Multiple Sclerosis Differential Diagnosis

This video shows MRI findings of diseases known to mimic multiple sclerosis
Another video on multiple sclerosis mimics: • Multiple Sclerosis Mimics
Selected Sources:
MOG Antibody Positive Optic Perineuritis: an Observational Study in Han Chinese: assets-eu.rese...
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy: www.researchga...
Binswanger’s disease: www.stroke-man...
CADASIL: www.ecnp.eu/pr...
Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis: pubs.rsna.org/...
Case report: Susac syndrome-two ends of the spectrum, single center case reports and review of the literature: www.frontiersi...
Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a misdiagnosed disease entity: pmc.ncbi.nlm.n...
Multiple cerebral gliomas mimicking central nervous system inflammatory demyelinating diseases: pmc.ncbi.nlm.n....
Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS Syndrome): A Case Report and Literature Review: onlinelibrary....
Neuroradiologic manifestations of Erdheim-Chester disease: pmc.ncbi.nlm.n...
Open Access
A rare case of nonenhancing primary central nervous system lymphoma mimic multiple sclerosis: nsj.org.sa/con...
Severe myelopathy after denture cream use - Is copper deficiency or excess zinc the cause?: www.sciencedir...
Comment or ask questions below! I would be happy to answer!
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

[@suzanneknepp849]

I realize your target audience is comprised mostly of medical professionals but as a patient I find this type of video very informative. Thank you for sharing your knowledge.

[@DrBrandonBeaber]

I figure many people just want to know things even if it isn't directly applicable to their life. I am not usually thinking of a target audience when I make videos.

[@lararose9106]

Dr. Brandon i have MS and im currently having a severe sciatica attack. Im unable to take strong meds like lyrica because i already have chronic disabling vertigo. My blood work shows high WBC of 16..and CRP almost 10..the GP could not figure where the infection is from and i cant take steroids obviously. Do you thnk the infection is causing the leg pain to worsen? And the 2 counts unrelated? Im not sure if taking an antibiotic will help ease the pain but as a neuro what would you advise to stop the inflammation? Im bedboud and in a wheechair and because of positiinal vertigo as well unfortunately i cant switch positions in bed i have to always be upright

[@EvenSoItIsWell]

Geeking out with Dr. Beaber with my morning coffee. I love this kind of content. I am in so many MS groups online where many believe “lesions” in the brain or spine mean MS. I will definitely be sharing this video in them. Keep up the good work!

[@DrBrandonBeaber]

There are 10,000 other diseases not mentioned in the video, many of which I have never seen or heard of.

[@user-xk3lj3sc5p]

I've seen your MS mimics video in the past. These type videos are very informative as well as interesting. They are a great addition to have in my MS information folder for later too. I would love to see more videos on MS mimics, especially those that include symptoms related to severe, chronic GI conditions as one of the symptoms as well as symptoms similar to MS. Also, thank you for all the extra time you take to prepare these videos for us. You cannot imagine how helpful they are to us.

[@lesliex7894]

Hope you and your family, friends and patients are safe from the fires.

[@andrewreisinger6860]

Could you do a video on the use of psychedelics to treat MS? Specifically Ibogaine. There was a small open label study published d in the journal Nature in January of 2024 that had 30 Special Forces veterans with TBI participate in a Stanford study that looked at the effect of taking Ibogaine to treat depression and suicidality experienced by the veterans who were disabled due to TBI. This was small, open label study, but the results were tremendous. It has been theorized that due to observed neuroplasticity, it may be a potentially very effective treatment for those suffering from both Parkinson's and MS. There have been studies done on animals with EAE where very positive effects were observed. There are some few clinics both in Mexico and Canada that perform this treatment. There was an excellent interview done by Joe Rogan recently.

[@bmiller949]

Thank you Dr. B. My vocabulary has been expanded.

[@karentweed3504]

Interesting! Showing all the various MRI images helps understand why MRI isn’t absolute/conclusive in diagnosing MS rather a clue.

[@Roxy.T]

Thank you very much for the explanations, super informative video .

[@DrBrandonBeaber]

Thanks

[@orkhanzamanli]

Great overview! Thanks.

[@DrBrandonBeaber]

You're very welcome

[@mayfly1963]

Thank you for your videos. They're always so informative. I'm curious to know if you aware of instances where Systemic Sclerosis might cause neurological symptoms that could be misdiagnosed as Multiple Sclerosis.

[@MysticalDreamFire]

Thank you very much for this video!

[@Geneu97]

Trident sign should be called the Rebel Alliance sign lol

[@stupud818]

So do you know how long before we can get our hands on pipe-307?

[@sergeychalkov4]

Dr. Beaber, thank you for your insightful videos! I have a suggestion for a future topic. I recently started taking Saxenda to manage my weight (BMI 27 feels challenging, especially among slim and fit friends). Without a prescription, I obtained 10 pens through a friend in the field and have noticed a significant decrease in appetite, which I’m very happy about. I recently came across an article suggesting that drugs like liraglutide may suppress systemic inflammation. This made me wonder: could such medications have potential benefits for MS patients, particularly those with higher BMIs? I’d love to hear your thoughts on this!

[@zozefineee]

Hi, thank You for such a informative video! I have Mog diagnosis that now other doctors think is MS. I have lesions only in optic nerves and in medulla oblongata. Doctors says that medulla is typical for Ms. MOg tests in my country was without titre-just positive. Isn’t that lesion in medula is also typical for Mog? And aren’t so few lesions more like Mog not like MS? As far as I know usually Ms pantients have 10-15 lesions. Aquaporine is negative and I have 2 mild oligoclonal chains found in CFs. On Rituximab, got relapse shortly after full dose 1 g.

[@vlewis1602]

I only have lesions in my c-spine and t-spine. no brain lesions. I have been told that this is atypical. are there other diseases that would only have spinal lesions? Thanks

[@DrBrandonBeaber]

This is a typical in MS but not impossible.

[@brainangles]

Thanks for the video. Does Sjogren's present with the same type of lesions in the brain, optic nerves and spinal cord?

[@DrBrandonBeaber]

Yes. Sjogren syndrome can cause neurological manifestations including optic neuritis, transverse myelitis, and also neuronopathy (injury to the dorsal root ganglia).

[@MrMikk532]

I love whenever a video says its less likely to get MS if you're Asian. If asians are 1/10th less likely to get MS, as half Asian, maybe I'm 1/5th less likely 😂 Thanks for another great information video

[@DrBrandonBeaber]

I'm publishing a video specifically on Asians and MS very shortly.

[@MrMikk532]

@DrBrandonBeaber I haven't been on KZbin much recently so I didn't see your community post!!! This is exciting! I'll look forward to it

[@adrienchavatte]

for future video I'd like to have your point of view on Vidofludimus Calcium, As always your vidéo is very instructive.

[@DrBrandonBeaber]

Thanks for the suggestion.

[@dejv8581]

Dmts doesn t stop this process on first mri?

[@DrBrandonBeaber]

I'm not sure what you mean.

[@dejv8581]

do we see active changes in the ms video? do DMTs help to turn off this activity ?

[@DrBrandonBeaber]

@@dejv8581 Yes. The video shown demonstrates new/active lesions which should be suppressed with effective disease modifying therapy.

[@Rene-uz3eb]

So basically MS and neurocysticercosis are the only diseases that look the same on mri and are not rare?

[@DrBrandonBeaber]

Neurocysticercosis has unique features on medical imaging and is not typically mistaken for multiple sclerosis (there are rare exceptions to this).

[@Yaya-oe2qs]

What if the mri showed lessons that were smaller and diminishing?

[@DrBrandonBeaber]

There are many possibilities. I can't comment on your specific situation.

[@jamesroos8125]

What can you tell us about Bruton’s Tyrosine Kinase (BTK)

[@DrBrandonBeaber]

I have a video on this: kzbin.info/www/bejne/hn68oIOLlrJ0hrM

[@harrisonfnord5871]

CLIPPERS sounds like something right out of a House MD episode. And Erdheim-Chester IS right out of a House MD episode...

[@DrBrandonBeaber]

...but these are very real, and I have seen both of them in real life.

[@monirallahyari]

Dear doc I follow your videos, and I have a vital,crucial, important.........question, pleasssssssse tell when NVG291 comes to the markets pleassssssssssssssssssssssssse answer to this question,dear doc

[@joaodotcodes]

This might sound a bit arrogant (?) from me, but in the start of my journey with MS, when told I had it according to the McDonald criteria by the neurologist, I tried to put some other hypothesis, as a patient, like I don't know lupus and other diseases that crause brain lesions. She then asked me if I wanted to be 100% sure then they could do a brain biopsy. I thought to myself "hell no" and said no not needed :) hahaha Since then I did have some stuff like my right leg not working, which was fixed by steroids - which... confirmed that it prooobably is MS.

[@karlitabug]

Did you have CSF tested?

[@joaodotcodes]

@ i did! Through a lumbar puncture and it did indeed also added to the diagnosis of MS

[@FatmaSebei-b8b]

I am not interested in videos that do not constitute curative treatment schlerosis

[@Ennugia]

What the duck is that? Also, if you're not interested, don't watch.

[@MrMikk532]

Part of effective treatment is correct diagnosis and proper understanding of the disease. Not all videos are for everyone, but if you interact with the video like commenting as you did here, you'll get more similar videos. There is no cure currently, so there will not be a video describing a cure, and any other video that claims to should be looked at with great skepticism