Inclisiran - recently approved and how does it work really?

Drs. R. S. Wright and Kopecky will discuss a new drug, Inclisiran, that was just approved by the FDA on how inclisiran works to lower cholesterol. Dr. Wright will answer these important questions as well.
Are there any other lipid effects , for instance, does it affect Lp (a) levels? What do we know about side effect symptoms, incidence, and timing?
Other than injection site , are there any MSK side effects? GI, renal, or respiratory? How is it administered ? Can it be self-administered? How long is the observation period after injection? When to check lipids ? Any other testing required?
What are the FDA indications? Did the FDA suggest/require any concomitant medications? Is effect additive to statins, ezetimibe and beneficial to use together?
What do we know about fatal and non-fatal CV Event reduction with the drug? Any off-target effects? Drug-drug interactions?
What is the cost estimated to be and ease of insurance coverage? When should we use this drug ? Who is the ideal patient? Who should not receive it?