MTHFR Mutations - Should You Be Worried? - Dr. Osborne's Zone

This week, Dr. Osborne is joined by Dr. Ben Lynch, the best-selling author of Dirty Genes and President of Seeking Health, a company that helps educate both the public and health professionals on how to overcome genetic dysfunction. He received his doctorate in naturopathic medicine from Bastyr University.
Dr. Lynch and Dr. Osborne discuss the MTHFR genetic mutation and its implications. MTHFR is a genetic mutation that some people have. It can affect how your body detoxifies and processes certain substances. If you have this mutation, you may need to be more careful about what you put in your body and avoid certain things.
Their conversation also covers the misconceptions and fears surrounding MTHFR, such as the need for lifelong folate supplementation and the use of certain medications.

Make sure to join us at 6 PM Central on Tuesday for this deep dive!
Chapters:
00:00:00 - Introduction to MTHFR and Genetic Testing
00:07:24 - Detoxification and Gene Function
00:14:53 - The Importance of Folate and MTHFR Genetic Variation
00:22:29 - The Role of MTHFR Enzyme in Health
00:29:57 - MTHFR and Homocysteine Levels
00:37:09 - The Origins of the Word "Folic Acid"
00:44:37 - Driving Carefully with MTHFR
00:51:44 - Folic Acid Enriched Corn and Methyl Folate Absorption
00:59:28 - Methyl Folate and Folic Acid: A Comparison
01:06:27 - Outro: The Dr Osborne Zone
Find Dr. Lynch's book, Dirty Genes here: www.seekinghealth.com/product...
For more information on Dr. Lynch, visit: www.seekinghealth.com/
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*These statements have not been evaluated by the Food and Drug Administration. This video is not intended to diagnose, treat, cure or prevent any disease. It is strictly intended for educational purposes only. Additionally, this information is not intended to replace the advice of your physician. Dr. Peter Osborne is one of the most sought after alternative and nutritional experts in the world. A Diplomate with the American Clinical Board of Nutrition, a graduate of Texas Chiropractic College, and a doctor of pastoral science, Dr. Osborne is one of the world’s leading authorities on gluten, nutrition, and natural health. He is the founder GlutenFreeSociety.org, one of the world's largest informational sites on gluten sensitivity. In addition, he is the author of the best selling book, No Grain No Pain, published by Touchstone (Simon & Schuster). His work has been featured by PBS, Netflix, Amazon, Fox, and many other nationally recognized outlets. For more information, visit us at www.glutenfreesociety.org/ or call 281-903-7527

[@Indy1984]

Very good interview. I had bipolar 1 and anxiety for many years. A woman running the local vitamin shop suggested taking 5-MTHF and NAC, vitamin B's, and good quality Fish Oil. My life was changed. I went on a keto diet, exercised and felt like a new person. I can't believe I wasted 30 years of my life feeling like I was losing my mind when all it took was tweaking my supplements.

[@cornypinkuni9519]

❤❤❤❤

[@mary3659]

Man I wish every health care person understood your content.

[@jac1161]

understanding is one thing, the DESIRE to understand is another, the courage for doctors to face what they never new before (and they are pride-filled, sooooo....it's a lot of humility required). I agree.

[@g.s.5868]

ignorance is bliss... medications are costly and easy prescribed...

[@hc5327]

I’ve been following and reading his book since it came out 15 yrs ago. He is a genius who understands the whole body. He explains it in layman’s terms. It’s new but it’s saving people’s lives with this knowledge.

[@pamskaggs2788]

The fact that dentists are clueless regarding this is criminal. Also, the fact that they are still huge fluoride pushers.

[@il3mendo]

I have cried. I have been labeled as a google boy while I was having: seronegative celiac disease, hypothyroidism, atherosclerosis, a neurodegenerative disease called hereditary spastic paraplegia spg4 ( with bilateral babinski, hofmann and romberg signs) chronic gastritis with gerd and gastroparesis, lymphoproliferative colitis, mthfr mutation with pernicious Anemia, vitamin b2, vitamin D, iron deficiency lipidemia, metabolic syndrome, high hemoglobulin and hematocrit, mthfr mutation, and probably with polyctemia vera ( cd 19 maturation issues connected with my seronegative celiac disease) bile acid malabsortion. Adhd, Schizoaffective disorder , neurodevelopment disorder, hyper homocysteinuria and Eoe. It pisses me off that all started in the gut ( even the neurological disease is associated with amino acid malabsortion/ gad65 toxicity). Now that I do talk with doctor I am the teacher and it s not funny at all because I realize how ignorant the majority of them are.

[@g.s.5868]

you sound a hypochondriac

[@il3mendo]

@@g.s.5868 all of these are proven by DNA, tests, biopsy, and blood test. Here It comes the issue: hypocondriac while ............. I Will be more than happy to share with you my DNA, mthfr, Blood test and biopsy....

[@il3mendo]

@@g.s.5868 if i did gave my blood, for reasearch, for my neurodegenerative disease also Spastic paraplegia is a dump reasearch. If I am treated as a refractory celiac disease with many autoimmune diseases connected you can just disappear because you are ignorant. Bye bye

[@MsSilver41]

@@g.s.5868not helpful at all

[@il3mendo]

@@g.s.5868 Unfortunately this is my situation all proven with DNA Blood test ( neurodegenerative disease) and with my duodenal biopsy ( taken 5 times within 7 years), capsule endoscopy and colonoscopy.

[@jackics6540]

I have psoriasic arthritis. My reumatologist put me on Metrotrexate, with folic acid. I told him I have MTHFR in omozigosis. He said was NOT RELEVANT and he DOUBLED my dose of syntethic Folic Acid, since I was having HEAVY side-effects from Metrotrexate. I sent his recommendation to hell and started taking folate instead, and no more side-effects basically. This was one of the primary reumatologist in Italy and managing one of our primary hospitals. The situation is HIGHLY drammatic with our doctors. Thank you Dr Lynch for all of your work.

[@kimbermountains7464]

I believe that Dr. Elizabeth Bright is there in Italy. She is world renown. She also does virtual visits for everyone, even in the US.

[@jackics6540]

@@kimbermountains7464 I'm not familiar with her honestly, would you have some references to give me please, or clinic where does she work? And which is her area of specialization?

[@Vixinaful]

Classic. Doctors want the world on chemicals because chemicals are costly, not on the actual cure which is VITAMINS! Our bodies need NUTRITION, not chemicals but that lands them out of their jobs.

[@leavethemkidsalone860]

​@BelleSlayer-io3bj so infuriating that everything they told us to do back then likely caused the issue. Doctors are STILL doing this now, even for pregnant women and the elderly. Watch what you eat. No cereal since MOST has folic acid in the "enriched" flour.

[@satka2mau487]

methotrexate is an awful drug..plenty of side effects and longterm use damages the body. My mother was put on that drug for RA. she was often nauseous. I would seek out a functional medicine practitioner/naturopathe

[@tanyawieczorek6603]

Thank you for not putting ads in!

[@RightDoc]

Methyltetrahydrafolate Reductase. It’s an enzyme. Enzymes often transition our basic amino acids from foods to other essential chemicals in body. Example: tryptophan + l-methyl folate = melatonin and serotonin. Tyrosine + l-methylfolate = norepinephrine and dopamine. With poorly functioning MTHFR, we cannot produce l-methyl folate so folks lack production of adequate amounts of those particular neuro chemicals and often have lifelong low grade depressions and idiosyncratic reactions to certain treatments. That’s from a neuropsychiatric standpoint. MTHFR is also very involved in cytochrome p450 enzyme system which affects poor, normal or rapid metabolism if about half of all medications on market. Explains individual tolerance variations of many patients. Excellent point in folate vs l-methyl folate. The excess folate in prenatal vitamins most likely plays a role in post partum depressions as it interferes with l-methyl folates ability to produce mood chemicals in the CNS. Good talk Dr lynch. Neuropsychiatrist here. Tx.

[@kday9438]

Please Dr. more on MTHFR it’s horrible….not knowing one has it for our quality of life !!!!! Thanks ❤

[@g.s.5868]

did you do at least a genetic test?

[@laurasmith1831]

Love Dr. Ben Lynch!

[@therealjenniferrr]

So timely, Dr. Lynch just answered my question I sent to his website about taking DAO with caprylic acid. lol And if you read this Dr. Lynch, yes I'm actually already taking saccharomyces boulardii for the candida overgrowth! Originally because of the cdiff from 5 rounds of antibiotics for diverticulitis last year (ofc also 3 rounds for the cdiff and 1 for a uti it caused... last year was SO MUCH FUN). Dr. Osborne ty so much for having him on your show, I can testify I feel better with my Bs from SH vs another company I tried. The ones from the other company were a plant whole foods based B complex and I was increasingly unable to sleep, to the point that eventually I was awake for 2 days straight (and I say this as someone who suffers from chronic fatigue so it was not good). I have not done a gene test yet but keep meaning to do that. It will be quite fascinating to see what it says. I love the point he came to about carnivores feeling better because they are taking the nonbioavailable vitamins out of their diet by eliminating the prepackaged foods, as it's the same as your point in regards to grains and carnivores (sometimes subtraction can be a bigger benefit than addition). This fortifies the concept that we should be eating real, whole, unprocessed foods. Thank you both for what you do, you are both a treasure to the health community. 🙏

[@MsSilver41]

You said you got your Bs from SH. What is SH???The saccharomyces boulardii you mentioned taking for candida , is that a single probiotic ? Or in a multi??

[@therealjenniferrr]

@@MsSilver41 SH is Dr. Lynch's co Seeking Health. The strain I do get as a single strain probiotic, I got it on Amazon, brand is Carlyle. I take a multi probiotic too, but it doesn't have that strain and I needed it for the cdiff I had, Dr. Lynch said to use it for candida overgrowth as well (ironically both of those were only because I took antibiotics - sometimes a necessary evil).

[@user-ub6hs4nl2g]

Amazing interview. I need to watch this twice, so much info.

[@bogipepper]

Wow , Ben came across clearer then his own videos.

[@davidmoorman731]

I have been looking for a replacement for my former MD, Dr Rea in environmental health center Dallas. So glad to find you.

[@lisadehner3094]

Dr Rea has passed but the center is there and is agood place to recieve care for environmentally related illn ess!

[@SandyBatten1962]

I have same MTHFR SNPs as Dr Lynch plus PEMT, MTR, and a few others affecting detoxification. Wide familial hx of bipolar, schizophrenia, adhd, near cleft palate,neural tube defects/spinabifida resulting in death, fatty liver etc. interestingly my dad had episodes of “break back fever” from malaria contracted in UK naval service prior to making 12 kids with my mum in NZ. My 2 pregnancies both abnormal ( preterm twins placental abruption at 26wks, nxt child couldn’t birth due to short umbilical cord). Gas made me vomit. Recently had closed reduction on wrist fracture w/o gas or meds. Rather have 30 mins pain over several weeks of feeling toxic and unable to function with brain inflammation. I used to live in Rotorua which is our Sulfur tourism destination in NZ. Was very unwell. Now postmenopausal I’m acutely aware of my need for choline with the MTHFR and PEMT combo. Great episode. I credit Ben Lynch with educating me on the importance of epigenetics. Dirty Genes is awesome and Stratagene is a top repository of genetic information

[@SB-qv3yo]

fascinating! Thank you for sharing.

[@user-ye9zw2pc5k]

Thanks both of you for the information.

[@Mo-yj3wf]

Thank you once again for this podcast 💙💫

[@stardustgoldcrochet]

Truth! It took me 13 years to get my diagnosis. And I was the one doing the leg work and just confirming it through requesting specific tests and bringing NCBI articles to my docs to back it up. But I have recordings from every visit from 2015 on because I thought I was dying

[@dianamanlove3574]

All 4 of my MTHFR genes are damaged. I get infusion every other week and has restored my ability to function well.

[@tanyawieczorek6603]

Infusion of what?

[@dianamanlove3574]

@@tanyawieczorek6603 vit C, B vitamins (methol... ones) methol folate, glutathione. Spelling not correct I'm sure. Functional Dr. Ordered for me. Getting biotin also right now. 70 yrs old. Feeling like 50 again lol. Of course insurance doesn't cover but worth it.

[@jactac838]

How are they damaged? They're genetic snps

[@kaycurrie9356]

Dr. Osborne, I really needed this. I will go back & watch again. Thank you so much for this interview. I tend to have high homocysteine. Grateful for all the hard work!

[@laelmom]

I am a doctor google, you tube, and books. My confirmation is through pray Yahuah answer my concerns. Thank you for B2 info HalleluYah

[@kellyforgotch7348]

gratitude for sharing this ❤

[@supersport22]

Great interview! So much good info

[@backinblackskin23]

Just found this channel. Great content brother ✊🏽

[@alwayslearning8365]

Thanks I ordered your guests book. It should be an interesting read.

[@reneegossage8609]

Great discussion. Thank you!

[@laurakamal8842]

Great video. Thank you so much for explaining this process. It's very helpful.

[@mariannereno-db4db]

Information is power. Thank you.

[@ChrisMac00]

Man Dr. Osborne do I got questions. I'm former pro football player. And 2009 I got diagnosed stage 3 medullary thyroid cancer. Thyroid was removed plus lymph nodes in neck n upper chest. Developed type 1 diabetes 5 Year ago, I grew up 1 mile from biggest mine fire in US, Centralia PA. Tons of sulfer in air, water supply. They built Coal generation plants all over the area. Thyroid problems run rapid in area. I had inflammation issues going back to HS, my homocysteine level is low. Choline is severe low. VitK low, Magnesium, Biotin, B12 , and I also showed several amino acid n oxidant levels that were badly low. I struggle w fatigue, constipation, brain fog in evenings. Don't sleep well. I've asked my endocrinologist at Univ of Maryland to do genetic blood work on me and get well my insurance won't pay for it?

[@btudrus]

"Choline is severe low. VitK low, Magnesium, Biotin, B12 " do you eat enough meat and eggs?

[@ChrisMac00]

@btudrus yes. I eat ribeye grass fed steak and eggs every morning . I don't use artificial sweetners, I don't follow fad diets

[@keyshi6257]

Start carnivore asap

[@ChrisMac00]

@keyshi6257 I watch these natural homeopathic Dr Shows and they constantly talk about thyroid problems but never talk about people who lost thyroid from cancer. Nobody ever talks about Medullary. What it does to the body from a cellular level. Antioxidant and Amino acid level. Organs etc. Mine got found at 36 and I went into cardiac arrest shopping for picture frames for my wife. I was saved by a ENT off duty in the store or I'd died. I got to hospital and they saw me physically w amount of swelling And my skin n eyes I had cancer of some kind. My wife got to ER said he's been complaining of fatigue n swelling for yrs. I had biopsies done for years on thyroid always w same answers .u got goiters and hypothyroidism. No I had cancer.

[@ChrisMac00]

@keyshi6257 and I eat carnivore my entire life. Keto and all that is BS. Only thing I stay away from is bread unless it's homemade and my mother bakes it herself. She can't eat gluten. I shop at organic market for 90% of my foods

[@il3mendo]

Serotonin is mainly located in the distal ileum and large intestine. In the distal ileum you also have the vitamin b12 and folate final absprtion.

[@lmwlmw4468]

Great video.

[@dannegiles8216]

Thank you!

[@rossanajoubert4881]

Thank you ❤

[@teschchr122]

Great intro Dr. Osborn!

[@horstraedel9010]

Thanks from Germoney!🇩🇪❤

[@commoveo1]

Thank you for the time you have so freely given. Taken a daily vitamin with a healthy breakfast all my life. Sincerely Grateful, Howard

[@JMSsssssss]

Fantastic interview. I just found Ben's book on my bookshelf, I forgot I had it! I bought it a few years ago and hardly looked at it - maybe because I didn't know enough to process the info. Since then I have had genetic testing done and I know I have a dirty MTHFR. I just took the book out and will give it a read with everything I now know. I DO get beet red when I exercise. My father's side of the family is riddled with alzheimers, including him and most of his siblings, as well as cousins. Who can say for sure why, but maybe MTHFR. I actually just went back and looked at my dna results. I recently bought methylfolate, but it turns out I should be avoiding it and going with folinic acid instead. Thank you for putting that on my radar!

[@cinderellalifestyle]

Amazing! I have wondered for years why I get so red in the face with exercise. I'm not alone, it's a common question for many. As the Facebook listened did, I'll give the advice a try. I have up wearing a red bike helmet. Together with my beet red face, I looked like a mad thermometer after a vigorous bike ride! Been like this since I was a child. Especially in Summer heat. So thank you.

[@lenkavolnhals7197]

Thank you

[@stardustgoldcrochet]

This entire interview and all the studies here don’t even focus on the main thing that MTHFR causes. SPINA BIFIDA. They started the enrichment program because of this. 1 in a thousand babies are born with neural tube defects. But folic acid only reduces the instances of SB by 30%. I’m just blown away Spina Bifida isn’t mentioned here. You need to be recommending methyl folate in prenatal vitamins. Folic acid causes anxiety. My anxiety is gone. I don’t eat enriched foods at all. Anxiety disappeared.

[@ronnalewellen2583]

What is MTHFR?

[@maryblessing2205]

Methylenetetrahydrofolate reductase The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins.Oct

[@lenkavolnhals7197]

The interview between two cannot cover it all

[@chuck0837]

Thank you doctors! I stand by your view that variations in genetic snips are all a survival tool given the right situation ; we need to be happy with our genetics and just learn how to live with them. I have 1298 and 766 both. Methyl cobalamin works fine for me, but methyl folate makes me hurt all over. I will try the folinic acid - maybe that will do the tric 👍 I found out that I had a MTHFR problem because I had low methionine levels and elevated homocysteine, along with high lead, mercury and elevated tin. Then genetic testing proved the theory right. All of the antioxidant proteins are a big help, but the thing that really helps me is Ascorbal Palmitate; I used to cough and choke from pollution but when I started using it - big help , esp with diesel exhaust. Thanks for the thought on folinic acid . I’ll try try that Thanks for your effort on your talks - super appreciated

[@GramGramGenX-ln5sc]

I thought the acronym said "MTHRFKR"...

[@lindastrang8703]

😂😂😂😂😂😂😂😂😂😂

[@ClassicJukeboxBand]

Sounds like a mutation you get growing up in the inner city...

[@abscondis]

That was my initial impression too.

[@stardustgoldcrochet]

Regarding this…you seem to have a good knowledge. But please please please make it clear to people that “folic acid” is not folate. It’s toxic to people with MTHFR. I have C677T heterozygous. My story is a LONG one…but started with losing my hair, gaining weight, severe panic attacks, in 2010. And more. In 2015 my grandson was born with Spina Bifida. I was in graduate school for bioinformatics. I was in a wheelchair unable to walk. MTHFR nearly killed me. When I became vegan and allergic to yeast, I became malnourished. In 2020 I found out I have it running my own genome. When I hear people say “it’s no big deal” it absolutely IS a big deal. I have ADHD / autism and so does my grandson, and daughter. Have PCOS, MCAS, POTS (fixed), HSD, Fibromyalgia (cured it myself), deficiencies in B12, folate, D, E, A. Fibro cystic breast disease, bad teeth. Ugh. Thorne basic B saved my life. You can’t just walk through life without knowing this crucial information and how it can literally make you not alive anymore

[@lseh4720]

Regarding laughing gas, I now know when my health started to deteriorate. It was after I had my wisdom teeth taken out when I was 19 years old. It took me almost 6 hours to wake up after the surgery. I realize I had no allergies and no health problems until then. I know for certain too because my parents had no health insurance when I was growing up and I went to UCLA medical school to have my surgery to save money. I read dirty jeans and know that I have an MTHFR problem. Wow.

[@beam3819]

Hi doctors. A question: We see an uptick in cancer among young people and the cancer is no longer treatable. Some scientists say it started with the rna vaccine, some say 5 years ago we saw the rise in certain cancers. Agressive and no longer cureable, according to dr Dalgleish. And what is this? A new turbo cancer or have we come to the line where enviromental poison has made our bodies inable to survive cancers? Ret nurse, Norway.

[@MandyPS119]

31:05 red face when exercising info for Santa

[@brid5415]

Thanks!

[@MandyPS119]

Tried taking folinic acid before my workout and face was still red. I will try a different kind and see if it works. I have 2 copies of MTHFR A1298C. My Dad as a pro basketball player was teased in highschool for his red cheeks. So i thought i inherited that.

[@stardustgoldcrochet]

Wow! I played RollerDerby for 7 years and ALWAYS had a red face

[@lenkavolnhals7197]

Epinephrine etc thank you I recommend Anna Lembke on Dopamine

[@ginamcgrath6731]

Hi. Thank you for this very interesting topic. I also have the MTHFR mutation. ? for Dr .Ben Lynch... in 2009 I did the Genelex diet related gene test (about 18 genes) I agree, the program was not the best, but i have always persued the holy grail of a personalized diet. Fast forward and I'm now persuing the blood type diet and debating the SWAMI program. I would be very interested to hear your opinion on the merit of such a program? Tia.

[@Amber-mw8nb]

Great interview. Thank you. Wanted to mention another possibility regarding people who don't do well with Methylated Folate. If a person has a suboptimal SHMT1 Gene they don't do well with Methyl Folate and should take Folinic Acid.

[@catcan221]

I heard that if you only have the A1298C (homozygous) you do not supplement with methylfolate and B12. When I tried that it made me agitated.

[@MsSilver41]

PA girl back again . Is it possible with Pernicious Anaemia that they stopped research to early when the could make a synthetic version of B12?? The solution whiteout finding the cause ??? My way of thinking was it wasn’t just the B12 that kept patients alive - it was the 120-240g liver and 100 g beef/mutton which did the trick- not one thing all the things . All the nutrients and minerals that liver supplied. Made me think of one of your interview where u talked about making a combined nutrient tablet for the most popular drugs that cause drug induced nutrient deficiencies . Is there a combination supplement for PA?? We have support groups which talk of taking B combo, folate, (some say folic acid is best . Magnesium, potassium, COQ10 plus more … iim wondering f we stopped all that and had say 100g liver once a week or liver tablets if that would work , along with the injections of course .. but then you mentioned the sublinguals instead of injections but I get palpitations with sublinguals. Don’t suppose you could devote a video for pernicious anaemia treatment?

[@cornypinkuni9519]

I had heart palpitations too but my ND prescribed magnesium glycinate and that resolved that.

[@bwryuun]

Yes. I worked at an 800 phone line giving out pesticide info. We always had calls from mostly women who would get sick when they lost weight but get “well” when they gained the weight back. Chelation was considered “ woo woo” treatment (80’s) but some people swore by it

[@raydawg2115]

Can someone summarize this? If you have the gene mutation should you take methylated folate then?

[@jactac838]

Depends on mutation, buy his book Dirty Genes

[@Boobear500]

On the mthfd1 ...how does that lead to fatty liver? I have nafl ,I've had gall bladder removed because of sludge. Can I take anything to improve it?

[@lenkavolnhals7197]

You are my morning rescue

[@suechumrau7901]

Just order the book. Thank you for this info. I had my genes done and the one MTHFS. SAID genetic cause for avoidance for folinic acid or Leucovorin At 57:26 Dr Lynch said “ wish they used folinic acid , it’s more stable” any comment on this?

[@g.s.5868]

the folinic does not have to be converted and could go to the brain more easy?

[@FritzNizzle]

Any resources we can appeal to on How we can get folic acid taken out of our food?

[@juliciahernandez3566]

Omgosh I have learned so much and as a mthfr carrier I am going to be changing alot of my supplementation. My only concern I have I had gastric bypass in 07 so my absorption of nutrients is severely hindered and Have been Ketovoure about a year lift weights 4days a week if he could give links to supplements I'd appreciate it greatly

[@jactac838]

Buy his book, it's a life saver

[@juliciahernandez3566]

@@jactac838 just got it

[@cornypinkuni9519]

I had abdominal surgery also but 3 days of a simple chewable methylfolate (b9) w methyl cobalamin (b12) changed my life!

[@vanessac1965]

I had the mthfr test. Found 400mcg methylfolate is the sweet spot, too much makes me feel bad. Choline has been good too. Heme iron supplements. Definitely have better moods, depression has fallen away. It was worth addressing for me, especially because of low stomach acid and egg intolerance making it hard to get choline out of food.

[@cornypinkuni9519]

❤❤❤❤

[@RaisingIndigo]

So what's the best way to detox?

[@MsSilver41]

One of the pernicious anaemia support groups I’m in has an admin who will ban anyone that mentions Ben’s name .. she’s also the one who told me giving up bread and carbs had nothing to do with health… and yet she has some of the sickest people in her group

[@tanyawieczorek6603]

Why are you still in that group?

[@therealjenniferrr]

I believe that, some of the health FB groups are the worst. Carnivore ones can be really bad too. I hope those that are in her group also join other PA groups so they can see the difference.

[@MsSilver41]

@@tanyawieczorek6603 it was the first group I found , I pop in from time to time to see if anything’s changed ..

[@MsSilver41]

@@therealjenniferrr me too , we have another group and some people have joined .

[@cornypinkuni9519]

Wow, she sounds like a paid shill for big food and big pharma that needs to be sued by those she is misleading and harming. And criminally charged once her crimes are better understood by the masses.

[@lenkavolnhals7197]

Another thing out of concept but still an interesting topic I got to it my dog being poisoned I gave done if rat poison bug cannot read more right now I am too hurt the vitamins and what it does how it substances in the body etc the K vitamin sticks out in many studies

[@norasmission7394]

Omggggg. Exactly ! My thoughts about carnivore as well .. they are just avoiding the crap !

[@satka2mau487]

my MTHFR genetics mean i have a 40-50% decrease in methylation.....B vits SAMe etc...for life most probably although the past year i have changed my diet yet again..more greens, veggies salads etc..my biilrubin isnt too high but my eyes are still slightly yellow and my skin also..improvement but not perfect. i need a very clean diet

[@maryblessing2205]

Methylenetetrahydrofolate reductase The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins..

[@cindymorris564]

My sister and I were told by the neuro surgeon that treated my mother’s fatal stroke, that we needed to be tested for the Mthfr gene. I was negative apparently, but I have many of the metabolic symptoms. My sister tested positive. She and I have suffered from various health issues over lives and she was unable to carry to term. How is it more doctors dont know about this??

[@cornypinkuni9519]

Because there's more money in keeping people sick.

[@gif24gt60]

Is dr Nathan's nitric oxide logenges ok?

[@alanbloodworth2653]

That’s a good question.

[@lyns2686]

I've studied health and nutrition most of my life. I like Dr. Osborne so I watched this. I have no idea what this is about. Since I'm healthy. I'm not going to try to figure it out. Too confusing as I don’t understand it. I'm sure it's helpful for a lot of people though.

[@cornypinkuni9519]

It was life changing for me. My energy was low and my inflammatory pain from even mild exercise was high. After 23 years of no help from doctors (despite their best efforts) Learning about MTHFR fixed these problem and several more within 3 days.

[@lyns2686]

​@cornypinkuni9519 Awesome and interesting. I'm going to figure out what this is as it's apparently a good thing. Thank you for the info.

[@cornypinkuni9519]

​@@lyns2686It also reduced my sugar cravings and made it easier to breathe. It may not be relevant to you but it's a common situation for many and can show up in subtle ways. So may be helpful to be aware in case it impacts anyone you know...

[@lyns2686]

​@cornypinkuni9519 Carnivore took away my sugar cravings quite a bit, but I still want sugar sometimes so this may be helpful for me in that respect. I'm not strict Carnivore either - I eat avocados and cucumbers occasionally - so that may be keeping my sugar cravings from going away completely. Thanks for the info.

[@cornypinkuni9519]

​@@lyns2686I'm not full on carnivore but significantly increased my protein intake consistently in recent months and feeling great from it. Still like some balance between macros but I always do much better when I avoid wheat products (in my case definitely the mthfr sensitivity to folic acid versus folate) and stick to whole foods, made by me, with focus on high protein. My energy has improved so much thanks to these methylated b vitamins and related cofactors to improving methylation status and my quality of life along with it but still learning what may impact or impede. I'm glad this is my issue and not some other genetic issues!

[@Lovebuzz11-11]

i have mthfr double homozygous . I have multiple health issues...i am trying to eat clean, suppliments and other, yet i devwloped an autoimmune disease, stopped dairy and gluten. started IV remicade with all of this and Im at least functioning. ... exhausting at times :

[@cornypinkuni9519]

❤

[@cornypinkuni9519]

Do you take methylfolate and methylcobalamin and any other b.vitamins?

[@nancymarihart1835]

MTHFR is on the rise due to vaccinations of all kinds. Thus older Japanese did not show hardly any Cades of MTHFR

[@il3mendo]

Celiac disease with hypothyroidism, with high hemoglobulin and hematocrit. Previously had folate deficiency, iron deficiency ( despite the carnivore diet) b 12 deficiency ( chronic gastritis) and I have Babinski, ahiffmann and Romberg signs. What the hell should I do ? My homocysteine is still mildly elevated. Unjabed

[@il3mendo]

My homocysteine was 30 4 years ago, went to 8 and now it is at 16.

[@joyinjesus12]

​@@il3mendohowd u accomplish that

[@il3mendo]

@@joyinjesus12 for the neurodegenerative was really easy: genetic test on the chromosome 2p ( ai have got the disease from my father). Celiac disease has been the harder once since i struggled so much, almost all my life. Doctor took the genetic test in which I was positive for the hla dq2 then with the first endoscopy the atrophy of my duodenum was a Marsh 3b with negative serology. Then for the EoE and the non responsive celiac disease I waited 4 years ( Marsh 3 a) with the other endoscopy with biopsy and flow cytometry with the aberrant gamma delta population. Gastroparesis and bile acid malabsortion was diagnosed with the video capsule endoscopy: the capsule stated in the stomach for more than 5 hours while from the distal ileum to the anus it took a really short time. For the mthfr gene I have got the inspiration from my brother who has epilepsy and is homozygous for the c677t. Then my Alt/AST increased so much after the first year of a GF diet and they reached 99 ( non alcoholic fatty liver diseases eredicated with a pure carnivore diet now at 30). Thyroid was due to my Tsh which went to 7 ( I had struggled with mental health, metabolic syndrome and hypo/hyperglycemia). The vitamin B12 and folate Anemia were diagnosed with the high concentration of Mcv and Mch with hyper homocysteine (30). I also had the IgE Elisa food test allergy and whatever cross reacts to wheat ( even all cereals labeled as a GF have a strong reaction). I also was tested for leucemia and they analized the TCR receptor which is in a polymorphism state. Now I do struggle with high hemoglobulin : I do not have any iron deficiency but I have an hemangioma in my life and doctor will take a biopsy next week. For the primitive reflexess I don t know since my conditions has improved drammaticaly: either were the Gad 65 antibody cross reacting to the Purkenjee cells or maybe they were the Tg6 ( antibodies that causes gluten ataxia). The Gerd was also diagnosed with the videocapsule endoscopy and also they found some inflammation on the distal ileum.

[@sarahb.6475]

I believe that if you only eat the muscle meat (like ground beef or other cuts) and not any organ meats like liver you are not getting copper. You need copper to absorb iron. And I think it also depends on the amount of exercise. You can sweat iron out too especially if you do heavy exercise or endurance exercise. I believe that most athletes have to supplement iron.

[@il3mendo]

@@sarahb.6475 no no I eat the heart, slowly grilled and seasoned with iodine salt and then I dress it up with crude olive oil. Liver I do the venetian style ( if my Chron s is not active) : i slow cook red onion with water for 20 minutes and then I blend some white wine. When the onion are almost glazed, I add the liver.

[@user-tj8hv7vr9i]

What about gasoline fumes?

[@deeT02]

This is hard to understand. I don't understand how to apply it to all my issues especially high inflammation in my whole body.

[@therealjenniferrr]

This may or may not even apply to you. Best to work with someone if you have a lot of issues, or to start researching your symptoms if that's not possible.

[@cornypinkuni9519]

My high inflammation and low energy were both fixed from methyl folate and methylcobalamin. But I had a naturopathic doctor help me figure it out and she could also read blood work.

[@daviddeiss7907]

So where would someone go to get genetic testing done?

[@cornypinkuni9519]

I got mine from 23 and me. Took the raw data to my ND and she submitted it to an epigenetics firm she trusts. Great info. Worthwhile.

[@GodWasAnAlien]

My ex wife swears I have this but I'm not so sure. She always adds a K in there when she says it.

[@cornypinkuni9519]

😂

[@cornypinkuni9519]

It isn't uncommon. Lol. Get a dna test and prove her right or wrong. Lol

[@karenbutton9763]

Stop with the initials What is it

[@cornypinkuni9519]

MTHFR is methyl-tetra-hydro-folate reductase. Its impractical to say every time so sane humans shorten to the initials. A simple google search of the initials would tell you what it is.

[@lenkavolnhals7197]

I even thought if Oxytocin loosing my dog being traumatised very badly I got to dance through van Damme

[@paul-webster]

So is carnivore bad or good?

[@g.s.5868]

dr. osborne, did you change your mind on folinic acid? previous videos you were against...

[@MandyPS119]

Folinic acid is different from folic acid ...

[@g.s.5868]

@@MandyPS119 you clearly did not listen to his previous videos where he said,no folic acid (off course) nor folinic...

[@MandyPS119]

Thanks for your response. I will go back and watch Dr O's video on folinic acid

[@il3mendo]

What if you have vitamin b2 and folate deficiency with an mthfr mutation ?

[@g.s.5868]

take supplements? 400 mg b2 and a few mg of folate

[@il3mendo]

@@g.s.5868 I increase naturally my folate (at least the serum) with Questran which is a medicine use for Chron s disease that treat bile acid malabsortion. I did try at the beginning with Folic acid ( my serum was 0,9) but I had bad reaction. Since I got better with this medicine I do not take any methylfolate. I just keep an eye on my iron/ferritin status. I eat a lot of organs such liver and heart. ( Twice a week).

[@il3mendo]

@@g.s.5868 my B2 is still low but I think that the complication of my late diagnosis of celiac disease has compromized my glutathione and vitamin b 2 status but I prefere not take any other supplements ( I do take Just vitamin D3 which is blended with organic olive oil)

[@il3mendo]

@@g.s.5868 take your all status of the vitamin B status, vitamin D3 and magnesium/sodium.

[@smarzig]

So herx means your over detoxing?

[@insertmyidentityhere]

pretty much

[@g.s.5868]

not over...just too fast...lower whatever you are taking and built it up slowly...

[@lseh4720]

What about when your homocystine is low, 5.7

[@tbsnwbrdng7]

I have this gene mutation plus th H677 something my daughter knows about this. But your right mother just increases susceptibility (only) my issue is blood pressure. I’ve taken 7 different meds which I’ve stopped due to side effects. I really need to find why I have this issue. My mom had a stroke and has high blood pressure which is not controlled to well either. My bp is anywhere from 180-200 over like 120 -140is “ grounds for going to emergency. I have ehlers danilos but NOTHING ELSE. I’m going to be 62 I’ve had a head injury I’m super scared of stroke. What would you do next??? Dr want to try more pills. I don’t. What causes blood pressure to be so high?

[@cornypinkuni9519]

I would see a well recommended naturopathic doctor with a biochemistry background or a functional medicine doctor and tell them your entire story.

[@cornypinkuni9519]

Osborne has a video on this too

[@TheSweetValentine]

I got red face as a child.

[@OfeliaVillanuevaDMD]

i want to be a member

[@stevierusso529]

Transcript, no transcript?

[@MsSilver41]

Is that 6pm CST or CDT? You don’t change for daylight saving time ??

[@isa-manuelaalbrecht2951]

Nope, it was dr.Peter D'Adamo who taught us all this in 2005 first...😊😁😆🤣🤩🤭😏

[@dinosemr8141]

❤️💖🙏❤️💖

[@user-em3np4vr8c]

What's wrong with laughing gas, I used to always have it years ago and enjoy!

[@cornypinkuni9519]

For some people the effects are not enjoyable

[@arturturk5926]

That mutation is a ..... I'll just go.

[@cornypinkuni9519]

It sure is!

[@robertruge2916]

I am going to gobble a lot of spinach salad.

[@cornypinkuni9519]

Good plan. That has helped me in a few ways.

[@Mo-yj3wf]

Beet juice powder in my B complex. It increases nitric oxide I guess. Does it harm me? 🤔 MTHFR dirty the same as dr Ben’s.

[@jactac838]

Needs to be non gmo

[@LizzyCnote]

Beets are very high in oxalates.. not good

[@lenkavolnhals7197]

Ok, I am tired will listen this one more time. mY mind picks up methyl folate. The thing was listening to you two guys I thought you are going nowhere. You need background on trauma. Take for example Caroline Leaf you guys definitely need a neuroscientist to make a step forward

[@g.s.5868]

trauma is overrated when nutricial deficiencies are the cause...

[@chrisjones-rd8it]

i saw a hell of lot of people with mthfr on the I-5 this afternoon - all over the place old ladies, teenagers, coppers with cherry tops, right lane , left name punks in rice burners, lambos - all of them mthfr's ------------------- nah just kidding the only mthfr i saw was in the mirror - thank GOD i got home! peace and if this is real may ABBA shine HIS face upon them

[@annegaynor9627]

You don't want to know what I thought that acronym was for

[@lseh4720]

But how did your kids dentist pull up their wisdom teeth without laughing gas?

[@nancymarihart1835]

Unfortunately, he still believes in the debunked hypothesis of evolution. Not a good sign of knowledge.

[@cornypinkuni9519]

Stop your mythology. This is serious science that helps people instead of catering to your god complex of an overrated ego.