brands, but the concentration is lower because they contain way more water. Thus you can more easily vary the rate of absorption by just drinking it slower, well, that and they have sugar free flavors that actually tastes decently good and they use sodium citrate instead of phosphoric acid, which I in my madness have convinced myself is slightly better for my teeth. Even if it is a chelating agent.

[@Dragonia]

@@LabCoatz_Science if the labels are 100% ocrrect and my calculations from back then arent wrong thne most caffeine ive ever had was about 1g (monster coffes and energy drinks, dont remember exact amounts), that combined with lack of sleep (for various reasons) and being forced to carry heavy things up and down a few flights of stairs for a while once made me think i was gonna die, by the end i think i passed out on my bed when i got a break. 0/10 experience, never did anything like that again. Otherwise my caffeine tolerance is quite good though. my family members basically avoid even touching the coffee i buy due to how strong it is (effect/caffeine amount-wise) compared to normal coffee lol

[@theKashConnoisseur]

@@Dragonia I used to have 600-1200 mg of caffeine daily, for about 5 years. It was a night shift job and I never could get the hang of sleeping during the day, so I was always tired. Somehow, I made it out ok despite all the caffeine and getting

[@dinadaughtry8993]

Love the taste of the monster coffee drinks but if i drink two cans of the 300 Monster coffee i have a hard time getting to sleep in the evening