Methotrexate in Dermatology - Drug, Mechanism of Action, Use, Side-effects

[@fathisoobe7745]

Thank you very much sir, i hope you will also add dermatology diseases which let us to gain more of your experience. Very fruitful ved i have ever seen in KZbin. Thanks doctor

[@sabhderma]

Thanks for watching. Yes, I will be adding videos on clinical dermatology, and pathogenesis of various disorders in due time. 😊

[@amygdala551]

Amazing lecture sir. Will share with my friends also, This channel needs more viewers❤❤❤

[@sabhderma]

Thanks a ton. Please share the link to the channel among your friends. We will be continuing videos every week, covering important and esoteric topics in dermatology in an easy manner. Till then keep watching and sharing videos 😀😀

[@shreyaskololgi1907]

Amazing lecture sir.. thank you soo much

[@sabhderma]

Most welcome 🤗🤗

[@shubhamchopra1099]

Wonderfully Explained sir 🙏🙌🏻

[@sabhderma]

Thank you ☺️

[@vikaspurushottam8542]

Thank you sir please complete leprosy series as soon as posible

[@sabhderma]

Surely, we will discuss leprosy in a stage wise and detailed manner. It is a very important aspect of dermatology and is filled with concepts that are improving to understand. ☺️☺️☺️

[@tushar2919]

Thank you sir

[@sabhderma]

So nice of you to reply 😊😊

[@gryffindor5345]

Thankyou sir very useful 😊

[@sabhderma]

Welcome 👍😊

[@khushbujadav4869]

Thank you so much sir🙂

[@sabhderma]

You are welcome 🤗

[@دكتورهايفيتسوريال]

would you make a video about treatment of psoriasis in children please?

[@sabhderma]

Thank you for commenting ☺️. There is a video where we discuss the use of biological therapy in psoriasis. We learn about British and American guidelines. It's there on the channel, you may want to see that. Let me know if that helps. 😊😊

[@SadikshaAdhikari-x6n]

Sir..I would be grateful if you could upload basic dermalogy videos…

[@sabhderma]

Sure I will. 😊 We are currently doing a series on STI topics. Do watch those videos in the meantime. What all topics do you have in mind from basic Dermatology?

[@SadikshaAdhikari-x6n]

@@sabhdermaThanks for your response..I am 1st year pg resident of Dermatology from Nepal..I am trying to make my concept clear on topic Cytokines…so it would be real help for me sir..

[@amygdala551]

​@@sabhdermaanatomy of nail and hair is difficult sir. Tried to read from rooks, bolognia and Fitzpatrick but still not able to recollect, land up with a lot of difficult

[@BasmaBasheer-p4x]

Sir please do a video on jak stat inhibitors

[@sabhderma]

Sure, I have added it to the suggestion list. Will make one on this topic. ☺️

[@drarshadiqbal4220]

Is it true that 10 percent of methotrexate converts to the polyglutamate form? Is this not the case for 100 percent?

[@sabhderma]

That's a very good question. I have found varying %s of glutamate conversion. I am listing 1 reference below that mentions 52%. Just remember that polyglutamate residues do not leave the cell, but has the activity of MTX. You can read the below article. Kuehl M, Brixner DI, Broom AD, Avery TL, Blakley RL. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice. Cancer Res. 1988 Mar 15;48(6):1481-8. PMID: 2449950.

[@aye_puniya]

Thank you sir :)

[@sabhderma]

Keep watching other videos too 😄