cAMP - ATP, ADP, cAMP - Adenylate cyclase - Protein Kinase A - G-protein, Cell Signaling - Physio

[@MedicosisPerfectionalis]

💊🤷‍♂️ Cardiac pharmacology is on SALE: www.medicosisperfectionalis.com/products/ 💊🧫 My antibiotics course is on SALE: www.medicosisperfectionalis.com/products/courses/antibiotics

[@mikkit876]

I have epilepsy and miss a lot of my lectures due to seizures, your videos have helped SO much in me being able to learn biochemistry and medicine. Thank you! You make it so entertaining as well

[@alaynaguzzi2017]

You have brought forth joy and passion that I have been lacking this semester. Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@aydaabdolmanafi]

In the first three minutes i got all my confusion solved, the confusion that has happened after reading a university pamphlet for hours nonsense!

[@MedicosisPerfectionalis]

Thank you so much for watching!

[@ficklepepper]

EXCELLENT resource to put concepts together of what 2 textbook, paid courses and expensive books can offer. After watching your video I feel that I can practically track where the process begins and ends forward and backward. Forever grateful. Thank you

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@ficklepepper]

@@MedicosisPerfectionalis heck yeah!!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@MalynLaReina]

Of all the videos and articles I read this made the most sense. Thank you for breaking it down, and making it fun with your side comments. Really helped me grasp the concept!

[@MedicosisPerfectionalis]

Thank you 🙏

[@Veteran365]

Holy shit!! You are an amazing teacher!

[@MedicosisPerfectionalis]

Thank you ☺️

[@jamierayevalmores3109]

i love your videos. it makes pharmacology fun and a "lil bit" easier. please keep making more. you're the best

[@MedicosisPerfectionalis]

Thank you 🙏

[@Chris-tg8gr]

"Pharmacology makes perfect sense once you understand what the flip you're talking about!...." I felt that!!

[@MedicosisPerfectionalis]

:)

[@lisagonzalez2902]

I've been searching for videos on cAMP, cGMP, and found some very good ones but I wanted to see if you also had a video on this subject, and I found it! Thanks for your effort. Funny, repetitive, really makes me understand better.

[@paulakiaraluna1969]

I love your videos so much!!! I am preparing for my MCATs and I watch your videos to deeper learn topics. Please keep making more! Thank you for all your help!

[@MedicosisPerfectionalis]

My pleasure 😇 Good luck with your MCAT.

[@saraxcardoso]

You are so funny and you expalin these concepts so well and so clearly! I love this video, thank you sooo much 💖🙌🏼

[@najumudhina.m.k3966]

Your videos are really unique, its reflecting your hard work and by God Grace, you will reach million subscribers soon

[@MedicosisPerfectionalis]

Najimudhin A.M.K Thank you so much 😊 I am so happy right now!

[@lisagonzalez2902]

I noticed a mistake at 13:05. You say Ca+ channel blockers 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞 cardiac contractility, however, the drawing states that it 𝐝𝐞𝐜𝐫𝐞𝐚𝐬𝐞𝐬 (this is correct).

[@MedicosisPerfectionalis]

They decrease contractility. Thank you so much for correcting me.

[@lisagonzalez2902]

@@MedicosisPerfectionalis I have a question! I'm not very clear on the cAMP effects on Angiotensin? Doesn't it inhibit this process (therefore, causing vasodilation)? I've tried watching that part a few times but I don't understand. Please, enlighten me!

[@lisagonzalez2902]

Does cAMP cause both vasoconstriction and vasodilation? Beta-agonists increase cAMP, therefore causing vasodilation. But Beta-blockers cause vasodilation by decreasing cAMP because of the A-T pathway? Why doesn't cAMP *only* cause dilation/relaxation in smooth muscle?

[@santoszinga2617]

I really love this video,that makes sense .

[@MedicosisPerfectionalis]

Thank you 🙏

[@ayeshamuhammad6553]

Your videos are simply amazing. I have a much better understanding of many topics including cAMP!

[@MedicosisPerfectionalis]

Awesome 👏

[@luciararocha]

I can't believe I finally understood this!!!! Thank you so much 💓

[@MedicosisPerfectionalis]

My pleasure 😇

[@Southerngrl]

I bet the plaquenil video wld get you lots of views esp with zpac! Even though it’s “off label” hard for lay pll to understand the ramifications of these meds! You can explain it so much better for us all!

[@MedicosisPerfectionalis]

That’s a great idea 💡

[@sathvikgowda1348]

Hi...at 12:10 you say the cAMP causes vasodilation and decrease BP and also you say..via RAAS pathway vasoconstriction occurs and BP increases. Which one is predominant?

[@sunnrayy11]

this mannnnnnnnnnn is great

[@MedicosisPerfectionalis]

Thank you so much!

[@cynthianyanda3842]

Thank you so much! I've been stuck confused and didn't want to watch this video coz it's longer than the other cAMP KZbin videos by like 15 minutes. But I was confused even after watching them so I wasted my own time and here I am.

[@Robert___3f]

Pessimistically acknowledging the power of a smile.

[@Afshu97]

Nice explanation thank you so so so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@nhhao_medi]

i love the way you make it ez to understand From Vietnam with luv ❤

[@MedicosisPerfectionalis]

Thank you!

[@nermeengamal5441]

The way you talk so unique, funny, beautiful. ❤

[@MedicosisPerfectionalis]

Thank you so much 😊

[@anahmoon522]

I laughed when you said "it's common sense" 🤣

[@calvinrich363]

if you use b-blocker, which means b1 receptor is not working, so no stimulation of Gs, so no cAMP. no cAMP means contractility is decrase and vasoCONSTRICTION, no???? means b-blocker can cause vasoconstriction leads to increase BP please correct me if i misunderstood

[@farhaelsharif9317]

thank you for this video its perfect you're saving lives

[@MedicosisPerfectionalis]

Thank you 🙏

[@gamagarcia3037]

just of curiosity are those receptors receiving information outside the membrane which because of the signal they RECEIVE, the START the process of producing the cAMP? , are they the G protein couple receptors?

[@ComPasPharm]

Thx. Beautifull lecture!!!

[@sama_albairmani]

INCREDIBLY AMAZINGGGGG

[@markusguerrero9593]

This is amazing. Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@rania0.1]

❤ love your vibes How to explain and I love your voice more

[@MedicosisPerfectionalis]

Thank you 😊

[@jesusbrownies]

Everything is soo clear after watching this Thank you so muchhh

[@MedicosisPerfectionalis]

My pleasure 😇

[@monika246]

Wowwww...just loved it

[@MedicosisPerfectionalis]

Thank you so much 😊

[@aroor1785]

Is there a place i can get the transcript of this lecture from ? 18 minutes video made me understand so much about antiplatlets therapy, and some of the most common shock hf interventions we take ,, and even aminophyline toxicity .. thank u man

[@arunaacharya3849]

PDEs are also of different types...There is PDE1,2,3,4.Could u shed some light on the location?..are they all present in the cytoplasm?

[@a30694]

cAMP acts on smooth muscle of blood vessels and cause vasodilation and a decrease in bp. On the other hand it increase angiotensin ii and aldosterone and causes vasoconstriction and salt and water retention and increase bp. So which is the predominant effect? Please help me out.

[@tylerwilliams6882]

did you find an answer to this? I'm wondering the same thing

[@georgep.7492]

I am not even studying pharmacology this year, but this was nice

[@muhammaduwais5323]

Really helpful

[@MedicosisPerfectionalis]

Muhammad Uwais Thanks 😊

[@muhammaduwais5323]

@@MedicosisPerfectionalis if u don't mind. Can you share about muscle reflex?

[@MedicosisPerfectionalis]

A video?

[@muhammaduwais5323]

@@MedicosisPerfectionalis yes

[@MedicosisPerfectionalis]

Muhammad Uwais like the knee jerk reflex, ankle reflex,...etc?

[@danagreenberg945]

this was perfect

[@rathodnehal2869]

can you make video on cGMP mediated vasodilator

[@olaabdallah3607]

Amazing video ❤ Btw love your accent, are you egyptian? 😂

[@MedicosisPerfectionalis]

Yes!

[@banjitkalita8556]

How cAMP contract heart muscle and dilate smooth muscle??

[@doctorgvlog]

Lovely sir

[@MedicosisPerfectionalis]

Thank you 🙏

[@Srun-p2b]

Hello ! Anyone can explain me why a2 receptor -> Gi pathway -> low c AMP, but it cause relaxation? (Source: b. α2 Receptors are located on sympathetic postganglionic nerve terminals (autoreceptors), platelets, fat cells, and the walls of the GI tract (heteroreceptors). often produce inhibition (e.g., relaxation or dilation). Mechanism of action: Gi protein, inhibition of adenylate cyclase and decrease in cyclic adenosine monophosphate (cAMP). )

[@ضحىيوسف-ع2ت]

Thank u for this video and please teach us the biochemistry

[@MedicosisPerfectionalis]

ضحى يوسف I have a biochemiistry playlist

[@ABC-fv7ow]

Superb 👌

[@MedicosisPerfectionalis]

Thank you!

[@frodobeutlin4368]

you son got a new customer ;)

[@MedicosisPerfectionalis]

Haha 😂

[@MedicosisPerfectionalis]

Frodo Beutlin Welcome to the family!

[@Dr_fonesz]

Very informative.

[@MedicosisPerfectionalis]

Alphones Kuma Thank you so much 😊

[@JoyceGem]

HAHAHAHA your wit tho 🤣🤣 tbh this is the way I study too. Lmao "this is common sense" HAHAHA

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@bealambwouldya]

This easier to understand then my teacher 💀

[@dianalynvillanueva1216]

this is so cool. hahha thanks for yhe good pneumonic 😎

[@MedicosisPerfectionalis]

My pleasure 😇

[@sonya1500]

I am a simp for medicosis perfectionalis.

[@MedicosisPerfectionalis]

Haha 🤣 Funniest comment ever!

[@sonya1500]

@@MedicosisPerfectionalis I am dead serious babe

[@black.beerd.gaming]

completely savagery, I'll be rewatching this video for fun

[@MedicosisPerfectionalis]

Thank you 😊

[@immadisarojini2775]

Super

[@MedicosisPerfectionalis]

Thank you 🙏

[@elizabethrouse4182]

you misspelled messenger ;-)

[@MedicosisPerfectionalis]

Oops 😬

[@elizabethrouse4182]

@@MedicosisPerfectionalis Words are my jam. 🤓 Wish I was better at science.

[@polarispolaris1705]

شرحك ممتاز

[@MedicosisPerfectionalis]

🙏🙏🙏🙏🙏🙏🙏

[@artbylupiv]

Man you are asm just awsm

[@MedicosisPerfectionalis]

Thank you 🙏

[@lujnas]

god, his voice..........

[@MedicosisPerfectionalis]

Good or bad? 🤷‍♂️

[@lujnas]

@@MedicosisPerfectionalis shy to say 🏃🏼‍♀️

[@juliandionne7209]

great

[@MedicosisPerfectionalis]

Thank you 🙏

[@hemanth.sgowda702]

👏👌

[@MedicosisPerfectionalis]

Hemanth.S Gowda 👍👍👍👍

[@thinkpositive8328]

😎😎

[@MedicosisPerfectionalis]

:)

[@aroor1785]

Convert it into trash called degradation products ahhahahhahahahhahahhahhahahhahahahahhahahahahhahahahah

[@MedicosisPerfectionalis]

😂

[@evaneckhart9648]

L accent