Vitamin B12 (Cobalamin) 🐚 🥩 🐠 - Most Comprehensive Explanation

[@MedicosisPerfectionalis]

💊 Antibiotics Course: www.medicosisperfectionalis.com/

[@nurbekraki6002]

this guy is sooooo underrated!!!!, i love his sarcasm AND his way of teaching using the visual and sound methods~~ tbh he mentioned everything and more of what i have and need for my vitamin biochemistry lessons~

[@MedicosisPerfectionalis]

Thank you 😊

[@MedicosisPerfectionalis]

🍌 🥬 Nutrition playlist: kzbin.info/aero/PLYcLrRDaR8_ejLKk85pAr8txLCVmNAVMq&si=o9goLcceJIcxDSBR

[@zainabalshamaa1870]

i love him so much im in tears he makes learning genuinely fun and logical and doesnt overcomplicate things at all

[@MedicosisPerfectionalis]

I appreciate you very much, Zainab! Would you please help me by sharing?

[@MedicosisPerfectionalis]

🍇 Biochemistry Playlist: kzbin.info/aero/PLYcLrRDaR8_dKo6Nu1Dw1efJGkDpuZGEy 🍌 Metabolism Playlist: kzbin.info/aero/PLYcLrRDaR8_f99ZucuCvQ6ecD3KzTVCi0

[@moizazahid8970]

your videos make this dry subject much more interesting than one can imagine. Absolutely stunning videos❤

[@MedicosisPerfectionalis]

Thank you 😊

[@jonbog6479]

Your style of teaching is really something unique.. much impressed!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@vitalia5962]

I did have b12 deficiency for years. This video and "intro to the playlist" saved me. Thank you!

[@MedicosisPerfectionalis]

Thank you! Best of luck!

[@marouabouzennada9456]

"Pale and tired tired and pale sometimes i have angina ...." Quote for history

[@MedicosisPerfectionalis]

:)

[@l.gregory3866]

😂

[@primeraprim1907]

Your videos are spectacular. Straight to the point, no Micky mouse nonsense but so intricately & constructively explained it's very impressive. Love the diagram step information and "Wisdom " not just knowledge. Thanks ☆ peace ( Even explained the difference between Natural and Artificial sources) Great. Wholefood vitamins.

[@MedicosisPerfectionalis]

Thank you so much 😊 I appreciate you!

[@LarryMorrow2]

Speed learning, ready GO! Boom, I'm smart now, thank you! This is the funniest educational video I've ever seen. Loved it!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@cathoderaytube1613]

Oh yiisssss! Just finished up all the folate stuff.....this is absolutely perfect timing! Thank you my dear virtual Professor!

[@MedicosisPerfectionalis]

You're very welcome 😊

[@samilazkani1720]

Well-organized, concise and informative yet. Thank you!

[@WoundedSnake]

Your videos are the source of my serotonin

[@MedicosisPerfectionalis]

Haha 😂 Thank you so much 😊

[@primeraprim1907]

Black Walnuts = serotonin

[@Smith-he6bg]

@@primeraprim1907 what about regular walnuts?

[@primeraprim1907]

@@Smith-he6bg yes there good . And Turkey. It all starts in the stomach. I think so . Still so so much to learn about life.

[@Smith-he6bg]

@@primeraprim1907 awesome! Great info to know! Thanks!

[@Dr.SheldonShelby]

Legendary monologue would always end in “‘ Oh Shut up“‘ 😹😹🤣

[@MedicosisPerfectionalis]

Haha 😂

[@callenscreations574]

That's over alot of people heads. I however, respect and love all who know the origin! CHARGE!!!!!!!!!

[@gitafernandes8143]

Strongly toxic

[@zelmabuile5345]

I absolutely love your way of presenting the knowledge, especially the phrase ''get your head out of your sphincter'' :D This is just what's needed - to step out of the box of old-school and dusty attitude and to keep up with time and broader horizon. Just what's loooots of physicians are missing. Prescribing pills instead of getting to the root cause and actually solving the issue. You are a source of great inspiration in my way to becoming a nutrition therapist!

[@MedicosisPerfectionalis]

Thank you so much 😊 Good luck 🍀

[@tahreemmumtaz481]

The most awaited video. 🎉

[@MedicosisPerfectionalis]

Thank you so much 😊

[@janislil]

Love this guy and no doh love his way of teaching. Much needed, lol. Thank You!!

[@MedicosisPerfectionalis]

Thank you 😊

[@izzzzzz6]

Some info here. This guy is an expert. Amazing stuff! I did not know that about nitrous oxide, tried some the other day. There is a big hype going around at the moment that nitric oxide is beneficial, could be interesting to see a video on the differences between the two. Vegan 20yrs+ no supplements till last week, Now taking creatine, B12, K2.

[@ashtonsneedensequeira8803]

Indian medical books have set up high standards proud to be an Indian 🇮🇳

[@MedicosisPerfectionalis]

I really liked that book 📖

[@tanthai3653]

Proudly using this video as a reference in my 2nd year assignment 🙏🙏

[@MedicosisPerfectionalis]

Best of luck!

[@gregorykarimian3813]

Minor correction. In eukaryotes, the formation of deoxyribonucleotides from ribonucleotides is catalyzed by an iron containing enzyme, and not vitamin b12. Some organisms do catalyze this reaction with the help of vitamin b12, just not Eukaryotes.

[@kennythelenny6819]

You sir are very correct!! Those organisms are the archaebacteria, eubacteria and bacteriophages.

[@235suhanathasneem6]

Thank you for making this tipic easy.... And for making me fall in love with my huge biochemistry textbook❤ love from india🤗❤

[@umamalhotra3619]

Exceptional teacher you are 😍Thanks a lot ,keep making such videos :)

[@MedicosisPerfectionalis]

Thank you 😊

[@ImSoooRad87]

I just love the way "Cyanocobalamin" rolls off the tongue. Reminds me if the Chris Delia Eminem impression. *quit panickin, your just lackin cyanocobalamin, we'll give you a shot and have you come back again*

[@malinduanjana3071]

Ohhh! Thank you , You give this before my exam

[@MedicosisPerfectionalis]

Awesome 👏 Good luck to you!

[@tiaraanisa2338]

rizal

[@alfalfaalfalfa3133]

Lmao i love d sass n attitude while teaching 😂😂 makes it easy n concentrated.

[@MedicosisPerfectionalis]

Thank you so much for watching!

[@fbbWaddell]

Just going to point this out and you all can do with it what you want. If you look up vegan sources of B12 on the NIH website you will find articles explaining actual plants old plant and mushroom sources of B12. There are 3 types of mushrooms and 3 types of seaweed that contain enough B12 to be sufficient for a vegan diet to prevent deficiency. There are also several other plant sources of B12 that do not contain a sufficient amount of B12. I would also like to point out that B12 is not produced by animals but by bacteria and that the animals that you are eating that have B12 were either given B12 supplements with their feed or they are ruminates and ruminates have bacteria in one Of their stomachs that produce B12. There are also bacteria in healthy soil that produced B12 and you can actually absorb it through your scan by digging in the soil. This will not produce enough to prevent B12 deficiency but it is a way to get B12.

[@mrshah1431]

Everything is so beautiful defined. Awesome

[@MedicosisPerfectionalis]

Thank you 😊

[@MDPowerhouse]

Another excellent video!

[@MedicosisPerfectionalis]

Thanks 🙏

[@Ladyofvirtue247]

🤣🤣🤣 the different voices...SUBSCRIBED!! I love it, great info!!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@tomg.8904]

😉

[@aasemahsan]

5:00 Vitamin B12 metabolism 13:34 Cobalamin & Follate 15:05 16:25 Deficiency

[@tarirogonye1722]

Why am I discovering this channel today????😭😭😭. Brooooo, you are so good at this. I literally just subscribed after watching it for 5mins😂😂😂. Never broke the subscribe button that quick before. Anyways, this is my new favourite channel😊🤗❤.

[@MedicosisPerfectionalis]

Wow 🤩 Thank you 😊 I appreciate you so much!

[@olegssh6452]

Foods that contain Propionibacterium are a natural way to get B12. For example, fermented coconut kefir. Or you can use probiotics with Propionibacterium.

[@alec1113]

Hello , you are missed two cobalamins, Methylcobalamin Adenosylcobalamin. Cyanocobalamin is the cheapest b12 to manufacture (chemically made , contains cyanide and aluminum as a preservative ) and has to convert in the body into Methylcobalamin. I'm not trying to undermine you just passing on information ,all the best .

[@EfrahNaz]

Awwwwww...i needed this video Thankyewwwwwwww so much from Pakistan

[@MedicosisPerfectionalis]

My pleasure 😇

[@stephaniew4168]

LOVE this video - do you do consults or chat with people at all? So many alarms went off for me watching this - my daughter has severe POTS/Dysautonomia and then went on to develop nerve pain all over her her body. She was bedbound at 6 yrs of age for a year then at 7 was when the nerve pain kicked in - shecouldn't stand up her feet wereso sore shecouldn't put clothing on she just laid there crying. Doctors wouldn't help and blamed ME! I flew her to Canada where I'mfrom and got her B12 shots and after 3 shots the pain was gone! Now, 2.5 yrs later, I'mstill trying to get tests to evidence the B12 issue and seeif we can ever heal the POTS. I think we did have a fish tapeworm from eating sushi - we took a lot of albendazol to get rid of a parasite and pinworms about a year before she became bedbound (she was symptomatic from birth tho so not sure). I also have a B12 issue and I breastfed her so maybe it was that? Trying to figure this out without any knowledgeable doctors is so hard but FINALLY we are getting the amino acids plasma and organic acids urine panels and MMA serum...so maybe an answer but what if they are "normal"???

[@MedicosisPerfectionalis]

Hey Stephanie, You can book online sessions with me on my website: www.medicosisperfectionalis.com/services/

[@JamieHumeCreative]

This was great. Than you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@smodoctor7558]

13:30 function of B 12 starts.

[@ruggerogabbrielli6831]

Interesting. I am having a little problem with the conservation of mass here, though. What is the definition of "essential"? Is it something that "your body can not make" or something that "you absolutely need"? These are two different concepts that I see often sold as if they coincided.

[@tombullish3198]

Impossible to follow, but great information

[@amym4752]

I adore your videos! But I’m confused about the amylase. It’s just for CHO digestion according to my research. Isn’t it a pancreatic protease that cleaves B12 from protein, in the duodenum?

[@THEPLANETEARTH]

Anyone here who suffered from folic deficiency BUT has c677t mutation where you have to aonly eat food that has it?

[@l.gregory3866]

what about methylcobalamin as a supplement option?

[@jjooeegg1]

Good video . Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@Onlyangel-g2t]

Thank you!

[@MedicosisPerfectionalis]

You're welcome!

[@markme3259]

What if the stomach is removed?..does injecting cyanocobalamin bypass the necessary intrinsic factor ?

[@SokTamo]

Very nice, thanks! What will happen if you have biotin deficiency, but normal levels of B12? Will MMA get high in that case? Will that one have B12 deficiency symptoms? Tnx!

[@poojagupta6333]

Thankyou so much.

[@MedicosisPerfectionalis]

You're most welcome!

[@loubnadr7407]

Honestly, I can't thank you enough

[@MedicosisPerfectionalis]

I appreciate you!

[@aasemahsan]

And the Thomas Sowell references keep coming 😁

[@birage9885]

Question: if liver is recommended for B-12 deficiency because of a vegan diet, how do the animals, who are basically vegan by nature, produce the B-12 in their liver? Shouldn't these animals be deficient by definition, as well?

[@kennythelenny6819]

They have bacteria in their stomachs that synthesize the b12. The animals must eat grass that is rich in cobalt to supply these microorganisms the necessary ingeredient to synthesize b12.

[@sayiddatunniesa5314]

thank you so much for the sharing

[@bobeighteen]

I'm trying to work out why someone would have low amylase and high serum cobalamin but my brain isn't working this out. Any ideas anyone please?

[@oldmanJ]

My doctor has said vitamin B12 can be of assistance with a NAFL is this true.

[@Moosemoose1]

Hey Medicosis I have a question: does B12 deficiency cause hyperammonemia? I know it causes a buildup up Methylmalonyl Coa, does it also cause a buildup of Propionic Acid as well? Because if so, why doesnt it present with symptoms of malignant organic acidemia and Hyperammonemia like Methylmalonic Acidemia and Propionic Acidemia? I would expect Ketoacidosis, Metabolic Acidosis, Hypoglycemia, Hyperammonemia as well as severe hyperventilation as respiratory compensation in addition to the other B12 symptoms. Also, since Succinyl CoA is also necessary for Heme synthesis, wouldn't a lack of B12 decrease production of Succinyl CoA from the Organic Acid pathway, thus leading to decreased heme synthesis and also exacerbate anemia this way as well?

[@angela1981]

Lmaoooo at when you said ,if I eat a bunch of clams will I get chlamydia?! Oh shut up! Lmaooo

[@MedicosisPerfectionalis]

Haha 😂

[@maxlichtenberger7447]

I couldnt find literature to the Niewegs hypothesis, to which reference are you referring to?

[@Snakelegs-go8qo]

Thanks for your awesome explanations. I heard an “expert” say that cyanocobalamin was made from a cyanide molecule which is left in the body after it’s consumed. Is this dangerous?

[@MedicosisPerfectionalis]

I personally take cyanocobalamin.

[@kavish1109]

Thank you.

[@MedicosisPerfectionalis]

My pleasure 😇

[@AhmedKhaled-yj2hv]

The Alexandrian liver is the best😂, Big thanks for your amazing content❤️️🇪🇬

[@MedicosisPerfectionalis]

Thank you so much 😊

[@hudamansour9262]

hello doctor, i have a question about reticulocytes, i know that reticulocyte is immature RBC and it will increase due to hemolysis and bleeding but some website its written that b12 deficiency anemia is megaloblastic anemia and that reticulocytes will be elevated. ( Additionally, the reticulocyte maturation parameters performed on the peripheral blood may also be helpful to differentiate megaloblastic from nonmegaloblastic causes of the macrocytosis. An elevated reticulocyte maturation value is more suggestive of a megaloblastic rather than a non-megaloblastic anemia). im confusing now.

[@needless2say723]

So do drugs that give you a dry mouth interfere with the salivary amylase and then therefore B12 absorption and therefore an effect on detoxification because B12 is needed?

[@kennythelenny6819]

Unless you are on that drug for more than 4 years.

[@mosab0164]

what is the name of the book he mentioned ?

[@MedicosisPerfectionalis]

I have mentioned many. At which minute did I mention it?

[@janebrown7231]

Oh no!! So disappointed!! I really thought you would be aware of active and inactive B12. Total serum B12 is NOT an indicator of whether someone is B12 deficient. Active B12 may be only a tiny percentage of total serum B12. That's what the problem is, with diagnosis of pernicious anaemia! the NHS tests ONLY total B12 so it never identifies genuine B12 deficiency (lack of bioavailable B12). B12 in your blood is no good unless it's available to your tissues. Get private testing guys - through Medichecks active B12 testing. Apart from that ABSOLUTELY CRUCIAL point it was a really good presentation, thanks.

[@izzzzzz6]

I bought méthylcobalamine powder. Is that ok Taking 300mg 2x per day perhaps it should be 500mg or 1g 2x per day? no instructions on my product. lol

[@nagatsatti8426]

Excellent thank you too much sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@tayabaShykh]

Kindly provide mcqs alsoooo?😢

[@MedicosisPerfectionalis]

Thank you so much for letting me know!

[@tayabaShykh]

But now I need mcqs related to your lecture....?😭

[@babakgholian3467]

You didn't mention racing heart ( eregular heartbeat ) . You made me laugh 😆 😂😂😂

[@rebeccasimpson2988]

Haha! “If I eat too many clams...” 😂

[@MedicosisPerfectionalis]

Haha 😂 Yup! People ask some wonderful questions all the time 😁

[@justsamira4477]

Amazing

[@MedicosisPerfectionalis]

Thank you so much 😊

[@seaweedaf]

this is amazing 😂 I remember things better if I laughed at it

[@MedicosisPerfectionalis]

Thank you 🙏

[@angela1981]

You know what sucks, when your b12 deficient, yet have a strong cobalt allergy like what to do in that case 🤷‍♀️

[@lilo7741]

You can’t be allergic to b12. If you take cyanocobalamine supplements you might react to the cyanide molecule in it or you suffer from histamine intolerance. B12 supplements raise blood histamine. I’m almost positive that you aren’t reacting to cobalamine/b12

[@mrdee8158]

Are mouth sores a sign of b12 deficiency??

[@thomassvensson1523]

Yes it is

[@hiraaqsa8689]

Hey, can you make a video on pyrexia of unknown origin? I have my exam next week. Please help🙏 its so complicated

[@MedicosisPerfectionalis]

Thank you so much for your comment! I don’t think I will be able to finish it before next week.

[@hiraaqsa8689]

@@MedicosisPerfectionalis ohh, alright! I'll still watch it after my exam.

[@olivialim545]

AMAZING

[@MedicosisPerfectionalis]

Thank you 🙏

[@jamesarkon5836]

Thanks!

[@MedicosisPerfectionalis]

My pleasure 😇

[@giuliopitali3861]

Hi, First of all, Great videos! I' m a biology student, and I became vegan 1 year ago. Six month ago i tested for my B12 levels and they were ok. I take a B multicomplex where the Daily dose of B12 Is 150%. In your opinion, it could be enough? I Will go to test B12 again soon Just in case. Sorry for possible bad english. Again, top videos, suscribed.

[@colinthomson5358]

Your body can store loads of B12. I think it can take several years to deplete like 3 maybe more. So, having a good b12 score a year into the diet could just mean you are tapping into your stores. However, the fact you are taking the supplement should stop you from being deficient. I don't know how good they are compared to food. Do you know what type of b12 it is? Maybe getting a b12 injection twice a year if you can afford it would be a good idea. If you are morally against eating cows or chickens what about things like muscles and clams? Adding them to a meal once a week or fortnight would be a good idea if you are ok with that. You'd still be vegan 95% of the time.

[@needless2say723]

There is no known upper limit of B12 it's non toxic they say.

[@SincerelyWavey]

Does anyone know the multivitamin he’s using as a reference in the video?

[@MedicosisPerfectionalis]

I used Walmart’s brand and Costco’s brand. I’ve personally used both. They are not sponsoring me!

[@SincerelyWavey]

@@MedicosisPerfectionalis I appreciate you responding. Would you happen to have a name?

[@westwoodoralsurgerydentalgroup]

You are freakin’ amazing

[@MedicosisPerfectionalis]

Thank you so much!

[@SecondComingTwice]

Not that I caught much detail-wise but learned quite a lot re the "big picture" and since laughter is the best medicine an inner smile probably translates to laughter with the correct molecule hitchhiking and then reabsorbed at the proper subatomic level via quark induction into a parallel reality via implosion .. Oh shut up already silly.. 😂😈

[@MedicosisPerfectionalis]

That’s a great comment:)

[@venkybly]

Tq , soo much

[@carolinamagda1116]

SUPER!!!!

[@MedicosisPerfectionalis]

Thank you 😊

[@danielamuller7718]

Thanks for this great Video ! I still have some questions though. I study veterinary medicine and i know that B12 is supplemented so most of the factory farm animals, who do not have contact with soil or grass (even ruminants who have B12 creating super power due to their crazy intestinal system ;-) I also found papers where the Vitamin B12 deficiency is linked to hygienic circumstances and different Weather-conditions (soil in Australia without enough cobalamin leads to white liver disease in sheep, which is linked to B12 deficiency) My hypothetical (!!!) Question is, could a human get B12 of soil and contamination just as non human animals do, or is this not possible, am I missing something? I even found a paper where the authors treated B12 deficiency with something called Koprophagie, the explanation why this worked was that even humans have vitamin b 12 producing cells in their body but it is not possible to resorb it where it is produced in the jejunum. It would be so great if you could help me figure this out.

[@MedicosisPerfectionalis]

We need evidence that this is the case...The plural of anecdotes is not data. For instance, Vitamin C excess can cause bladder cancer in rats, but that doesn’t necessarily mean that it will cause cancer in humans. The way to know is to compare farm animals who receive supplements to farm animals who don’t receive supplements using a sufficient sample size.

[@danielamuller7718]

@@MedicosisPerfectionalis Thank you for your answer, but I wanted to know if the cobalamin in soil for example would work for humans - so if humans would stop washing their vegetables - there is a lot of data in reviewed papers who are suggesting that. In your video you list a lot of non animal sources but there are a lot of papers which suggest that the vitamin B12 in those sources is useless for humans. I am sorry if my question was confusing, I already know what is going on with farm animals and B12, there is a lot of data. I wanted do know if there is evidence to your knowledge that those papers that suggest that contamination of water (mud water) for example, or soil would be a source of B12 that a human could use, are wrong. And if you think those papers are wrong, why. I know this is a lot to ask but it would be great.

[@MedicosisPerfectionalis]

Can you refer me to these papers?

[@danielamuller7718]

@@MedicosisPerfectionalis Of course: »"Vitamin B-12: plant sources, requirements, and assay." The American Journal of Clinical Nutrition 48.3 (1988).« www.deepdyve.com/lp/oxford-university-press/vitamin-b-12-plant-sources-requirements-and-assay-LuCW8lizW5 , and : »Studies on Euflena and Vitamin B12« www.jstor.org/stable/2482180?seq=1 Thank you

[@danielamuller7718]

Hey, I found a paper (Vitamin B12 among Vegetarians: Status, Assessment and Supplementation. Nutrient.2016 doi: 10.3390/nu8120767) that explained what I did not get ! My misunderstanding of all this came from the distinction between active forms of B12 and inactive forms (pseudoB12). Thank you for your time and your videos. Have a great day

[@queen1990ful]

come for the medicine, stay for the jokes

[@MedicosisPerfectionalis]

Haha 😂 Thank you 🙏

[@felicijavi]

Very funny way to explain B12. 🤣

[@MedicosisPerfectionalis]

😁

[@parulseth7641]

What does he say at 21:47 ? If you're __ ?

[@naweenkumar6675]

B17 I need

[@pleasesayhi4009]

So entertaining.

[@MedicosisPerfectionalis]

Thank you 🙏

[@sabujohn4116]

Your song has good Rhythm. Next time narrate like a speech in low speed or do not show your video. No one can understand what you have in mind.

[@abbybluemusic]

I'm a vegan and I recently found out that I have increased levels of B12 🙈 I guess I should make a break on my B12 supplements sometimes Thank you for getting our heads out of the sphincter 💛

[@MedicosisPerfectionalis]

I am so happy that you’re very detail-oriented. Thank you for watching!

[@AmanSingh-hf8gw]

My b12 level is 132 and i m suffering with fatigue and acidity issue too.. Could you please describe your supplements

[@asha-ko3hw]

Hi ,can you do a video on why some people have very high level of B12?is there something to be concerned about?

[@sumeenahmed5099]

@@asha-ko3hw facing same problem how r u now

[@karinarodriguez4218]

Which type of vitamin b12 did you took? It’d be very helpful

[@banzobeans]

Such entertains

[@mayarmm7122]

From Alexandria egypt you are right we have dirtier amazing liver meat that maybe from dogs 🐕 and the streer seller sell them as a cow liver😭😂😂

[@MedicosisPerfectionalis]

😂

[@ahmedsalah5239]

I didn't understand anything, you are very fast

[@Pinkfortressyickkkk]

I love you so much

[@MedicosisPerfectionalis]

Thank you!

[@mineteam0]

ah yes, clamidia, my favorite STD.

[@ideal1402]

‏‪13:25‬‏ 😂

[@atmanand5802]

🌟 Amazing... I love you too eternally fellow dearly beloved 👁 #Aum #SatChitAnanda 🎄

[@pennyhull1101]

Just because you dislike President Trump doesn't mean you needed to show case that dislike in your video. He has nothing to do with trying to find info on a vitamin

[@realyashu2401]

cry abt it

[@outboardfixer]

This GUY is making fun of Trump????