MALIGNANT HYPERTHERMIA, Causes, Signs and Symptoms, Diagnosis and Treatment.

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Chapters
0:00 Introduction
0:54 Causes of Malignant hyperthermia
2:21 Symptoms of Malignant hyperthermia
2:48 Diagnosis of Malignant hyperthermia
3:36 Treatment of Malignant hyperthermia
Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible.[1] Symptoms include muscle rigidity, high fever, and a fast heart rate.[1] Complications can include muscle breakdown and high blood potassium.[1][2] Most people who are susceptible are generally otherwise normal when not exposed.[3]
The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are susceptible.[1][3] Susceptibility can occur due to at least six genetic mutations, with the most common one being of the RYR1 gene.[1] These genetic variations are often inherited from a person's parents in an autosomal dominant manner.[1] The condition may also occur as a new mutation or be associated with a number of inherited muscle diseases, such as central core disease.[1][4]
In susceptible individuals, the medications induce the release of stored calcium ions within muscle cells.[1] The resulting increase in calcium concentrations within the cells cause the muscle fibers to contract. This generates excessive heat and results in metabolic acidosis.Diagnosis is based on symptoms in the appropriate situation. Family members may be tested to see if they are susceptible by muscle biopsy or genetic testing.

[@yarasleman1298]

Thank you this is helpful and satisfying 🙏🏿💜

[@sarahbrandao6028]

Clear as water. Thank you very much.

[@binitapoudel1]

Omg such an awesome video. Very well explained. Thank you very much. You just got a new subscriber :) :) :)

[@mullumadaan]

Super informative video 👍🏼

[@Elpersegidor]

Hey, great video! I just want to point out that you have mistake at 01:30, the proper name of the gene is CACNA2D1. Cheers, keep up the good work!

[@yihuacao1629]

「明確なメッセージ、明確な構造、理解しやすい、ありがとう」、

[@sajaalhaj8468]

This is so helpful.. Thank you♥️

[@MedicalCentric]

You’re welcome 😊

[@masumrabbani9996]

Nice

[@dinaalbushra5364]

Thaankkk uuu♥️

[@junpre9721]

My body temperature is on the red 384 f. I show no symptoms

[@Mobius95]

Had this happen to me a few months ago when getting surgery on my appendix. Not a fun time at all. Had to get flown to a different hospital

[@keyone415]

Had this too 3 weeks ago during the appendix surgery!

[@Mobius95]

@@keyone415 that’s insane!!!

[@arthurmccarthy4099]

「とても良くて面白いビデオは素晴らしいエンターテインメントの感覚をもたらします！」、

[@saltywalrus]

Thrax: "careful I'm contagious"

[@user-lv7xz3qv4i]

I'm dying of stress..I wanna pass this exam...this exam is my life..Will I be able to pass?

[@coolperson4582]

did u pass

[@davidagent7079]

Hyperthermia caused the metabolic acidosis and because of that the level of carbon dioxide will decreased not increased.

[@MedicalCentric]

You are correct. Hyperthermia, which is an elevated body temperature, can indeed lead to metabolic acidosis, primarily because it can affect various metabolic processes and lead to increased cellular activity and breakdown. In metabolic acidosis, there is typically a decrease in the level of carbon dioxide in the blood (a condition known as respiratory alkalosis) due to increased respiratory rate as the body tries to compensate for the acidosis. Thank you for the clarification.