What is MTHFR? MTHFR Mutation Explained

[@Spartacus69]

I've been gluten free for 11 years due to gluten intolerance. I just heard about this MTHFR, decided to try Mythelfolate 1mg as an experiment. Within 3 weeks I'm completely regular and can enjoy a wheat treat randomly. amazing!

[@OswaldDigestiveClinic]

Thanks for sharing!

[@Mind69420]

Oh man don't get my hopes up!

[@elkeschmitt9285]

Abdolutely awesome

[@almandoi]

Does this really work? Can't wait to try it. My diet is so restricted due to this gene's mutation.

[@SkylarComeaux]

Thank you for the most succinct presentation I’ve heard yet on the MTHFR gene mutation.

[@elkeschmitt9285]

Check Dr. BEN LYNCH

[@IreneYoungFoto]

For me, this is the best MTHFR video I have seen. Thank you!

[@OswaldDigestiveClinic]

Wonderful!!! Thank you for watching and commenting!

[@ciaransmommy]

Agreed

[@ginamiller6259]

Thank you for more information.my phycologist actually tested me for adhd and it came out I had mthfr and ask me if iv had miscarriage I was surprised how she new it it was not for my phycologist I would of never found out

[@OswaldDigestiveClinic]

Wow! I'm so glad you got connected to a great psychologist. If you ever want to explore the nutrition side to things - we are here for you. Thanks for sharing your experience!

[@sarahbarnier1819]

This was a very clear and informative video. Thanks for posting!

[@OswaldDigestiveClinic]

This is music to our ears. Thanks for your support, Sarah!

[@acsearchingfortruth]

Fruits and veg increase my inflammation and digestive issues.

[@OswaldDigestiveClinic]

Thank you for commenting. There are many fruits and vegetables that can cause more digestive issues, likely due to a microbiome that is not diverse or other underlying causes. I recommend working with a practitioner to sort out root cause.

[@mac-ju5ot]

Me​@@OswaldDigestiveClinic

[@Cinnamon349]

The fodmap helped me find what fruit and veggies were bothering me. Try that❤

[@naturalwitchery]

I recommend the fodmap as well

[@MatthewWright001]

Best video on this ever! So clear. 🙂

[@OswaldDigestiveClinic]

Thanks Matthew! We appreciate your support!

[@minimal9001]

Do not forget organ meats like liver, way higher nutrition, no antinutrients. People fixed their MTHFR gene mutation by consuming the enzymes in the liver. Also the liver heals by eating liver(from a healthy animal).

[@SuperSnarr]

This was an incredibly well done video. This is the best explanation I found, and I’ve tried to watched a lot of videos to understand it this. I’ve just started taking methylated folate and everything seem to be fine but I think I overdid it and it came down incredibly sick. Terrible nausea and just felt horrible for about three days. I’ve stopped taking it now and it must be a dosing issue. Have you found, any side effects from taking too much methylated folate? Thank you so much and I think I’m going to schedule an appointment.

[@tanyawieczorek6603]

Did you try taking folate again and what happened?

[@SuperSnarr]

@@tanyawieczorek6603 So my reaction to the methyl folate was extremely negative for me. I must have a serious problem with that form. That said I did some research and found a supplement on Amazon from a company called PINK STORK that uses a natural FOLATE that worked really well. It was started by a woman as she needed to find a good solution for her own personal situation.. and I am very impressed with it for me. It fits my system well. :) Thanks for asking.

[@Anna-yh5kb]

Thanks for this great information on MTHFR and explaining everything now i understand what that gene is.

[@BhaktiRosin108]

I'm wondering if there's a connection between Spina Bifida & the mthfr gene mutation since I was always told that a lack of folate can lead to SB

[@OswaldDigestiveClinic]

Some studies have found that there is a higher risk for spina bifida when there is a MTHFR mutation present.

[@SherylRosano]

Hello, thanks for the information. Does the mutation affect our gut health?

[@OswaldDigestiveClinic]

Yes, it can.

[@tylergrimm2666]

I had a gene test done. I have a c677t mutation. My folate levels came back on the high end of normal. My homocysteine levels came back normal. I toke L methyl folate for about 5 days before the blood tests were done

[@OswaldDigestiveClinic]

The supplement you are taking will give a higher lab result.

[@GraceHarringtonMurdoch]

One thing to also address is finding out if you are over-methylating, which often does not favor methylated folates and methylated b vitamins from what I have learned.

[@OswaldDigestiveClinic]

Thank you for sharing!

[@chrismyers9951]

If I overdo it with TMG it changes my mood for the worse.

[@OswaldDigestiveClinic]

Self-awareness is good and certainly helps to keep you feeling your best!

[@RealFakePhD]

I have the heterozygus mutation and seem to be the only one out here having a good time.

[@sarabear7432]

Wait cleft pallet???? My son has a cleft in the soft part no one knows why. I have the double mutation my daughter only has the one mutation. Could this be to he also has the mutation or the mutation in me caused it maybe?? We are driving 4 hours tomorrow for his cleft team.

[@OswaldDigestiveClinic]

It may be possible as research does suggest there is a connection.

[@nolamayer4101]

Thank you for the informative video. I too have the double mutation and Gilbert’s syndrome which I’m starting to think is behind my CFS. I wonder if others have a problem taking the supplements you mentioned like I have even in tiny amounts? I am now trying a B complex powder plus B9 but in the folinate form as appposed to the synthetic folic acid 🌻

[@OswaldDigestiveClinic]

Thank you for sharing. Everyone has an individual response to supplements. Some are more sensitive than others.

[@samanthaketterer3064]

Hi, ive been taking LDN for 2 years, which reduces inflammation. So will my Homocystein levels be wrong? Meaning is LDN hiding the fact that i have high Homocystein?

[@OswaldDigestiveClinic]

No. Homocysteine levels are connected to vitamin deficiencies.

[@cg1811]

Does your clinic have experience working with Lyme and Mold patients who also carry the MTHFR?

[@OswaldDigestiveClinic]

Hi CG! Yes, Katie can help with this, and you can schedule with her here: secure.gethealthie.com/appointments/embed_appt?dietitian_id=1143185&provider_ids=%5B1143185%5D&appt_type_ids=%5B144062%5D

[@debmom978]

Do you have any info about the COMT gene mutation?

[@OswaldDigestiveClinic]

The book Dirty Genes by Ben Lynch is a good resource.

[@elementsofbeing8203]

I’m Taking SamE how long taking it til I notice a difference

[@OswaldDigestiveClinic]

It can take up to 6 weeks to feel a difference when taking SamE. Always advised to take a supplement for 3 months to see full benefits.

[@SanFranMission415]

Thank you so much!! I recent had a test done with Genomind due to depression and ADHD and why medications weren’t working. My MTHFR gene came with the following C677T: C/T A1298C: A/A They recommended that I take Deplin or L-Methylfolate and exercising instead of using SSRI’s. I noticed the following day after taking L-Methylfolate, I felt happy and sharp. I was able to hold a conversation without forgetting what I was talking about and just felt happy overall. But unfortunately that only lasted a week. What do you think went wrong and what can I do to feel normal again? I did buy a small bottle Niacin as I read an article it may help. Many articles say L-Methylfolate takes 2-3 weeks to kick in but for me it started working the next day. I have taken several medications in the past and never had results like that so I am sure it wasn’t a placebo effect, at least it felt real to me. I don’t drink alcohol or caffeine, workout 5-6 days a week and my diet can be better but I try. I can’t eat certain veggies as they make me sick but I do try to make up for that with vitamins. Any recommendations you can provide would be appreciated. I do have IBS, get migraines and headaches, have sleeping issues, high cholesterol and pre diabetic. I had these issue since I could remember. Cheers.

[@OswaldDigestiveClinic]

Hi Calirican! I'm so sorry for not seeing your comment here sooner, but I hope this reaches you. You are on the right path, with looking for root causes to your symptoms instead of settling for medications that don't give you full results. With mental health, there can be many possible root causes, and often multiple at the same time. I'm guessing this is happening with you. With IBS, there is a gut - brain connection, so I would suggest exploring this further. At our clinic, we have helped clients get rid of IBS (and I got rid of my own IBS many years ago, too, prior to starting our clinic). Migraines and headaches can have their own root causes, which could be what's going on with your gut, or it could be a nutrient deficiency like magnesium is very common (and low magnesium can cause some of the other symptoms you're experiencing either directly or indirectly such as causing sleep issues), pre-diabetes could be contributing to hormone imbalances, contributing to mental health challenges, and more. Do you have insurance? I really feel our clinic could help you - you are so similar to other clients we have and we'd be thrilled to get to work with you on the journey of feeling better! You can schedule here if this sounds aligned: www.oswalddigestiveclinic.com/schedule

[@ditchy5512]

Check out a low carb or carnivore diet, Dr Ken Berry has heaps of info on here

[@sisterfrennn]

Try eating beef liver! It’s been helping me!

[@nehaan8323]

Hi! Thankyou for this video. One question- if i have this gene mutation but also have thalassemia minor, would methylfolate work/help or would it work against?

[@OswaldDigestiveClinic]

It would be beneficial, but best to get labs tests to see where your folate levels and homocysteine levels are before beginning supplementation.

[@nehaan8323]

@@OswaldDigestiveClinic thankyou :)

[@janebass4057]

Best explanation ever!!!!

[@tifffteal]

My mthfr1298 is GG. What does that mean?

[@OswaldDigestiveClinic]

Common variant of a homozygous copy. This means it increases the relative risk of many chronic diseases, but this does not mean it will cause you to have that disease.

[@brendan3081]

How does this gene mutation effect those seeking depression and anxiety treatment? is there data that shows how medications do or dont work well in treatment due to this mutation?

[@OswaldDigestiveClinic]

Research has shown that C677T mutation may contribute to reduced neurotransmitters due to low folate levels. With a reduction in neurotransmitters, anxiety and/or depression may present in an individual.

[@jy7841]

​@@OswaldDigestiveClinic what treatment do you recommend for those suffering from anxiety/ depression?

[@OswaldDigestiveClinic]

There are many things that can contribute to anxiety/depression. Working with a dietician/nutritionist may help uncover things that are playing a role in your mental health.

[@Lucylucid111]

Check out genesight testing google it.

[@ezzovonachalm9815]

Why should I take a grain of salt before I take folate to be methylated ? If I forgot to take that bloody grain of salt, can I take it after folate ?

[@OswaldDigestiveClinic]

Folate is best absorbed when taken with vitamin c containing foods or supplementation. Salt has been shown to help folic acid to be absorbed better, however, it is best to stay away from folic acid supplements and consume a methylated form of folate if needed.

[@ezzovonachalm9815]

@@OswaldDigestiveClinic Thank You for Your precise response.I 'l keep these precious and hard to find engramms - even on Google !

[@ezzovonachalm9815]

@@OswaldDigestiveClinic Thank You for Your clear answer.

[@Amanda-cl6lh]

Can this cause elhers danlos

[@OswaldDigestiveClinic]

Due to the low folate bc of the MTHFR mutation, it may be a factor in Ehlers Danlos.

[@peterlanephotography]

I know 2 people with MTHFR mutation and double dose of B6 in the blood. Does it mean that it can’t be turned into active form and the body is in deficit? Do they have to supplement with the activated form? How to get rid of this blood excess? They don’t supplement.

[@OswaldDigestiveClinic]

Thank you for watching and commenting. When taking supplementation for MTHFR is recommended to take the activated forms, because due to the SNP's individuals are unable to methylate them properly. If there is a high amount of B6 in the blood, the way to reduce is to eliminate supplementation until levels reduce. To find underlying causes of high B6, I recommend they work with a practitioner.

[@vaniakazan1930]

What if my 3.5 years old have high b12 without even supplementing or having egg or fish in her diet ? Doe that that means she has the gene ? Plus she is low on b9 Her b12 is level is 1100

[@OswaldDigestiveClinic]

It is recommended to do MTHFR testing to rule it out and help you take the next right steps! labs.rupahealth.com/store/storefront_84by1nw?storefrontProduct=strprod_GxElPXO

[@williamhenry3337]

I am also a mutant. A1298C G/T and C677T G/G. For whatever reason I do not show any of the symptoms. I'm also Apoe2 so maybe that helps.

[@OswaldDigestiveClinic]

What symptoms are you watching for? Low B12 or folate? It may be showing up as high homocysteine levels, hypothyroidism, conditions such as diabetes, high cholesterol, and high blood pressure or obesity

[@williamhenry3337]

@@OswaldDigestiveClinic Just about longevity. I'm 75 years old and I have never had a blood test. Other than 1 colonoscopy my last doctors office visit and physical was in 1969. I have only had one prescription in my adult life (antibiotic for a root canal). I am Apoe2 so that might help my longevity. I have kept a 19.5 BMI my entire adult life. Really good video.

[@samanthaketterer3064]

I am compound. My only B vitamin affected is high B6. But I also have high Renin and Aldosterone. Do you know much about how MTHFR mutation affects those hormones?

[@doddgarger6806]

Jacks up sleep, haven't slept right in years or my mother, watching her fight through decades of working without sleeping properly it almost killed her I just wondered if we both have this

[@OswaldDigestiveClinic]

You can do a MTHFR test to get a definitive answer.

[@ArthurShelby-PB]

I'd like to get tested for this gene mutation to see if I have it or not. I live in the UK and don't know how to go about getting tested

[@OttoNommik]

You have the internet, doofus

[@OswaldDigestiveClinic]

You may want to speak with a naturopath or DO physician, there are online labs that may send internationally...

[@naughtydog9843]

Great video, thanks !

[@divergentmind2023]

omg i have insomnia since early on changes of humor allergies to food and everything adhd dyslexia memory loss digestive issues weight issues for the last few years strokes i will give it a try bloating 24x7 no one was ever able to help me in 30+ miscarriages

[@OswaldDigestiveClinic]

Thank you for watching! Sounds as though you have had many health issues over the years. It would be recommended to work with us to help you find health again. www.oswalddigestiveclinic.com/schedule

[@anywherenutrition]

Bravo, Katie!!!

[@AnnA-jd4xm]

If theyre so common and can cause so many issues why do they not test for it as kids?! its insane to me that they dont. so much made sense once I found out I had it

[@OswaldDigestiveClinic]

Thank you for watching and taking time to comment! There is some conflicting data in mainstream medicine as to what this mutation may cause. You will find Functionally trained physicians will screen/test for this.

[@LauraHickmanLauraHickman]

Also, MTHFR has only been known about since 2013 , so 10 years. Many doctors are woefully under informed

[@AnnA-jd4xm]

@@LauraHickmanLauraHickman I hope that changes in the future!

[@laurasophiaparedes863]

Soy homocigota nunca gracias a Dios con mis 35 años he tenido ningún problema de salud, de niña era hiperactiva y me enteré tras la perdida de embarazo ahora tengo una nena y obviamente es si o si heterocigota la alimento muy BN es la mejor manera de cuidarnos

[@sallypettit7156]

Loved this

[@OswaldDigestiveClinic]

Wonderful! Happy it was helpful!

[@GinoGraziano8]

I wonder how easy it is to get a test for the mutation in MTHFR genes.

[@OswaldDigestiveClinic]

It is very easy. Here is a link to test for MTHFR. Thanks for stopping by! labs.rupahealth.com/store/storefront_84by1nw?storefrontProduct=strprod_GxElPXO

[@psalm23s]

You can also get it tested through 23 and Me which will give you a lot more information regarding many other genes. You take the raw data from your 23 and Me and run a report through a gene database. It's about the same price and gives you so much info!

[@jy7841]

​@@psalm23s just curious if it will tell you what parent you got the mutated gene from... Of if that is too specific? I got a genesite test that is actually performed for prescribing psychiatric medicine and it showed I had the gene mutation.

[@grace683]

I got it done by doing a blood test .

[@GygaxGirl]

Many of us also have slow COMT which makes the methyls problematic to us.

[@OswaldDigestiveClinic]

Good to point out there are other pathways that may inhibit methylation. Thank you for watching and commenting!

[@hayleythompson1690]

What do we take for double mthfr and slow comt?! I have both

[@GygaxGirl]

@@hayleythompson1690 same. I'm seeing a functional dr. I've been taking folate and b minus vitamins in 1/4 doses daily for a year. I'm now also getting rid of heavy metals with his assistance. It's slow going for those of us with ultra slow methylation. Find a really good functional dr.

[@MegBHikes]

I don't understand why you said eat beans then you said eat anti-inflammatory a minute later... legumes are totally inflammatory! Kinda confusing honestly

[@OswaldDigestiveClinic]

Legumes may be inflammatory for some individuals but not apart of the top most inflammatory foods.

[@kingpetra6886]

If 50% of the popu;ation has this "mutation", then why is it a mutation to begin.

[@kayjay-kreations]

Because the mutation is passed on

[@OswaldDigestiveClinic]

Thank you for watching and taking time to comment. As the commenter below indicated the mutation is passed genetically. Having a parent or even a close relative with MTHFR may increase the likelihood of a person inheriting the same variant.

[@MsBuffalopoo]

Hey, wait a minute! Hold up. Am I seeing things? Aren't you the same woman who gives homesteading tips on Instagram? Do I usually see you talking about chickens and stuff?

[@OswaldDigestiveClinic]

Yes! You are right! Thank you for watching and commenting!

[@katelynnvifquain9629]

Important correction: you mention ~3:00 mark that we get folic acid from food … this is NOT true, as it is NOT naturally occurring! As you explain later in the video, folic acid is the synthetic man-made version of folate, which IS naturally occurring in food. This is a very important distinction, as our bodies CANNOT use folic acid until converting it to folate via the dihydrofolate reductase (DHFR) enzyme. Many people - estimated to be a good 40% of the population - have genetic variations that result in limited DHFR activity … thus, these individuals are especially prone to the health consequences of over-consuming folic acid (because so much of our processed foods are supplemented with it) and over-accumulating metabolically inactive folic acid in their bodies. So, please share that in fact our bodies DO NOT get folic acid from food, and that MTHFR uses FOLATE - NOT folic acid! One great resource if you or your viewers want to learn more on this clinically significant distinction is to do a Google search on the topic and Dr. Ben Lynch.

[@OswaldDigestiveClinic]

Thank you for the correction. Folic Acid is not naturally occuring.

[@luciouspyro9524]

She had to be working in a kindergarden before as she kind of joyfully addressing the childrens some sort of events and activities and not to nearly cripples suffering of poor methylation . Sounds like fun not to breath normally after a minimum of actinty and suffer panic attacks for no reason at any time but functional medicin its a money making business its suppose to be like this

[@OswaldDigestiveClinic]

Thank you for sharing your thoughts.

[@luciouspyro9524]

@@OswaldDigestiveClinic you are welcome

[@OswaldDigestiveClinic]

1) Schedule your INITIAL APPOINTMENT (Now Accepting Insurance!): www.oswalddigestiveclinic.com/scheduling Schedule with Katie: secure.gethealthie.com/appointments/embed_appt?dietitian_id=1143185&provider_ids=%5B1143185%5D&appt_type_ids=%5B144062%5D

[@OswaldDigestiveClinic]

2) DOWNLOAD YOUR FREE GUIDE: 5 Ways To Improve Gut Health And End Food Intolerances For Good: odc.mykajabi.com/FreeGuide

[@asherasator]

Homocysteine is from methionine in the first place. To simply focus on converting homocysteine with coenzymes/vitamins is not the most practical view for treatment. To me the most rational is lower intake of methionine foods from the get go. That way you lower homocysteine from it's starting point. MTHFR "disorder" is not a disorder, it's simply from the genetics of ancestors that did not eat high levels of methionine foods and have to deal with the higher levels of toxic byproducts. It's basically also a good argument that most peoples ancestors came from more vegetarianish or low meat diets since methionine is higher in animal flesh products.

[@OswaldDigestiveClinic]

Thank you for sharing your thoughts.

[@asherasator]

@@OswaldDigestiveClinic Hi, here's something I found in two of my books: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment. 'Homocystinuria' the treatment is "Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6]. Which B6 is naturally found in fruits, veggies and grains. (2) Enzymatic Reaction Mechanisms, pages 846-850; Cobalt coenzymes with FADH enzymes attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine. Normally SAM would create the methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH can also do the job. But the the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other reactions. So lowering methionine with focus on natural foods with cysteine along with B2 and B6 seems to be a better route.

[@asherasator]

@@OswaldDigestiveClinic Hi, my reply didn't show so I'll post again. I found this in two of my books: (1) Geigy Scientific Tables, 7th edition, page 449; Inborn Metabolic Errors and their treatment. 'Homocystinuria' the treatment is 'Diet low in methionine, but higher in cysteine and pyridoxine [vitamin B6]. Which B6 is naturally found in fruits, veggies and grains.' (2) Enzymatic Reaction Mechanisms, pages 846-850; Cobalt coenzymes with FADH enzymes attacking SAM [S-adenoslymethionine] creating methyl-CoB12, which then turned homocysteine back into methionine. Normally SAM would create the methyl-CoB12 by the enzyme NADPH, with a "defect" and lower ability to metabolize the Cobalt enzymes with FADH can also do the job. But the next pages 851-863 show that methyl-CoB12 '... appears to function secondary methylation category... methylates mercury, palladium, lead, platinum, gold, tin, arsenic, selenium, and chromium' in the environment creating toxic chemicals. High doses of methyl-CoB12 is well known to increase oxidative stress and has many other reactions. So lowering methionine with focus on natural foods with cysteine along with B2 and B6 seems to be a better route. Methionine is carcinogenic and involved in angiogenesis and creates blood vessels to tumors. The common ideas of methionine being "essential" is overrated because even with no MTHFR "defects" the toxic effects of methionine to homocysteine recycling can affect anyone.