Melatonin's Metabolites: POTENT Antioxidant & Anti-CANCER Agents

[@tadmarshall2739]

I'm listening to The Cancer Code by Dr. Jason Fung and it's fun to hear many of the same concepts expressed differently and in different contexts. Fung, unsurprisingly, believes that cancer is primarily a metabolic disease with DNA mutation as a mechanism and not a root cause in most cases, and your connecting the disease with mitochondrial issues follows a similar path. Thank you for explaining the details so well!

[@butterflyeffect772]

Me too ! I love all viewpoints

[@DrCaseyPeavler]

I love listening to Dr. Fung, he is a very bright guy. The Cancer Code was very enlightening for me also!

[@gulms1352]

Where did you listen to him, is there anyway you know to reach him, I tried but couldn’t

[@tadmarshall2739]

@@gulms1352 I'm listening to a book that Dr. Fung wrote, purchased from Audible, an audiobook seller that belongs to Amazon. I have never met him, but I've watched many videos of him on KZbin. I've listened to at least two other books about cancer and The Cancer Code is the first place that I have heard the theory that cancer is an "atavism" in which cells decide to act as individuals instead of as part of an organism. Pretty sure that this isn't the last word on this group of diseases.

[@DrCaseyPeavler]

It’s true, instead of cohesion, we see a free for all type picture.

[@donaldkraft7371]

I look forward for your videos, I’m catching morning sun watching this with morning tea. The cancer growth on rectum is shrinking very very fast, low dose chemotherapy, 16 hr fast, two meals, adding off label drugs and supplements. Thanks for your dedication to inform us.

[@DrCaseyPeavler]

I am so excited to hear your cancer is improving! It’s my pleasure to inform you!

[@bferrell1797]

Which off labels and supplements are you using? Under physician or on your own?

[@gulms1352]

@@bferrell1797I want to know that tooo

[@gulms1352]

Pls share the drugs and if you have physician pls share

[@DrCaseyPeavler]

@donaldkraft7371 you’re fellow mitochondriacs are curious to what you are using as am I!

[@ws7001]

Thank you for your videos! And yes- Doris Loh recommends 4+ grams daily in her published protocols for some cases. She eats it with a spoon.

[@DrCaseyPeavler]

4 grams! That is an insane dose! Just shows how non-toxic it is that someone can tolerate that!

[@jacknimble7950]

Thank you for your short, informative videos. I read a lot of papers concerning application of generic drugs as cancer treatments (from S. Korea, China) and they can be burdensome for the layman. It's nice to have a professional as yourself who cares enough to guide us through some basic biochemistry. Your repetitive and concise reinforcement is surely turning on a lot of cranial light bulbs 💡

[@DrCaseyPeavler]

Very kind of you! I am happy to be of any help to you!

[@raykinney9907]

Yes, light bulbs are certainly popping! Hope they don't get out of control too much, massive info to assimilate.

[@raykinney9907]

Maybe, I just to take more breaks outside in DAYLIGhT, rather than have more coffee??!!

[@DrCaseyPeavler]

More outside than not is a definitive recommendation. I would bet you would be less jittery drinking coffee outside than in due to improved cortisol/catecholamine levels.

[@raykinney9907]

@@DrCaseyPeavler Noted! I'm heading outside with my half cup now.

[@KRose-jz7fj]

Thanks for info. Been battling the ovarian cancer, so appreciate all info!

[@DrCaseyPeavler]

It’s my pleasure. I am sorry you are struggling with that :/

[@JordanHH20]

Thank you for the great video Dr. Casey distilling the research!

[@DrCaseyPeavler]

You are very welcome!

[@jerrycash5606]

Interesting. Glad to find your channel.

[@DrCaseyPeavler]

I am also glad! Take care!

[@raykinney9907]

So, wow, what a 'raft' of beneficial mechanisms of action with melatonin and metabolites! And, even per oxidation modification help. I'm glad to note that Pb toxic effects may be countered for lipid per oxidation of membranes.

[@DrCaseyPeavler]

Melatonin and Vitamin D are 2 de-centralized master protectors. But related to light and dark…

[@DCGreenZone]

Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives

[@DrCaseyPeavler]

We are getting to that part of the story, just bear with me!

[@DCGreenZone]

@@DrCaseyPeavler You are on the right track, thank you for these. 👍

[@DrCaseyPeavler]

You are very welcome, thanks for your support. Very encouraging for me.

[@ezvahedi1387]

THANK YOU DEAR DR.

[@DrCaseyPeavler]

You are very welcome!

[@williambuckley6128]

Does Cancer fight back? During my protocol, I'm constantly assaulting my metastatic prostate cancer that spread to the bone. I've noticed cancer fights back with pain at the end of my fast when I implement IVC, and O3. Am I giving it energy or is it cancer's defense when it takes a hit.

[@DrCaseyPeavler]

That is an interesting question and horrible observation you have had to make. I am sorry you are dealing with that. It sounds painful. Cancer is associated with inflammation (pain signals) and if you have bony metastases the expansion of those tumors inside the bone must hurt like hell. I don’t know honestly if you would call that fighting back. But maybe..

[@lindaanderson1921]

Good Morning !

[@DrCaseyPeavler]

Good morning fellow mitochondriac!

[@NZ_Andy]

Thanks for the Video, It is very interesting that "massive generation of reactive oxygen species (ROS)" occurs, but only in cells with damaged mitochondria (so probably cancer cells), so this could be good to take with HBOT treatment, stressing out cancer cells. When someone buys melatonin, what are they normally getting? or what metabolites are generally sold as "melatonin"? thanks again.

[@DrCaseyPeavler]

HBOT’s proposed mechanism is creating oxidative stress that your normal cells can handle and cancer cells cannot. But HBOT as a stand alone therapy is nearly useless. Have to cut off glucose, glutamine, and glutathione (PPP) first.

[@JohnMoreau1111]

​​@@DrCaseyPeavler it's strange how Glutathione works differently in cancer cells. Do you have a video on why it's good for healthy people and not good for cancer patients? I need to do more research into Glutathione, if I'm not mistaken our body makes it daily no matter what we do?

[@DrCaseyPeavler]

It’s not a bad idea. But unlike melatonin and vitamin D which actually do the exact opposite. Glutathione does the same thing, powerful antioxidant. It just gives cancer an unfair advantage and is being hijacked against oxidative therapies to kill cancer.

[@NZ_Andy]

@@DrCaseyPeavler thanks for your reply, I'm researching things to stack that cause oxidative stress to cancer, along with keto and things that lower Glutamine uptake and usage in cancer. Hydroxychloroquine is an interesting one see: PMC5718030

[@DrCaseyPeavler]

Happy to be of any assistance. Will check it out.

[@teva197]

Understand you can't recommend a dose but is there a safe dose range for Melatonin?

[@DrCaseyPeavler]

I have seen integrative oncologist recommend anywhere from 30mg nightly to 180mg nightly to 120mg 4x/day. Some of the folk here on this community, are taking gram quantities multiple times per day without significant side effects that they are reporting. I hope this helps. The specific context will dictate dosages. However, I would urge you to maximize endogenous production before supplementing.

[@teva197]

@@DrCaseyPeavler Thanks! That's information I was looking for.

[@DrCaseyPeavler]

You are very welcome!

[@raykinney9907]

AFMK effects reducing glutamate neuroexcitotoxicity, is 'exciting'! Certainly could have benefit in non-cancer diseases too. And, thinking of adverse effects of Pb on neurons. So, NIR getting regular fairly deep brain tissue exposure, inducing more melatonin in mitochondria, might also have produced higher AFMK availability? And could be a mechanism of action beneficial to countering Pb neuropathology in brain???!!!

[@raykinney9907]

And, MSG inclusion as a 'food ingredient' to promote desire to eat more processed food, melatonin and associated AFMK might be useful to counter these effects??!! Hmmm, a lot more lit searching to do, better have another cup of coffee, and hide out from chores a bit longer. How much anxiety in people may be alleviated by more NIR regularity? And, by getting NIR back into indoor environments when getting outside just does not happen enough.

[@raykinney9907]

Hmmmmm, sure points out the problems associated with the lack of realistic inclusion of NIR in lab environments, or at least paying attention to the adverse effects creeping into experimental paradigms, by being unaware of the need to control for this?!

[@raykinney9907]

How much toxicologic and other biomedical research outcomes could have become far better by realizing consideration of light effects on the experimental outcomes? How many further misconceptions are brought by this, into the literature?

[@DrCaseyPeavler]

It was a really cool finding. Certainly can mitigate oxidative stress from heavy metals. Since those are the major metabolites so one would have to assume it’s increased whenever melatonin levels increase.

[@raykinney9907]

And, we are all the time being told 'to get out of' the daylight??? And my friends, relatives, and future potential friends are all being told 'to get out of the daylight' and indoors with LEDS???

[@AntonioGonzalezESP]

Would this be beneficial for Lentigo maligna melanoma? Would/should the approach be different with skin cancer? Thank You!!

[@DrCaseyPeavler]

All cancers including skin cancers are associated with vitamin D deficiency and I would guess low melatonin levels. So essentially these individuals have a sunlight and a darkness deficiency. I would look heavily into why someone with melanoma got it in the first place? Obesity? Diabetes? Insulin resistance? Excess stress? Artificial light at night? Poor sleep? Exposure to nnEMF. When one has cancer, one must critically scrutinize their environment. You cannot get well in the environment in which you got sick…

[@raykinney9907]

@@DrCaseyPeavler Yah, AND better start scrutinizing ahead, for prevention it seems!!??!!

[@DrCaseyPeavler]

An ounce of prevention…

[@raykinney9907]

@@DrCaseyPeavler And, so much can be done FOR FREE! It appears. My head is spinning, and the medical paradigm seems to be so massively diverted from chronic disease causation/ progression/prevention LOGIC..... by money and hubris, and 'busywork' w/o time to think critically. Jack's focus on Ferrari engine maintenance certainly seems appropriate toward higher functioning medical paradigm potentials. Doctors NEED time to THINK! This emerging community seems key! Into the light!

[@DrCaseyPeavler]

Unfortunately critical thinking and just general curiosity is in short supply at this moment in history within medicine.

[@ea6051]

i think this just goes to show how todays society set up/structure is so out of tune with what nature intended for us to be healthy. dont get me wrong, i like ac/heat when needed, but dang! we are meant to be outside moving around, not sitting in our chairs all the time (most of the working population?).

[@DrCaseyPeavler]

I know! It’s not like immune to this problem, I work in a nnEMF hell hole, fluorescent lighting 24/7…so I get it.

[@raykinney9907]

@@DrCaseyPeavler Yah, this stuff, you just can't un-see it again! A LOT of work needs doing quickly IMHO.

[@DrCaseyPeavler]

We need like a parallel society that minds those important details….i have seen these low/no EMF neighborhoods/communities that are being organized/built…

[@ea6051]

@@DrCaseyPeavler Im all for going the amish style of living myself. small community, self sufficient, slow paced, honest work etc. although having a car/truck when needed is nice too lol

[@DrCaseyPeavler]

It would be hard to give up a lot of things we have in modern life…

[@raykinney9907]

I'm trying to get a sense of, if mitochondrial production of melatonin does contribute extracellular melatonin to circulate in blood or lymph to a significant degree, as melatonin or metabolites as well. This info may be right in front of me in these papers, and I just did not retain it well enough yet. Such a massive production happening, given adequate NIR in mitochondria, but does it also augment circulatory system supply (to add to the 5% from the pineal)? Hmmmm, better review the papers once again, I guess, maybe with more coffee on board (or better sleep first).

[@raykinney9907]

What might be mechanism of transport to extracellular pools?

[@DrCaseyPeavler]

I am also not quite certain. In the paper it’s saying most is used locally intracellularly and for adjacent cells, but then the study is looking at blood/serum melatonin….

[@raykinney9907]

@@DrCaseyPeavler Yah, that was my question.

[@DrCaseyPeavler]

Id love a follow up to this study being a little more precise with methodology to remove some variables (UV and Exercise)

[@ws7001]

Dr Russel Rieter says no, mitochondria produced melatonin does not enter blood stream

[@HMNOURA]

❤🙏❤️

[@DrCaseyPeavler]

Thank you for your support!

[@emilybruce368]

Another great video, thank you Casey ! To everyone going through this, don't let the Devil use to to discredit God. Jesus is with you and that's why the natural healing happens, natural foods and herbs to heal from all diseases. Jesus gave us free will, which means the greatest things happen and also the saddest/evil things. Use your free will and ask Jesus to heal you. He will always direct you to natural docs and videos like this on YT, also books too.

[@lindaanderson1921]

That's so true! If we got hit by a car, we wouldn't blame our mom/dad , we would blame the driver of the car. Also, a lot of us took the medical procedure c19 , our choice. Also the bad food we eat, our choice. Don't blame God when it's bad and only praise him when it's going good. If we ask for Protection, He will protect us. Pray daily for Protection and Healing.

[@butterflyeffect772]

You tell em!! It takes faith to believe in the bad times. Stay faithful. He will give you the victory. Never lose faith. Just becuz im sick , it doesn't change the gospel or Jesus existing , also creation.

[@DrCaseyPeavler]

God bless you!

[@anthonyedwards7019]

Remember that you are talking to laymen, so cut out the technical crap and get to the nitty gritty.

[@DrCaseyPeavler]

I appreciate the feedback, but the "technical crap" is important.

[@BLOCKsignallingUK]

We want the technical info. Thank you, Dr.