Mitochondrial Medicine in the Pandemic Era by Douglas C Wallace

Distinguished Lecture on “Mitochondrial Medicine in the Pandemic Era” by Dr. Douglas C. Wallace, Ph.D., Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Disease Director, Center for Mitochondrial and Epigenomic Medicine (CMEM) Children’s Hospital of Philadelphia Professor, Department of Pathology and Laboratory Medicine University of Pennsylvania

[@kenneth1767]

To those complainers I would suggest the simple act of going to 12:30 for Doug Wallace's talk. Let's be thankful that we have this information available for free.

[@arle888abc]

great lecture by Dr. Douglas Wallace. Cheers!

[@samieramohamed2467]

What a great topic and what great mind ? Thank you, very grateful. God blessings.

[@thebodyclock1]

He's the GOAT

[@johnchase2148]

From experience with my symptoms, surviving was by instinct and complex. This is the best way for medical care and thinking. I have to forgive many doctors.

[@Lukas-ye4wz]

🎯 Key Takeaways for quick navigation: 01:19 *🎓 Professor Doug Wallace, a pioneer in mitochondrial biology, has spent decades studying mitochondria, shedding light on the origins of humankind.* 08:45 *🧬 Professor Douglas Wallace is a pioneer in human mitochondrial genetics, having contributed to fundamental discoveries such as the exclusive maternal inheritance of mitochondrial DNA.* 13:43 *⚡ Mitochondria, symbiotic organisms within cells, provide 90% of the energy used by the human body.* 17:34 *💡 Traditional anatomical approaches in medicine, focused on organs and tissues, may not fully explain common diseases like diabetes and Alzheimer's. * 19:56 *🔍 Mitochondrial genetics, often overlooked, may hold the key to understanding and treating common diseases related to energy production.* 25:39 *🔄 The process of energy production in mitochondria involves complex enzymatic pathways along the mitochondrial inner membrane, crucial for maintaining cellular energy levels.* 27:29 *⚡ The membrane potential generated by mitochondria is essential for sustaining life, highlighting the critical role of mitochondrial function in human health and vitality.* 28:09 *🔬 Mitochondrial function distinguishes between life and death, crucial for understanding health.* 29:04 *⚡️ Efficiency in ATP production varies among individuals, impacting energy utilization.* 30:10 *💥 Mitochondria produce reactive oxygen radicals, which can damage cells.* 31:33 *🧪 Mitochondria regulate calcium levels, apoptosis, and respond to oxidative stress.* 32:42 *🧬 Mitochondrial DNA encodes essential proteins for energy production and regulation.* 38:32 *🌍 Mitochondrial DNA variation traces human migration patterns and adaptation to environments.* 43:48 *⏳ Accumulation of mitochondrial DNA mutations contributes to aging and disease.* 45:21 *🏥 Energy deficiency in mitochondria underlies many common diseases and conditions.* 46:00 *🧬 Various mutations in mitochondrial DNA can lead to diseases affecting different organs.* 50:58 *🐭 Mouse models with mitochondrial defects exhibit behavioral symptoms akin to neuropsychiatric disorders.* 52:47 *🦠 Mitochondrial defects can lead to Neuropsychiatric disorders due to dysregulation in immune responses.* 54:38 *🧬 Certain mitochondrial haplogroups increase the risk of autism in populations, especially in males, indicating a strong association between mitochondrial DNA and autism.* 56:15 *🧬 The same mitochondrial mutation can lead to different clinical phenotypes depending on the percentage of mutation, genetic background, and somatic mutations.* 59:27 *🧬 Mitochondrial genotype quantitatively influences nuclear gene expression and the epigenome, affecting phenotype manifestation.* 01:02:41 *🦠 SARS-CoV-2 inhibits mitochondrial function, promotes glycolysis to support viral replication, and induces host compensatory mechanisms.* 01:07:10 *🧬 SARS-CoV-2 infection impacts oxidative phosphorylation gene expression differently across organs, with significant effects in the heart, liver, and kidney leading to organ failure.* 01:16:50 *🧠 Brain fog in Long COVID may be linked to mitochondrial dysfunction in the brain.* 01:17:43 *🦠 Virus infection alters mitochondrial transcription, impacting host response over time.* 01:18:50 *⚙️ Virus affects mitochondrial DNA assembly, leading to unfolded protein response and increased ROS production.* 01:19:32 *🔥 Oxidative stress from ROS leads to inflammation but also activates innate immune system against the virus.* 01:20:25 *🔄 Virus manipulates host mitochondrial and nuclear functions to promote viral replication while inhibiting host defense mechanisms.* 01:21:30 *🧬 Mitochondrial DNA mutations and haplogroups play a role in environmental adaptation and susceptibility to diseases like COVID-19.* 01:28:30 *🦠 Mitochondrial dysfunction exacerbates COVID-19 severity, particularly in individuals with pre-existing metabolic conditions.* 01:37:51 *🧬 Non-coding RNAs may play a role in modulating mitochondrial function and response to viral infections.* 01:39:22 *🧬 Experimental challenges exist in delivering RNA to mitochondria for potential therapeutic interventions.* Made with HARPA AI

[@imaginaryuniverse632]

6:38 The processes of Eve.

[@sasidharanc7632]

Dr. Douglas, how much it will affect, the communication between nucleic dna and mitrochondrial dna will affect the optimize function of the particular cell.

[@samieramohamed2467]

12.31 minutes wasted before dog Wallace started. He started immediately, no none sense.

[@samieramohamed2467]

Why wasting time by local professors on none sense empty contents . Please go direct in subject and do not repeat ask professors to address the gathering. This is a silly annoying routine outdated and not time effective.