Mechanism of Extrinsic Pathway of Apoptosis | TNF Path

Two theories of the direct initiation of apoptotic mechanisms in mammals have been suggested: the TNF-induced (tumor necrosis factor) model and the Fas-Fas ligand-mediated model, both involving receptors of the TNF receptor (TNFR) family coupled to extrinsic signals.
TNF path :
TNF-alpha is a cytokine produced mainly by activated macrophages, and is the major extrinsic mediator of apoptosis. Most cells in the human body have two receptors for TNF-alpha: TNFR1 and TNFR2. The binding of TNF-alpha to TNFR1 has been shown to initiate the pathway that leads to caspase activation via the intermediate membrane proteins TNF receptor-associated death domain (TRADD) and Fas-associated death domain protein (FADD). cIAP1/2 can inhibit TNF-α signaling by binding to TRAF2. FLIP inhibits the activation of caspase-8. Binding of this receptor can also indirectly lead to the activation of transcription factors involved in cell survival and inflammatory responses.[34] However, signalling through TNFR1 might also induce apoptosis in a caspase-independent manner. The link between TNF-alpha and apoptosis shows why an abnormal production of TNF-alpha plays a fundamental role in several human diseases, especially in autoimmune diseases.

[@valaguilera2897]

you saved my life right before the quiz man, thank you so much. keep up the good work

[@hussainbiology]

tha Val for appreciation.. Glad it helps ✌️

[@mankauraage6963]

I gained 10 marks presentation with the help of your lecture ❤thanking you from 🇸🇴

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@SuperJasmine110]

great video! Helped so much.

[@hussainbiology]

Thanks Jasmeen for the appreciation, really glad to know that it helps......

[@ASITV]

your accent is very strong indian, but you really made me get the clue. thanx from germany

[@hussainbiology]

thanks for appreciation.... English is not my native Language that is why the accent sucks....

[@molecularunity]

Excellent vid, very informative, perhaps a little too fast and perhaps a little more explanation of the separate stages would help, but otherwise, it is excellent, thank you.

[@hussainbiology]

Thanks for appreciation Sir..Glad to know that it helps ✌️

[@lailanasser1154]

Keep up the good work.

[@hussainbiology]

thank you for appreciating my work........

[@joshuavandenberg7927]

Great video helped me so much.

[@hussainbiology]

thanks for appreciation

[@SajitaKu]

awesome video....it helped me a lot in this self study time during lockdown. plz tell me the meaning of recruit which u used in video.

[@hussainbiology]

To bring.....

[@SajitaKu]

@@hussainbiology thankyou😊

[@alqemavet7430]

شكرا جزيلا لك يا حسين أنا من سوريا

[@hussainbiology]

Thanks ✌️

[@justanotherguy9690]

Thanks for the great video

[@FerozKhan-mc9hf]

Ammazing♥️🔥

[@hussainbiology]

thanks for appreciation..Glad it helps....✌️

[@sheebazafer5476]

Thank you 😊

[@hussainbiology]

Thanks Sheeba for appreciation.....😊😊

[@taqiomar1327]

caspase cascade stops or starts ??? great video btw

[@hussainbiology]

Starts..... and thanks for appreciation

[@Bromocriptine777]

Very nice

[@hussainbiology]

thanks for appreciation...Glad to know that it helps ✌️

[@ayaaljmi6469]

Thxxx❤

[@hussainbiology]

Welcome 😊

[@sheljasharma737]

Sir can u plz explain how ros increase tnf alpha mediated apoptosis?.... I actually have a presentation after 2 days and i need to know this.plz help

[@hussainbiology]

kzbin.info/www/bejne/oKvddmmchKasjsk

[@hussainbiology]

We need Cytochrome C to make Apoptosome , but this cytochrome c is in Mitochondria , so in order to drive the Apoptosis , we need to pull out the Cyt C and this is done by ROS ,,, the ros makes Peroxidase , which then drives peroxidation of Cardioilipin ,, and that way Cytochrome c is relieved off from Mitochondria. Do watch the video that i have linked in the comment kzbin.info/www/bejne/oKvddmmchKasjsk

[@sheljasharma737]

Thnx sir

[@sheljasharma737]

Can i say that ros increases activation of jnk and promotes apoptosis initiated by tnf alpha.ros also inhibits Nf-kB pathway,so that cell survival pathway do not start

[@sheljasharma737]

@@hussainbiology the reason u mentioned is for intrinsic pathway of apoptosis.I need to know about the effect of ros on extrinsic tnf alpha mediated apoptosis.

[@-_-ok9550]

thx a lot

[@Bot12-w9u]

Asalamualikm..Eid Mubarak sir...sir plants manz cha same mechanism apoptosis suk operate gasan...

[@hussainbiology]

The enzymes are the same and even pathway drives thru same mechanism but cross talks and activation differs...

[@Bot12-w9u]

@@hussainbiology sir wish you to discuss apoptosis in plants as a separate lecture as eeidi on this auspicious day..

[@Bot12-w9u]

@@hussainbiology sir wish you to discuss apoptosis in plants as a separate lecture as eeidi on this auspicious day..🙂🙂

[@hussainbiology]

@@Bot12-w9u InshaAllah Zaroor

[@Bot12-w9u]

@@hussainbiology sir jaldi hi bnana papers 10 din me start hone wale he

[@ritwikpathak4493]

What is TRADD and FADD????

[@WaniBilal-ul6db]

What is your profession sir?

[@nurulalam7243]

great

[@hussainbiology]

Thanks for appreciation....

[@aadilaif]

Nice

[@mahamT38]

You need to speak louder, video is great though

[@pullannagarinikhil1481]

Too fast explanation..

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@carmenrasquinigrassiotofil1517]

couldnt understand a word :(

[@Bromocriptine777]

Learn to speak English then.

[@Ivy-or3wi]

Expanding your English vocabulary might be necessary. I understood pretty well but that's only because I had to learn a lot of English recently.

[@esrakucukaydn842]

bu nasıl ingilizce şaka mısın ya

[@aadilaif]

Nice