4. Enzymes & Metabolism

[@melusimgwenya5844]

this series has reminded me how interesting biology is

[@oximas]

this seies have taught me how much I don't know about biology

[@tomato-v8x]

@@oximas well typically the more u learn about something, the more u’ll realize how much you don’t know about that field.

[@xeno_phobik]

Same, I forgot that phospholipid bilayers we're my favorite part of biology. They're just so interesting!

[@timothywheeler671]

ikr! 😁

[@rakhiar]

21:47 should be corrected to glutamic acid not carboxylic right? 18:03 I am sure functional properties of the RBCs are hugely impacted by this base pair change as well as protein interactions. Sickle cell anemia adopts a rough pushed structure compared to its normal biconcave disc structure that largely influences a spacious surface area required for oxygen binding and transportation. Wouldnt this be hindered when RBCs beta globin is mutated forming a sickle shape and adopting a structure with a much more smaller surface area. On top of that limiting oxygen binding and transportation across the body.

[@송예은-h7b]

Thank you MIT for this course! So helpful in my studies:)

[@davidhansman7190]

Is this a 1st year course? She is covering this in detail that I only got in 2nd and 3rd year. Great lecture!

[@CharteriousLiberax]

The polymer protein stand carrying the Peptide carboxylic ameno chain, carrying primary genetic sequence for autonomous Operation production is missing from your Chromosome stick recount uptake. Your body collects polymer protein stand's from each autonomous system for G_nome Dna replication. Is that correct? Is the sickling caused by Iron Oxide as a Hexide Polygon bonded molecules that are imobile for renal expulsion?

[@GadgetMuhsin5000]

Great lecture, but what she said about the choice of Enthalpy vs Entropy argument IS INCORRECT. It is a bit long to explain clearly, so I am not doing that, but please do look it up.

[@danielhu2756]

The way I understand it is: I guess if T=0, a cold environment is like a ball rolling in static potential, the only stable state is a local minimum of energy (H), the bottom of a potential well, with excess removed by friction. But otherwise equipartition wants to share excess energy with the environment (or in chemistry, the other side of the equation) in a way that depends on entropy, hence we need free energy. Basically, energy is conserved so it must go somewhere, rather than everything wanting to be at minimum energy. Systems with more entropy (e.g. more particles) are willing to accept more energy. For example in air, a molecule wants to bounce around, not be still. Of the many types which are just a Legendre transform apart, Gibbs free energy is chosen because its sign indicates reaction direction (spontaneity) under conditions of constant pressure and temperature.

[@ralph5941]

28:00

[@sderese]

Cat(cut)abolic @39, that is how I remeber 🙏 for a great lecture

[@Emmy_pathy]

Thankss

[@مريم-ف6ق1ث]

Is hemoglobin heterotetrameric or homotetrameric as the prof mentioned?

[@orger2000]

I think she misspoke, and it is heterotetrameric

[@MasonRVs]

I was under the impression that Tyrosine was Polar Uncharged? Is this a point of contention amongst biologists or was I misinformed?

[@woloabel]

(On Sunday of January 29, 23023). Introductory to Biology: 1) Enzyme (Reactive Protein) and Metabolism (The Collective Processes both Catabolic and Anabolic In A Homeostasis Context); The Ideal of Substrate to Product Always Involves a Chemical Reaction (Catalytically Driven by a Protein) usually by a DNA Molecule-Encoded Protein (Rather than a Denatured, Spontaneous or Pathological Protein [Prion]); Pharmacology has the best of time with the Identification of the Protein and Processes of a Disease (Receptor-Ligand Identification) and the best of the profits in the Pharmacologic Inhibition (Although Agonism is Another Therapeutic Venue); The best of therapeutic However employ DNA-Encoded Proteins (ie Immunoglobulins [Antibodies and Recombinant Human Antibodies) and Links these with the Actual Pharmacologic Entity (The Best of Chemotherapeutics because of High Specificity and Metabolism Thereafter Yields Less Non-Targeted Toxicity). Here too the Bonding (Non-covalent for the Links) and the 150 kDa Monoclonal Antibody (Which is the Epitome of Sensitivity and Specificity in Any Case); Enzymes and the Proteomics therein are not the same as it was 10 Years let alone 50 Years Ago; Anyway, the best to those who deserve the Optimum (Optima est Mea Imperatrix) PhD Barbara Imperiali. Heil!

[@helios5730]

does someone have the slides (PPT)? please

[@mitocw]

This course doesn't have any lecture notes but there recitation notes, readings, assignments: problem sets with solutions, and exams with solutions. See ocw.mit.edu/7-016F18 for the course materials. Best wishes on your studies!

[@zorga0001]

Anabolic steroids is how I remember the anabolic is about building (muscles) and catabolic breakdown.

[@farahali5754]

ليس مجالي علمي فانا ادبي ولكن احب اتعلم

[@jasminemasown]

Wow that's an amazing thing!

[@mohammedbleiblo3243]

what confused me is, Haemoglobin, isn't a quaternary structure protein?

[@mohammedbleiblo3243]

ok, got the answer i was lookin for

[@Thakur_Kartavya_Singh]

​@@mohammedbleiblo3243 haemoglobin is quaternary str. Protein.

[@mohammedbleiblo3243]

@@Thakur_Kartavya_Singh thanks for clearing it out.