Making anisole

This was reuploaded because I made a mistake and claimed that there was a charge separation in methyl iodide due to electronegativity.
Today we are making some anisole! Anisole itself doesn't have many direct applications, and it's mostly used as a precursor to perfumes and pharmaceuticals.
I plan on using anisole to make anethole, which is 13x sweeter than regular sugar.
References:
• Chemplayer's anisole video: • Video
• SN2 in more detail (benzyl chloride video)l: • Making Benzyl Chloride
-------------------------------------------------------------------------------
Merch - nilered.tv/store
-------------------------------------------------------------------------------
■ NileRed is now available on Nebula! go.nebula.tv/nilered
(when signing up with this link, a portion of your membership directly supports the channel)
Join the community:
Patreon - / nilered
Discord - / discord
NileRed Newsletter - nile.red/home#newsletter
You can also find me here:
Facebook - / nilered2
Instagram - / nile.red
Twitter - / nilered2
Nile talks about lab safety: • Chemistry is dangerous.

[@Drjusmar]

Nile, the fact that you'll reupload just for a error you could cover with an annotation is admirable. Keep it up dude.

[@NileRed]

Thanks for the support :)

[@johnb820]

I can imagine, back to camera and mic, then the editing program, then export, then upload! What a job! love this guy.

[@KnakuanaRka]

Especially since KZbin dumped all its annotations as of recently. Yeah, people were spamming them, and getting them to work on mobile was problematic, but look at all the cool things people did with them; don’t throw the baby out with the bathwater!

[@ATLTraveler]

They got rid of annotations in like 2016 buddy...

[@comando1911]

Hell. major news sources dont even do that!

[@exys2086]

I would like KZbin devs to add a feature to see how much time you've spent watching a single channel. Knowing nothing about chemistry, I still watch a lot of those :\

[@clintonbehrends4659]

knowing KZbin they'll somehow do the complete opposite

[@drasiella]

I need that for Nile Red and SEA

[@toxiccan175]

@@clintonbehrends4659 Knowing KZbin, they already know

[@druidofthefang]

isn't that a thing already?

[@nekrugderzweite8298]

Same

[@fefemess]

I remember watching this in high school and thinking it was really cool. Now I'm actually studying these reactions in college and they're beautiful

[@AmidaNyorai48]

😀

[@smerdyakov_11]

Indeed man, organic chemistry is the best

[@xXHatsuneMikuFanXx]

i feel like the person that named anethole just said anisole, but with a lisp

[@butterflygroundhog]

It's probably a chemical isolated from aneth and anise seeds, both are from the apiacea/carrot family, so that would make sense

[@turgidbanana]

No

[@jastintheceooffinanasapost6204]

@@turgidbanana why?

[@dampandrew]

anis hole

[@dougsteel7414]

@@dampandrew don't like those words near the word 'moist'

[@twizz420]

My parents made an anisole... I call him "brother"

[@heathc148]

I dont get it

[@bcl56]

@@heathc148 Anisole sounds like a**hole

[@conservat1vepatr1ot]

My brain read the title of this video the very same way lol.

[@cDoogle]

i thought this was wholesome and you were calling him sweet. :(

[@violetvargas9387]

@@cDoogle same

[@JohnLeePettimoreIII]

" ... I'll get on that. Eventually." You sound like me on one of my good days. 😃

[@grazen321]

Too much commitment for me..

[@frosthoe]

Thanks again NileRed. Sharing Knowledge is awesome, and I feel fortunate that you take the time to explain things to us less Chemistry savvy folk.

[@zhiang0113]

The anisole undergoes 4-substitution (via aromatic electrophilic substitution) with propanal to form 4-(1-hydroxypropyl)anisole, which is protonated by the acid. Water leaves as it is a good leaving group, producing a benzyl carbocation which is stabilised by the benzene ring, and Cl- attacks it to produce 4-(1-chloropropyl)anisole. Pyridine acts as a base to eliminate HCl from that to form the C=C double bond, thus producing anethole! :)

[@PatrickStarthnxroxrock]

I like your funny words magic man.

[@ChemEDan]

@@PatrickStarthnxroxrock anethole is what bugs bunny calls wabbit hunters.

[@NileRed]

Follow me on Twitter: twitter.com/NileRed2

[@chrischristen8904]

NileRed hey. how's it going?

[@hh7h137hhh]

Hmm... the methoxy group of the anisole is ortho/para directing due to its electron donating effects so assume a nucelophillic attack at the activated aldehyde? Then I assume the alcohol group present after the attack will protonate generating a good leaving group and from there a chloride ion can attack at the alpha carbon and displace the water?

[@NileRed]

***** haha thanks

[@NileRed]

Alex Blitz Good and you?

[@NileRed]

David Ashworth Sounds about right :)

[@MrRishik123]

Yay more content. Will you ever make something like paracetamol? I think it might be a good video.

[@NileRed]

I plan to go from aspirin to paracetamol! So aspirin --> phenol - > p-nitrophenol --> p-aminophenol --> paracetamol

[@MrRishik123]

Can't wait :D

[@krisztianszirtes5414]

+NileRed Couldn't you go like PET -> terephtalic acid -> benzene -> chlorobenzene -> phenol and from that the same as yours but cheaper and larger quantities? :D

[@horaciorodriguez3280]

Paracetamol in industry is made from phenol-p-nitosophenol-p-aminophenol-and acetilating.....N-acetyl p-aminophenol(paraacetamol), right? is the most easy pain release of make, I think.

[@horaciorodriguez3280]

No, that way is not , the way in industry is,,,,phenol-p-nitrosophenol-p-amino phenol-and acetilating...N-acetyl p-aminophenol-paracetamol.

[@daddylong69]

I love your dedication to accurate information.

[@Chrissy4605]

Nile, you are very entertaining and educational. And kudos for doing a follow-up on your error!!!

[@Danielisyourfather]

I’ve always liked chemistry but watching him really inspires me

[@ASandwichNinja]

For the mechanism of the reaction to form anethole, I would assume in step 1 the first thing to happen would be that the oxygen in the propionaldehyde would be protonated to make the carbonyl carbon more electrophilic. It would then undergo a Friedel-Crafts acylation by reacting with the anisole at the para position due to favourable resonance forms of the Wheland intermediate, removing a hydrogen from the benzene ring as a proton and forming a carbon-carbon bond between the ring and the aldehyde (which is now an alcohol). I think that the alcohol group would then be protonated by HCl and via a nucleophilic substitution reaction (like Sn1 due to the possible resonance forms of the carbocation intermediate) water would be lost sand replaced by chloride. In step 2 the pyridine acts as a base and initiates an elimination (possibly E1 for the same reasons as for Sn1, and especially if the pyridine is dilute). The pyridine abstracts a proton the carbon adjacent to the halogenated carbon and the hydrogen's electrons are donated to form a carbon-carbon double bond as the chlorine is kicked off as chloride. I think that's how the reaction would work, just trying to go off of what I've learned so far at uni.

[@bingbong430]

how much words are here?! XD

[@oldpop788]

@@bingbong430 yes

[@revolverguy]

But what happened to the phalanges ?

[@nushurasaher9876]

I think it’s not specifically a freidal crafts acylation since the reagents used are different here. Friedal crafts acylation is done using anhydrous Alcl3 and not H3po4 it is an acylation process but not friedal craft. Its actually an ESR reaction

[@alexnope2223]

Nice use of google. Next time change some words so it isn't verbatim.

[@Iridiumalchemist]

Really nice video. I appreciate the effort that went into reuploading it to correct a mistake!

[@FurryAzzre]

Sometimes I love watching people create interesting chemicels from scratch. Amazing video.

[@thecarrasius]

Really enjoy your videos, quality stuff :)

[@NileRed]

Thanks!

[@ExplosiveBrohoof]

You've already extracted limonene from orange peels, right? You should use that limonene to prepare carvone! You'll turn oranges into mint!

[@thatilluminati_3421]

Good on you for actually correcting your mistake. You'd be surprised how many youtubers are afraid of doing that.

[@sad6452]

good job with these videos they are fun to watch and help me at school with chemestry

[@CookingWithCows]

Not to be confused with Anusol

[@origamigek]

anus oil ?

[@CookingWithCows]

It's a brand name for a hemorrhoid ointment :P

[@origamigek]

ah

[@professorprotonfan7287]

I read anisole as anus hole.

[@Chrissy4605]

Now that IS funny!!!

[@austinhall3937]

When someone's mean to Mike Tyson he calls them an "anethole"

[@oldpop788]

BOOOO

[@banjobear3867]

Hahahahaha

[@danielhagen3739]

That neutralisation of the waste liquid looked really cool :)

[@bigbingus4542]

Watching these are so relaxing

[@fieromike1]

😂 I read the title of this out loud, “Making an a$$ hole” and my wife responded immediately “your parents already did that and I’d rather not watch the video “. Always quick with a good burn. 😂

[@binaryguru]

Every time I hear you say Anisole it keeps reminding me of Anusol.

[@editname6868]

Ikr

[@_puffy]

Interesting to watch you procure anisole - I was born with one!

[@hwyterrorist]

What a beautiful colour. Like a wizard's elixir.

[@fabiotonin3938]

You could use an alkaline reaction condition instead of sodium methoxide to have the de-protonation of phenol! Sodium methoxide is necessary for alkilic alcohols but for aromatic alcohols K2CO3 or some drops of NaOH are enough to have the deprotonation... cheers!

[@shubhrajit2117]

I also have the same doubt

[@sara6069]

Nile: suggest a mechanism! Me: *barely passed chem 30*

[@aech_two_oh]

I had no idea what anisole was when coming into this, but it's a good way to "spend" time

[@tobiasfraser6061]

I read the title 'anusole' and so I thought you were making hemorrhoid cream and just accepted it as a video concept 🤣

[@Thereadingmusiclover]

I read the chem as anus-all so i was expecting the opposite of this "nice- smelling" chem XD

[@deyvismejia7529]

It would be awesome if you could cover general orgo 1 and 2 reactions like this Williamson ether synthesis, or a playlist of relevant videos.

[@anonymousjoel]

I just want to say thank you you're awesome!

[@SycosTV]

I have no idea why I am watching haha, BUT its really interesting. I don't plan on using this information at all but I really enjoy watching your videos!

[@lemmerelassal610]

Nice video. Couldn't this be done using NaOH and Aliquat?

[@catonchronic5354]

Do more videos on synthesis of other phenylpropenes. Like elemicin, croweacin, exalatacin etc.

[@weekendguy100]

You can do this reaction quite easily with any somewhat basic base. Such as potassium carbonate, sodium hydroxide, etc. without having to use something as reactive as sodium, it’s also much easier

[@ars2995]

Coolest bong rig ever bro!

[@googleeatsdicks]

Your videos are worth watching twice. :)

[@NileRed]

haha thanks. Hopefully there are no errors in this one!

[@ritviksharma5901]

NileRed please make testosterone from cholestrol please. It might be a very interesting video to watch. Please nile please.

[@deplorableamerican9451]

that Dollar tree glass jar though

[@sebbes333]

*@NileRed* 2:25 Can you put the round flask in a bigger container of ice water to also cool down the reaction? Or does it need to be hot to trigger the reaction?

[@brianreddeman951]

Always awesome stuff

[@nushurasaher9876]

The reaction mechanism is Electrophilic substitution reaction. Since anisole is methoxy benzene and all benzene compounds undergo ESR pretty easily.

[@ethangormong7506]

This is just an alkylation reaction. Phenol already has a very acidic OH, which attacks the electrophilic MeI to make the aryl methyl ether.

[@nushurasaher9876]

Isn't alkylation a ESR

[@ethangormong7506]

@@nushurasaher9876 I think you’re thinking of Electrophilic Aromatic Substitution. But we are creating the phenoxide anion, which attacks the methyl iodide in an SN2 reaction. You are correct, however, that the product, Anisole, would undergo an EAS reaction rapidly due to high electron density in the arene ring.

[@MohammedAdain]

HCl breaks as H+ and Cl-. Cl- attacks the carbon of the aldehyde as that carbon has partial positive charge. The π electrons of C=O shifts towards O giving it a negative charge. H+ from HCl or H3PO4 is attacked by the oxygen bearing -ve charge. Further the oxygen is protonated and there is a loss of water molecule, giving the + -ve charge to the carbon where the Chloride had attacked. Then electrophilic substitution reaction at para position as the Ortho position reaction is difficult due to steric factors.

[@TheWiseSalmon]

Why would H2O be eliminated when the Cl which just added to the carbonyl is a much better leaving group? Any Cl- which attacks the C=O will be immediately kicked back out again, surely? I propose: 1. Electrophilic Aromatic Substitution at para position with the protonated aldehyde acting as the electrophile (para favoured over ortho due to steric reasons) 2. Protonation of the OH followed by loss of H2O leaving group. The lone pair on the MeO group can help kick the H2O out and stabilise the resulting positive charge. 3. Attack by Cl- at the carbon which just lost the H2O prntscr.com/ct3grs

[@LilGugz]

Agree 100% with TheWiseSalmon's synthesis mechanism. Modammed Adain --> the Cl- ion isn't a very good nucleophile, is far too good of a leaving group.

[@MohammedAdain]

SORRY, totally agree to both of you, I discussed the same with my Professor too and he gave another reason which supports you, that in a solvent (protic) in this reaction the anisole acts as a better better nucleophile. Thank you for correcting me or else I would had been under a wrong illusion.

[@NileRed]

Hey, can you message me on my FB or here on KZbin? I want to send the beaker that I promised

[@MohammedAdain]

Ya Nile red I'm here

[@moyrml]

Love your videos. As for making a botch of the mechanism, I propose this: At first, the hydrogen of the HCl (after dissolving in solution) is attacked by the oxygen of the propanal. This makes the aldehyde carbon positive, and free for an attack by the chloride anion. First step creates a 3-carbon chain with a chloride and an alcohol on the first carbon. Next, the H3PO4 creates a substitution reaction on the benzene ring. The carbon of the carbon chain attacks the double bond and attaches in para position. Next, a hydrogen from the para position carbon leaves, restoring aromaticity and transferees to the alcohol group. A water molecule leaves giving the product. It has been some time since finishing my organic chemistry course. Forgive me if i completely distorted the rules of chemistry.

[@danielkeith7593]

It was nice of Anna to volunteer her own soul for science.

[@AMDB1973]

I liked your video very much! And also most of the other videos. And specially I like videos about chemicals in spices and foods. And as the name "anisole" gives away, it's in anise Pimpinella anisum, and others. For me looks a little like a terpene, but anisol doesn't have enough C-atoms, to be a monoterpene (10 C-atoms). Have you thought about to try to make f.ex. menthol? ;) Anyway I think your channel is very entertaining, and it has become one of my favorites. Keep it up Nile! ;)

[@LiborTinka]

The amount of sodium fits perfectly my imagination of "reasonably sized" :)

[@masterlabLAB]

Anisole can be used also to make TA trinitroanisole which is widely used in melt casting explosive composition for multiple military application, and as high performance rocket propellant.

[@hamp9061]

Hey Nile. I got some options of other chemists for the synthesis of antethole from anisole. We figued that a possible mechinism would have the propionaldehyde converted to its enol form in a Keno-Enol Tautomerism. The Enol form has a good OH leaving group that would be attacked by the HCl. This produces the 1-Chloropropene that has a slight positive on the 2nd carbon. This is where we got lost. It seems like the HCl unless entirely depleted would attack the 1-chloropropene again but instead we need the activated ring to attack the 1-chloropropene double bond converting it into 1-chloropropane bonded para on the ring. I dont know if this will be helpful at all but I've been trying to work it out all day. Can't wait to see it!

[@chrisgg1968]

@NileRed: Thank you very much for the sheer amount of high quality chemistry videos. I enjoy every of youre videos I watch. :) Feel free to correct me, I still learn a lot about organic chemistry. My guess for the first mechanism: First you add the propionaldehyde to youre anisole in the para-position using the electrophilic aromatic substitution (SeAr), which adds a proton to the oxygen of the new group. Then this new OH-group gets protonized (using H3PO4 as a catalyst) and leaves the molecule creating a positive charged carbon atom, to which hydrochloride can create a bond, which sets free the 'used' proton and adds chlorine to the molecule (Sn1). My guess for the second step: You use the E2 elimination to get rid of a hydrogen atom of the second carbon atom of the propylgroup using pyridine, which simultaneously eliminates the clorine and creates a double bond.

[@tereziii]

so true

[@Mattes_______]

Nile what do you think about making some lidocaine?? The synthesis would fit perfectly to your channel^^ and maybe you could even try your own product on your skin

[@NileRed]

I am actually not able to get the precursors for lidocaine unfortunately

[@sleepful1917]

well he seemed to have figured it out hahahaha

[@editname6868]

A n a l L u b e

[@johnthebarbarian]

Coke

[@johnpapa8554]

You are the best!! please make Propylene glycol dinitrate one day if you are in the mood!

[@Mrshane288]

He's over here... "If you want to know more about SN2...." I'm still stuck on sodium being in mineral oil to preserve it. Yeah I didn't go far in science class in school. This is extraordinarily interesting and I understand most of what you're explaining but man I'm simply amazed at how much we collectively know. Humans truly are amazing.

[@IbnEmadAlmouaibed]

extract nicotine from cigarettes

[@horaciorodriguez3280]

Is like extract cocaíne chlorhydrate from coca plant

[@roro-mm7cc]

extract morphine from papaver somniferum (opium poppy)

[@tlowry6338]

Extract dmt from toads

[@notpulverman9660]

@@tlowry6338 poor toads

[@notpulverman9660]

I think he already showed use of soxhlet extractor to extract piperine or st.... So it would be the same as that, possibly with a different solvent if nicotine isnt soluble in alcohol.

[@astralchemistry8732]

Great video and good explanation of the polarizable bond! I just want to note that anisole would form an emulsion, and not a suspension with the water (10:00 at the DCM extraction).

[@xFaTeZzclan]

Looks like a nice bong

[@extv1p3r65]

I have no clue what any of this means but I’m intrigued!

[@markhoutman7721]

Hey NileRed, Would you still like to get the answer to your mechanism question on this video? In that case: The aldehyde is protonated. resonance occurs and causes the carbon from the aldehyde to become a carbocation. Now a "double bond" from the anisole attacks this carbocation. The hydrogen from the aromatic ring is eliminated and the "double bond" in the aromatic ring is restored. Thanks to a strong acid, like the phosphoric acid, the now synthesised wil be protonated. This makes an H2O-group, which is also a good leaving-group. When it leaves, it creates a benzylic carbocation, where the chlorine will attack, creating your desired product. A very interesting way of a nucleophylic aromaric substitution. Looking forward to it.

[@DagothXil]

having intrusive thoughts watching the beginning like "oh my sodium metal is dirty, better take it over to the sink to wash it off"

[@NitroTheCat]

This has been recommended to me over 300x

[@wermiliusgaming9136]

i thought this vid was releaded 4 days back lmao its 4 years back still enjoyed it

[@DaftknightLP]

"today we're making an ass hole"

[@toothless7849]

This stuff gave me blood-farts.

[@drasiella]

Try Anisol 2

[@ATLTraveler]

You should see a doctor man.

[@siberianstuntman3344]

I had the same problem with pure sodium hydroxide snacks

[@twizz420]

Anisole... Not Anusol.

[@ballisticbananadadude]

Let it absorb, let it evaporate, start back at square 1.

[@Caro1Purple]

Me at half asleep watching nilered: I like your funny words magic man!

[@sovchem1275]

Hello my friend, thanks for video!, please help me - How can I make 3-Hal-anisole and 4-Hal-anisole? (as 3-cloranisole or 4-bromoanisole)

[@daddyfatsack68]

I was just curious on how much your lab cost?

[@krisztianszirtes5414]

Seconding this, also mostlyy interested in the type/cost of glassware

[@Hawk013]

I honestly can barely follow what he's talking about half the time because my memory is so badly shot, but I still want the glassware because it's so cool looking. I know a guy that uses all scientific glassware in his kitchen instead of measuring cups and teaspoons and bowls, and it's awesome.

[@krisztianszirtes5414]

Using chem glassware in a kitchen is pretty common, my family does it too. Those glasses are very hard to break with heat

[@NileRed]

Several thousand I would think (if i include chemicals). I don't really track it though. In terms of glassware, probably a few thousand

[@Bender1]

Why do I watch these videos? I don't actually make any these... good video anyways

[@xPROxSNIPExMW2xPOWER]

its interesting

[@1HeartCell]

Thats exactly why you're watching them. You can't make it yourself. It would be somewhat hard to get all these chemicals e.g. in germany.

[@AureaPersona]

You could make this from household items and a little patience. Or from trees, rocks and sea water and A LOT of patience.

[@elephystry]

Dark Magician, Level 7, 2500 ATK 2100 DEF Perhaps on the off chance that you will.

[@Epck]

@@1HeartCell it shouldn't be too hard...chemistry is important more people should learn it

[@jugernoty9]

I only took basic science in high school so when you start talking about chemistry its a foreign language to me but i do enjoy watching your videos

[@tykjpelk]

Anisole is used as a solvent for PMMA used as a resist for electron beam lithography. The manufacturer says it's a safer and less viscous alternative to chlorobenzene, but I don't know what other reasons there are.

[@imogenruthburnett3867]

I don't know a thing about chemistry but I'm pretty sure that self stirring glass bulb was magic.

[@mindbound]

Imogen Ruth Burnett It uses a magnetic stirrer.

[@magey3794]

The glass bulb is not actually glass. It is a magnet and on the stirring thing there is another magnet that spins and because they are attracted the one in the container spins too. Hope I helped.

[@nattsurfaren]

I once used sodium instead of cheese on my sandwich. It tasted shit and I burped for hours.

[@nattsurfaren]

Don't do it. It is deadly. I was joking.

[@Swollencod]

nattsurfaren already did it

[@nattsurfaren]

My bad bro. ;)

[@Bender1]

Talk about explosive diarrhea.

[@nattsurfaren]

Roliath, Malebranche Of The Abyss Or explosive stomach. The thing will burn through your intestines. Stomach acid would become highly alkaline. If you survive they have to remove the stomach and connect it with the other end. I know there is one that drunk something corrosive and wanted to kill himself over a stupid girl. He survived and they did exactly what I describe.

[@pvcov3250]

man i know nothing about chemistry i wont even have chemistry in upcoming years in school because im in art but these videos are literally just . the one thing i can watch and work to, sleep to- i watched these in elementary when i did chemistry, not for class, for fun- i still had low grades in chemistry but you know not like i needed it anyway ^^

[@jseylar16]

This could be made more simply using phenol and NaH or NaOH to make the phenoxide in DMSO or DMF at ~100°C followed by the addition of the methyl iodide. Would also work with methyl chloride/bromide. I've done it myself. Could provide a source if you're interested.

[@kennethkeys2248]

I've never smelt anisole, but wouldn't one expect it to smell not unlike skatole?

[@Nathanmoney10]

no the anisole has a very different shape than an indole so it wouldn't nessicarily smell bad

[@kennethkeys2248]

It was a pun on the phonetic similarity of 'anisole' and 'anus hole'.

[@kennethkeys2248]

MrBabyBitch666 ...

[@kennethkeys2248]

It was a joke.

[@kennethkeys2248]

+MrBabyBitch666 Thanks.

[@phonotical]

You never made the Anethole video! I was pretty interested until I realised there wasn't a video 😔

[@slaveluna]

I went looking for it as well. Maybe he'll get to it eventually.

[@phonotical]

@@slaveluna three years!

[@noahater5785]

What would happen if you heated the phenol with a blowtorch, other than maybe the container its in melting due to the heat?

[@tenkkutn]

This brought me back to organic chemistry and o. chem. lab

[@DhanusMLal]

why don't you mix phenol and Na directly to get Na phenoxide

[@kayrakaya4719]

Methanol is important... For health

[@dipeshsomvanshi4383]

Your content is awesome. One of the best on youtube! I am quite addicted to it. Many youtubers upload shit everyday and they have so many suscribers and views. +NileRed you are doing a great job! Keep it up.

[@tjm9367]

On a scale from 1-10, how dangerous would it be to lick the contents crusted to that scale at 1:48

[@MillisecondFourthClockhand]

*I don't get all this, but it sure is satisfying to watch.*

[@Rhodanide]

I feel like I have seen this before. nah.

[@Rhodanide]

AHAH, WHAT? I see someone doesn't have the ability to sense sarcasmmmm! :) You're quite the frisky one.

[@googleeatsdicks]

+Binky Sop Dude, chill! You are more reactive than fluorine.

[@philidor9657]

I feel like I've definitely seen this before. Eh I'll watch it anyway.

[@rexmonarch2]

Brings back memories of the ol' basement laboratory days back in the mid-70's.

[@nivekzorantinez8872]

Me having no knowledge in Chemistry but making Kool-Aid: *"Interesting..."*

[@theoriginaldonutdude4950]

This guy must make great homemade bongs

[@nickoolay]

aldehyde is protonated by acid, which increases its electrophility. Then simple electrofilic substitution yeilding alcohol, which reacts with HCl by Sn1 to give chloride

[@haigosounds]

The HCl protonates the propanol. The nuceliphile is the para position on the benzene ring which attacks the propanol and water is produced as byproduct?

[@timg3584]

I have no idea what anisole but I'm ready to learn from red nile

[@MuzikBike]

How about a synthesis for hydrogen selenide?

[@fappingfoopa]

Woah I like the question thing

[@NhuNguyen-mm1qf]

After adding methyl iodide, we then refluxed it for 1.5h?

[@fauxpassant]

Under acidic conditions caused by HCl and H3PO4, the aldehdyde is protonated, forming an oxonium ion. The benzene ring attacks the oxonium ion at the para position (it can also attack at ortho) because the resultant cation is more resonance stabilised than at meta. The cation is deprotonated by a base in the environment to restore aromaticity in the ring. Next, the -OH group (coming from the oxonium ion) is protonated, forming -(+)OH2. Water is a good leaving group under such acidic conditions, and so it leaves, leaving behind a secondary carbocation which is actually resonance stabilised by both the benzene ring and also the electron donating -OCH3 group. Cl- acting as a nucleophile, now attacks the carbocation, forming the anisole-p-(1-chloropropane).

[@ahmetselcuk1400]

Anisol fiedel caraft reaction . Please??? Anisol +cloroaceton reaction p2p ????????????????? 1 saniye önce

[@jonathanschalken6050]

Hey man any chance you can put in the reaction mechanism in videos like this, would be very helpfull

[@merlix6304]

You should remove the Plug on the separatory funnel for faster phase separation. ;)

[@KazmaHD]

How did your sodium not react with the air after removing the oil?

[@TragedyStudios]

Is the mechanism Sn1 Halogenation using strong acid and phosphoric acid catalyst

[@Lacara4d]

I don't understand any of this. But it's super cool to watch.