Mechanism of mRNA deadenylation & decay

Scientific Animator: Inhye Park
Narrator: V. Narry Kim
Advisor: Kwanhyun Youn, Sangyoun Kim, Minjoo Kim
Scientific Advisor: V. Narry Kim, Hyerim Yi, Joha Park
Funding: V. Narry Kim, RNA Biology Laboratory, Institute for Basic Science and Seoul National University
Related study: H. Yi, J. Park, M. Ha, J. Lim, H. Chang, V. N. Kim (2018) "PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay" Molecular Cell, 70(6):1081-1088.e5. (doi.org/10.101...)
Copyright 2018 Inhye Park
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[@tomy34188]

This is a neatly visualized and informative video and it is presented at a good pace and in a clear fashion. The narration/voice-over could benefit from a more enthusiastic voice and clearer pronunciation, I think. Thank you for putting this out.

[@shezgeon]

교수님의 육성을 이렇게 집중하면서 들으니까 쏙쏙 머리에 들어옵니다. 교수님, 그리고 연구원분들의 노고에 감사드립니다. 항상 건강하셔요!

[@adilct3467]

Thank you..! Nicely presented

[@Pyrall0Isplaying]

Thank you for this clear & precise explanation! So poly A tail is dynamically synthesizes and degrades by PAP and Pan2/3 but when CNOT engages, deadenylation is definite and Poly A structure is no longer dynamic but irreversible?

[@zi3417]

amazing video!!!!!

[@jingyang9337]

Thanks

[@s.papadatos6711]

Hidden Gem.

[@ipm4606]

THANK YOU SO MUCHHHH

[@TomatoTomato911]

i wonder if creators of pacman already had this figured out in the 80s?