Making the DEA's Most Hated Decongestant

[@LabCoatz_Science]

Go to ground.news/Labcoatz to see how any news story is being framed by news outlets around the world and across the political spectrum. Use my link to get 50% off unlimited access with the Vantage Subscription. Also, it has come to my attention that one of the chemical diagrams was wrong: it's a small thing, but the double bond on the imine intermediate (produced from the norpropylhexedrine and formaldehyde) should be on the nitrogen's other bond...it's a METHYLimine

[@黄蟮]

Bro, can you do a course of oxytocin? And LSD,

[@highlander723]

6:30 As a fellow organic chemist..... "So you decided on madness and then eventual suicide the long way around."

[@williambradley611]

You should try Raney nickel as a reductant, it’s very cheap and a very good reducing agent.

[@GOOGLE-IS-EVIL-EMPIRE]

I think youtube probably unsubscribed me. So i reload app to check, then subscribe again. Just for you know. Not gaslighting, but first comment.🤡🤏

[@LifeGlitch1]

I edited in adding formic acid and the like from the comment disappeared.

[@ericcarabetta1161]

It’s funny that it would have been easier to *actually* make meth.

[@BsedMan-if6tb]

I feel like you could accidentally make meth with this process. Also it requires the same restricted precursor to meth.

[@yellingintothewind]

Making meth is stupid easy. Making _clean_ meth that isn't poisoned with toxic impurities, and without blowing anything up is the hard part (doubly so if you consume any of the product while making more). Most of the work in designing commercial viable synthetic pathways for drugs is finding ways to avoid _creating_ those toxic byproducts. Since they cannot be reasonably removed at-scale, the only solution is to carefully control conditions to not generate them in the first place. (Or if you are selling illegal drugs on the black market, just don't worry about your clients' future health).

[@herrapingviini2024]

@@BsedMan-if6tbso in theory i just accidentaly find a tutorial that shows how to make meth in youtube

[@Antiagony95]

@@yellingintothewind i think you can make 99.9% meth we believe in you, you might get the nobel prize for creating one or they might legalize it because of your formula.. we might call it yellingintothewind and end all world war while making world's productivity 100% more efficient, you could patent it and become the first human to achieve quadrillion net worth.

[@Kenshi795]

making meth literally needs 3 ingridients don't count products to produce a product but its to very easy

[@andrxw1]

we're so back (on the watchlist)

[@thisisaperson1536]

yessir

[@whatever-pw3tj]

Lol

[@jimgray4681]

Oh you're back

[@facediaper4607]

you left it 😂

[@1BobTheSubGenius]

Underated

[@Bludgeoned2DEATH2]

LabCoatz: “KZbin, this is completely legal you have no recourse to age restrict or demonetize” KZbin: “and I took that personally”

[@theKashConnoisseur]

It pays to remember that KZbin is a global platform, and what is "technically legal" in one country can be very much an illegal analogue in others.

[@PhysicsGamer]

@@theKashConnoisseur KZbin is an American platform, actually. California, to be specific.

[@crayzeape2230]

@@PhysicsGamer American company, global platform.

[@theKashConnoisseur]

@@PhysicsGamer Just because it has a US headquarters doesn't restrict the platform's use to California lmao.

[@PhysicsGamer]

@@theKashConnoisseur Sure, but they operate under California (and therefore American) law.

[@eRRoRoiDeRRoRoiD]

12:12 "As with most of life's problems, this was readily overcome with a healthy dose of acid" lmfao

[@dancoroian1]

fax 💯

[@segfault-]

Amen brother 🌈🌻

[@RayGalactic]

Oh now I get it. 😂

[@adenlols2999]

😱😱😭🤩🕺

[@von...]

"I have a sore throat" ****school nurse give you a thumbprint of orange sunshine****

[@ares395]

Careful, That Manchild might contact your family and their associates on you...

[@snoowbrigade]

😂

[@sivalley]

Definitely an IYKYK moment

[@LabCoatz_Science]

I'm not scared of the boogie man...I mean That Chemist...

[@sivalley]

@@LabCoatz_Science He may be That Chemist, but he's not Dank Chemist. 😎

[@AsmodeusMictian]

such a disappointing situation with that one. 😞 People can be really stupid sometimes.

[@hanifarroisimukhlis5989]

Make pseudoephedrine next to tell DEA (and FDA) it's dumb to restrict it. EDIT: Nice that google's first autocomplete result is propylhexedrine abuse...

[@norbert.kiszka]

IDK how it's in USA, but in Poland pseudoephedrine is 100% legal and You can buy it everywhere.

[@endleontiozae7061]

​​@@norbert.kiszka it *has the potential* to be converted into MDMA or meth. But so do the rest of the chemical elements in meth. Our DEA likes to make chemicals illegal without trying to help the people struggling with addiction. So yeah they just keep making more and more basic level chemicals illegal.

[@Magic-Conk]

​@@norbert.kiszkaIts very restricted, due to people using to to make meth. You can get it OTC, but its a pain​

[@philondez]

@@norbert.kiszka It's legal here too, can buy it at any pharmacy. You're just limited in the amount you can buy per month and you have to give your ID, which gets run through a centralized database to make sure you're not just running from pharmacy to buy more than you're supposed to

[@KoalaPlus]

It's a fully scheduled drug in my state, meaning you need a doctor's prescription for it no matter what and can't get it OTC or from the pharmacist. And yet, meth is still a huge problem here and has actually gotten worse since the pseudo-ban (pun intended). Shocker 🙄

[@DOJOMACE]

THE GOVERNMENT HATES HIM FIND OUT THIS MAN STAYS AWAKE FOR 7 DAYS STRAIGHT

[@quint3ssent1a]

and also half an hour gay

[@godgame9841]

@@quint3ssent1a +2

[@homeopathicfossil-fuels4789]

@@quint3ssent1a does that mean if you are already gay you will stay awake for 7 days gay and a half hour straight?

[@ivancrespogomez5777]

This is a known side effect of stimulant abuse. Many such cases

[@Chemiolis]

I love this structure!

[@deangilburry8216]

You two should do a collab, it'd be sick af

[@TsunauticusIV]

@@deangilburry8216agreed

[@TsunauticusIV]

I tried this, pharma made, one time and my goodness was it an amazing ride. I’ve wanted to do it again. I can see how some people end up in bad places with this type of thing.

[@theKashConnoisseur]

I remember when ChemPlayer got banned for making _precursors._ I know that drug chem (and energetics) gets the views, but I really hate seeing quality chem channel after quality chem channel go the way of the dodo.

[@LabCoatz_Science]

True, but ChemPlayer was also dabbling with more extreme precursors, like phenylacetone. KZbin chemistry is always a bit of a gamble, but as long as things stay legal (and far enough away from illegal drugs), things tend to go alright!

[@BackYardScience2000]

My white phosphorus videos keep getting deleted. KZbin really hates when you show how to make that...

[@theKashConnoisseur]

@@BackYardScience2000 It amazes me sometimes that you can find video after video of people playing with microwave transformers but videos about white phos don't fly. The only logic I can come up with is that there haven't (yet) been any, err... "conflict crimes" committed with microwave transformers. And that makes them more "ad-friendly"?

[@Chad_Thundercock]

​@@BackYardScience2000 They deleted a video of you gently heating the scrapings of a match box? That's crazy - why would they not want people to see someone collecting the red powder on matchboxes and gently heating it over a hotplate?

[@acmhfmggru]

LabCoats is speed running ruining his life. not even exaggerating. This is like the 8th in a long string of very bad choices that he has made lately. Dude is screaming for help, but he won't accept help, so he'll continue to spiral until he changes his mind or... well, you know how the story goes...

[@mortlet5180]

I believe the biggest issue was the impurities produced via the Henry reaction (it is well-known to be one of the dirtiest synthetic pathways, with enough unique impurities carrying through to the final product to allow for forensic fingerprinting), as well as the side-products formed from the uncontrolled LiAlH4 reduction. As an alternative route, you should really try doing a Grignand reaction with acetonitrile and the (bromomethyl)cyclohexane, which would allow you to directly reduce the formed imine to the primary amine in one pot. If you manage to exclude water, oxygen and CO2 (which excess Grignard reagent will also help to scavenge down to PPM levels if you seal the apparatus with something like a balloon), then this pathway will produce much a cleaner and easily crystallizeable primary amine: After the Grignand reaction is finished, cool down the resultant ether solution to around 0°C in an ice bath. Then, while still minimizing exposure to the atmosphere, you just need to slowly add some LiAlH4 or borohydride, with stirring and cooling.

[@art-thou-gomeo]

Mate congrats on the 100k subs! Your little self-aware text remarks had rolling. The troll face on the drug lab test results was *chefs kiss* very enjoyable watching your borderline legal videos

[@dancoroian1]

Those of us who have been particularly desperate when having issues getting ADHD meds have long been familiar with the Benzedrex last resort...nothing like those lavender burps to remind you you're having a horrible/great day!

[@bok..]

Bruh really? Having issues getting amphetamine and going to Benzedrex sounds like addiction. When I couldn't get opioids I would get like 2lbs of poppy seeds and wash them to get the latex off.

[@dancoroian1]

@bok.. both in the case of Benzedrex instead of amphetamine, and poppy seed tea instead of pharmaceutical opes, whether or not it reads like addict behavior depends mainly on the presence of a medical condition (or lack thereof) which the substance in question provides effective relief for, and also on the specifics around use habits -- not merely the decision to take a less popular/traditional substance

[@jackass6257]

Pro tip : pseudo is way better and literally meth without the dopamine but works wonders for adhd

[@dancoroian1]

@jackass6257 Pro-tip: your comment doesn't really make sense and is difficult to take seriously, considering that dopamine is THE primary neuroreceptor involved in ADHD...

[@eyezikandexploits]

I love benzedrex, PPX is beautifully fun drug

[@valfodr]

You didn't get a precipitate in the first step because of impurities and unreacted reagents. You can obtain a precipitate in the first step by washing with metabisulfite (or dumping the whole mixture into a solution of metabisulfite). This removes unreacted aldehyde that becomes water-soluble as bisulfite adduct. The material will then be much more likely to crystallize.

[@LabCoatz_Science]

That's a decent idea!

[@rocketlauncher6207]

Aren't carbonyl bisulfite adducts famous for being....water insoluble?

[@valfodr]

​@@rocketlauncher6207 I think it depends on the kind and size of group that is attached to the carbonyl. In a more general sense, the solubility of aldehydes and ketones is only mediated by the carbonyl oxygen acting as H-bond acceptor. In the case of adducts, there are way more oxygens that can participate in hydrogen bonds and there is the ionic charge of the salt. Whether or not the adduct will be very soluble in water, it will certainly be more soluble than the original aldehyde, and conversely it will be less soluble in the oil that we see in the video. It's a good way to separate the two

[@ghosttwo2]

I appreciate the irony of making fake urine to induce a fake failure of a fake drug test of a fake drug.

[@eaglgenes101]

The drug is very real, it's just not _that_ drug

[@Cavemankind_]

I appreciate the technical legality of this synthesis, but with that collective list of unique ingredients, the DEA may still be very interested based on numerous popular precursors for MDxx compounds.

[@RWZiggy]

that plus lab glassware is a door kicker

[@CatgirlExplise6039]

@@RWZiggy Yea, the CIA doesnt want u interfering with their meth business, thats a huge part of the American economy outside war.

[@UserNotSwipping01]

@@RWZiggy thats funny because in europe you can order any types of glassware and reagents and no one will come looking for you😂😂

[@RWZiggy]

@@UserNotSwipping01 varies by country as many do require registration and tracking of things considered precursors and also some solvents for the rather hilarious reason that many are also fuels. In USA, lab glassware is legal, but combined with possession of other things can be probable cause

[@Star88701]

That sulfuric and hydrobromic acid route is a nasty, dirty process that is very difficult to control without a professional lab.

[@Michael-cb3uw]

Eh, I've seen a high school graduate and a retired old man manage it on tv on a Motorhome

[@konstantinlee2275]

Nice work, even after getting such disappointing oil. Actually you can do TLC but on paper, ordinary filtering paper. Sure it'll be uncomparable with any external reference but you can put witness drops with source substances on same paper to get some references. And you can buy this pills or whatever OTC and extract taget substance from there for reference,if possible. Amines can stay oily because of presence of solvents and water. Try to dry in vacuum this oil to remove traces of anything volatile and then recrystallize.

[@ashishpatel350]

this is my domicile and i will not be harassed

[@LifeGlitch1]

Propylhexedrine HCl has a melting point of 123°C. When melted, it looks like a clear to slightly brown liquid. To solidify Propylhexedrine HCl, you need to cool it in the freezer and then refrigerator for a few hours. Also, using a Bovado Borosilicate Glass cooking dish to have more surface area can help with Propylhexedrine HCl. Propylhexedrine HCl should be hard crystals, but sometimes it's soft and pasty due to moisture or impurities from Petroleum Distillates based solvents. I think I need Pentane and Hexane. I also made Hydrogen using Aluminum Galinstan amalgam.

[@Thealchemistscorner]

this

[@Strobie_one]

Normally when you do RA, you add the aluminium and all of your reagents to the reaction vessel first. Then you proceed to add the mercury solution. This way, everything comes together in the same place and at the same time. Also it’s better (usually) (depending on your catalyst) to grind the aluminium up almost to a powder, but not all the way. This will prevent the reaction from occurring super slow by increasing surface area, and also prevent it from going to fast and foaming up, AND getting too hot.

[@Travluminatii]

Oh boy we made it to the list now!

[@maxamillionjazzhands4034]

"low abuse potential" i have like 500 empties in my drawer that would say otherwise, this stuff hits harder than any of the real stuff ngl

[@y33t23]

If you ever get around to doing an Amalgam reduction again, I'd love to see you do a Galinstan/Al alloy one. There's a post on science madness about it, it seems to work great and it's non toxic.

[@jimsvideos7201]

I rarely let ad reads play, but you’re on my cool people list.

[@genuinesaucy]

Benzedrex inhalers always seem to mysteriously sell out around midterms and finals week. If you know what to do with the cotton inside, you know...

[@aliveandwellinisrael2507]

weird!

[@000-v7j]

I got lemon juice on hand at all times, I know what to do, I know what I must go do again.

[@agustintellez136]

On the blue collar side...some mornings those cottons are the mandatory substitute to coffee....

[@Strobie_one]

Before you make fluorine, checkout the video on Ty of some crazy German/Austrian guy making a HUGE ampule of pure caesium. Can’t remember the final weight, but it’s way more than enough to burn a large building down 😂 he distilled it really well, and the final product was completely free of any oxidation. Absolutely stunningly beautiful to look at.

[@zsomborgyenge4359]

Advanced tinkeringis the name of the channel if anyone curious

[@Strobie_one]

@@zsomborgyenge4359 that is indeed correct!

[@RyanMercer]

I would have just put a label on the specimen jar, peed in it, and added a drop haha.

[@1BergerVongSchlauigkeitHer]

That wouldn't have given a definitive result due to all the drugs he's been doing.

[@RyanMercer]

@@1BergerVongSchlauigkeitHer 🤣

[@johnpeters6147]

He didn't because he's actually a meth addict so it would have contaminated the results😢

[@michaelf7093]

Avoid Al/Hg. Make an Al melt and make some pirate Raney nickel. It's not near as flammable as you might believe. I usually add some Zn as a promoter. Get a crucible and propane furnace and melt some beer cans. Thank me later.

[@Michael-cb3uw]

Foundt Walter White's alt account

[@c-Fos]

In the nitropropene reduction you could add LiAlH4 in thf to the nitropropene solution diluted in the same solvent, this would avoid the degradation of your starting compound

[@termiterasin]

Excellent video. Failure videos are great because we still get to see the process of experimentation.

[@bugabateinc971]

The HCl gas needed to be dried with calcium chloride and xylene dried prior.

[@dallas7077]

If taken internally (not as directed), propylhexedrine is a CNS stimulant and does have high abuse potential.

[@ethann1816]

I'm assuming he knew that but chose to omit it in hopes of not giving anyone any ideas lol

[@DangerousLab]

So much relief when I saw you using a testing kit instead of taste testing it this time Lol

[@Strobie_one]

A lot of your reagents are on watch lists. Still ok to buy since your not doing anything naughty, but defo expect a knock at the door at some point from some angry guys with a big stick up their asses, who are convinced you are the devil, and are paid a LOT of money to cause the problems that they are paid to also fix. Great, GREAT video!!

[@sir_no_name1478]

This was a really good transition to the sponsor. I mean probably the Best seen so far. Because this problem is so real

[@jamesleishman8025]

KZbin hate this guy for absolutely no reason

[@a564-c3q]

Because KZbin is evil.

[@Michael-cb3uw]

KZbin bans my comments for speakihg about chemical weapons manufacturers on Minecraft Letsplays comment sections

[@piparalegal2019]

Congrats on 100k!

[@AlldaylongRock]

when i interned for my BsC, i had to carry out the Friedel-Crafts acylation of thiophene with a nahphtyl-substituted chloride. It polymerized almost immediately in contact with the chloride and AlCl3. So i had to use an heavily diluted, on ice mixture of those, and dropwise added heavily diluted thiophene. It worked.

[@chevyboyforlife4234]

Everything should be legal....its none of the governments business to tell us what we can and can't do...as long what you do don't infringe on others rights and libertys then it should be completely legal

[@Michael-cb3uw]

I can tell you why the government would like to dissuade their civilian workforce from enjoying toxic/unhealthy harsh drugs such as meth it gives he country a bad look and a bad outcome of harsh drugs don't have a stigma nor law enforcement to pull down the addicts and drug dealers, the country would decline if the civilian workforce became addicted to harsh drugs PERIODT!!!, So it boils down to rich people can enjoy drugs in their homes until they die from OD but the poor are not allowed to be addicted to harsh drugs and they were pushed to work sober. For the sake of the nations reputation and to keep the status quo positive, I thinks. Law enforcement preventing the spread and creation of harsh drugs seems like it's purely for your health and to benefit the community but it's also to keep the country on a predictable positive trajectory

[@Michael-cb3uw]

Talk about freedom book, the Bible no rules just very laissez-faire no stigma or community peer pressure into making you a worker

[@goldempizza]

been waiting for this for a while looks great!

[@capybara5494]

Watching this before it goes down 😂

[@thengspjo4716]

I downloaded it just in case lmao

[@davidnemmers1563]

Dido lmao

[@davidnemmers1563]

Lol. There were two statements in here that will take this video down in a flash *when u say then that refuses or converts to anfetamine [purposefully spelled that wrong] Great video!

[@PW.Skyline.V37]

@@thengspjo4716same

[@samlassen5121]

This is so much more difficult than anything Walter White did, all he ever did could easily be done in a kitchen sink. Search up catalytic dehydrogenization.

[@lagrangiankid378]

Not on the scale he did though.

[@GCotugno999]

bro what 😂😂 nobody is making 99.1% pure ANYTHING outside of a pharmaceutical lab

[@UserNotSwipping01]

@@GCotugno999 you just need clean lab equipements and not goofing around and achieving 99% purity is feasible

[@davisbeauvais6965]

there's actually a closer legal molecule. levmetamfetamine is just meth's enantiomer and it's also a legal nasal decongestant. it's just one methyl is a wedge instead of dash

[@efeyzee]

Interestingly, both are Schedule I substances in Canada so you can buy a decongestant in Detroit, board a bus, and accidentally commit international drug smuggling

[@LifeGlitch1]

Cyclohexyl-2-Nitropropene can be reduced using Tin Chloride and HCl to Cyclohexyl-2-Propanone Oxime. Then Zinc dust reduces it to Norpropylhexedrine.

[@EliasExperiments]

Haha that is how these kind of synthesis usually go :D I completly feel your frustration.

[@kesakhan]

You could also try an iron reduction to a propanone from the nitro propane. Or a 2 step NaBH4 + H2O2/K2CO3

[@Sazoji]

those hyperlab screengrabs are gonna get you on a list labcoatz...

[@McLovinMods]

It definitely has abused potential. The only thing really stopping people from that is the lavender oil in it which can be easily extracted

[@scottm2553]

Super cool seeing your channel grow.

[@phiten40]

Watching this currently after taking a 25mg bronkaid for my usual winter congestion. Ephedrine should really get back to pre-2004 legality

[@SeijanIcks]

6:21 home sweet home...

[@jsnlgrrtt]

Study for chem test: no Watch someone do random synthesis: yes

[@LabCoatz_Science]

That's literally what I'm doing right now...I should get back to studying...

[@science_and_anonymous]

I'm a PhD level chemist, and I have had years of both academic and home chemistry experience. This synthesis scared me, in all honesty. Not because of the product being formed but the methods. You seem to have an undergraduate-level understanding of some of these reactions, which is incredible and I deeply admire, but you need to be far more careful with some of these reagents and make a safety plan lest something goes horribly wrong. Very close friends of mine have had their home labs burn down or nearly burn down, and they have graduate degrees in chemistry. ThatChemist is a great guy, and I hope you both have not only discussed synthesis but also safety. That Hg(II) is no joke also, and I hope it was properly disposed of. Love the channel, but I would hate to see you get hurt.

[@lagrangiankid378]

Mercuric salts were all safely given disguised as food to the children of a nearby orphanage, in full accordance with federal law and EPA protocols.

[@wildcatdan5072]

1:28 I don't remember that episode of SpongeBob 😂

[@BryanJohnson4891]

KZbin: “We’re gonna demonetise this video because we don’t want the creators responsible for our success to make money and this video isn’t advertiser friendly… BUT we’re still gonna put ads in it, because it’s advertiser friendly when WE make the money!”

[@arctic_otter]

That spongebob scene is hilarious

[@Harley-D-Mcdonald]

I've wanted to get into hobby level chemistry. I think what you're doing is interesting and cool.

[@LabCoatz_Science]

It's a great pass-time, and the "entry cost" isn't too bad either (a few hundred for the glassware and a hotplate, plus a bit more if you're committed and build a fume hood)

[@Nukle0n]

16:09 I'm by no means a chemist but I get the feeling whenever you see that orange vapour it's always something scary, bromine being a key example of scary orange vapour.

[@kajhansen2296]

"All colored gases are toxic, but not all toxic gases are colored" my HS chem teacher used to say.

[@mismatchingshoes5249]

0:25 nearly😁😁😁😁

[@TheBackyardChemist]

If you have a less...expensive imine available, I would be curious if the reduction could be done with Al/Ga instead of Al/Hg.

[@LabCoatz_Science]

I was thinking about that yesterday, lol

[@LifeGlitch1]

Cyclohexyl Bromide can react with Ethyl Acetoacetate Enolate made using Sodium Ethoxide NaOEt in refluxing Ethanol EtOH. Then it can react with HCl and heat and decarboxylate to Cyclohexyl-2-Propanone (Cyclohexylacetone).

[@dimitristsachakis9404]

Thank's for this interessting Video. My advice: for the elimination of the Hydroxy group to an alkene, i prefer Phosphoric acid (85%). It's a strong acid too, wich is able for the elimination. But it has a significant difference: it's much more harmless. 👍🏻🧑‍🔬

[@thelegion_within]

now that's a... rewarding... synthesis ;)

[@4crafters597]

I think this is a first time someone was happy to get positive results on that kind of drug test

[@TURBOMIKEIFY]

That SpongeBob bit had me riling in painful laughter and confusion! I spit my coffee out!

[@Aaron48219]

How long until LC does a video with Hamilton Morris? God that would be awesome. I digress. Having had pharmaceutical experience 21 years ago, this reminds me of something....that has quite a similar medication name (that I wont name) that I have not heard of in a *very* long time. Touche, you got me on the title. Well played sir.

[@antonschollum3128]

Nice brother👍

[@rattmcpossum]

I wonder if there’s a way to make an analogue of the OG ice “4-MAR” (4-methylaminorex but spelling may be off) I know analogues exist that are legal, but it’s barely been properly documented, so it might be worth looking into

[@Nuovoswiss]

There was an old thread on (i think) sciencemadness that did reductive amination with formaldehyde and metallic zinc powder. I'd love to see a video on that. Or alternative hydrogen catalysts like Raney or Urushibara nickel, or pyrophoric nickel produced by thermal (anoxic) decomposition of nickel oxalate.

[@Nuovoswiss]

Alternatively, I'd be very curious about making the methyl ether of ephedrine (and pseudoephedrine), and whether it has any interesting activity.

[@gcewing]

20:14 I was half expecting you to say "...so I'll first have to drink it."

[@generalingwer4341]

Super intresting.glad you put this video on.🙂

[@VoidHalo]

I thought this was going to be about Levo-Methamphetamine. Which is also used in decongestants and is more adrenergic than dopaminergic. I would argue that's closer to D-meth than even this. Although, I did not realize how close propylhexedrine was to meth, structurally. Very interesting.

[@bskull3232]

I think that would be impossible not to get deleted instantly. Most routes to L-meth yield 50/50 of the L and D types, and the L type is separated from the mixture later on. That's why L-meth is also being regulated -- you can chemically modify it a little bit, then modify it back, voila, you now have a 50/50 mix of meth.

[@therideneverends1697]

eh, L-meth is pretty useless, PPX is *something* the primary problem is its violently vasoconstrictive compared to its piers, doesent work quite as well and crashes like a plane into the second tower only a couple hours later at even responsible doses

[@actually_tes1]

Nice. Can't wait to synthesize this.

[@theodanielwollff]

Bless you for telling the DEA exactly your dreams :)

[@RileyGein]

We used to eat the brown bits of benzedrex inhaler cotton back in the day. Plenty of ravers parties off the cotton while hating ourselves for the terrible camphor taste bubbling up from our stomachs

[@AnthonyChinaski]

I have all the tools and ingredients readily available; now I have the knowledge

[@chrisvaiuso6010]

First time watching this channel. It's like watching Nile before he got stupid.

[@LabCoatz_Science]

He didn't get stupid...he just went more in the materials science direction lol. I do like his recent synths, like thioacetone and all of his glove/soda synths!

[@Cheezus]

the AI spongebob and patrick talking about benzedrex was wild lmao

[@von...]

***has sore throat*** "As with most of life's problems, this was readily overcome with a healthy dose of acid" ***takes 1000ug, see's god***

[@vincentdevries2369]

Perhaps you could have dehydrated the alcohol with the POCl3 you made earlier, instead of using sulfuric acid.

[@garrettmancuso4417]

I remember reading brightstar's synthesis on seedy forums 20 years ago. I knew where you got it from when I saw the mercury-aluminun amalgam. That's the part that scared younger, dumber me away from making happy sugars.

[@Arias.n]

i love writing lists, to do list, grocery list, watch list, I love making lists

[@208414]

A Grieco elimination would have been a better choice of reaction type to make the alkene in your first route. Also, I would have hydrated the alkene and oxidized to the ketone so you could do a reductive amination rather than an alkylation to install the amine.

[@gideonimolina8025]

2:32 6:30 "I like your funny words, magic man!"

[@Brendakye2468]

Even if someone did try to modify this pathway to produce some less legal analogues, my man would that be prohibitively expensive and comparatively difficult... Especially for something that can be made via a one pot method in like 15 minutes of which there are videos on KZbin of people doing said shake and bake methods.

[@Imaboss8ball]

I thought shake and bake is obsolete due to all the precursor bans.

[@DankNoodles420]

@@Imaboss8ball You don't know what your saying. The only thing you need that is regulated is pseudoephedrine. Some states you can buy it over the counter then you can get everything else at walmart, tractor supply stores, and dollar stores.

[@Brendakye2468]

@@Imaboss8ball some places have banned pseudoephedrine however there are so many ways to get around this... Like you can directly substitute ephedrine over pseudoephedrine and it will work (and you can buy ephedrine in bulk easily). Everything else required for it can be obtained from things like fertilizer and batteries. I genuinely mean it when I say everything else as it's your precursor+ammonia+alkali metal and that's it. It's dirty and dangerous but the people doing this don't care

[@lagrangiankid378]

​@@Brendakye2468few people are doing it anymore in the US as there is huge amounts of extremely cheap pharma grade mass produced cartel methampehetamine carried across the border from Mexico.

[@Brendakye2468]

@lagrangiankid378 people never did shake and bake because it's cheap (it isn't, it's one of the most expensive production methods), they do shake and bake because their dealer won't supply to them anymore and it is so dead simple. People are still doing it and I've literally watched people do it in parking lots outside of Walmart this year.

[@bronzewarner2689]

"Fortunately, as with most of life's problems, this was readily overcome with a healthy dose of acid..."

[@gregmagdits6421]

Question - @ 3:14 the chemist mentions that sulfuric acid "pretty much annihilated " everything in the reaction vessel. What was the problem with this step? specifically, what else was formed besides the desired terminal alkene?

[@Labdominals]

3:08 Casually drops producing the other forbidden candy

[@boothbytcd6011]

Onto 'the widomaker', as it was called.

[@dracodragon105]

8:43 looks like an orange soda with an icecube made of cola, which honestly sounds pretty good

[@_letstartariot]

This guy is a legit chemist folks. Much like NileRed, he has done things with chemicals that would give an ophthalmologist night terrors.

[@californium-2526]

Saturated meth synthesis, complete with similar synthetic intermediates, formaldehyde and mercury(II) solutions.

[@nihilgeist666]

Legalize, regulate, and tax ALL DRUGS!!!

[@Moritz___]

tax => black market

[@Chiberia]

"regulate" - you realize that's what's done, currently, right? the schedules are literally regulation.

[@lagrangiankid378]

​@@Chiberiaif you regulate everything you regulate nothing.

[@Chiberia]

@@lagrangiankid378 what does that even mean

[@lagrangiankid378]

@@Chiberia It means that over regulation of the legal market leads to the formation of a completely unregulated black market. It's the soap bar effect: the stronger you hold it, the more it flows out of your hands.

[@mathew2214]

but does this fill the lab with that nostalgic m-lab smell that send us back to our childhood days?

[@Thealchemistscorner]

In you last step you should have filtered off you reaction mixture added NaOH or another base to get as much freebase as posible, then stirred your nonpolar solvent(use DCM) suffecently with your reaction mixture, the DCM/base amine sould be washed with Na2CO3/NaHCO2 brine and 3x with water. Also you should genrate HCl using the upmost anhydrous conditions use dry NaCl and let the gas pass thrugh CaCl2 and then into your solution. You could also synthesise propylhexedrine from (1-cyclohexyl-2-nitropropene)CH2NP which you couldve synthesised from Cyclohexanecarboxaldehyde and nitroethane using ethanolamine acetate as you catalyst at room temprature(which gives higher yeilds), then use either H2O2/NaBH4 or just Fe(or Zn)/HCl (or GAA) to form the (1-cyclohexylpropan-2-one)CH2P(which can be purified using sodium metabisulfite), then form the imine using anhydrous methylamine(which can be fromed in situ using methylamine HCl using mol sives id recomend doing it in methanol) and reduce with NaBH4 to get your propylhexedrine with relativly good yeilds.

[@marconiandcheese7258]

When you mentioned pee, NileRed will show up wanting to transform it into drink. Lol

[@coreysayre1376]

PPX is indeed the most fun legal decongestant! Can't wait to see this one!

[@jordynozymandias374]

Thought this was gonna be about L-methamphetamine decongestant which I was kinda shocked to see chilling in a grocery store recently.

[@LabCoatz_Science]

@@jordynozymandias374 yeah, I would live to make it, but it's really hard to do without also making some of the very illegal dextro isomer lol

[@OtherWorldExplorers]

Doesn't regular table salt contain iodine. And is it in large enough quantities to even make a difference.

[@LabCoatz_Science]

It won't make a difference. If anything, there might be a few milligrams of propylhexedrine hydroiodide with the hydrochloride.