Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment

Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment. Aplastic anemia is when your bone marrow scores "F" on the final exam. It's failed.
Aplastic anemia is a Pancytopenia (anemia, leukopenia, thrombocytopenia) causing fatigue (tired all the time), infections, bleeding.
There are many causes of aplastic anemia; can be inherited or acquired.
MCV is usually increased in Aplastic Anemia.
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[@Xingaboo]

Phenytoin

[@MedicosisPerfectionalis]

Yes!

[@aditimandal1638]

Phenytoin

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[@crazyfangirlproductions6426]

This is a great video my sister has a aplastic anemia and we are getting ready to start the bone marrow transplant treatment for her

[@vikrampatil2245]

How was the treatment? How's your sister? Want to know everything about it

[@pravinjadgeri6980]

Hi I had a plastic anemia issue. But right now I have cure from it yes I have take allopathy(chemical) medicines. But later on I have shifted to ayurvedic medicine( natural medicine). After taking ayurvedic I have been healed/cured from it. completely Yes it can cured. And healed.

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​@@pravinjadgeri6980pls apu help me. What us the treatment. And how i conduct you?

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Bless her

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[@MedicosisPerfectionalis]

You're very welcome!

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[@omerali2597]

Nice review of aplastic anemia! Just wanted to add that sometimes you can get a hypocellular MDS that looks similar to severe aplastic anemia. Usually cell morphology and cytogenetics will help you differentiate the two (hypocellular MDS you would expect more chromosomal abnormalities, aberrant megakaryocytes + megs will be small in appearance), however clinically they can look very similar. Thanks for the video!

[@MedicosisPerfectionalis]

Thanks for your comment!

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This video is extremely concise and complete for a big topic of aplastic anemia. Came back here from reading harrison's. Contents can be confirmed as same. Thank you medicosis ❤

[@MedicosisPerfectionalis]

Glad it was helpful!

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The answer to the question is D. Phenytoin Thanks for the tutorial. It really helped

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[@TheThomprc]

Presently diagnosed with Pancytopenia, awaiting further evaluation. Your presentation is the the best I've viewed and highly reccommend it. Thanks for composing this video.

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Thank you AA patient. Recently diagnosed. This explains more than any doctor i have seen. Much love!!!

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[@MedicosisPerfectionalis]

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[@elenaprk5628]

Eltrombopag has been added to standard immunosupression for AA.

[@abukeabdela4928]

I am binging ur videos ...much appreciated ..why don't we consider aplastic anemia as one of the differential for dry tap as mylofibrosis or mylophtisis since it causes hypocellular bone marrow

[@JBsquirrel]

Thanks, helped out with my presentation on TERT gene mutations causing aplastic anaemia.

[@MedicosisPerfectionalis]

I am glad to hear that! Thanks for watching!

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Phenytoin, thanks for your explanation and efforts ❤

[@MedicosisPerfectionalis]

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thank you sm for this ive been in the hospital for a month so hopefuly i can get a bone marrow transplant thank you

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thank you for the helpful video but the KZbin ads make it very difficult with the constant interruption. Any way you can prevent that ?

[@Mazzawak]

Great video as always! I should note that Parvo-B19 very rarely causes Aplastic Anemia and is more often with Pure Red Cell Aplasia

[@MedicosisPerfectionalis]

True

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great explaination I hope you add video about Diamond Blackfan anemia

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And you WILL NEVER FAIL US

[@MedicosisPerfectionalis]

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The Answer for the Question at 18:53 is Phenytoin, a Sodium channel blocker.

[@mahbubamaria1742]

I have a question. If there is anemia why there is no hepatosplenomegaly (for compensating anemia) Why there is no lymphadenopathy(as there will be increased infection) Can you please answer these. I can't find any satisfactory answer.

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Thank you 🙏

[@ahmedabdirahman9918]

Phenytoin.... and thanks for ur time Dr.

[@hdey8653]

11 years a go when I was 10,I was diagnosed with aplastic anemia, Now,no sign of it,but it has brought PNH

[@shushree1772]

slow but very clear thank you

[@alinaswechitimbwa2607]

Lovely presentation Answer is phenytoin

[@MedicosisPerfectionalis]

Thank you!

[@nairdarumani5450]

Today i have to learn aplastic anemia for my tomorrow hematology class and this video was absolutely amazing and very helpfull. I got only one question.. I have read that the hypothesis that aplastic anemia is a state before mielodisplasic syndrome is not so strongly approved according to the new findings in the genome. I dont know how true this is but i read some good arguements

[@MedicosisPerfectionalis]

Thanks for your comment! You are absolutely welcome! As for that theory, I am not sure, to be honest!

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phenytoin... awesome explanation

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Really awesome video ... excellent !!!

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[@MedicosisPerfectionalis]

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My pleasure 😇

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Phenytoin.... Excellent and capsulated class

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Another great Video, Thanks! Phenytoin

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Phenytoin... Nice one!!

[@gamerberry2451]

Good day Sir, so I have a speculation as well as to why MCV is high is aplastic anemia.I’d love to know your thoughts. If MCV= Hematocrit(ht)/[RBC] This would mean that a decrease in [RBC] or increase in Ht should give high values of MCV right? We also know that in aplastic anemia, while Ht might remain the same (since all the other hématopoïetic cells are also affected), [RBC] is definitely low, hence giving high MCV values. Just a speculation, please correct me if I’m wrong😊.Thank you.

[@gerryadams2212]

MCV is also calculated via forward light scatter in flow cytometry. This gives each cell a direct reading of size

[@tj7683]

Answer- Phenytoin

[@Muskaan__12345]

Fetal anomaly caused by phenytoin is Fetal Hydantoin Syndrome And Lithium causes Ebstein's anomaly (atrialisation of ventricles)

[@yasoyoshikage]

I am trying to understand. It's so much fun. Thank you so so so much.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@iremsenabulbul5753]

you are a life saver!

[@MedicosisPerfectionalis]

Thank you 🙏

[@Bakbskshx]

i've applastic anemia. age:20years my doctor gave me horse atg with cyclosporine on 8thjanuary,2018.I'm also taking tab.eltrombopag 25mg but my platelet&hemoglobin count is not increasing.Last cbc report is below: HG-10.5,PL-34000,wbc-5.34 my hla type match is 10/9%. Now what can i do??? Please reply

[@maeb.6912]

Azmeer Hossan Joy I also have it for 3 years now 3 months ago I got a bone marrow transplant and I’m getting better

[@emiovy9594]

i have aplastic anemia too. i was given horse and rabbit ATG and i'm now in remission. i hope you the best of luck!

[@way2happiness400]

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[@mobrennanmcconnell7215]

My daughter starts ATG today. Praying it works for her with little side effects.

[@13litzkrieg65]

Got diagnosed last month with aplastic anemia, taking promacta, steroids and cyclosporine for 3 weeks now, waiting on chemo and stem cell transplant. The hardest part for me right now is dizziness and fatigue wish me luck, Im glad you all feel better , God Bless you.

[@وليدالعليي-ه3ق]

thank you for your a nice explanation

[@MedicosisPerfectionalis]

It gives me great pleasure! You’re always welcome!

[@drinkspartypack]

I go to the same school Eric Connor went to, he is one of the eight people in the world who has had aplastic anemea.

[@MedicosisPerfectionalis]

Aplastic anemia patients are more than eight.

[@drinkspartypack]

@@MedicosisPerfectionalis sorry, that is my mistake, my gym teacher told me that there are eight, but apparently that is incorrect.

[@MedicosisPerfectionalis]

No worries...There are way more than that. Thanks for being honest and open-minded...I really appreciate that :)

[@suryakantdongre3969]

Thank you sir

[@khamikos1]

perfect presentation very helpfuland easily comprehensive/thanks deeply

[@MedicosisPerfectionalis]

My pleasure! Please share with your friends! Thanks a million! 😃

[@MedicosisPerfectionalis]

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[@al21l51]

So it is low WBC and when blood is diagnosed they should show low in number. But again person can show leukemia. In other words, what will the WBC count be in acute myeloid leukemia and pancytopenia?

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[@Am-yo4hx]

what do you mean about pregnency and its associateion with acquired aplastic anemia and PNH and pregnency ...please explain how this causes occur.Thank you

[@dr_chiropractor]

Aplastic anemia with high MCV but normocytic?? I don’t understand or you made a mistake at the intro

[@anna26970]

what about using Eltrombopag to stimulate platelet precursors and bone marrow stem cells to grow?

[@drisaaccardinalbwalya4409]

Much appreciated!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mohammedsalahadin1680]

OMG what a video, many thanks 😭🌹❤️

[@MedicosisPerfectionalis]

Glad you enjoyed it!

[@analuisamartinez4597]

I was diagnosed with aplastic anemia with low rbc, low hgb, low hct, high MCV, but high reticulocytes, if bone marrow is not producing enough cells, why is reticulocyte count higher than normal? (Bone marrow cellularity is at 5-10%)

[@mustafacabdisalaan7306]

may b u had MDS[myelodysplastic syndrome has all you listed including hypercellular bone marrow]

[@elijahokoronkwo8610]

Could be relative reticulocyte count cuz its a percentage of whole blood. If it decreaces less than hct decreases then it’ll appear to increase. Theres a formula to get the adjusted retiuclocyte count in his earlier videos

[@mahiehussein]

Thanks 💖

[@sirbey9608]

Wow my Dr told me yesterday I was low in iron and need to take iron with orange juice she never went into this could be the cause of my headache which I think is nerve pain .thanks for the info

[@MedicosisPerfectionalis]

My pleasure...I wish you speedy recovery...Keep me updated...Good luck 👍

[@reemalajmi4870]

impressive!!

[@MedicosisPerfectionalis]

Thank you 😊

[@chathuranawarathna5300]

Thank you doctor. Is there any foods to supply indirect medicine for the pancytopania??

[@MedicosisPerfectionalis]

It depends on the cause. Unless you treat the underlying cause, it’s not going away.

[@zahrataky8511]

What if he is 12 and most symptoms match except for the count of retics is normal,no stains,nothing on nails and no white hair . ?

[@Sherry-ji3dc]

Very nice video, great 🤩

[@MedicosisPerfectionalis]

Thank you 😊

[@venukasharma1991]

please clear one of my queries not related to this video ....i.e why are neutrophils high in pregnancy state

[@MedicosisPerfectionalis]

Pregnancy is a physiological “stress” state.

[@hassinayazid9286]

phenytoin. thank you for your great explanation

[@MedicosisPerfectionalis]

Correct! Thanks for your nice comment:)

[@m2ym2y99]

@Medicosis Perfectionalis I had VSAA but was too old for transplant. Am in remission but still lacking stamina after 3 years. Is there a reason my oncologist didn't want me to take a vitamin B supplement after hATG, while taking Cyclosporine (Sandimmune) and Promacta? Every time I asked he would tell me to wait on that.

[@mishalahsan161]

How is your condition now?

[@m2ym2y99]

@@mishalahsan161 numbers are in the good range, but bruising very easily, and still lacking stamina. Grateful to be alive, try to live life as close to "normal " as I can.

[@shivampandey2363]

Are any curing of A Plastic Anemia other than bone merro transplant Plz reply

[@shivampandey2363]

@Rocio Ch. A. Rocio Ch. A. My Younger Brother Face with this from when he was of about 10 year old , And Doctor's was suggested for Bronemerro but we was not gone for bonemerrow. Now he is of 16 year old • And Blood transfusion has been happening every single day since last one week. And the doctor is speaking for the bonemerro😢😢😢

[@shivampandey2363]

@Rocio Ch. A. Now My Younger Brother is no more 😢😢😢😢

[@safaabdulla2165]

Thank you

[@MedicosisPerfectionalis]

You’re always welcome!

[@eddieaguilar6737]

I have a question for you. What if the the patient is producing RETICULOCYTES?

[@MedicosisPerfectionalis]

I don’t understand the question...Can you explain more, please?