Myelodysplastic Syndrome (MDS) - a precursor to Acute Myeloid Leukemia (AML) ?! - Hematology Series

[@MedicosisPerfectionalis]

📝 Hematology Notes (PDFs): www.medicosisperfectionalis.com/

[@asinglebanana]

After watching many of these videos, my brain size increased by 50%. This is definitely a very good prognosis!

[@MedicosisPerfectionalis]

Bed Potato I am so happy to hear this! I am honored...Thank you so much for supporting my channel by clicking on the "join" button...It means a lot to me :)

[@consolatajuma6755]

I agreee by brain size has increased

[@deemam.3334]

Never enjoyed studying hematology till i found your channel, thanks! It hella makes sense now

[@MedicosisPerfectionalis]

Thank you Thank you Thank you 😊

[@ongninam]

Same, you are a lifesaver medicosis! Love from Philippines

[@بيناتالموصلي]

قبل ايام كنت اشعر ان أمراض الدم شئ لن افهمه لان الطبيب البروفيسور الذي يكثر الكلام بلا فائدة جعلني اكره امراض الدم ولكن الان اشعر بمعلومات قيمة جدا … شكرا جزيلا 🎉❤

[@MedicosisPerfectionalis]

🙏🙏😊😊😊🙏🙏

[@fourdayhomestead2839]

Watching to understand my grandsons labs. Thank you for jogging my memory from collage classes.

[@euri161]

Didn't skip ads for you sir! Thank you! Harrisons has been difficult for a student like me with visual memory..

[@MedicosisPerfectionalis]

Thank you so much, dear! I appreciate you!

[@kerriann8836]

“Low retic count, because your bone marrow is a loser” 😂👌🏼

[@MedicosisPerfectionalis]

Kerri Ann Hehe 😁 Just a joke!

[@scylla324]

My go to channel when missed lecture! Thank you so much!! I can now sleep over in peace ORZ Saved millions of medical students worldwide!!

[@MedicosisPerfectionalis]

Thanks a lot!

[@tatyanarogachova2775]

I can relate

[@seanmock1135]

I have myeloid Dysplastic/AML...just trying to learn all I can. Thanks...my third cancer...papillary adenocarcinoma thyroid was 1st, the dermatofibroidsarcoma protuberance and now this. I also had a brain tumor...

[@MedicosisPerfectionalis]

Wow! I am so sorry to hear that! Keep fighting, and never give up.

[@rajeshwarpaulgaming3338]

Hey.. How are you now? I am also suffering from mds... I m 28. Can you suggest me the best possible treatment...

[@aqsaazhar6389]

Your videos are truly saviour!!! Its easy to read books after watching them... Thank you!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@elenaprk5628]

This video really helped me for my PhD interview! Thanks a lot. Great job. I am really interested in haemato-oncology so your videos are really helpful!

[@MedicosisPerfectionalis]

Yay 😃

[@Hawk89gt]

My father (75) was just diagnosed with MDS, this was a very good video. Thank You.

[@MedicosisPerfectionalis]

You’re very welcome! How is your father’s health?

[@michaelrambau7246]

give this man a medal... unbelievably easy

[@MedicosisPerfectionalis]

Thank you so much 😊

[@shahdismailalqatu9711]

so very helpful ,simple and rich content !! I don't understand why you don't have so much views !!

[@MedicosisPerfectionalis]

Thanks a ton, dear, for your kind words! Please share my videos when you have time...Thanks!

[@shahdismailalqatu9711]

sure! , I will :)) @@MedicosisPerfectionalis

[@MedicosisPerfectionalis]

Thanks:)

[@susudiwa7101]

i keep watching ur hematology playlist for my exam, thanks for good summary!

[@MedicosisPerfectionalis]

My pleasure 😇

[@RohanKayani]

Thank you so much. I was so confused between myeloproliferative, mylodysplastic, and aplastic anemia. You explained all of them brilliantly. Thank you so much!

[@MedicosisPerfectionalis]

My pleasure 😇

[@patrick_okora]

Thanks so much. This makes so much sense. Why haven't I been paying my school fees to you???? 😭☹️

[@Ravi97111]

This’s amazing, unbelievably good , Please please please make videos on CHF management, you make things look way easier and help me understand, big chubby thanks 🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@iuw3ug]

Amazing lecturing skills!

[@MedicosisPerfectionalis]

Thank you so much!

[@misstaniamaryam]

Thank you sooo much. Appreciate your hard work! You made it super simple to understand

[@MedicosisPerfectionalis]

My pleasure 😇

[@jacksparrow-wq1pb]

I just love your lessons ❤❤❤they make haematology clear and simple ❤❤❤❤❤

[@MedicosisPerfectionalis]

Thank you!

[@THX-2208]

I have a friend who was on the haematology ward with me. We both went through pretty intense Chemotherapy together and have become really good friends. I was rejected for a stem cell transplant because I became so poorly on the treatment and was very close to death a few times but thankfully my friend got though his treatment and had a stem cell transplant but unfortunately just over a year later he has told me he has been diagnosed with Myelodysplastic Syndrome and I don't know what this means. I was hoping someone here could explain what are his options. He had lymphoblastic leukaemia while on the ward and I don't understand how he could have gotten this after a stem cell transplant. Thank you so much

[@rajeshwarpaulgaming3338]

Hey.. How is your friend now... I am also suffering from mds.. Fully depended on blood transfusion

[@hamzagujjar8427]

In MDS, bone marrow could be hypercellular, hpyocellular, or normocellular

[@Shantanu.Shandilya]

Amazing explanation! Thanks for clearing up every possible doubt.

[@MedicosisPerfectionalis]

Glad it was helpful!

[@aolli2359]

There can be cytopenias in myeloproloferative disorders. Like myelofibrosis latter stage, full of cytopenias bro

[@reaganssali1438]

You’re making hematology look easy. Thank u so much❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@asmaaawad3084]

Excellent Last case open my mind❤❤ شكرا

[@MedicosisPerfectionalis]

You're welcome!

[@jeancharlesgagnon2594]

very good content - I subscribed to your channel. thanks for your work

[@MedicosisPerfectionalis]

Thanks a ton! I truly appreciate it!

[@lugieravhudzulo3311]

This is quite Helpful Prof thank you

[@MedicosisPerfectionalis]

My pleasure!

[@st1cks_and_crows]

Thanks, this helped with my project :D

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@dr.elaineluther6562]

Ringered sideroblasts occur only in the bone marrow. They are not seen in peripheral blood smear.

[@gayathrijinesh3004]

Good video. The classification has been updated in 2022 though.

[@srinivasaraosirasapalli5104]

veru nice sir.can you make video on pelger heut anomaly and pseudo pelger heut anomaly?

[@MedicosisPerfectionalis]

Yup...I will add it to my list.

[@prabalmajumder5179]

Sir all your lectures are just awsome...please elaborate the findings of DYSPLASIA in peripheral smear microscopy ..thanks

[@Saaraelamin]

you answered all my questions :) thank you very much

[@MedicosisPerfectionalis]

You’re welcome 😊

[@safari4342]

Great vid. I found your other haematology vids very useful.

[@MedicosisPerfectionalis]

Glad to hear that. Thank you so much for watching!

[@فراتهديربشيريحيى]

This deserves thumbssss up

[@MedicosisPerfectionalis]

Thank you!

[@mubassirkhan3997]

Seems like I am addicted to this channel Love and respect ♥️♥️🇵🇰

[@MedicosisPerfectionalis]

Mubassir Khan Thank you so much :)

[@Kem9s]

شكرا يسطا بحبك

[@omarbadr8187]

For the Question Why not CML?

[@maryamalrawi6645]

Still the best 😍❤️

[@munaalmozogy8755]

Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@geradmahega1570]

Thank you for good explanation on MDS and other vids

[@MedicosisPerfectionalis]

You’re welcome 😇

[@abwotdinnahech5366]

Thanks 🙏

[@MedicosisPerfectionalis]

My pleasure!

[@sushilchaudhary2189]

My wife has Mds..1st bone marrow biopsy.shows hypercellular marrow..after a year second was done..where it shows hypocellular..last 5-6months wbc on the rise between 16000 to 23000..no.blast seen on peripheral smear....am confused..Is it MDS?

[@mitanshusharma5944]

Very Good and simple way of explaining such complicated things. Great job

[@MedicosisPerfectionalis]

Thanks 🙏 I am honored! Can you please help me by sharing?

[@mitanshusharma5944]

Sure Sir, my pleasure in Tht.

[@MedicosisPerfectionalis]

Thank you 😊

[@riteshchaurasia8016]

Plz explain what is difference and clinical importance between large and nu cleated rbc n in which disease it occur..

[@glowingflower5632]

Really appreciate all the hard work you put into ur videos

[@MedicosisPerfectionalis]

Thank you 🙏

[@مولااحمد-ج7ه]

Really wonderful..thanks from egypt

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@مولااحمد-ج7ه]

@@MedicosisPerfectionalis ofcourse 😍

[@lamazfarsi6843]

i have many Qs plz 1- can you re define the MDS in arabic just to figure it out ! 2-what is den ova mutation? 3-in a favorable part>> how is the thrombocytosis could be a good prognosis ,furthermore its unfavorable increase num od cytopenia ....i'm confused! 4-also in diagnosis:how can we see leukoerythroblastosis and the cell is cytopenia?? ill be super apredicated if you just explain it to me .thanks for you time

[@MedicosisPerfectionalis]

Sure! 1. I can’t explain it in Arabic, sorry...but think about it as bone marrow is dying and fighting for its life, so it keeps sending out crazy, immature cells. 2. De novo mutation means “brand new” mutation that didn’t exist before. 3. If the bone marrow is dying, and we find that it’s still able to produce lots of platelets, then may be that’s good news. 4. Leukoeryhtoblastosis is lots of “immature” cells, but cytopenias is less number of “mature” cells. There is no contradiction. Let me know if you have any questions.

[@lamazfarsi6843]

yes i got it (T) but when i red the definition of MDS>> (steam cell w/ ineffective hematopoietic defect maturation of cell of amyloid )i got lost and confuse!!1! @@MedicosisPerfectionalis

[@MedicosisPerfectionalis]

Yeah! Textbook definitions are so complex, and not easy to digest...That’s why Medicosis is here!

[@mortal9870]

Thanks sir❤

[@MedicosisPerfectionalis]

My pleasure!

[@farkh76]

Really grateful for your work Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@placo10100]

Hello and thank you for this most informative video my mother was recently diagnosed with MDS she is currently 15 to 20% blast with a left shift can you say what life expectancy under these conditions and best treatment she is in her eighties

[@MedicosisPerfectionalis]

Hey...Thanks for the question...I am so sorry that your mother and you are going through this...Unfortunately, I cannot do that based on this information, only her doctor who knows all her history, physical exam, labs, biopsies and radiology imaging can make that decision....Regarding her age, its harder, but again, the pros and cons of treatment should be discussed with her physician...Sorry I couldn’t help...Also, if she doesn’t like her doctor, both of you can seek a second opinion...Take care!

[@Sky-sr2bf]

what is the cause of monocytosis here ?? n thank you so much

[@billdrumming]

Why is MDS called a group of cancers if it’s pre cancerous ?

[@azizmarshal9438]

I think our college has to make your video as it’s guidelines

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@vishnuchaitanya1835]

Simply superb 👌

[@MedicosisPerfectionalis]

vishnu chaitanya Thank you 😊

[@juansanchez6382]

Any links to getting mds with laser tattoo removal?

[@madmed7556]

Isn't it normal to see blasts in the bone marrow? I don't understand why we consider this a symptom of MDS.

[@MedicosisPerfectionalis]

It depends on how many (percentage wise)!

[@user-sl3rv8hs2k]

thank you doctor

[@MedicosisPerfectionalis]

My pleasure 😇

[@annamarianalumansi3178]

thank you sir

[@ranahanna160]

Amazing! Thanks

[@MedicosisPerfectionalis]

You are very welcome!

[@heyitsdiamedico5538]

I liked the video before even watching 🤭♥️

[@MedicosisPerfectionalis]

I am honored 😃

[@heradio1000]

Thanks for your video. Why is 5q deletion favorable in mds, yet unfavorable in aml? Is this correct?

[@MedicosisPerfectionalis]

You’re correct regarding the fact...However, I have no idea why that is the case. It’s just the way it is. But, that’s a great question!

[@superfc7787]

it is treatable with Lenalidomide (Revlimid)

[@eshraqashoor3237]

Thank you very much ☺

[@MedicosisPerfectionalis]

My pleasure!

[@amalawad2036]

hi it’s very useful vedios almost done with oncology with u plz add mor vedios soon

[@MedicosisPerfectionalis]

Sure, I will...Stay tuned for more videos!

[@amalawad2036]

plz i have exam end of august i spent most of the time on ur vedios

[@MedicosisPerfectionalis]

I promise to do my best...Good luck!

[@04harshaala84]

U are simply awesome...

[@MedicosisPerfectionalis]

Thank you so much 😊

[@abbieguerta9071]

Thank you!!!!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@sosonageb3720]

thanks alot

[@MedicosisPerfectionalis]

My pleasure 😇

[@Sh3lbz]

My sister has this. She is 20!!!

[@MedicosisPerfectionalis]

I am so sorry to hear that!

[@docblue8081]

You are really amazing Sir!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@saheltahzibi1443]

That was sooo perfect 🤩

[@MedicosisPerfectionalis]

Thank you 🙏

[@harsimrankaur1815]

Thank u so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@106bagishrabha6]

If MDS occurs between 60-80 years then how could it be transformed to AML. Since AML occurs between the age of 40-60 years? 🤔

[@محمدفاضلمحمد-ج1ك]

You are amazing 😉 thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@giuseppebruno3169]

Grande bro ❤

[@jemimahorake6185]

Can this affect young men. Say ages of 29-30yrs?

[@MedicosisPerfectionalis]

Yes!

[@sanaliaquat7211]

Superbbb 👌👌

[@MedicosisPerfectionalis]

Thanks 🙏

[@GeorgeToby-r2u]

Stanton Road

[@alangarfias6075]

Hey medicosis im a big fan of your work and I would like to do the same as you do but for all the spanic speakers, im from México and I would be very grateful if you could tell me whats the name of the app in wich you make your notes! Thank you very much for all your work!!

[@MedicosisPerfectionalis]

Please send me an email: [e-mail]

[@MedicosisPerfectionalis]

Thanks for your email 📧…I replied to you. Hope the apps help you. Wishing you the best of luck!

[@alangarfias6075]

@@MedicosisPerfectionalis thank you so much! I hace recibed the e mail, thanks for the tools and the good wishes I hope I can help people as you do! Keep up the good work youre awesome Dr!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@praveenlawrence832]

Thankh

[@MedicosisPerfectionalis]

My pleasure 😇

[@asannajat6173]

You are really amazing

[@MedicosisPerfectionalis]

Thanks 🙏

[@elasantes5728]

I love your videos!! and love you too Really, are very useful, thanks so much!!

[@MedicosisPerfectionalis]

I am so happy to hear that! Please let me know if you have any questions!

[@ilovesunny8887]

do more mcq !!!!!

[@MedicosisPerfectionalis]

Thank you for letting me know!

[@salwadabbousdabbos4777]

Hypoplastic mds lecture and ttt, diff from aplastic anemia

[@MedicosisPerfectionalis]

I am not sure I understand

[@harshitasrivastava7931]

very nice video

[@MedicosisPerfectionalis]

Thanks 🙏

[@gonegirl1374]

We love you

[@MedicosisPerfectionalis]

Thanks a lot! Same here :)

[@RudolphLaurel-p5r]

Grant View

[@DohertyMax]

Thomas Daniel Lopez Sharon Miller Timothy

[@BorisRynne-m2s]

Goodwin Squares

[@144.gali.tanmayi8]

Can we see pancytopenia in AML??

[@MedicosisPerfectionalis]

It’s possible, but WBCs are usually high.

[@144.gali.tanmayi8]

@@MedicosisPerfectionalis thank you for the reply.

[@MedicosisPerfectionalis]

My pleasure 😇

[@rona2863]

This was really good TYSM 🙏🏻

[@RhodesStan-n7m]

Ceasar Brook

[@AnikaSharma-s3f]

Lewis Helen Perez Kimberly Brown Linda

[@madhukardeshpande563]

Nice explanation

[@MedicosisPerfectionalis]

Thank You 😊

[@gordonmansfield6838]

Harris Donna Gonzalez Linda Gonzalez Jessica

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Smith Susan Hall Charles Anderson Thomas

[@JacksonSilon]

Thompson Mary Johnson Sandra Davis Donna

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Lakin Dam

[@amalbadr483]

Greet💙💙

[@MedicosisPerfectionalis]

Thank you 🙏