Systemic Corticosteroids (Part I) in Dermatology - Drug, Mechanism of Action, Use, Monitoring

[@Skin_MD]

Sir you are gem🎉

[@sabhderma]

Thank you so much for your appreciation. Your comment made my day 😄😄 keep watching and sharing other videos. Thanks for commenting 🙂🙂

[@faiqabathool5355]

Thank you sir for the valuable knowledge you share … really helpful

[@sabhderma]

So nice to hear that ☺️ I hope you found this video helpful. Do consider becoming a member of the channel if you like these videos. Many more to come 😊😊

[@arunareddygunreddy3811]

Thanks

[@sabhderma]

Welcome 😁 thank you for your time 😊

[@cutekannu8685]

Thanks sir kindly cover other topic as well

[@sabhderma]

Sure 👍we will certainly. Please keep watching and giving valuable suggestions. 😊😊

[@anandstanley09]

Thank you so much for excellent class sir .

[@sabhderma]

You are most welcome. Hope it was helpful 😀

[@aye_puniya]

Thank you sir 🌸

[@sabhderma]

You are most welcome!! 😊😊

[@tushar2919]

Thank you so much sir

[@sabhderma]

Most welcome 😁

[@prajaktawaghmare4454]

Sir can you please explain why we avoid giving systemic steroids in psoriasis , what’s the Patho mechanism . Didn’t find the satisfactory answer anywhere.

[@sabhderma]

Hello, sorry for replying late as I was busy. Systemic steroids are not recommended since they are known to cause disease exacerbation when the doses are reduced or altered. Additionally, these issues may happen. Systemic steroids are not recommended for treating psoriasis because of the risk of disease deterioration after dose reduction or withdrawal. Risk of flares: Systemic steroids can cause disease flares, especially after dose reduction or withdrawal. Pustular flares: Systemic steroids can cause pustular flares of the disease. Lack of literature: There is a lack of literature addressing adverse effects of systemic steroids in psoriasis, such as rebound, pustular, or erythrodermic flares. Systemic steroids are synthetic derivatives of the natural steroid, cortisol, produced by the adrenal glands. They have profound anti-inflammatory effects. As steroids suppress all arms of inflammatory cascade, a decrease in doses can further destabilize the disease.

[@sabhderma]

You may read this article Psoriasis flares and rebound phenomenon following exposure and withdrawal of systemic steroids: A systematic review and meta-analysis Long, Valencia et al. Journal of the American Academy of Dermatology, Volume 87, Issue 3, 660 - 661 Doi 10.1016/j.jaad.2022.01.006

[@sabhderma]

Let me know if this helps. Thank you for your query 😊 keep watching other videos

[@drjaleena9918]

Does prednisolone has more immunosuppressant action and dexa has more anti inflammatory action?

[@sabhderma]

Thank you for asking your question. It depends on what article you are referring to. The anti-inflammatory potency of dexa is nearly 5 times of methyl pred. That's what the pharma textbooks mention. Regarding immunosuppressive effect, it has been found to be similar on a dose to dose comparison. A good choice would be to keep the side effects and physiological action like t1/2 in mind while prescribing, rather than how much immunosuppressive a drug is. We may discuss in person if the need be in some conference or anywhere. But I could not find a good reference for the statement. Will share with you and others if I find something. Thank you again for your comment. ☺️☺️

[@mubssk3537]

Sir please make a video on tapering of systemic corticosteroids in various acute and chronic diseases

[@sabhderma]

There is no clear cut guidelines on how and when to taper steroids. It depends on a lot of factors like the disease activity, dose and duration of steroids, side effects, adjuvants used etc. will surely cover the basic concepts behind it in a separate video. 👍👍😊