Myelodysplastic Syndrome (MDS) - a precursor to Acute Myeloid Leukemia (AML) ?! - Hematology Series

[@MedicosisPerfectionalis]

📝 Hematology Notes (PDFs): www.medicosisperfectionalis.com/

[@deemam.3334]

Never enjoyed studying hematology till i found your channel, thanks! It hella makes sense now

[@MedicosisPerfectionalis]

Thank you Thank you Thank you 😊

[@ongninam]

Same, you are a lifesaver medicosis! Love from Philippines

[@asinglebanana]

After watching many of these videos, my brain size increased by 50%. This is definitely a very good prognosis!

[@MedicosisPerfectionalis]

Bed Potato I am so happy to hear this! I am honored...Thank you so much for supporting my channel by clicking on the "join" button...It means a lot to me :)

[@consolatajuma6755]

I agreee by brain size has increased

[@بيناتالموصلي]

قبل ايام كنت اشعر ان أمراض الدم شئ لن افهمه لان الطبيب البروفيسور الذي يكثر الكلام بلا فائدة جعلني اكره امراض الدم ولكن الان اشعر بمعلومات قيمة جدا … شكرا جزيلا 🎉❤

[@MedicosisPerfectionalis]

🙏🙏😊😊😊🙏🙏

[@reaganssali1438]

You’re making hematology look easy. Thank u so much❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@euri161]

Didn't skip ads for you sir! Thank you! Harrisons has been difficult for a student like me with visual memory..

[@MedicosisPerfectionalis]

Thank you so much, dear! I appreciate you!

[@fourdayhomestead2839]

Watching to understand my grandsons labs. Thank you for jogging my memory from collage classes.

[@MedicosisPerfectionalis]

😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/medicosis 📗 Get my notes in pdf files at www.medicosisperfectionalis.com/ If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/

[@delevoyeguillaume9126]

I'm doing a machine learning project on data from HSCT. My hematology courses were 5 years ago I had forgotten nearly everything. Now all my old memories come back thanks to your videos... Thank you ! It could be really perfect if you'd think some day of changing the batteries of the smoke detector that we hear every minute or so :D Otherwise these are really, really cool videos thanks

[@MedicosisPerfectionalis]

Haha 😂 You’re very welcome 😊

[@seanmock1135]

I have myeloid Dysplastic/AML...just trying to learn all I can. Thanks...my third cancer...papillary adenocarcinoma thyroid was 1st, the dermatofibroidsarcoma protuberance and now this. I also had a brain tumor...

[@MedicosisPerfectionalis]

Wow! I am so sorry to hear that! Keep fighting, and never give up.

[@rajeshwarpaulgaming3338]

Hey.. How are you now? I am also suffering from mds... I m 28. Can you suggest me the best possible treatment...

[@aqsaazhar6389]

Your videos are truly saviour!!! Its easy to read books after watching them... Thank you!!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@michaelrambau7246]

give this man a medal... unbelievably easy

[@MedicosisPerfectionalis]

Thank you so much 😊

[@scylla324]

My go to channel when missed lecture! Thank you so much!! I can now sleep over in peace ORZ Saved millions of medical students worldwide!!

[@MedicosisPerfectionalis]

Thanks a lot!

[@tatyanarogachova2775]

I can relate

[@basicmedicalscience.3435]

one is best channel for WBC 🙌

[@kerriann8836]

“Low retic count, because your bone marrow is a loser” 😂👌🏼

[@MedicosisPerfectionalis]

Kerri Ann Hehe 😁 Just a joke!

[@saadkhan2255]

The way you teach is so commendable💯🙏🏿

[@shahdismailalqatu9711]

so very helpful ,simple and rich content !! I don't understand why you don't have so much views !!

[@MedicosisPerfectionalis]

Thanks a ton, dear, for your kind words! Please share my videos when you have time...Thanks!

[@shahdismailalqatu9711]

sure! , I will :)) @@MedicosisPerfectionalis

[@MedicosisPerfectionalis]

Thanks:)

[@jacksparrow-wq1pb]

I just love your lessons ❤❤❤they make haematology clear and simple ❤❤❤❤❤

[@MedicosisPerfectionalis]

Thank you!

[@Hawk89gt]

My father (75) was just diagnosed with MDS, this was a very good video. Thank You.

[@MedicosisPerfectionalis]

You’re very welcome! How is your father’s health?

[@susudiwa7101]

i keep watching ur hematology playlist for my exam, thanks for good summary!

[@MedicosisPerfectionalis]

My pleasure 😇

[@Shantanu.Shandilya]

Amazing explanation! Thanks for clearing up every possible doubt.

[@MedicosisPerfectionalis]

Glad it was helpful!

[@elenaprk5628]

This video really helped me for my PhD interview! Thanks a lot. Great job. I am really interested in haemato-oncology so your videos are really helpful!

[@MedicosisPerfectionalis]

Yay 😃

[@asmahanijamaludin4465]

thank you for the great video, my 4 yrs daughter was diagnosed with MDS with monosomy 7 recently and this video helps me a lot!

[@MedicosisPerfectionalis]

I am sorry to hear that about your daughter...How is her health now?

[@asmahanijamaludin4465]

@@MedicosisPerfectionalisthank you for reply, she is doin great, will undergo a Haplo - HSCT in June this year.

[@MedicosisPerfectionalis]

I wish you the best!

[@misstaniamaryam]

Thank you sooo much. Appreciate your hard work! You made it super simple to understand

[@MedicosisPerfectionalis]

My pleasure 😇

[@waqasawan4771]

Great work thanks for that much effort it was always confuse in MDS topic before i watch this video but now u cleared my concept ...

[@MedicosisPerfectionalis]

Thank you 🙏

[@98pushpanarayandas62]

Super simple explanation in short video ..Huge thanks .. cheers 🥂

[@MedicosisPerfectionalis]

Thank you 🙏

[@vasanthmagenta9491]

Superb one.. Appreciating your noble efforts

[@MedicosisPerfectionalis]

Thanks a million!

[@Ravi97111]

This’s amazing, unbelievably good , Please please please make videos on CHF management, you make things look way easier and help me understand, big chubby thanks 🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@edwinchesi1294]

Woow, so educative, thanks alot.... Was hard understanding MDS but now it's so simple

[@MedicosisPerfectionalis]

Thank you 🙏

[@فراتهديربشيريحيى]

This deserves thumbssss up

[@MedicosisPerfectionalis]

Thank you!

[@asmaaawad3084]

Excellent Last case open my mind❤❤ شكرا

[@MedicosisPerfectionalis]

You're welcome!

[@dr.elaineluther6562]

Ringered sideroblasts occur only in the bone marrow. They are not seen in peripheral blood smear.

[@riteshchaurasia8016]

Plz explain what is difference and clinical importance between large and nu cleated rbc n in which disease it occur..

[@THX-2208]

I have a friend who was on the haematology ward with me. We both went through pretty intense Chemotherapy together and have become really good friends. I was rejected for a stem cell transplant because I became so poorly on the treatment and was very close to death a few times but thankfully my friend got though his treatment and had a stem cell transplant but unfortunately just over a year later he has told me he has been diagnosed with Myelodysplastic Syndrome and I don't know what this means. I was hoping someone here could explain what are his options. He had lymphoblastic leukaemia while on the ward and I don't understand how he could have gotten this after a stem cell transplant. Thank you so much

[@rajeshwarpaulgaming3338]

Hey.. How is your friend now... I am also suffering from mds.. Fully depended on blood transfusion

[@iuw3ug]

Amazing lecturing skills!

[@MedicosisPerfectionalis]

Thank you so much!

[@nyile012]

Thank you thank you thank you thank you !!!!!!! Just need to confirm something MDS (myeloddysplasia syndrome ) and MPD (myeloproloferative disoder) are TWO different things / diseases MDS is when bone marrow is making abnormal cells ( dysplasia) and they DONt go out bone therefore cytopenia Where as MPD neoplastic proliferation of mature / myeloid lineage cell and the cells do go out of bone marrow and causes CML/PV/ET/ and MF..( based on which cell predominately produced ) So am I right ??

[@MedicosisPerfectionalis]

Yes, you are!

[@nyile012]

THANK YOU!

[@MedicosisPerfectionalis]

You’re most welcome!

[@prabalmajumder5179]

Sir all your lectures are just awsome...please elaborate the findings of DYSPLASIA in peripheral smear microscopy ..thanks

[@mubassirkhan3997]

Seems like I am addicted to this channel Love and respect ♥️♥️🇵🇰

[@MedicosisPerfectionalis]

Mubassir Khan Thank you so much :)

[@hamzagujjar8427]

In MDS, bone marrow could be hypercellular, hpyocellular, or normocellular

[@johnny.3693]

Thank you for the very informative info on MDS.

[@MedicosisPerfectionalis]

I appreciate you!

[@lugieravhudzulo3311]

This is quite Helpful Prof thank you

[@MedicosisPerfectionalis]

My pleasure!

[@omarbadr8187]

For the Question Why not CML?

[@kainat3474]

Please make cardiology videos Your videos saved my life

[@mitanshusharma5944]

Very Good and simple way of explaining such complicated things. Great job

[@MedicosisPerfectionalis]

Thanks 🙏 I am honored! Can you please help me by sharing?

[@mitanshusharma5944]

Sure Sir, my pleasure in Tht.

[@MedicosisPerfectionalis]

Thank you 😊

[@patrick_okora]

Thanks so much. This makes so much sense. Why haven't I been paying my school fees to you???? 😭☹️

[@Saaraelamin]

you answered all my questions :) thank you very much

[@MedicosisPerfectionalis]

You’re welcome 😊

[@PavitraTalamani]

thank you so much sir for all the beautiful informative very helpful videos..

[@MedicosisPerfectionalis]

My pleasure!

[@glowingflower5632]

Really appreciate all the hard work you put into ur videos

[@MedicosisPerfectionalis]

Thank you 🙏

[@Sky-sr2bf]

what is the cause of monocytosis here ?? n thank you so much

[@safari4342]

Great vid. I found your other haematology vids very useful.

[@MedicosisPerfectionalis]

Glad to hear that. Thank you so much for watching!

[@hillaryyatich2669]

best tutorial ever

[@infodiff]

Your videos are like watching an interesting movie. Thank u.

[@MedicosisPerfectionalis]

Thank you 😊

[@mika8148]

Thank u so much for all your great videos. 🖤🖤

[@MedicosisPerfectionalis]

My pleasure 😇....Please consider sharing my videos, it really helps!

[@farheenmalik1342]

Excellent! thoroughly enjoyed it!

[@MedicosisPerfectionalis]

I am so delighted to hear that...Thanks:)

[@Kem9s]

شكرا يسطا بحبك

[@jeancharlesgagnon2594]

very good content - I subscribed to your channel. thanks for your work

[@MedicosisPerfectionalis]

Thanks a ton! I truly appreciate it!

[@st1cks_and_crows]

Thanks, this helped with my project :D

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@geradmahega1570]

Thank you for good explanation on MDS and other vids

[@MedicosisPerfectionalis]

You’re welcome 😇

[@aolli2359]

There can be cytopenias in myeloproloferative disorders. Like myelofibrosis latter stage, full of cytopenias bro

[@heba_seyh9]

that was amazing

[@MedicosisPerfectionalis]

Thank you so much!

[@amineaboutalib]

what about mixed MDS/myeloproliferative disorders?

[@srinivasaraosirasapalli5104]

veru nice sir.can you make video on pelger heut anomaly and pseudo pelger heut anomaly?

[@MedicosisPerfectionalis]

Yup...I will add it to my list.

[@maryamalrawi6645]

Still the best 😍❤️

[@rehanullah6366]

Interesting loving your lectures.. Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@farkh76]

Really grateful for your work Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@vishnuchaitanya1835]

Simply superb 👌

[@MedicosisPerfectionalis]

vishnu chaitanya Thank you 😊

[@Hhhhss9553]

Thank you for this amazing video

[@MedicosisPerfectionalis]

My pleasure 😇

[@abwotdinnahech5366]

Thanks 🙏

[@MedicosisPerfectionalis]

My pleasure!

[@مولااحمد-ج7ه]

Really wonderful..thanks from egypt

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@مولااحمد-ج7ه]

@@MedicosisPerfectionalis ofcourse 😍

[@madmed7556]

Isn't it normal to see blasts in the bone marrow? I don't understand why we consider this a symptom of MDS.

[@MedicosisPerfectionalis]

It depends on how many (percentage wise)!

[@andytse5281]

For MDS, it could be hypocellular too right?

[@heradio1000]

Thanks for your video. Why is 5q deletion favorable in mds, yet unfavorable in aml? Is this correct?

[@MedicosisPerfectionalis]

You’re correct regarding the fact...However, I have no idea why that is the case. It’s just the way it is. But, that’s a great question!

[@superfc7787]

it is treatable with Lenalidomide (Revlimid)

[@cwapstra1397]

Hi, does anyone know why the classification of AML is done on blast cells rather than reticulocytes when compared with MDS ? Is it because the immune system effects are more significant than the anaemia ? Cheers.

[@gayathrijinesh3004]

Good video. The classification has been updated in 2022 though.

[@jeanwarech4982]

I have always enjoyed Hem-oc! You make it so enjoyable. I’m the one with ET

[@MedicosisPerfectionalis]

You mean essential thrombocytosis?

[@jeanwarech4982]

Medicosis Perfectionalis Yes Sir

[@jafarsaif182]

Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@lamazfarsi6843]

i have many Qs plz 1- can you re define the MDS in arabic just to figure it out ! 2-what is den ova mutation? 3-in a favorable part>> how is the thrombocytosis could be a good prognosis ,furthermore its unfavorable increase num od cytopenia ....i'm confused! 4-also in diagnosis:how can we see leukoerythroblastosis and the cell is cytopenia?? ill be super apredicated if you just explain it to me .thanks for you time

[@MedicosisPerfectionalis]

Sure! 1. I can’t explain it in Arabic, sorry...but think about it as bone marrow is dying and fighting for its life, so it keeps sending out crazy, immature cells. 2. De novo mutation means “brand new” mutation that didn’t exist before. 3. If the bone marrow is dying, and we find that it’s still able to produce lots of platelets, then may be that’s good news. 4. Leukoeryhtoblastosis is lots of “immature” cells, but cytopenias is less number of “mature” cells. There is no contradiction. Let me know if you have any questions.

[@lamazfarsi6843]

yes i got it (T) but when i red the definition of MDS>> (steam cell w/ ineffective hematopoietic defect maturation of cell of amyloid )i got lost and confuse!!1! @@MedicosisPerfectionalis

[@MedicosisPerfectionalis]

Yeah! Textbook definitions are so complex, and not easy to digest...That’s why Medicosis is here!

[@placo10100]

Hello and thank you for this most informative video my mother was recently diagnosed with MDS she is currently 15 to 20% blast with a left shift can you say what life expectancy under these conditions and best treatment she is in her eighties

[@MedicosisPerfectionalis]

Hey...Thanks for the question...I am so sorry that your mother and you are going through this...Unfortunately, I cannot do that based on this information, only her doctor who knows all her history, physical exam, labs, biopsies and radiology imaging can make that decision....Regarding her age, its harder, but again, the pros and cons of treatment should be discussed with her physician...Sorry I couldn’t help...Also, if she doesn’t like her doctor, both of you can seek a second opinion...Take care!

[@eshraqashoor3237]

Thank you very much ☺

[@MedicosisPerfectionalis]

My pleasure!

[@aytakchichak7456]

thank you for your helpful videos..we all like how you look like...☺☺

[@MedicosisPerfectionalis]

Haha 😂

[@LoserCruiser43]

love ur analogies

[@MedicosisPerfectionalis]

Thanks 🙏

[@106bagishrabha6]

If MDS occurs between 60-80 years then how could it be transformed to AML. Since AML occurs between the age of 40-60 years? 🤔

[@Kotavinod29]

My mother MCV 88.6 , was diagnosed MDS EB 2 . Not getting relief after 7th session of chemo ( 7*7) around 50 days Azacitidine but still 15% blast cell. Please suggest age 68

[@AnkitaParmar-ex2qi]

Hi, Do you have Transfusion Medicine related Videos? Like related to Medical Laboratory Technology

[@MedicosisPerfectionalis]

I have a video on “Transfusion Medicine” in my surgery playlist.

[@AnkitaParmar-ex2qi]

@@MedicosisPerfectionalis thank you

[@saheltahzibi1443]

That was sooo perfect 🤩

[@MedicosisPerfectionalis]

Thank you 🙏

[@sushilchaudhary2189]

My wife has Mds..1st bone marrow biopsy.shows hypercellular marrow..after a year second was done..where it shows hypocellular..last 5-6months wbc on the rise between 16000 to 23000..no.blast seen on peripheral smear....am confused..Is it MDS?

[@juansanchez6382]

Any links to getting mds with laser tattoo removal?

[@srinivasaraosirasapalli5104]

thank you sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@khamikos1]

THANKS SIR. THAT WAS GREAT.

[@MedicosisPerfectionalis]

Thank you, Sir...I am humbled!

[@afridi8877]

It's amazing sir❤️❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@safari4342]

are you going to upload any videos on Hodgkins and non Hodgkins lymphoma?

[@MedicosisPerfectionalis]

Yes, of course...Stay tuned.

[@mortal9870]

Thanks sir❤

[@MedicosisPerfectionalis]

My pleasure!

[@abeeralyemen1]

Thanks alot

[@sanaliaquat7211]

Superbbb 👌👌

[@MedicosisPerfectionalis]

Thanks 🙏

[@asserm.8047]

*blows a kiss to the sky * for medicosis

[@karandhiman1143]

Your videos are really good. Its because they are so good that i just watched a 5 min long ass Ad without skipping so that you can profit even if a little bit😂. I will continue to do so in every video 😃

[@MedicosisPerfectionalis]

You’re such a good person! Thank you so much 😊

[@prathikpawar5582]

Your lectures are amazing ❤️❤️ Please if you could make videos on Hepatopathology it would be helpful 🙏🏻🙏🏻

[@MedicosisPerfectionalis]

I have a playlist called “hepatology”.

[@prathikpawar5582]

@@MedicosisPerfectionalis yeah I checked it later and now if feel stupid 🤣

[@giuseppebruno3169]

Grande bro ❤

[@udarapandikorala6777]

nicely done. thanks for making this

[@MedicosisPerfectionalis]

My pleasure 😇

[@user-sl3rv8hs2k]

thank you doctor

[@MedicosisPerfectionalis]

My pleasure 😇