Multiple Sclerosis is Becoming Milder [Data Presented by Neurologist]

[@AlexAlwaysWins]

I was diagnosed at 16. Next month il be 33. I’ve spent half my life with MS, my edss is a 3.5. I have over 20 lesions across the spine,brain and optic nerves. I also have three black holes that resemble a sad face :(. live a completely normal life and no one could even guess something is going on with me. When I think about it, MS has not stopped me from doing one thing I wanted to do. I realize this may not always be my case, that’s why I’m taking advantage now!

[@stonz42]

I've also spent half my life with MS. I had my first attack at 19, but wasn't diagnosed until 35. I'm now 38 and legally blind in the right eye with many lesions across my brain and spine, but my EDSS is very low, probably around 2. I continue to be as active as I can and share your feelings about taking advantage of life while I still can.

[@EvenSoItIsWell]

Thank you for some good news this morning. It is so encouraging to see that MS is becoming milder and we are living with less disability over time.

[@lesliex7894]

Agreed, need some good news now.

[@zoemcgonegal7734]

Double agreed

[@stonz42]

Nice to wake up to good news. 👍🏼 I’m hoping a cure is found in my lifetime.

[@aleien302]

Be patient and confident. We are so close!

[@1Kittywicked24]

Good morning to all . I hope everyone has a wonderful day , love and hugs to all ❤❤ You got this MS warriors ❤❤

[@stuwhite5597]

Nice vid, Dr. B! Likely multifactorial: wider appreciation - and adoption - of lifestyle changes + early diagnosis + meds in PwMS + neurologists, but also ? decreasing/altered antigenicity/cross-reactivity of EBV mutations over time (-> less 'lethal'/more prevalent)

[@laurarosanne]

Thank you for this good news. I just finished reading your book on resilience in the face of MS. Very interesting and inspirational! A video idea: the role of food/diet in the management of MS. Have a nice day!

[@aje120]

That *is* good news, Brandon! Thanks for making all these videos for us.

[@amym.5960]

Wow, that is great for the MS community (and future MSers) overall! I so wish it were true for me; I've had MS for a long time and it took a big turn for the worse/more disabled 3 years ago even though I've been on "more effective meds" in recent years. I accumulated more disability on Gilenya and Kesimpta than on anything else.

[@谢特妈惹法克]

I'm also using Kesimpta. For more than a year, I didn't feel any benefit to my health. I didn't see any signs of relief. I felt many side effects, and I doubted its effectiveness.

[@lauracarlson9260]

Today, of all days, we need good news ;-) I'll share with others. For years I've been waiting to see the impact of better MS understanding and treatment

[@MrKostitsyn746]

I love the way you present and explain information. I work business and try to model my presentation style after you. Thank you for all the work you put into these videos.

[@DrBrandonBeaber]

Thanks, though there are far superior video creators than me.

[@dominicheinz3255]

Maybe awareness plays a role. If I am aware that something not good is happening, I behave accordingly.

[@DrBrandonBeaber]

Yes awareness and more diagnosis of people with "milder" multiple sclerosis could be contributing to this.

[@Rene-uz3eb]

10:20 the placebo one says something changed in the environment, my guess is the smoking bans. Indeed smoking has been linked to higher risk of progression so there we go.

[@DrBrandonBeaber]

Smoking rates in women rose during much of the 20th century but have recently declined (since a peak around 1970), though the decline is much less dramatic than for men.

[@Rene-uz3eb]

Good point, which points to the effect being mostly from second hand smoke esp indoors. It's plausible because progression risk seems to be around 2.5x for smokers, so even second hand smoke could have substantial risk, and the smoking rate for ms in women is probably quite a bit lower than in general (having a chronic disease). Which reminds me, I was inundated with secondhand smoke in the period of my life when I had migraines. It's probably the large amounts of iron in tobacco smoke. MS research is recognizing the problem with iron. Iron in multiple sclerosis - Neuropathology, immunology, and real-world considerations, 2023

[@janeca10]

Tks Doctor, this approac is so important for Mental Health, because many Doctors focus on the worst case scenario and it is not always this way. New drugs along more knowledge on fitness and nutrition all together play a part. Tks for bringing this forward. ❤

[@Robin-me8fe]

Thank you , dear science .

[@DrBrandonBeaber]

Indeed

[@Melanie-uz9mi]

Thank you! Die research news is making me confused. One article says keto diet helping MS, then the next article talks about saturated fat being the culprit. They are complete opposite diets!

[@johndehosson]

Thanks Brandon, you always do great work! I enjoy all of your presentations with your super interesting methods of analysis, and great information delivery. My MS seems to behave slightly aggresively, so I'm happy residing in Sweden for the reason that policy is to tackle things full on from the start. Rituximab for the win at this stage, and a bunch of crossed fingers! Have an epic week, and thanks for another fanastic vid! /John

[@DrBrandonBeaber]

It does seem Sweden has been quicker to adopt early intensive therapy for multiple sclerosis compared to other countries, so hopefully this works out well for you.

[@scores718]

Becoming better??? Ppms 35+ yrs. Now 78f. Neurogenic bladder. IT COULDNT BE WORSE

[@tropicallyfit]

I agree!! These MS drugs are nonsense!! People need to learn about HSCT... earlier the better.

[@radnewiliw1330]

@@tropicallyfit did you do hsct ? If yes where ? And how is your condition post hsct ? please some info would be good

[@dnjmcdonald1506]

Thank you for posting this. I was diagnosed 15 years ago. With lesions across my brain and down my spine. I've spent the last 13 years trying to prove that I have MS. That's how little the disease has affected me

[@adrianc224]

I think like you say it’s been diagnosed more quickly giving a chance to change lifestyle with diet, exercise, and vitamin D, also the disease modifying therapies are getting better all the time giving us hope. With all the amazing science

[@ichabod13]

I think it is just more people being diagnosed like you mention. We have access to so much more healthcare now so 'Aunt Louise with her silly limp because she has a numb leg' does not go undiagnosed like it did years ago. I even have talked to many people on the reddit MS page who were diagnosed accidentally after a injury or random seizure event and have little to no lasting symptoms. This makes sense to see a slow increase in 'milder MS' as diagnosis is easier and happens sooner.

[@jameslewellen2715]

Where do conditions like ' blood clots and infections' come from so I can work on that? In reference to early mortality.

[@DrBrandonBeaber]

People with significant mobility problems have an increased risk of deep venous thrombosis and pulmonary embolism. Staying active can reduce the risk. Having good cardiovascular health, being judicious with the use of immunosuppressants, and getting appropriate vaccinations can reduce the risk of infections.

[@golub1marko]

I had covid 2 or 3 years ago when I was on Rebif and I am on vitamin D since first day and covid was exactly like this and I counted everything. In 10 days I coughed 7 times,without pneumonia,lungs were healty and clear,I had mild strenght lose( I don't know how to translate that word),fever just in first day 37,8 and change in smell of mayonnaise and just mayonnaise.

[@TotalRookie_LV]

Now - 8 years after first significant flare-up (middle of November 2016), my disability fluctuates during a day somewhere between 4.5 and 6.0 on EDSS scale. Sometimes might even be as low as 4.0 or as high as 6.5, if it's hot outside, I'm sick, tired or hungry. I'm carrying a fordable cane with me just in case and have already gotten a nice tax-paid wheelchair (at least we got universal healthcare here). So... Seems I might be on the slightly worse part of those stats, as I'm not even 50 yet, but I do need cane and walking more than 100-300 meters can be challenging.

[@JorisS-j4v]

I think the amount of MRI scans taken has also exploded the past decades and so the benign ms group is now in the statistics I think that’s the only reason. If you would look at absolute numbers of people with edss above 6 in total population it would be just the same I think

[@rosieposie9564]

I think I agree with you.

[@monicatheyeti]

Thank you for this video. Would love to see a video on thinking behind different trajectories/outcomes for men vs women. Is it because generally men take less better care of themselves or are there other thoughts of what drives disease progression differently in men vs women?

[@sivanmahadevan2458]

Thanks Doctor, good video, As you said it's getting milder but on average and individually it can differ. I have PPms and am on ocrevus and till now it's not mild but getting aggressive daily. Can't Walk more than 20 meters without support however still hopeful 😊

[@DrBrandonBeaber]

Yes of course it is not mild for everyone, and even people with less severe symptoms might take offense to referring to it as "mild."

[@josephvered3991]

Hi from Israel thanks for this video gives a hope?

[@jimsperlakis5634]

Bull Crap. Mine isn't milder today than 20yrs ago...

[@PlatinumRatio]

not milder just increasing in cases x 10 with many that would never be diagnosed with MS earlier, and now it still takes the whole 10 years of RR to become progressive to be diagnosed.. if you're men.

[@DrBrandonBeaber]

Yes. More/earlier diagnosis could contribute to this phenomenon as I mention near the end of the video.

[@sc78187]

You are what u eat.

[@phalabowles7942]

Go Vegan

[@IreneHowe-d5y]

Great news.

[@ericag2233]

Could global warming be acting as if we were all moving closer to the equator. For me, (Nova Scotia, Canada) my symptoms become troublesome in the winter and disappear in the summer.

[@ldjt6184]

Dr. Beaber, were you saying that the majority of women with multiple sclerosis are smokers? @14:00 I think that's what you were saying but I just want to be sure. Thank you!

[@matthewwilliams8475]

No, he said the majority of cases of MS are in women (as opposed to men). Smoking has fallen over the years in general but not necessarily amongst women, so that is possibly not the cause of the decline in MS.

[@matthewwilliams8475]

That is, the decline in MS severity.

[@DrBrandonBeaber]

No not the majority, but smoking rates are declining overall. Prior studies show a slight association between smoking and prognosis of MS (smoking being associated with worse disease)

[@dianefresca6896]

What about the PPMS. Tell me something good

[@GoGo717Entertainment]

Why aren't people with ms studying it and researching it

[@DrBrandonBeaber]

Some of them are.

[@simonthe.dealer7877]

Thanks

[@Roadwaymike]

Well obviously it’s getting milder because I have it now.

[@Mucozime]

i still have trouble ejaculating but i can walk and run like i used to.

[@PlatinumRatio]

... but milder where B cells are stopped. Probably more RR meds work than I know of. The studies show efficacy where I see cascading effects - coz I'm not proving something. There would be drugs bthat me, at PPMS would find appreciably effective. More effective than an wholistic and every adapting lifestyle / health protocols, well, nah...

[@RickeyBobby-x2e]

Cc: FYI/FYR: CC: FYI/FYR: November 12, 2024. Progress notes: The Rationale: Here, when I use Nicotine lozenges, they tend and do make me very dizzy, but if and were I to take Antivert, the dizziness symptoms, along with the benefits of my augmented Tincture, would likely work in the opposite way, ... in the same way, as to both Mitigate, Abate, and address the problem Dizziness, MS often causes; - all while adding the Clemestine in, say it's liquid form, (I've found some), ..to the Liquid Tincture, taken now 3 xs per day. I am now using.., " The regular and provided 1 ounce eyedroppesized eyedroppers that come [ in the 2 ounce bottles]. * I take 3 eyedropper squeezes; about a Third to a Quarter full when you squeeze for the liquid. I take it this way: I take: post 1.) Breakfast, 2.).Lunch, and lastly 3.) Dinnertime. All of this in order to address the MS typical symptoms caused by the microscopic, difficult to detect, that do hide inside red blood cells, that are obviously changing their pedestrian and normal red blood cell functions and behaviors; see book, Parasite Rex; ...eating /.feeding on the fatty and obviously Tasty and Preferred Protein lipids, that makeup the Meyelin Sheath, .... and I do believe, the new response; ordinary Clemestine, will now begin, - * to slowly begin 1.) rebuilding and 2.) regrowing the damage done previously to the obviously and rather delicate Meyelin Sheath. The goal: To Reverse neurological damage done by microscopic Parasitic Infection, and restore the subject person back to normal. ..*.. I think I will be adding the Clemestine, Antivert, and Neuriva soon, to the evolving Tincture for a [ Comprehensive Therapy Treatment ] . 👍❤❤❤❤

[@blackprotaco]

Blood clot?

[@justathought274]

are you talking about ms or rr ms?

[@DrBrandonBeaber]

All multiple sclerosis, though certainly the majority of people with low levels of disability have relapsing MS.

[@justathought274]

@ thank you for clarifying. Really helpful video. 🙏🏽

[@kod4486]

Another possibility is that more are following an MS diet as word gets out about them.

[@DrBrandonBeaber]

I would be skeptical of this as people with MS have higher rates of obesity and diabetes compared to prior generations.

[@KevinKrunch]

@@DrBrandonBeaberI swapped my diet to all organic plant based Whole Foods the second I discovered I had MS. I love everything you do, and would love to one day get to talk to you in person! I was JUST diagnosed and am terrified of taking DMTs. I’m very much a believer of wholistic medicines, but I’d love to talk to you about this if there’s a chance!

[@mballer]

What percentage might be fixed by a carnivore diet? kzbin.info/www/bejne/kJiUdqGmbZiceJY

[@hcm444]

A carnivore diet for MS? I have never heard of this. I know there are all sorts of diets. It's personal choice. I follow George Jelinek's diet.

[@joojoojeejee6058]

Vitamin D supplementation?

[@DrBrandonBeaber]

Possibly, but my opinion is the overall evidence for vitamin D supplementation in MS is quite weak.

[@ahmedfowad6882]

Yes you previously mentioned that Cochrane analysis failed to show efficacy. I think that analysis has limitations as dose used in that analysis was on lower side as compared with doses used in coimbra protocol. You may clarify my concepts​@@DrBrandonBeaber

[@DrBrandonBeaber]

@@ahmedfowad6882 Yes, those studies do not have anything to do with the coimbra protocol.

[@scores718]

You are kid