Mark Mattson: Building the Brain: Glutamate as Sculpture and Destroyer

[@mjeffn2]

Cool. My son completes his veterinary surgical residency in July. Yeah, veterinary medicine is a super tough path to take. Instead of medical school, he decided he liked animals more than people. LOL

[@coreyneil8763]

OMG this is such a fascinating topic!!! - Mental Health Counselor

[@coreyneil8763]

LC made such a good point about the horse naturally keeping its head up. It touches on how important “initiative “ is… if that horse was sprinting in the context of a “story” it understood, damn right it would keep its head up!

[@Philusteen]

Love that you got Mattson - his science really contributed to my fasting regimen. Really valuable work.

[@nda4591]

Very interesting conversation! Thought I’ll listen to it in 2 “one hour parts”, ended up listening to the whole thing and wishing they will hold another episode together.

[@saeidaliyounkhajehdizaj9903]

Thank you for doing this.

[@dosesandmimoses]

There are not enough thank you’s. Egelston hospital should have my records from ‘92.. I was on 1200mg of tegretol - egelston should have initial MRI- I have MRI from eeg from 2018 in NV (these were overnight - 36 hour continous EEG tests - I have three external hard-drives and 2TB iCloud Drive

[@MrLcowles]

Another great show. I like to think that I can feel my neurons forming new connections, Is that artfulness?

[@NicholasWilliams-uk9xu]

Yeah, the free energy principle is not a theory of general intelligence, it's a benchmark. The specifics of how information is integrated is the most important element (Parallel distribution of temporal sequential information processing). The dendrites are doing a more sophisticated parallel sequencing, correct/incorrect, amplification/degradation threshold activation, than current neural networks. In a lot of the current neural networks, sequential information processing isn't really there in the way it is in the human brain. However you can (amplitude falloff over time frame) condition latent space activation, (input spike falloff/time, with subsequent reinitialization [previous increases in the data input have ambient persistence, you could also have this ambient persistence within the hidden layers as well]), this gives that extra temporal sequential context.

[@randylamonda460]

When Lawrence was talking about Action Potential, was he trying to say the charge is like lightning starting at the ground then going to the clouds?

[@ivannegri7724]

Great podcast, very informative, I'm going to add some science about brain fuel: glucose, ketones and oxygen. Ok, so hormetic changes in the first two, glucose and ketones, were discussed and I learned that ketones upregulate GABA, but oxygen as related to hormesis wasn't mentioned, So, in mice studies u can show that chronic, low level oxygen deprivation has a hormetic effect on brain cells, less cells die if you induce a stroke in conditioned mice. So, if u use an altitude chamber or practice or some other method you can make your brain more resilient to the effects of stroke. Forgive me if I got my science wrong, I'm just an amateur. Anyways, thanks for maintaining a high standard of engaging intellectual output😊.

[@USS-SNAKE-ISLAND]

I think an interview with Johnjoe McFadden would augment this interview quite nicely.

[@NicholasWilliams-uk9xu]

This is good stuff. :)

[@sheilawade433]

Know the stars to see the Starlinks

[@dr.samierasadoonalhassani2669]

They look like brothers.