mTOR Signaling Pathway: mTOR Complexes, Regulation and Downstream effects

[@maximilianUTU]

Fantastic, JJ, thank You so much! With this video even an old brain like mine could easily understand the complex interactions and dependencies of those pathways. Wonderful, I surely will become a JJ-addict.

[@scottunique]

Once again you're in depth explanation shed light on the complexity of cellular metabolic regulation. I particularly enjoy your side comments relating to other aspects of cellular control up stream, because they give me a look into the grander scheme of life processes. Keep up the excellent work JJ!

[@melvinrowan9892]

You all probably dont care but does someone know a method to log back into an Instagram account? I stupidly lost the password. I appreciate any tips you can offer me

[@melvinrowan9892]

@Cristiano Troy I really appreciate your reply. I found the site through google and I'm in the hacking process now. Takes quite some time so I will get back to you later with my results.

[@melvinrowan9892]

@Cristiano Troy It did the trick and I now got access to my account again. I'm so happy! Thanks so much, you really help me out :D

[@cristianotroy3675]

@Melvin Rowan no problem xD

[@nyoubelieve9178]

Was searching the web for information on Epilepsy. I was diagnosed about 3-4 years ago. Since then my understanding of my brain has baffled me. I opted out for surgery, it's not under control even with medication throughout the day. I view knowledge is power & thank you for putting everything in a way I can comprehend. I was also diagnosed with short term memory loss. My Doctors all said it's normal to loss your memory sometimes, I like to think they are Quacks with a good paying job. But have to realize they know far more then I do. Thanks for the information. Made all that fancy talk my Doctors do make some since. 😜 Will be looking forward to watching more of your posts. Thanks Again

[@JackM-un8co]

Hi, I know it's been ages since you posted this comment, but have you ever tried the therapeutic ketogenic diet?

[@nyoubelieve9178]

@@JackM-un8co yes had to go off it, do to liver issues. My sister had to also for heart problems.

[@JackM-un8co]

@@nyoubelieve9178 interesting that's unfortunate. Was it a condition that arose from doing keto, or was it pre existing beforehand and keto made it worse?

[@nyoubelieve9178]

Started after, had a friend put her husband on it do to high blood pressure. It dropped so quickly Doctors had to watch closely but still they stayed because it was best for his health conditions

[@JackM-un8co]

@@nyoubelieve9178 wow that's interesting

[@vks-c4w]

Thank you so much genius man...... Your all lectures are much more detail and simple explanation I am from India 🇮🇳 really salute to you heartly..... ❤❤❤❤❤

[@bpandit9302]

Awesome job on this JJ, I have been trying to learn how mTOR gets activated/inhibited and the things it does, and you do a stellar job of explaining this.

[@cathyli1661]

Thank you for the really clear introduction that makes the complex signal network easier to understand!!!

[@benarfasara9014]

Thank you for this video i had trouble understanding mTOR and how is it related to autism and all my teachers had no idea about it. Thank you so much it's really well explained.

[@moonlight34134]

Thanks for explaining everything. I have Tuberous sclerosis complex and I’ve been wondering about what it affects in terms of genetics, so understanding how it normally works is interesting to see and fun to learn

[@deliberatepractice1238]

22.08.04. mTOR Signaling Pathway: mTOR Complexes, Regulation and Downstream effects mTOR actually upregulates ATF4 to increase expression of MTHFD2 (purine synthesis) (Ben-Sahra et al., Science, 2016). I will correct it in the video. I'm very sorry for the mistake - hope it didn't make things too confusing :)

[@InquilineKea]

8:40 was the most importance sentence also after so many years this was the FIRST day I understood the entire diagram...

[@kylekrantz3025]

I thought I was weird for checking this out for fun, then I see it has 88k views. Good to see all the other freaks and geeks

[@dena3107]

I find this on the day of my exam... I seriously should have checked youtube for cell signalling lessons

[@codyellsworth7927]

Hi, a little late (on my part), but what course were you taking? Cell metabolism?

[@dena3107]

@@codyellsworth7927 Hi, haha yeah its been 2 years. The course I was enrolled to was Biological and Medical Science. So basically the course was a little flexible in what modules we want to study. I picked a lot of biochemistry, pharmacology, and some physio+pathology modules. Im intrigued, why do you ask?

[@codyellsworth7927]

I'm currently a junior working on my bio degree looking to get into aging research after graduation. Pathways like mTOR are pretty relevant in aging, so it would be cool to take a course that has some relevant info like this.

[@dena3107]

@@codyellsworth7927 ahh that is a rather challenging field. You might be dragged into cancer research too as cancerous cells are immortal. The course I took was in UK (are you in UK or America?) I can send you a private message about it if you would like

[@codyellsworth7927]

@@dena3107 I'm in the US, but who knows where I'll end up lol... there aren't very many programs specifically geared towards the biology of aging over here. I'm trying to get at least a year of research in and perhaps co-author an article before applying anywhere, but it's kind of difficult to do that when everything gets put on hold (COVID).

[@abvmoose87]

Thanks for uploading this, really good stuff.

[@zk1coach]

ur channel is perfect. thanks for your effort.

[@정주안-k8d]

Thank you so much from South Korea !

[@berkan7161]

Other hormonal actions that are less or not affected by insulin resistance and may even be upregulated with the concomitant hyperinsulinemia include upregulation of PI3K-AKT dependent lipogenesis in hepatocytes and of the mechanistic target of rapamycin complex 1 (mTORC1) activity, the latter resulting in increased protein synthesis and impaired autophagy (91-95). Increased systemic insulin levels and concomitant insulin resistance during the progression to type 2 diabetes is associated with chronic overactivation of the mTORC1 signaling pathway and cell stress in the context of a high protein synthesis rate (96). During insulin resistance states (and concomitant hyperinsulinemia) there is, varying between tissues, phosphorylation of several Forkhead Box O (FOXO) transcription factors and their retention in the cytoplasm. resulting in suppression of muscle autophagy and protein degradation, among other effects (86, 97-99).

[@KenzyFarid]

you are wonderful! very simplified, and beneficial. thanks too much

[@doctorhim0076]

Thank you so much for these videos on Cell signaling. I had a hard time trying to understand these mechanisms. You made a superb job. Now everything is crystal clear to me. How did you collect all sorts of info? Can you please provide me some reference books on those cell signaling pathways? It would be so much helpful.

[@Littleprinceleon]

Molecular biology of the cell, when I graduated in 2003, the major findings (including all kinds of interesting stuff from different life forms) fitted (in a rather abbreviated form) into a cca 1200 A4 pages book (at average letter size about 2-3mm but with excellent drawings approximating the size and shape of some proteins)

[@samanthasantos8221]

Is the mTOR found in all cell types?

[@berkan7161]

mTORC1's ability to inhibit autophagy while at the same time stimulate protein synthesis and cell growth can result in accumulations of damaged proteins and organelles, contributing to damage at the cellular level.[60] Because autophagy appears to decline with age, activation of autophagy may help promote longevity in humans.[61] Problems in proper autophagy processes have been linked to diabetes, cardiovascular disease, neurodegenerative diseases, and cancer

[@RainBow-xj5vq]

amazing presentaiton, thank you for this

[@rajaneshcmcg]

Is there a software or application or website which allows the creation illustratons of such pathways? It would be really be helpful if someone was able to provide the info

[@shopnobalika]

thank you so much for making it

[@annazhai9068]

Hi, amazing video! And I am wondering would you please share the ppt? thx!

[@eliuq4157]

Its many pathway activation are super interesting foe building muscle, i love L Argining, also Adenosine Disodium Apt and 5G of Leucine

[@leggy12]

Hi there, great videos! I'm not sure if you answer questions here, but I'm not sure if I've got this right? mTORC1 is obviously promoting protein synthesis, but in your Insulin video you show p70S6K as inhibiting IRS1/2. So that would inhibit AKT and then mTORC1, so mTOR is also downregulation itself?

[@慶弘王]

17:53 thank you , thumb up already

[@alaamuayad5877]

great explanation

[@ruhitagupta]

this is amazing, more videos on important pathways please

[@Zack-xj7jg]

great job👍Any video explaining ErbBsignaling pathway?. Thanks

[@notsnikko649]

Thank you for this video that clearly explains how mTORC (specifically mTORC1) works, how it is regulated, and the signaling pathways it has to elicit protein synthesis. If possible, do you happen to have the reference books for this information? I would appreciate it if I could access this information to better understand the mechanisms of mTORC1.

[@Littleprinceleon]

And what about to read some reviews on PubMed? Those are mostly comprehensible: the newer and better ones are behind paywall but surely you find at least a few interesting for free

[@Userr4062]

as we know in lymphocyte T , we d'ont have lysosomes , so this mTOR signaling also valid in lymphocyte T ? thank you

[@冯卫宽-y2l]

hi, JJ, I have a question that which drugs could inhibit mTOR. one is Rapamycin, what is another one? I didnt hear it clearly and I can't search it in the internet. Your vedios are very helpful for me. I want to let more people know in my country, can you allow me to translate your vedios into Chinese and put them on Chinese video sites only for study?

[@nachinathan3846]

Torin was the other drug if still relevant

[@canyoncreekster]

berberine or metformin

[@GodfreyMann]

So this presumably explains why body builders eat carbs AND protein after a workout, because they will upregulate mTORC1 and especially having consumed protein there’ll be lots of amino acids to synthesise proteins for muscle building?

[@lucasaraujo9592]

Thank you so much! It helped me a lot !!!!

[@shutinghan6946]

can you make more videos of mTOR? this is so help me so much to organize and remember by watching you video! thanks a lot

[@丛莹]

Very useful. Thanks

[@sohaibsalama2657]

what is cytoskeletale reorganization

[@lilianmariawiens4781]

Magnificent thanks

[@thesheel100]

Thank you sir.

[@ryanweber7826]

I like all your videos. Most of the time I watch them on my cell phone. Its not under my namme so I can't tap the 'i like this' button.

[@amandagar6362]

Awesome information in vedio

[@shutinghan6946]

and i wonder where did you read about ATF4 is inhibited by mTOR , cuz mostly i read is ER stress can upregulate ATF4 and then mTOR is activated by ATF4 , so i will be more than grateful if you can share your reference with me !!!

[@jjmedicine]

Hi shuting han! Thanks for the comments :) Actually, this is a mistake - I'm not sure why I said that, but mTOR actually upregulates ATF4 to increase expression of MTHFD2 (purine synthesis) (Ben-Sahra et al., Science, 2016). I will correct it in the video. I'm very sorry for the mistake - hope it didn't make things too confusing :)

[@shutinghan6946]

no problem at all :))

[@samuel8097]

Bro I need your help desperately Studies have shown that PDE4D binds to RHEB and prevents it from activating mTOR but in the presence of excess cAMP the PDE4 breaks free from binding RHEB so RHEB can activate mTOR I have low levels of cAMP and high PDE4 how can I break the bond between RHEB and PDE4D without cAMP?????

[@aang7505]

Amazing thank you thank you!!

[@СедаГаспарян-д8к]

Thank you !!!

[@sanjaisrao484]

Thanks

[@Owen-C1997]

Fucking awesome videos man THANK YOU saves me all the reading and confusion!

[@phsal5182]

thank you

[@bbdoll152000]

I’m gonna take a complete shot in the dark here. My daughter (15) was recently diagnosed with a mutation in her DEPDC5 gene. She also has Fragile X Syndrome. So far none of the docs have a good explanation as to what’s going on with her DEPDC5 gene expect she is very aggressive and nonverbal. I understand most of FXS but I’m lost on the new diagnosis. Is there anyone out there who can explain what’s going on in her body?

[@SudiptaNaskar]

Thanks..

[@IvanBowen-i3c]

41250 Keagan Parkways

[@ViolaZafar-o8l]

Eliane Roads

[@dogcrazy25]

Ugh. I'm a layman and this is over my head. All nutritional researchers talk about motor but still cant figure out what it is. I need a simple explanation does anyone know places I can find motor for dummies?

[@jjmedicine]

Hi Sue! Sorry about that. I hope you found another resource that could help you. I will probably make a lesson in the near future on mTOR in a more simplified way :)

[@dogcrazy25]

@@jjmedicine thanks. I'm sure your intended audience needed the info. Sorry about my spelling. I fight spell check.

[@GaryTaylor-i4i]

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[@khalidbhat4619]

Flabbergast !

[@samirelzein1095]

time for bio people to speak average human language? Need to be more immersive on the task.

[@__-bc4bs]

Raptor... XD

[@tombuur]

Since you ask for feedback. I was disturbed by your excessive use of the word “actually”. Try listening yourself and count. Otherwise I am happy with presentation.

[@Suburp212]

Great explanation

[@mandys8156]

Thank you sooo much , very very very useful video!

[@sakkariyaibrahim2650]

Thank you

[@eguapo]

Thank you!