Mitochondrial Energetics and Insulin Resistance of Aging

[@martinirving3824]

Interesting, Goodpaster comes to the same conclusion as Frank Shallenberger did a long time ago. The real factor is the loss of fatty acid metabolism and increasing reliance on glucose (which requires less oxygen to convert that fuel to ATP) as the hallmark of aging, and accelerated aging in younger subjects. To be a fat burning machine you need mitochondria that happily burn fat in high oxygen states. That probably means eating less glucose-promoting foods and more healthy fats along the way.

[@charlespackwood]

Amazing information. EVERYBODY needs to know this! Thank you, for putting this on KZbin.

[@rliao]

The older, shriveled-up mitochondria illustration cracks me up

[@petercyr3508]

I would bet 90% plus of people newly diagnosed with type 2 diabetes have tons of insulin in circulation if the doctors would just measure it. BG goes out of control when the insulin resistant liver produces and releases way too much glucose and then the patient piles on with all the crap they eat. Since 2018 the ADA guidelines have a lukewarm but actionable acknowledgement that a low carb diet is treatment for T2D as part of a patient centered approach. I have been successfully controlling my BG since 1998 this way since diagnosed at age 40.

[@thehealthychefri]

Lift weights, the more muscle you have the more insulin sensitive and fat adapted you will be!

[@250txc]

Mr Goodpaster lays his findings pretty well I'd say .. ESP the part on 'just do something' as your exercise routine ... Do whatever to accelerate your heart rate and stay with it over yrs ...It really is this simple for most of us ...

[@OGMann]

I lived on Galveston in the early 90s. My family had a restaurant in a hotel next to Sealy/UTMB. We had a lot of the burn victims and their families stop in.

[@osamaafif]

Following to what the speaker says around 8:00 to 8:30 What I understand is Insulin works with Glut4 (one out of 14 glucose receptors) to bring glucose into cells for (only) storage. A cell can take glucose for energy anytime if needed. Is this correct?

[@wmp3346]

Get up and move people, how is older defined? Last slide was very blurry, but I liked the concept

[@lauracerva9716]

This was awesome. Thank yoi

[@jamesgordon8867]

I hope you look into photobiomodulation and mitochondrial health.

[@voidisyinyangvoidisyinyang885]

meditation takes the 2/3rds of the brain power biophotons that normally go out of the eyes - turn them back around to create a 17 watt holographic laser for quantum nonlocal healing via de Broglie's Law of Phase Harmony.

[@elenabenjamin9980]

Thank you for such as amazing work!

[@health-seeking]

Great research . Thank you!

[@rossentownsend4936]

Maybe metformin kept exercising folks effects low. It inhibits Strength training.

[@wmp3346]

Poor diet leads to insulin resistance and time restricted eating plus exercise help maintain your mitochondrial health - my experience and opinion

[@netto682]

👏👏👏🇧🇷muito bom trabalho

[@voidisyinyangvoidisyinyang885]

dang "centers on aging" gotta be raking in the funding considering the demographics.

[@Ron-rk6iz]

I think the entire uncertainty about health studies, lies in the fact that we do not understand our Microbiome completely due to its complexity. One person is fat and eats the same as a slim person, the answer is to be found in the Microbiome...

[@voidisyinyangvoidisyinyang885]

tape worms

[@LTPottenger]

Sounds like muscle tissue actually turning into fat cells with disuse.

[@grmalinda6251]

My daughter runs marathons but is overweight and pre T2D. She also runs daily and uses weights. ???

[@voidisyinyangvoidisyinyang885]

exercise doesn't lose weight. Fasting does.

[@medicalpanorama]

Point proved.

[@mhayato3]

5:11

[@xelazip]

Lecture starts at 53:54

[@clementmariostlouis6686]

Further degrade glucose to triose and see if mitochondria like it , that diabetes disappears . let me know .

[@elenabenjamin9980]

I mean subcutaneous fat in the glúteos

[@elenabenjamin9980]

The point is how can located fat in my glúteos? Oh please is there some tricks?

[@bnmsa]

Yh cool but who has low abdominal fat and high thigh fat?? 🤷 exactly not much people especially men