Mechanism of Action for Adenosine

[@EagleEye1104]

Notes: adenosine binds to receptor coupled to inhibitory G-Protein in SA node cells --> activated inhibitory G-protein --> subsequent inactivation of adenylate cyclase --> subsequent inhibition of CAMP and PKA synthesis. Final result = decreased Ca influx into cell and K efflux out of cell --> SA node hyper-polarizes = delayed SA node action potential

[@qamarali6579]

Thanks 🙏

[@rename_525]

God

[@ChristopherGray00]

absolutely amazing breakdown, no oversimplifications yet explained in a way that is easy to pick up on and understand. thank you.

[@RonShenkar]

Concise and to the point. Thanks!

[@mollylee9953]

thank you! very clear and helpful.

[@vineshmanohar9978]

Thank you! Could u please make a video on how Ranolazine works :)

[@E4M8T6B2]

Is it not the AV node? Considering that adenosine is used primarily for SVT, would it not make sense to regulate cardiac rhythm at the AV node?

[@JJMomoida]

You are correct. It ALSO exerts its effect on the SA node.

[@tenisokamuoliukas]

How exactly does reduced PKA synthesis cause a K efflux? Is potassium channel activity decreased by phosphorylation?

[@Cmartgixer]

Is this occurring on the pre or post synaptic neuron?

[@divyajoshi5496]

Please explain adenosine decrease the k eflux or increases the k eflux?

[@erikruizmd]

isnt a2 receptor ? instead of a1

[@juno8169]

you just saved my exams in 49 seconds

[@PeteHob]

Very intricate exclamation all the way down to the cellular level. Now all we need is a little addendum warning the patient how he will feel if God forbid he ever needs this drug.

[@musicforaarre]

HOW DO I GET RID OF (NOT BLOCK) ADENOSINE ! I AM CONSTANTLY TIRED, AND I THINK I AM SWIMMING IN IT. Aarre Peltomaa of Mississauga, Ontario

[@immadisarojini2775]

Very nice

[@jeffweaver955]

Very concise, did not understand a single word

[@cselphenator]

What he said..

[@AnimeBee25]

Normally it resets the HEART

[@Cleisthenes2]

now you node