mTOR Signaling Pathway | Nutrient and Cell Stress Regulation

Lesson on mTOR Signaling Pathway: In-depth Overview of Upstream Nutrient and Stress Regulators and Regulators of the mTOR complexes.
Hey guys! In this lesson I give you an in-depth, detailed analysis the many ways in which the mTOR pathway is regulated by nutrient signaling pathways and cellular stress pathways such as DNA damage and hypoxia.
WARNING: This video is not for the faint of heart - this is another video with a lot of information!
Hope you all find it helpful.
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
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JJ

[@doubleflipking]

Im so glad I found your channel! Concepts are explained so clearly and easy to understand, about to watch all your videos! Keep it up!

[@smedleyjefferson1450]

Amazing, very clear explanation!

[@zhouliangbian194]

a very clear and informative description help me understand!

[@GhaziFaisalMajid]

Very good explanation. Thank you.

[@glittersoop]

your videos are fantastic, thank you!

[@vinayakkapatral4246]

Excellent 🎉

[@habibalamgamaryani6977]

Greatest 👍

[@mano2407]

thanks for the video!.... very well explained. I like the slides as well... very easy to follow.... what program did you use to create these animations?..... Thanks!

[@arhielab754]

So cool, what program did you use to create these animations?

[@afkehenriettex_]

Hi, I'm wondering which paper(s) you used, or how do you know the regulators of mTORC2. You say regulators at mTORC2 involve regulations through rictor. Do you have a paper for these caspases, p70S6K and GSk3?

[@ashlynnundlall]

Where can I find an explanation of the notation ?

[@lucasaraujo9592]

👏👏👏

[@petroslitos3595]

How does exercise leads to inhibition of mTORC1 since its a factor that activates in in the first place? Especially when the diet factors are on point (ex.sufficient nutrients and amino acids such as leucine and BCAA's,caloric surplus,etc and let us not forget insulin's role and especially insulin sensitivity and glycogen replacementin muscles).Exercise leads to muscle fiber damage which is a crucial aspect in Sarcoplasmic hypertrophy and also contributes to the muscle hyperplasia which is the multiplication of muscle cells.And since mTOR leads to cell multiplication,how can exercise suppress it given the above?

[@HankFuller333]

thats not what he said

[@gusforyou]

Correction: there is no such thing as muscle hyperplasia on weight training, it is a different thing from hypertrophy. And you are taking external factors of lifting into account, such as lifestyle. But exercise on itself is a stress on the body, which makes necessary for the body to start focusing on immediate energetic needs, so it makes sense that during exercise protein synthesis is inhibited.

[@patrickclosefitness]

It could be referring to aerobic exercise as this inhibits mTOR

[@scotthall9365]

WTF?

[@zekeriasvarg530]

very much claims no proofs in literature