Metabolizing Alzheimer’s: A New Key to Stopping Brain Damage

[@bradp1983]

Nick, this is my new favorite channel. Love your content. Clear and concise presentation on topics that are quite relevant to the life of me and my family.

[@nicknorwitzPhD]

Glad you enjoy it! This is so very kind

[@bathurstststudios]

Totally agree

[@ronaldmartin9881]

I couldn't agree more. Thoroughly enjoying what you do Nick! Thanks.

[@p.b.9428]

And he has enough common sense to keep most of his videos short enough to keep the mind engaged through the entire video.

[@heftyjo2893]

I've been taking care of my Mom for the past 3 years and she is in the moderate stages of Alzheimer's. When I first moved in to help take care of my aging parents I noticed my Mom was eating a bunch of junk food. The fridge was full of 12 packs of Cokes and the pantry had 4 or 5 bags of potato chips. My parents were also eating tons of take out and fast food. So, they were eating tons of processed food full of seed oils, lots of sugars, and deep fried foods. And they also loved to slather margarine on their food. She has difficulty talking and quite often has bouts of paranoia and hallucinations. Also needs help with self care going to the bathroom and getting dressed. Also she has badly swollen legs that required XXL socks just to fit over the ankles. So, yea she is having all kinds of metabolic issues. I've taken control of her diet and cut way back on the sugar intake and when I do give her a little coke as a treat I give her a Mexican Coke with the real cane sugar instead of fructose corn syrup stuff. I stopped the potato chips entirely as I learned that those cause uric acid inflammation. And I've cut the seed oils back quite a bit and thrown out all the margarine. I try to make a majority of her dinners from scratch and only use Olive oil and real butter when preparing foods. Last visit to the neurologist and they noted that her verbal skills seemed to be improving. And I can certainly see she is doing better with self care and getting dressed on her own. And she hasn't told me she sees people walking around in the house for a while now. Also the swelling in her legs has reduced quite a bit and we can actually wear normal sized socks again. I really do believe that a large percentage of chronic diseases are pathologically linked to poor diets. And my parents were certainly a victim of the disastrous low fat, high carb food pyramid scam that was foisted on the public.

[@nicknorwitzPhD]

Thanks for sharing this heartfelt story. Your mother is certainly lucky to have you as a kid. She clearly did something right raising you.

[@shannon2003]

Thanks to people like you, it’s staring us in the face. I’m old enough to remember when Alzheimer’s was unknown to most of us. I saw a chart showing the correlation between seed oil use and the rise in Alzheimer’s. My father died of Alzheimer’s and looking back, he was metabolically impaired and abusing alcohol. I believe the correlation is well known among the food industry. Helping your mother to improve is a wonderful gift to her.❤

[@carnivorewhisperer5823]

If you aren't already doing this I would make sure your parents get plenty of meat, especially red meat. That's where all the natural brain food comes from. Plants do not feed the brain. Meat does. It has all the nutrition the brain needs to thrive. It's far better than supplements.

[@ChessMasterNate]

It can be easy to be suckered by all the misinformation on KZbin. What makes "processed" unhealthy is Advanced Glycation End-products(AGEs). The AGE associated with every major disease of aging, especially Alzheimer's, kidney disease, cardiovascular disease, and type 2 diabetes. Our intuition as to what is processed is not adequate. Take a look at the paper titled "Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet." Olive oil and butter are high. Skipping fried foods is the right path, but that is incomplete. Avocado oil, pistachio oil, corn, sunflower, and safflower are the lowest in AGEs. But oils should not be that prominent. Fresh and/or frozen vegetables should be center: artichoke, collard greens, kale, butternut squash or pumpkin, summer squashes, peppers, mushrooms, legumes, potatoes (you can slice and eat without mashing and adding oils), and cruciferous vegetables. Some whole grain (but any toasting should be very light, if it is the form of whole gain bread. I prefer oatmeal, and wild rice), dairy in the form of milk and unfermented cheese is good: cottage cheese, ricotta, mozzarella, and string. Fruit other than grapes (grapes have fluoride because of the cryolite pesticide the vintners all use. Fluoride is a neurotoxin) are good, but fruit juice should be limited. Fiber in the fruit reduces the issues with the sugar. Nuts and seeds are good but should not be roasted or toasted. Peanut butter (and other nut and seed butters) is virtually always made using roasted nuts, and the blending process is also capable of generating lots of AGEs. Meat preparation is where you have to be very careful. Cooking must be done with water. Either submerged, or with just a little water in the bottom of the pan, or as a stew, or something in tomato sauce like chili, soup, stew... Skillet cooking where oil is used or the meat is thrown in the pan is no good. No pan-frying, no deep-frying of course, no grilling, no broiling, no roasting, no BBQing. This is a big piece of why our food is killing us. The trick to making this work and still enjoying the food is learning to use spices instead of the Maillard browning reaction that makes AGEs. And instead adding other things for flavor like celery, onion, garlic, peppers and mushrooms. Hibiscus tea is great for fighting and preventing Alzheimer's as well. It does not have to be sweetened, or could be sweetened with stevia. I only use actual stevia...no fillers. There is also an alternative to exercise, if one can't. That is sauna. It can elevate the heart rate similarly and has some of the same benefits. You have to be careful, though, and they must be watched. And it takes time to acclimate. It may take weeks to even build up to a therapeutic level.

[@Beachlife4567]

Suggest u drop the olive oil also. More butter is much better.

[@billtrudell1636]

One thing that I used that got rid of brain fog as it's called is Acetyl-L-carnitine. I'm a software engineer and I'm 66. I seriously thought I would need to retire due to basically not being able to think well enough to perform my job. I started taking it along with a keto diet I had been on for a couple of years without any improvement but after adding Acetyl-L-carnitine that all changed. My brain seriously needed energy and was failing but now it's working better than I ever remember. I struggle through most of my life but it got so bad I was ready to give up. Now in the daily scrum my manager did something I never heard him say that my updates were among the best he's heard. Clear consise. It doesn't sound like much but for a guy who spent most of my life trying not to talk because I couldn't depend on the words coming out it is amazing to me.

[@DCGreenZone]

Hal Cranmer in his 3 retirement homes in Mesa Arizona, had dementia residents, he made a deal with the children of these residents, he made them swear off bringing in donuts, candy, chips etc. He put them on meat, period. Many regained their cognizance, some went home to live a normal life. The video title is This is scary. Shawn Baker is the man who interviewed him.

[@CairnsLobster]

That sounds interesting. Shawn Baker does cool content. Andre

[@jcm4923]

Yes, Hal Cranmer is a fascinating figure in elder care. There are many interviews with him on KZbin. My question is: how old do I have to be before I can just eat all the crappy junk food I want and be allowed to die?😅

[@DCGreenZone]

@@jcm4923 Mikhaila Peterson just put an interview with him in here.

[@jcm4923]

​@@DCGreenZoneThank you. Will search and view it. I love Cranmer's humility too. He's not afraid to say he tried vegetarian diets and failed with them. He learned by trial and error but succeeded!

[@aloha224]

Thank you for sharing!

[@benwallman5378]

Nick, you forgot to mention that omega 3 supplementation has no benefit when homocysteine is high (b12 status low) and supplementing b12 without omega 3 has no benefit. Supplementing methyl b12 AND omega 3 shows HUGE benefit for dementia. This is clearly shown in the literature and a shame you missed it, worth reposting with the edit!

[@n0name1450]

or eat beef and salmon, for b12 and omega3

[@isidorocotugno7920]

Or just eat beef, specifically grass fed and you'll have both. I wouldn't consume fish at this point unfortunately.

[@PhillipJermakian]

This must be the answer I was looking for, I took a b multi and felt great then the next time it seemed to do nothing. Did it just burn through the omega 3 my body had stored?

[@Ssss-3z]

Good Catch @benwallman5378 The studies I’ve seen show that both B vitamins and Omega-3 help reduce brain shrinkage but the combination of the two does show the greatest improvement. The website for “Food for the Brain” has more about it. They’re a UK organization geared toward preventing Dementia. They also have a Cognitive Test available similar to the one a Doctor would give.

[@davidspain7398]

@@PhillipJermakian

[@ngana8755]

To reduce your risk of dementia: 1. Exercise: 4:48 min 2. Adequate sleep: 5:05 min 3. Long-chain omega 3 fatty acids (EPA and DHA) in your diet, 4. Lower carb and higher fat diet for those with a genetic risk factor for Alzheimer's (APOE4 allele).5:48 min 5. Enjoy life 6:04 min

[@rjules1083]

Thank you 🙏

[@artsiecrafty4164]

I would say eliminate all starches, sugars and seed oils. ALL. TAKE EXTRA VITAMIN b1. Fish oils turn rancid long before you open the bottle of them. Exercise if you can. Fasting for a few days, after you acclimate to this diet.

[@tristanhnl]

GREAT advice towards the end of the video. My dad currently has advanced alzheimer's, and does not even know how to hold a spoon to feed himself. He's essentially a big infant, needs someone to feed, bathe, and change his diaper everyday. The time when his dementia started accelerating....was when he retired and literally stayed home every single day, and hardly EVER ventured outside the house. He rarely had guests/friends over. That's why the advice at the end of this video resonates with me so far. Go outside, get exercise, enjoy life, enjoy friends, companionship and fellowships, get lots of sleep.....

[@raviboppudi]

Nick, Love your short and sweet videos. Thanks for the education. My mom was vegetarian(due to religious reasons) and was diagnosed with Parkinson's around 2.5 years ago. Her protein intake was minimal. Last November I spent time with her and changed her diet and increased Paneer and Whey protein. Almost Keto. No more Parkinson's symptoms. Her shuffling of feet(while getting up from a chair) and shaking of hands stopped completely. I managed to convince her to eat 2 eggs per day and she is much stronger and active right now. I thank all the Drs like you, Dr BAker, Dr Berry, Dr Bikman, Dr Bredesen who post educational videos on SM.

[@karenbuchert3377]

Maybe even more eggs. The chickens are very happy, especially free range natural ones. Eggs are so nutritious. She was so deprived of nutrients. All the best to your family. ❤

[@elloohno1349]

The pictures help so much with understanding what you are saying. This is very interesting! Thank you

[@nicknorwitzPhD]

Glad it was helpful!

[@LobsterMobility]

Nick is a gifted content maker.

[@RizwanMuzzammil]

I would add one more thing: Get adequate sunlight. Not just for the UV which helps with Vitamin D production, but also IR, which helps clear oxidative stress. Also, switch off any night lights while sleeping.

[@glenliesegang233]

And, measure D levels, and consider vit K2 to boost absorptionof D.

[@plinble]

It's worth the effort to make the bedroom as light safe as a darkroom. Not easy when you want good ventilation and light coloured walls.

[@karenbuchert3377]

Hello Nick! That was an amazing video!!! Cascades of thanks to you for your videos you create for us. Your showmanship and design were awesome for the public to enjoy, follow, and understand, and you gave us a wrap up homework assignment in eating smash fish! Your enunciation and rate were fabulous. The visual aids were just right also. They really kept the viewer tied into your message. Thank you, Nick!! ❤❤

[@nicknorwitzPhD]

Thanks Karen!

[@drsvs]

This is one of your best, Nick. Please know your efforts are greatly appreciated.

[@nicknorwitzPhD]

Much appreciated!

[@ndp777]

Hal is far more informative than the Alzheimer’s Society and others! Keep up the good messaging Hal!

[@nicknorwitzPhD]

Hal? Seems like you’re referring to me?

[@scaler2296]

Love the presentation style, showing the simplified breakdown of the metabolic processes involved. Great video!👍

[@nicknorwitzPhD]

Thanks! Appreciate it

[@joannamazur2117]

I love your channel....I thoroughly enjoy your videos and the subject matter that you cover...without dumbing it down..❤

[@twiggyfitness]

Another great video... and perfect timing, I shared it with a friend who needs to hear this information .

[@nicknorwitzPhD]

Thanks for sharing!!

[@cynthiafasulo3828]

Watched this again. You give so many hope in so many ways. Thank you, Nick.

[@nicknorwitzPhD]

Glad it was helpful!

[@aprilek6003]

Bravo Nick, This may be one of your best overall videos yet. I love the science review and then the helpful suggestions to keep your brain healthy. It will be interesting to see if this drug will be repurposed and offered to patients. I recently read Dr. Paul Marik's book, Cancer Care The Role of Repurposed Drugs and Metabolic Interventions in Treating Cancer. You are making a difference Nick keep it up

[@nicknorwitzPhD]

Thank you April. Appreciate it :)

[@zacharylark6739]

Nick, great video. You explain the topic and the subject in a fantastic way. It was information dense and well ordered. Definitely going to rewatch it and share it with a few folks.

[@ClovettCC]

“Enjoy the ride “- I love it!

[@nicknorwitzPhD]

Thanks... deep wisdom ;)

[@loewenberg11]

Food, exercise, sleep and joy ❤

[@nicknorwitzPhD]

The last has the most flavors...

[@Desertflower743]

Proper food, single ingredient food, no food with lists of ingredients with unpronounceable names. AND definitely exercise, sleep and joy. Very beautiful comment ❤

[@blankblank4130]

Sex

[@zuleikadobson]

Particularly excellent, well-explained, and -to me - personally very helpful.

[@nicknorwitzPhD]

Thank you 😊

[@w4rsh1p]

Have you read Tetsumori Yamashima’s work concerning seed oils causing dementia?

[@nancytait3075]

Thank you! This is really a great, hopeful and uplifting video! ❤

[@nicknorwitzPhD]

Appreciate you appreciating it :):)

[@CaseyInsights]

Really important piece of the puzzle. Thanks so much for the clarity📌👍🏾

[@nicknorwitzPhD]

Cheers. Happy to 😊

[@kennethyuman1940]

SMASH: salmon, mackerel, anchovy, sardine and herring. I failed to capture the snapshot as they swam away quickly

[@nicknorwitzPhD]

😅 good one …

[@ken3marcus]

Impressively clear presentation, and useful.

[@nicknorwitzPhD]

Glad it was helpful!

[@jonmoceri]

Thanks Nick! Medical News Today has a good article that covers what Nick is talking about. 'A new drug may help treat early-stage Alzheimer’s by targeting brain metabolism'

[@nicknorwitzPhD]

Looks like it's on NPR too... fancy that... but I like my cover better ;)...

[@karenbuchert3377]

Way before taking a drug, folks need to eat a low low carb keto diet to feed themselves properly. ❤

[@Corolla97ww]

Great content on this channel.

[@nicknorwitzPhD]

Appreciate

[@wichetleelamanit6195]

Love channel. Smart information.

[@nicknorwitzPhD]

Cheers

[@ngana8755]

What about brain photobiomodulation (red light therapy) as a preventative measure for dementia? Retired Harvard Medical School professor Dr. Michael Hamblin did lots of research with red light devices.

[@juanpe8512]

I would include fasting in the practices to protect against any mental illness. A serious one, namely >72 hours, when the real interesting things at regeneration level start.

[@karenbuchert3377]

Excellent point.

[@erniewhite1382]

Thanks Nic for another thought trail

[@nicknorwitzPhD]

Very welcome Ernie :):)

[@Jack-hy1zq]

This is very promising news.

[@nicknorwitzPhD]

I'm optimistic

[@mr8966]

Love the new graphics. Impactful. And acronyms are always great. Never heard of the SMASH acronym! Nicely done as always. 🎣

[@nicknorwitzPhD]

Glad it was helpful.

[@TimoJordanov]

Nick, great video. Besides inhibition of astrocyte glycolysis, amyloid and tau also inhibit the glucose uptake of neurons. It is probable that there is a reason for this 'energy sabotage', which is worth to explore in my opinion. I think that Alzheimer's disease may be caused by neuronal energy deficits, because this energy crisis mimicks the metabolic state of neuronal infection. Pathogens use nutrients of their host cell for survival and replication, leading to cellular energy crisis. Amyloid and tau show potent antimicrobial activity, but not all AD patients have cerebral infection. This 'starvation' mechanism may be evolutionary conserved to protect neurons against infection: during reproductive age, neuronal infection is probably the most common cause of neuronal energy crisis. The neurons with energy crisis produce amyloid and tau aggregates, which sacrifice the cell by limiting further glucose supply to the cell, starving potential intracellular pathogens and preventing pathogen spread to healthy neurons. This also explains why neurons become insulin resistant: to limit glucose supply to potential intracellular pathogens. In late onset AD, however, neuronal energy deficiency is not necessarily due to infection, but a consequence of aging and chronic disease. Aging and AD risk factors (DMII, CVD, depression, low mental/physical activity) are characterized by increased neuronal energy stress. This energy stress may mimick infection related energy stress, triggering an anti-infectious response characterized by amyloid and tau aggregation and the 'starvation mechanism'. In actual infection, the starvation mechanism prevents spread of infection. In AD, it happens first in the neurons that are most susceptible to energy stress (cortex, hippocampus) as they require the most energy. This explains the pattern of tau phosphorylation and atrophy witnessed in AD. By the way, this could also explain why ketone therapy is so promising: intracellular pathogens use glucose but are not efficient at using ketones. In AD, neurons block the influx of glucose but not ketones:))) It would be an honor for me if you considered this theory, as I think it may explain a lot of observations that we see in AD. I have two video's on my channel explaining this theory. Once again, amazing video! Cheers!

[@RuiBarreiras]

Great comment Timo!

[@franshartman4378]

Beautiful video! 🙏🏻 I enjoyed life (#4 on your list) just by watching this.

[@nicknorwitzPhD]

Awesome! Thank you!

[@LobsterMobility]

Awesome video sir, Andre. Fascinating.

[@nicknorwitzPhD]

Glad you enjoyed it!

[@denniswilson486]

I understand from Dr. Rhonda Patrick that lactates that results from exercise can be transported to and pass through the blood brain barrier. Would this lactate help replace the lactate that is not being produced in the brain that is a problem and a cause of dementia and Alzheimer's?

[@smoath]

Brilliant content again.

[@nicknorwitzPhD]

Cheers... appreciate it.

[@michael-qp9xd]

Thanks for update here. Very interesting. You mention amyloid increase ID01 and increase in ID01 limits movement of lactate to neurons which is needed for neuron function. But then why many drugs tested over past 10 yrs that reduce amyloid by clearance dont help those with Alzheimer’s? Thanks efforts here.

[@ashleylittle4142]

It has to be more than just exercise. I still believe this is more to do with diet. Our diets in the the US are straight up killing us.

[@ronaldmccutcheon1329]

Amen, Ashley. I've been bodybuilding/personal training for 43 years. I eat high fats, low-moderate carbs ( rice), and high protein. Lots of dessicated liver. I tell my clients that they're eating poison. I have virtually stopped eating in restaurants.

[@liverleef]

Another great video! I'll add that recent studies in mice have shown that the brain doesn't really clear any more toxins at sleep than awake.

[@drlorishemek]

Great info Nick! 🎉

[@nicknorwitzPhD]

Thank you Lori :)

[@Phoenixpapagei]

Thank you Nick! thatś amazing !

[@nicknorwitzPhD]

My pleasure!

[@Rohitsoni-db9wo]

I have read many books, I listened to many KZbin videos by many of the world's leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.

[@neemabisht5132]

she talking about some things that nobody thought me

[@sandipsandipparmar3798]

great book for everyone searching just found it on her website just search for the hidden herbs

[@gulabbagale7931]

truly a great book

[@shanusharma-il1vi]

read it a few days ago, truly a great book

[@ankurking1936]

heard about it before, thanks for sharing!

[@richardbyrum4618]

You are amazing!

[@nicknorwitzPhD]

🤓thank you🙏🏻

[@Keithzzzzt]

Brilliant info.

[@nicknorwitzPhD]

Cheers 🥂

[@maranscandy9350]

How concerning is it that EPA and DHA experience noticeable oxidation at 122F which increases further at higher temperatures? Would deep frozen sashimi be a better choice? What are your thoughts? Interestingly, a 4 oz serving of grass-fed beef contains about 23 mgs of DHA and egg yolk from pasture-raised chickens contains about 120 mg of DHA and 23 mg of EPA per large egg.

[@rnancyp7986]

wowwww! thanks Nick

[@nicknorwitzPhD]

you're very welcome

[@trentriver]

In the words of Mr. Spock - FASCINATING!

[@nicknorwitzPhD]

In the words of the Dothraki, "It is known,"

[@CatherineHurley-wk8ef]

@@nicknorwitzPhD (In the words of an avid viewer, could you set up the 'Vulcan Mind Meld' on your channel so we can instantly absorb the information without having to backspace? Thank you 😉)

[@TheClo-d8o]

Keep doing what youre doing

[@nicknorwitzPhD]

I will!

[@toni4729]

As the brain is 60% fat and 20% cholesterol I'm inclined to eat plenty of all animal and fish fats I can.

[@nicknorwitzPhD]

“You are what you eat” isn’t really a thing…

[@bertcollard6619]

Good video

[@nicknorwitzPhD]

Cheers

[@shelleyhodgkinson1341]

Excellent explanation

[@nicknorwitzPhD]

Thanks Shelly

[@davidzaharik5408]

Excellent video and well explained. So it is a bit more complex than Type 3 diabetes?

[@nicknorwitzPhD]

Yes, certainly. That’s a term I once used but now avoid.

[@Dr_Boult]

Nice review. A bit surprising that neither the paper nor you talked about how ketones can provide energy, which might help pick up the slack from lactate. You implicitly get tit for those with Apoe4 but its true in general.

[@Zeon7510]

I recall that exercise makes muscles absorb kynurenine and avoid it being made into quinolinic acid that is an NMDA agonist and neurotoxic.

[@fadiyt8816]

Thanks, I liked and shared.

[@nicknorwitzPhD]

Thanks for sharing!

[@L.J.01]

If brain astrocytes turn glucose, through glycolysis and fermentation, into lactate which then supplies energy to the brain's neurons, does eating lactate/lactic acid fermented foods increase energy to the brain? Does this have any effect on dementia? Studies seem to be limited but is there any anecdotal evidence of this?

[@truthseeker9701]

Nick… I consume your content to supplement my saturated fat intake 👍

[@nicknorwitzPhD]

You butter believe it

[@karenbuchert3377]

Nick’s videos are like yummy butter!! I agree!!

[@dunichtich100]

One can also use strobe light therapy to increase glial cell activity.

[@mailill]

Is there any connection between this and the other video that suggested that metabolic syndrome can be cured by increasing GLP-1-levels? Or is Alzheimer's a different form of metabolic disease?

[@nancysmith-baker1813]

Thankyou , i struggle with dleep will try more fatty fish .

[@brauliobo]

B12 and MCTs are also very effective and reverse alzheimer

[@nicknorwitzPhD]

What makes you say this?

[@brauliobo]

​@@nicknorwitzPhDon B12 many doctors reports showing low levels on people with dementia

[@KetoMama777]

Thank you Nick im ketovore and carnivore and I feel better lost 90 pounds and now I love eating sardines with a spoonful of olive oil

[@nicknorwitzPhD]

Fantastic!

[@DawnSmith-nn2fp]

Please tell me what you add in to meat butter eggs coconut oil

[@mike_oe]

"enjoy the ride", yes I'll subscribe to that one for sure. And btw, I exercise and eat sardines almost every day 😉

[@shinn-tyanwu4155]

Thanks thanks 😊😊

[@nicknorwitzPhD]

Welcome 😊

[@russellgallman7566]

Very interesting.

[@nicknorwitzPhD]

Glad you think so!

[@TyphoonPilot1]

Is it deep sleep or REM sleep that is needed to clear the brain? I notice as I age I get less deep sleep and does that impact the metabolic cleaning required.

[@nicknorwitzPhD]

Truthfully, you need both.

[@SeanLoBiondo]

I'm in on the fatty fish. Mackerel are one my favorites ever.

[@nicknorwitzPhD]

Let’s go!

[@arubaga]

Can neurons use ketone for energy, say from MCT oil?

[@KathleenMottinger]

Could this cancer drug help with protracted benzo withdrawal?

[@arckocsog253]

1. Exercise 4:50 2. Sleeep 3. Long chain omega 3 fatty acids 4. Enjoy life

[@jimw6801]

"Uncreatively named PF068" you crack me up

[@nicknorwitzPhD]

It's true...

[@jimw6801]

@@nicknorwitzPhD I agree completely

[@lloydhlavac6807]

Great info, as always, Nick. Keep up the good work! As for potentially repurposing that cancer drug to treat Alzheimer's, I see some pharma company making even MORE money. But at least there is hope. Out of your list of things to do to help prevent it in the first place, my major issue is not enough sleep, generally 5 or 6 hours a night, which I've been aware of for a very long time, but nearly impossible for me to rectify given the way things are in my life.

[@nicknorwitzPhD]

I get that... trust me... MD PhD life wasn't the best for my sleep habits all the time... but at the end of the day we all have to structure our priorities... and it's often impossible to get everything right.

[@Tanya-lp6rq]

What is the carb cut off point for those that enjoy fruit and veggies?

[@darkhorseman8263]

IDOL1 activity is regulated by the Aryl Hydrocarbon receptor, which becomes dysfunctional when exposed to dioxins or benzopyrenes. Plays a significant role in NAD metabolic disorder with age. At least the tryptophan to NAD metabolic pathway.

[@davidmiller6010]

And keep your eye out for Cassava Sciences (SAVA) who are using a folded protein to get good to remarkable results. They have one P3 study just ended now and another P3 study concluding in March 25.

[@0861USMC]

I wonder if patients with dementia/alzheimers have a higher hsCRP? The inflammation marker show higher inflammation of the brain.

[@nicknorwitzPhD]

"ultivariable-adjusted ORs for all-cause dementia and for AD prevalence increased significantly with increasing serum hs-CRP levels" www.nature.com/articles/s41598-024-57922-1

[@ItsJustElectric]

How about stopping uterine polyps from forming? How to cure that with a metabolic diet?

[@Tammar_Tammy]

Thank you 💜

[@nicknorwitzPhD]

You’re welcome ☺️

[@OGFC]

?… when we lift weights and produce lactic acids does that help the astrocytes?

[@FutureLaugh]

without access to these cancer drugs, is there a way to naturally inhibit IDO1?

[@WMeier-kd8hz]

Bone broth containes no sugar but instead Tryptophan . How about eating an ancestral food ?

[@sethyanow3535]

Nick, What is the name of the drug that effects IDO1? Thank you for your work.

[@CairnsLobster]

Tryptophan seens valuable in general, need it for seratonin too. So these omega 3, choices etc like fish will ensure adequate amounts of available tryptophan? Andre

[@claudiawilkinson8769]

I follow Dale Bredesen’s work and eat a low carb, paleo with dairy, ketogenic diet for this reason. I’ve eaten the same way now for 8 yrs - can you explain why my fasting glucose is usually 6mmolL going up to 7 after an hour dog walk or exercise class. It only gets down to 5 just prior to supper ( I eat IF 18/6 omitting breakfast & am LMHR - but only just) then goes up to 7 then back down to 5-6 by 3 hrs later. I can get it lower with fasting - 36hrs & glucose is 4.5 & ketones approx 1.2. A 72hr fast got glucose in 3.5-4.5 range and ketones 3-4. A fasting insulin taken 5 yrs ago was 2! Surely having these high levels of glucose sloshing around is not good for me, won’t I be glycating everything and causing inflammation? Why is this happening ? Is it physiological insulin resistance? Is it because I’m overweight - BMI 26-27, but why? Is it too much progesterone on HRT? Is it too much protein? Thanks!

[@waldenmathews8059]

What many will take away is "ask your doctor about cancer meds to prevent dementia." You mention low carb and keto as limp afterthoughts. Why all the emphasis on the glucose energy pathway? A brain with sufficient ketones would never fall prey to the enzymatic disorder you are making the star of the show. What is the connection to insulin resistance?

[@blackswan2010]

After watching the video, a crutial question come to my mind; Is metformin cause Alzheime Disease because of lactate. Some researches say metformin lowers AD. What is your final opinion? Thank you.

[@lawrenceleske3470]

What is the advantage of lactate over ATP for brain energy?

[@nicknorwitzPhD]

Lactate is used to make ATP

[@norsegaud]

My dad and I are ApoE 3/4. He responds really well to Keto and I've been lowish carb/limited sugar for many many years. My grandfather ate a traditional diet (kind of a crappy one too) and died of Alzheimers complications. Question: would someone like me in my early 30s benefit from low-dosing this cancer drug, or is it too soon and dangerous?

[@nicknorwitzPhD]

I would say "too soon" ... also you'll never be able to get you hands on it. Some people think there's something to micro-dosing lithium... it's a GSK3beta inhibitor, which phosphorylates tau... and there's an inverse association between trace lithium in drinking water and AD across geographic regions

[@joeberrouard3743]

Maybe you should try low dosing a keto diet!

[@economistfromhell4877]

Yep follow your dads diet now and forget the drugs - and Nicks advice! Earlier the better!

[@Marc_de_Car]

Thank you

[@nicknorwitzPhD]

You're welcome

[@DJake78]

So would eating turkey (not cold cuts) be beneficial seeing it releases tryptophan? Plus isn’t potent curcumin shown to help break up amyloid plaque?

[@toni4729]

Well, I'm not sure how you can exercise your brain with exercise but if you say so. It doesn't have muscles. But I'm inclined to agree with all else you've said.

[@jcm4923]

I guess 'exercise your brain' means doing word puzzles, reading mystery novels, trying to name the 50 states on a map, laughing along with comedy videos, organize your photo albums, etc....painless ways to use your mind.

[@edl653]

What do the "epsilon-# mean" on the graph show at 5:38? Cheers

[@nicknorwitzPhD]

You mean 5:55? That's just remarking on the combination of ApoE alleles, epsilon-34 would be one copt of ApoE3 and one cope of ApoE4.

[@cleob9956]

Subscribed

[@nicknorwitzPhD]

Welcome and thank you 🙏🏻

[@this-abledtheextravertedhe5299]

Look up Boyd E Haley PhD. He showed how to mimic it by Hg.

[@plinble]

1:12 fermentation in the brain !! No need to drink?

[@SchmittsPeter]

"Enjoy life" is a bit like "get into a caloric deficit" 😂.

[@nicknorwitzPhD]

Is it though?

[@Ge1Ri4]

Life is what happens to us when we're making other plans...

[@elloohno1349]

how so? :D

[@SchmittsPeter]

@@elloohno1349 Question is not if you should enjoy your life or not. Rather, how to live an enjoyable life.

[@elloohno1349]

@@SchmittsPeter aaaah that makes sense :)