Pfizer COVID 19 FDA Authorized Pill "Paxlovid" Explained

Roger Seheult, MD of MedCram illustrates how the Pfizer coronavirus pill called Paxlovid works, its efficacy, and its side effects. See all Dr. Seheult's videos at: www.medcram.co...
Clinical trial data for Paxlovid show that if taken within 3 days of symptom onset, hospitalizations and death were reduced by 89% compared to placebo.
(This is Update 144 in The MedCram Coronavirus video series. It was recorded on December 29, 2021)
Roger Seheult, MD is the co-founder and lead professor at www.medcram.co...
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:
Pfizer Announces Additional Phase 2/3 Study Results (Pfizer) | www.pfizer.com...
Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate (Pfizer) | www.pfizer.com...
How Pfizer's New Drug Fights COVID [PAXLOVID] (Simplifying Synthesis) | • How Pfizer's New Drug ...
The SARS-CoV-2 main protease as drug target (PMC) | www.ncbi.nlm.n...
Covid-19: Pfizer’s antiviral Paxlovid effective against severe disease and Omicron variant (Pharmaceutical Technology) | www.pharmaceut...
All coronavirus updates are at MedCram.com (including more discussion on new COVID variants, fluvoxamine, Pfizer covid pill, and more).
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Media contact info: www.medcram.co...
Video Produced by Kyle Allred
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DISCLAIMER:
MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #Omicron #Coronavirus

[@Medcram]

Dr. Seheult is the speaker in this video - Please visit MedCram.com where you'll find his full collection of videos on over 60 topics (Asthma, diabetes, heart failure, pneumonia, etc.). Thanks for your support!

[@fredkaramanol4993]

I tested positive for Covid on Wednesday, got a prescription from my Dr on a tele-health call the same day. Couldn't get help getting the prescription (due to a death in the family). Finally got the prescription on Friday. Within 1 hour my fairly persistent cough, pounding headache, nasal mucous disappeared. I'm in day two of my treatment and I am so comfortable. I coughed once today! In my opinion, this medication is completely effective. I would recommend it for anyone. I am a 72 year old male.

[@DrAlvinEng]

As a Cardiologist, I have to commend you for your clear explanation that any layperson should be able to follow and understand! Keep up the great videos!

[@tiny.terrorist.negotiator]

I was prescribed this yesterday and can say that I have done 3 doses so far and I already feel much better!!!! It does make everything taste awful but compared to how I was feeling, ill take it!

[@ahmedsgallery3507]

Oh im glad you did ok. How are you now? did it do a much different experience in a good way?

[@timothyberlinski2299]

Man i wish we had a viral replcase inhibitor that has been proven safe, been around 40 years, cheap and won the nobel prize. That would be so nice

[@americanpaisareturns9051]

Clear and straight to the point. No fear mongering. No propaganda. Thanks for the info Doc.

[@some_random_guy_lol]

I’m so thankful to have a clear, concise, non - political description of a really important intervention in our collective battle with Covid-19. Thanks doc! (PS I started taking Paxlovid yesterday and I’m on my third dose - still feel pretty crappy but my doc explained safety, not symptom relief, is the main reason for taking it. Also, my tongue tastes like I licked a light pole covered in dog feces.)

[@vaevictis_]

That doesn’t sound good at all lol

[@eddiesneeh4266]

This man should be given a medal for educating both health professionals and the general public in a scientific, objective way that we can trust. The US should follow Bahrain's example. No political agendas, no financial motives. A trusted model of integrity and knowledge, Dr. Seheult is who I'd rather have as the Director of the NIAID.

[@nickace843]

my question is the only question that matters what are the long-term effects of this pill what comes later on in life due to taking this pill... That's the question that a lot of us want answers for

[@averageguy1261]

I wonder if someone who has mild COVID should take this or should just let it take its course. Getting better faster is great, but is there a hidden health cost? THE BEST EXPLANATION ONLINE. Thanks Doc!

[@usneome]

It would be interesting to have a similar video about Ivermectin, an already approved FDA medication with known long term safety.

[@Medcram]

Or better yet fluvoxamine which has all of those attributes plus a positive large randomized controlled trial that showed it worked.

[@MoonstruckExploring]

Just wanted to say I got covid, even with all the precautions including being vaccinated and boosted. I did take Paxlovid within 3 days of getting symptoms and four days after that I tested negative. Paxlovid worked well for me.

[@JC-vz9vn]

This is the only channel I trust regarding COVID. THANKS Dr Seheult!

[@epicchannel4724]

It's a 3CL protease inhibitor just like Ivermectin but not as good.

[@llunaeldas8055]

These pills and vaccines should go through the rigorous process of testing and more testing. Then they should be transparent about their findings. Instead you have pfizer saying they won't release any documentation for 75 years and if you die, you can't sue. If I were you, I'd wait 15 years before taking any of these treatments.

[@buck10539]

I only got through 2 doses before I had the worst diarrea of my life. Food and liquid went through me like a seive. I finally had to take imodium to stop it. Same thing happened to my wife. So far the side effects have been worse than the virus. I'm on day 5 after testing positive and am feeling much better just letting the sickness take it's course.

[@stephanielopez2612]

I was prescribed paxlovid.On Saturday And day3. I’m feeling better with no symptoms and day 5 took home Covid test and now I’m negative. It gave me a bad taste in mouth. But it saved my life for getting worse or even death. Thanks to Dr and Pfizer for saving my life♥️

[@girlgeniusnyc272]

Dr Medcram, How does Paxlovid compare to NAC / L-Glutothione?

[@spiritualspinster4222]

As a nurse I was hoping for a concise explanation of how Paxlovid works, How effective it is, what the usual dosage is, and the prevalence of adverse effects. You explained all that very well. Now all I need is a list of the most common and the most serious side effects experienced. My guess is liver damage due to the use of Ritonovir.

[@brastmonkey]

Why was NAC banned for sale in the US?

[@bobthrasher8226]

Was it compared to ivermectin?

[@davidspero1125]

The question is not whether "it works," but if it's safe and necessary.

[@PEDRO-lq9ph]

Do you have anything better? 🤔

[@marilynkolodziejczyk6290]

I look forward to all your videos. Thanks Dr. Seheult!

[@senorphilippe6324]

Paxlovid works. I tested positive via AntiGen Monday morning. I was unable to connect with my PCP to have her prescribe Paxlovid. Good thing there’s virtual doctors that was able to prescribe me Paxlovid. I took the first dose last night and another dose this morning. Its 2pm and I feel great! I will still keep on taking paxlovid for the next 4 days.

[@senorphilippe6324]

Oh yes the after taste after taking paxlovid is the worst part of it. But I don’t mind as long as I feel better 🎉

[@lorraine1219]

An otherwise healthy, 89 y.o. unvaccinated family member of mine is currently taking Paxlovid and felt better after 1 dose. He has taken 3 doses and his oxygen sats went up 2%. He feels less winded and less achy. No side effects except a bad taste in his mouth. He started on day 6 of illness. And he only paid $8 for the RX with Medicare. Prior to getting infected he was on vitamin C, D, zinc, and quercetin.

[@samfisherman8507]

I was tested positive of Sars Cov II/ Covid-19. Took 18mg once a day for 3 straight days and tested Negative on day 4....(I'm 75kgs). It worked great for me! Only speak of my own experience.... Love ❤️ your presentation Dr. Seheult. Thank you for concise explanation!!!

[@MrSfdude]

My wife and I both have Covid, and are starting our 5th day on Paxlovid. We started it on day 3 and day 4 from start of symptoms respectively. Within 24 hours, we definitely started feeling better. The worst symptom is the horrible taste in your mouth, and it appears to be far more prevalent than indicated in the published literature. We also both found it has made us very sleepy and drowsy.

[@grievousangel09]

I tested positive last Friday evening and also started Paxlovid the evening of day 3 (Monday) after my dr prescribed. Thankfully for me by then my symptoms had near fully subsided, Sunday being the absolute worst with a severe sore throat and terrible congestion headache. I’d recommend researching “Paxlovid rebound” as there’ve been a small amount of people for whom symptoms are simply delayed by taking the drug, only to return a short time later.

[@AnoNymous-dh2sv]

Not sure those testimonies say much, considering the current dominant mutation has relatively mild effects compared to the original sars-cov-2, and it is mostly gone with ~5 days.

[@andysalinas3163]

Have had a rebound on COVID

[@koofdome]

On day 4 of paxlovid. Within 24 hours I was feeling WAY better. Covid made me more fatigued than anything I've felt in my life. After only a day, was feeling normal. Insane. The taste is horrible though to be honest lol. 24 hours a day for 5 days you will basically taste old bitter stale coffee and metal. But no big deal, just annoying. Tastes like a vitamin on your tongue. Paxlovid is unbelievable

[@trey18244]

I’ve had covid twice now. Last time I was hospitalized. They wrote me this today just took my first dose.. I really hope it works.. covid feels so awful.. it almost feels like death. Hoping this stuff will get me well and back to work on the ambulance.

[@thomaskeenan2208]

MedCram exercise for our minds. Inspiring work. Thanks.

[@retarskhjjk]

Hi. I couldn’t finish it. I took only half the first two packs did excellent work. Open my throat immediately, but the side effects are terrible, super dry mouth, no saliva, my tongue were completely dead, even the water didn’t wet it. So my dr call me on the 3rd day an I explain her how I was fealing she told me take one more package today and leave it. So i don’t know how I did it, but I quit it after that one. My throat stay swollen and I had cough for one more week after I quit it, my dr send me to ENT dr, he prescribed me anti inflammatory drug and a gargle liquid. After 3 days taking it I’m finally fealing 90 percent better. This virus is made in hell.

[@robertmetz1912]

Ivermectin does precisely the same thing. Dr. John Campbell lays it out very well with receipts.

[@jesicadelfin1099]

Hopefully doctors can prescribe it. In WA state they tell you to just go home and wait until it gets very bad, then go to the hospital. I wish they would prescribe this and other meds when people first get it so people can get better at home.

[@davide_design]

It really worked for me. Within 3 days I feel like myself again. Thank god. I was super sick.

[@GoodnightJLH]

Could you please discuss rebound infections after a course of Paxlovid? My friend tested positive, took Paxlovid, tested negative by the last day of the 5 day course. Then all symptoms abated for a few days. He started coughing again and he is testing positive today. I looked it up and this is happening to a significant number of people. It seems like it may be higher than the 1-2% that Pfizer is claiming. My friend is high risk due to age 60, diabetes and heart disease. He has had 2 Pfizer vaccines and a Moderna booster.

[@itmaster3805]

$530 per course of treatment( patented formula) IVM, $20 avge per course (patent long ran out and cheap to make) Anyone else see how this will play out????

[@yugogurl6911]

The doctor should get a Nobel, partly for pronouncing these antiviral medications.❤️

[@nipagandhi7251]

Sounds very familiar with a much older medicine already there for last 40 years and much cheaper.....

[@3wishes777]

As a doctor I have to Thank You for the explanation you did well

[@bigtenfans5831]

Ritonavir is an old HIV medication, correct? Would have appreciated a quick historical summary of that med since there is certainly data available. Also, reducing trial participation to only 1200 ppl across 5 counties, half of whom get placebp, means a few dozen ppl received the trial medication in each site. Seems very small for a drug trial of this importance.

[@alyssaleland1763]

I'm sorry if this was already answered... but were the participants vaccinated? Did that matter?

[@melanybyrd7420]

I took paxlovid. I had no idea part of the drug was an hiv drug! After taking for 3 days I started feeling alot better. However, the metallic taste was pretty gross. But I did feel alot better. After the finishing of the dose, about 3 days later some symptoms came back but slowly went away.

[@jwhinds]

These videos inspire me to learn about the biochemistry of our bodies and the organic chemistry from things we put into our bodies (vaccines, medicines, foods, etc.) and the importance of nutrition, sunlight, exercise, stress-reduction, and sleep, and how it all relates to maintaining and improving our health and immunity. Thanks Dr. Seheult for educating us on all of the above 👍🏽

[@Medcram]

Jerry. Thank you for your comment. This is the first order purpose of why we do this! Especially regarding sunlight, exercise and the other things you mentioned. More to come on these topics…

[@charliemiller2277]

I am watching this in 2024. First time getting Covid and this makes me feel better. Thank you for doing this

[@alexandracorbettdekanova9137]

Thank you for what you do for us and Best Wished for 2022 from New Zealand and Slovakia. Does not Ivermectin work the similar way as Paxlovid?

[@Mikelennon78]

People who work in this area are heroes. Seriously, really smart people who deserve more credit

[@girlgeniusnyc272]

Thank you Dr Medcram and Team Medcram!!

[@Medcram]

Thanks for your comments and support!

[@weefree4705]

it’s $500 for this treatment . the greed

[@dalvatrash]

Ivermectin blocks the replication of the virus At multiple sites, is much cheaper and safe in humans and should be used. You should do a video on it. I’ll wait for it.

[@Medcram]

We’ve done many videos on that topic. You do not have to wait for it.

[@JessicaMartinez-jj2kf]

It worked wonders for me. I started having mild symptoms on Thursday tested positive on Sunday. Started paxlovid Sunday evening and felt fully recovered by Wednesday. Vaccinated+booster with Hashimoto’s and lupus. The only side effect was dry mouth and my food tasted bitter but I’ll take it over being hospitalized.

[@vioseven3799]

Thank you, a true professional!

[@krismarsiglia9095]

Thank you for taking the time out of your busy day(s) to educate those that choose to gain as much information as possible, about many topics! Much appreciated!

[@chas766]

On my 3rd day on Paxlovid. I had all symptoms prior, fever, sore throat, night sweats, body ache, cough, and lungs were tight. Since taking Paxlovid, all symptoms but my cough are gone. lungs feel good. cough is productive. side effect. diarrhea, loss of appetite, and mild metal taste. I'm high risk so this was given within 3 days of symptoms.

[@pippilongstocking-qs7fm]

How are you feeling now? I just picked up my prescription after testing positive yesterday. No fever, no cough or congestion but my legs hurt & I get chills off & on. I'm researching this drug as fast as I can to determine if I should take this medication in the morning

[@ted356]

Appreciate the in-depth information. This is one of the best information channels on KZbin!

[@hearshot187]

I am currently on this medication right now, it is very helpful and has kept me out of the hospital thus far. The only side effect that I have is the awful taste it leaves in your mouth for the duration you take the meds. It is a chemical metallic flavor that stays in your mouth no matter what you eat or drink.

[@mikeyjets526]

Taking it now. Feeling better after just 1.5 days on it. The taste is horrible though

[@grievousangel09]

@@Kpkp-p9u This drug has been in use for several months and the metallic taste is most widely reported. Read more video comments, lol. I had it too. Btw, how many days after symptoms/positive test did you start? Look up “Paxlovid rebound” cuz there’s a portion of people for whom the drug simply delays full onset of COVID, only to have symptoms return a short time later.

[@adriennem1003]

Currently using now. I like it. Just not a fan of the 3 pills for each dose ( morning & night). I've had no real side effects thus far.. Besides the chalky after taste& little headache& slight body ache.

[@AuntieWanda]

Several pts are having reinfections after one week post tx. Many are concerned that they are infectious after testing positive again. Do you have any updates on this? Thanks for keeping us informed.

[@kenweinreich8472]

Best educational translation of scientific data (medical or otherwise) I have ever seen. Exactly the right amount of detail on the biological science and efficacy mathematics for the lay person. The supporting graphics were incredible. Awesome job to all the guys and gals involved in making this!!

[@bersl2]

I've been on a medicine sensitive to P450 3A4 for years. I miss grapefruit. :(

[@devinemsm05]

Do you have any info yet on Rebound Covid after taking Paxlovid? Mine started around day 6 after finishing Paxlovid and I tested Positive again.

[@debbieandmarc]

Thank you Dr. Seheult for all these informative videos. I'm learning so much that is useful in the ICU. Especially like the ventilator pearls. 😊

[@spanchagn]

Great explanation 👌 what was the vaccination status of the 2 groups in the pfizer trial?

[@AlphaMale_1]

And how did the FDA make it available for emergency use? And how much does it cost?

[@tripd4949]

Doesn't this make all vaccine mandates and any vaccine requirements from work, universities or schools illegal?

[@pokerus4511]

Man this medicine definitely has some weird side effects such as making myself have a constant bitter taste and I usually get sleepy after taking it(but could be covid exhaustion). The only thing is it’s hard to say if the medicine is helping or I am just getting over the hump. I am glad I got the medicine because I do have some underlying conditions that could have caused Covid to be way worse. Better safe than sorry.

[@mvanphilips]

Clear and comprehensive elaboration of the pharmacodynamics of this new anti-viral drug against SarsCoV2. Thanks for your contribution to educate me as a general practitionar.

[@matssvensson5752]

A new study published on the preprint server bioRxiv assesses the antiviral activity of stenoparib against four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs). This study also focuses on the inhibition of the SARS-CoV-2 Alpha variant by a combination of stenoparib and remdesivir. The researchers of the current study also evaluated the inhibitory action of a combination of stenoparib and remdesivir against the Alpha variant. When combined, the drugs acted synergistically and plaque inhibition increased to over 90%.

[@robr9292]

How about issues with interaction with other drugs?

[@JoyceMartincream]

Something to think about: In Washington State, (where my brother lives) When his family tested positive 1/3/2022 they were all given a bag of vitamins, instructions, and details how to treat themselves, where in Cleveland Ohio you are given nothing, u have no idea how to treat yourself or y family. Very very confusing, it's not fair alot of us have no direction, and every doctor has a different opinion.

[@Truthseeker552]

Would live to see a study done that pits this drug against Ivermectin. This would include knowing the side effects, which we already know are extremely rare for Ivermectin.

[@Medcram]

You’ll be happy to know that the Together Trial study on ivermectin was stopped early for being futile. However it did find a benefit to fluvoxamine. It was a trial specifically designed to find cheap already available medication for early use in COVID 19. I surprised you did see those results.

[@pjhey947]

I’m on day 3 of treatment. I received a 5 day prescription of Paxlovid and a steroid. I’m no longer having any symptoms of Covid which were mild/moderate. I have this horrible bitter taste in my mouth. Just horrible but I can get through two more days. I’m vaccinated and boosted but I’m in the high risk category.

[@TheMrBennito]

What is not known yet is if this treatment positively affects the possible occurrence of Long COVID symptoms. I took paxlovid mainly in the hope that it would have a positive effect on that.

[@gmhefner1]

Love Dr. Seheult's videos! Please keep them coming! :)

[@angielovelace888]

None for me ty. I'm healthy, have a good immune system. How long have they experimented with the pills?

[@arprintsa]

Dr. Seheult should receive Nobel Prize in medicine. ASAP.

[@talitafourie9154]

Would this pose a risk for people with liver problems?

[@johnoconnor1397]

Would you recommend Quercetin 500mg along with zinc and vitamin D to take in between boosters?

[@tymartin1508]

I got Covid and started Paxlovid the day I tested positive. My symptoms were minimal at best. Completed 5 day course. Day 7 the rapid test line was very faint. Day 8 I woke up with heavy nasal congestion and retested. The rapid test line was very dark. I finally tested negative on day 17. I believe it was Paxlovid ‘rebound’. I didn’t experience the metallic taste.

[@barbaraloeppke152]

What was the placebo?

[@manawa3832]

I love your videos because it provides clear information about treatments without sounding politically motivated. Just raw data and information. No subjective assumptions about what is "safe and effective".

[@stephenkrus]

Thanks Doc! You made the explanation of the pill so easy to understand. 🤔

[@stephenr7176]

PLEASE explain WHY this new varient is so.much more infectious... is it smaller, lighter, more airborne....what's causing its increased transmisibility

[@Leamoyer]

It seems to me that since this study was done last year ( 2021) during the delta surge and delta was lower in lungs causing far more hospitalizations & death compared to omicron, that we should have updated studies and updated relative risk percentage as it pertains to the changing virus.

[@moonminglevu3692]

I just got out the ER yesterday for COVID and today I'm feeling better with the paxlovid

[@LemmeCheckMark]

The only Dr is who hasnt been canceled by youtube. Nice.

[@truckingwithtobee]

So this video was made a year ago. I can attest that it does work. I am on day four of five. I have one more day of taking this stuff. Three days ago I was so sick I couldn’t get out of bed today. I almost feel back to normal. I’ve had Covid for the last seven days. And I can tell you what it was like death. It hit me that I am a type one diabetic also that’s why this was prescribed to me because I was high-risk. I’m 49 years old but I can tell you right now this stuff 100% worked. I no longer have it in my chest it was settling in. I had a lot of bad phlegm in my chest and throat, the fever was not going away. The bodyaches were awful. This was like no sickness I have ever had an old 49 years of life. It hit me hard and it hit me fast. I picked it up in New York City when we were there from December 14 through December 20 by December 21. I was so sick I feel bad for the person that sat with me on the plane because most likely they have Covid as well, but I did not know that I had it at that point. It was just a slight scratch in my throat. The worst side effect I had was a bad taste, other than that I didn’t experience any other side effects.

[@claudiaoctavia6340]

What strain of covid were the groups infected with for this study?

[@kathryncainmadsen5850]

Thanks! Does it matter if the subjects were vaccinated or not? We’re they all unvaccinated? Would you give this to someone vaccinated or would that interfere with the immune response from the vaccine so early in the disease?

[@Medcram]

They excluded people with vaccines because it would be very difficult to show efficacy as the vaccine prevents hospitalization and up to 90% of patients already.

[@IconzGlobalNetwork]

WOW! This was PRICELESS!!!!!!!!!!!!!!!!!!!!!!!!!!!

[@jwoolridge]

I was prescribed Paxlovid 3 days ago. You have to take it before the 5th day of being diagnosed with Covid. I'm starting to feel better on the 3rd day after taking it. The only think I don't like is the bitter taste in my mouth and the diarrhea. I have to take it for 5 days twice a day.

[@Frank.Melendrez]

I’m about to take it today. Have you had any Covid reinfections in result of taking Paxlovid?

[@chrisheredia2907]

I will take bad taste and diarrhea over hospital and day of the week

[@JYO2023]

I can only speak for myself but I am really truly sorry hearing about COVID-19.

[@sampal5352]

So do we know if this is causing liver damage?

[@mmb1572]

My doctor gave this to me based on my age, but I was too afraid to take it because it hasn't been approved and had side effects. I am a healthy 64 year old, no cormobidities. I am also fully vaccinated. No booster. So far I have had mild symptoms and I am on Day 10

[@chanceceee3659]

Hi hi, when you say mentioned the U.S. purchased 10 million packets around 19:45 are you referring to the FDA? Or which entity exactly?

[@trinitywright7122]

This is well done. Thank you so much. I also sent it to a friend because I'm afraid she won't finish her medication she was afraid to start it because of the side effects and I told her that side effects are way better than dying so she went ahead and started it. But here in writing is the proof which you being an empty have no doubt right about many times. And that's what I like to see and that's how I like to explain it to friends who have these phobias about medications or vaccinations.

[@67hr74]

5 days after finishing Paxlovid I had a rebound and tested positive again. It took another 7 days for me to test Neg.

[@footybaltimore2833]

Im taking this now and its really helping. Thank you for this breakdown. I really appreciate it . It was very informative and objective

[@suzannehartmann946]

Great any chance those particular proteases will cleave something critical to my health?

[@Medcram]

Over a five day period. Doubtful.

[@javierrubio343]

We all need people like you.. well explained facts for a layperson to understand and take the best decision. Keep it up!

[@cindybogart6062]

Are these new medications available now or do you know when they are available??