Metallothionein Explained & How To Raise Low Levels

[@felix-harder]

[FREE GUIDE] The Vitamins That Cured My Chronic Fatigue: www.felixharder.net/vitaminlist Chronic Fatigue Recovery Program & Practitioner List: www.felixharder.net/program - Related Videos - Copper Zinc Ratio: kzbin.info/www/bejne/ZpnHq42Gr71jqtU - Timestamps - 00:00 Introduction 00:34 What Is Metallothionein 01:45 Why Is Metallothionein Important For Health 03:10 Metallothionein's Role In Illness 05:08 How To Test Metallothionein 06:00 How To Increase Metallothionein

[@keylanoslokj1806]

Does activated charcoal help?

[@inittiela4934]

Finally someone talking about real way of chelating metals out from the body instead of taking outside chelators or saying that vegetables will do that work. Biggest problem in health community is that they have no idea how different pathway works in body and they are magic like thinking

[@hcx1853]

Zinc, cysteine, selenium, curcumin/turmeric, vitamin c, vitamin e, glutathione

[@inittiela4934]

Curcumin is bad idea especially for men because it lowers testosterone and gluthatione is also not good idea because you may disturb oxidant to antioxdiant balance, cysteine is much safer because it will boost metallothionein and gluthatione if you add glycine(collagen) to that

[@hcx1853]

@@inittiela4934 Would a precursor to glutathione be safer for pro/anti-oxidant balance. - e.g. niacinamide?

[@eeaotly]

​@@inittiela4934 Asian men eat a lot of turmeric combined with black pepper.

[@inittiela4934]

​@@eeaotly they may, I don't deny it but it still lowers DHT testosterone and thats fact because it targets those enzymes. Some people may use it for their adventage for example post menopausal women may benefit a lot from it

[@vanessac1965]

​@@eeaotlyDifference between taking teaspoons of turmeric and a small amount in a serving of curry

[@j.sch.8266]

Very timely video. A few days ago, I asked ChatGPT if the body has some sort of natural defense mechanism against heavy metals. And yeah..basically what you said. Glutamine, Glycine, Cysteine, Zinc, Selenium.

[@laurab3706]

Great video!

[@LifeIsThePrayer]

Very informative! Thank you! I had never heard of this before.

[@minimal9001]

Shellfish is a great source of selenium, as are organ meats.

[@musaire]

I'd recommend some cruciferous vegetables, onions and garlic and legumes for cysteine. Enough cysteine from those sources! :) Excess of sulfur-containing amino acids is not healthy for many reasons; starting from contributing towards metabolic acidity and so towards saturating salts into crystals and stones in kidneys and elsewhere, using up glutamine from muscle (to buffer acidity at the kidney site with ammonia from glutamine). Animal protein with excess methionine (more sulfur) would have more risks in this. All that comes along with acidosis (higher cortisol triggered by kidneys etc). Secondly, excess of sulfur-containing amino acids inhibit the synthesis of healthy levels of H2S in our tissues. As H2S is one of the major signaling molecules, it affects our health a lot. We don't don't want the excess of H2S in our intestines (usually we get it via high-fat diet induced taurine heavy bile) but we want a healthy levels in our tissues. Levels in tissues and the gut don't correlate :) So we need cysteine but let's keep it in balance. In western world, usually there is excess, I think, personally. Let me quote from doi: 10.1016/j.ebiom.2019.04.005 (The impact of dietary protein intake on longevity and metabolic health): "H2S can readily diffuse through tissues and has pleiotropic and beneficial effects at the cellular, tissue and organismal levels with the potential to contribute to stress resistance by exerting positive effects, including anti-oxidative/anti-inflammatory effects [53]. The restriction of dietary sulfur-containing AAs (SAAs), including methionine, leads to stress resistance and longevity by increasing TSP-mediated H2S production (Fig. 3). Hine et al. demonstrated that 50% of the DR-induced liver protective effects against ischaemic reperfusion injury are abolished by the addition of SAAs, including methionine and cysteine, through the suppression of DR-induced H2S production [54]. Additionally, adult mice subjected to long-term MetR for 4 months in addition to fasting every other day or 20-30%DR for 6 weeks exhibited increased H2S production capacity in liver and kidney extracts compared to control mice fed a complete diet ad libitum (AL) [54]. Moreover, in fruit flies, maximal H2S production capacity was observed in whole-body extracts of flies subjected to varying levels of DR and MetR [54], which are correlated with the maximal lifespan extension [55]. In C. elegans and S. cerevisiae, lifespan extension or chronological lifespan extension was observed in a H2S production-dependent manner [54]. The effect of DR on longevity is mediated through SAA restriction, leading to increased endogenous H2S production via increased TSP activity, while the addition of specific SAAs and mTORC1 activation inhibits TSP and the H2S production pathway."

[@eion-stephenson]

Is mRNA safe and effective?

[@musaire]

@@eion-stephenson lol a random question. I could ask back a random one hmm 🤔🤔 what about what digital audio workstation to use, you think Reaper is the most flexible (I think it is)? Anyway, the question about mRNA needs to be expanded. Our cells every day in every one of us, yes, produce mRNA that is transcribed from DNA - to deliver info ribosomes as to what proteins to code, and also to other cells at times, as part of exosomes. So, indeed, it is effective and a natural way of how it happens. :) I don't like the idea of exogenous mRNA, synthetically delivered to our cells to trigger immune reactions as, for most antigens, that would not be a natural way for our immune system to come into contact with in that way - for example in case of antigens from cold viruses, that would leave out the initial contact at the mucous tissues of our bodies where different, native immune system, cells react to these antigens and so train this branch of immune system at first - important step in developing natural killer cell behaviour for example. And much more could be said about it obviously. It's what comes to mind first. Maybe could be usable in a very specific type of situations, in future, only. For substituting some protein translation in rare genetical diseases for example, and it's also theoretical at this point only.

[@eion-stephenson]

@@musaire :) I am with you all the way. 100% Absolute Fact. Reaper... I will take a look. Thank you

[@donkeyking475]

Raise your hand if you only knew of selenium because of William Shatner advertising that cereal.

[@SoilworkWT]

If you eat enough meats, which you suggested for cysteine and zinc, you can scrap vit C, since meat have its own (dhaa) which does this job just better

[@musaire]

For "enough meats", please see my fresh comments somewhere above. We wouldn't wanna overdo it. Very little meat is needed in actuality ;) That's because the excess of certain proteins shut down some other antioxidant systems in our body. So metallothionein is of little help. We need a balance. And for balance, negligible amounts of meats are needed, on average. Also, paradoxically, meats as the fat-containing living structures, collect the most heavy metals and other toxins that the metallothionein is supposed to take care of otherwise. So, the overall effect, in reality, is the opposite. Meats have 10 to 100x the levels of heavy metals and toxins compared to other food items providing the same macro nutrients.

[@franciscosifuentes3007]

@@musairehey you know a lot I wish I can talk to you 🙏✌️❤️

[@SoilworkWT]

@@musaire Please show me data for those, i would love to see it, because it just sounds wrong with all the information ive read in past few years

[@LifeIsThePrayer]

@@musairethank you for sharing that. I think it’s a valid concern that not enough people are talking about. As I understand it our own bodies tend to store away toxic metals say in organs, especially the liver and bone, also fat but less in muscle. Can only assume other creatures do the same as to minimize the damaged caused by free floating toxins. Seems like a crap shoot trying to minimize exposure to anti nutrients, excess sugars and starches, herbicides, pesticides and heavy metals all while trying to heal.

[@musaire]

@@LifeIsThePrayer I'm not aware of any so-called antinutrient that actually act as anti to our nutritional requirements. Phytic acid, oxalic acid, lectins - all of these are regilators of nutrient absorption, transport, chelation. Absolutely required for proper regulation. As oxalic and phytic acids carry the minerals to oh so important colon bacteria our health depends on and that we could't survive without - these bacteria turn bad if not getting correct natural mineral complexes with these acids and in fibers. All this regulate the absorption for our body as well. as quick minerals spikes are not healthy for our body and kidneys push these out. Lectins regulate the sugar absorption but not in gut - these also bind to sugar moieties on cancer cells and serve as anti-cancer substances. And more to it. Generally its hard to over-eat these. But when the gut is compromised, there could be temporary inability to metabolize everything correctly. Genetic problems are a rare thing. But not that rare if we count the gut bacterial gene pool in - after all, that's even bigger part of our cells - we are a multiorganism. It's best to have 20-30 types of plants per week to preserve the diversity in the gut - different bacteria specialize in different types of fiber, so variety of plants are the most optimal. Not even much required from each - even herbs and spices and coffee fibers count as a type of fiber, each. We can't add much with sensitivity to something. Desensitization/deleting immune memory required first.

[@xanxus8272]

7:28 Correction: Brazil nuts are not a good source of selenium because, depending on the origin of the nuts, an overdose of selenium can easily occur.

[@adim00lah]

That's why you only eat 1 my guy.

[@LifeIsThePrayer]

@@adim00lahYes this! While it’s important to know how easily you can overdose it’s also just as easy to prevent that. Buy a small amount and eat only one a day. I find they can go rancid more easily but that may have just been my experience. So I buy small amounts.

[@jordanesquetyson8223]

So eating organic beef liver would be healthy?

[@musaire]

No. Certainly not in big amounts. Meat products contain 10 to 100x the toxins and heavy metals that the alternatives would contain. So the net effect is certainly not beneficial in most cases in case used in excess or even too often. Cruciferous veggies, instead, are known to be most helpful in contributing to detoxification pathways. I'd add these. And dandelion, and, yes indeed some Brazil nuts at times, as the video author says, these are a nice idea. Along with some other healthy nuts and seeds. Zinc from pumpkin seeds etc.

[@ainahaga]

@@musaireI sleep much better when I eat organic chicken than if I eat plantbased foods during the day.

[@LifeIsThePrayer]

@@musaire I’m certainly not going to argue with you about the meats because I think you’re right. At the same time plant foods come with their own levels of natural anti nutrients and “organic” doesn’t necessarily mean grown or raised without chemicals. It just means there are some chemicals that cannot be used on organic foods. Regarding the liver question I would recommend calf liver or chicken livers as they have less time to accumulate toxins. Organic if possible.

[@musaire]

@@LifeIsThePrayer that's the point of "anti" - nutrients - to act as regulators. Antinutrient is quite a silly term someone has conjured up :D. In fact, that's the point of phytic acid and oxalic acid, for example, to carry the minerals to colon bacteria and keep them slow releasing - if you quick-release these, we don't get proper blood levels - for example, even with magnesium - if you get your magnesium from refined sources or tablets, or even worse, from liquids, the levels of Mg will rise quick in serum and our kidneys are actually regulating and reacting to it and removing quickly the excess to set the levels right in blood - this could finally lead to even lower Mg levels in the body compared to when not administering Mg at all, as balancing systems can over-act to high Mg spikes in blood. Not even talk about the micro elements and minerals that the colon bacteria require to grow their correct strains - we get bad bacteria growing when not delivering minerals with fiber and phytic/oxalic etc acids to colon - so its not only about fibers, its also another components of food matrix that create important complexes to regulate the absorption etc. The same way lectins - lectins bind to simple carbs in the digestive tract and make them inhibit quick glucose spikes in blood - thats why legumes are good for diabetes prevention. The same way, lectins in our tissues bind to, for example, sugar molecules on abnormal cells and cause trouble to them - that's why lectins act as anti-carcinogens. Huge lectin levels would obviously cause troubles for our intestines as well, but we don't get huge levels in normal foods. I like liver though. But I don't eat it keeping the nutrition in mind. So I eat it couple of times a year only. We just have the tradition here to make liver pâté for Christmas time etc. or some birthdays. :) My family ate more meat and liver etc in the past. But then some of us got kidney stones (metabolic acidification - salt saturating to crystals at certan acidity at metabolic junctions, as sulfuric acids from sulfur-containing amino acids, rich in meat, cause extra acidity, unless well buffered with Mg, K-rich plants), two got gallstones (saturated fat + other factors), and heart failure (lack of natural B9, phytonutrients, fiber)