Metabolism of Drug (Part 01) | Introduction to Drug Metabolism | Metabolism | ADME | Pharmacokinetic

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Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.
Drugs are metabolized through various reactions including:
(1) Oxidation
(2) Reduction
(3) Hydrolysis
(4) Hydration
(5) Conjugation
(6) Condensation
(7) Isomerization
There are often two phases of drug metabolism.
(1) Phase I: Non-synthetic reactions such as cleavage (e.g. oxidation, reduction, hydrolysis), formation or modification of a function group.
(2) Phase II: Synthetic reactions such as conjugation with an endogenous substance (e.g. sulfate, glycine, glucuronic acid).
The most common and important enzyme group involved in the Phase I metabolism of drugs is the cytochrome P450 (CYP450) superfamily of enzymes. This group of enzymes acts as a catalyst for the oxidation of many drugs. It can, in turn, also be induced or inhibited by many drugs and other substances. As a result, the metabolism of some drugs is affected by the presence of other substances. This is what is known as a drug interaction.
Some of the important enzymes in this family include:
CYP1A2
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A4
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[@solutionpharmacy]

Thank you for your love. See when we take drugs then it goes for metabolism and as per the chemical nature of drug it produce action either directly or by converting in its metabolites. Few drugs get inactivated but by oral route and not by parenteral. Thats why we study about such drugs.

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Hi sir, I am having one question.....Paracetamol is inactivated after metabolism then when we will get its action. As per your last videos when we are taking any medicine after absorption it goes to portal vein and by portal vein drug goes to liver and after that remaining amount of drug goes to different parts of the body. So, in case of paracetamol after metabolism by liver when we will get Action. Kindly reply.....I am confused please

[@solutionpharmacy]

Metabolism inactivate the drug that menas reduce its potency so we have already calculated this fact in making dose calculation