Musculoskeletal System | Neuromuscular Junction | Sliding Filament Theory: Part 3

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the neuromuscular junction and go into detail on the sliding filament theory. During part 3 of this series we talk about calcium's effect on the myofilaments, the cross bridge formation, and how that will affect the A bands, I bands, and Z discs. We also talk about the repolarization of the cell, and the movement of calcium back into the sarcoplasmic reticulum. We hope you enjoy this lecture and be sure to support us below!
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[@Pro0osh]

I think I will release some Ach into the synaptic cleft to open my ligand gated ion channels to allow Na+ to enter my fiber cells and cause my Ryanodine receptor to open my sarcoplasmic reticulum allowing Ca+ to release and bind to my Troponin- C which changes the shape of Troponin- T causing my tropomyosin to move away from the active site of my actin allowing my myosin to bind to my actin which pulls my thin filaments using power stroke to finally get over one another Which allows my palm and forearm muscles to contract in a way that moves my finger towards the like button and clicks it...

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[@888167]

Hey dude, thanks once again. I want to add one thing, that I thought was a bit misleading: The hydrolization of ATP moves Myosin to an "unconfortable position", since it's the position of high potential energy. Therefore you need energy to reach it. The powerstroke occurs because this Myosin is moving from the "uncomfortable position" to it's "comfortable position". After the stroke it's NOT in an unconfortable position, it's simply bound to Actin. The position after the stroke is the preferred position of the Myosin head. Then the detachment occurs just as you said and the cycle continues, as long as there is enough Calcium present to "unblock" the Actin-Binding-site

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Such a talented person he was born to be a teacher

[@choozomano977]

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Never stop doing what you do ❤

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Thank You Ninja Nerds Lectures!

[@Navneet1980]

I like your videos at the start of it Because ik they are legit the best one 🤷🏻‍♀️♥️

[@jigarthakker1880]

Amazing video, in 2 days I covered the structure of muscle to NMJ part 3 and I felt like, It’s worth it nearly 5 videos back to back This is so better then watching Netflix I feel.. Thank you soo much for being there.

[@aspired2be]

Dude if only my professor explained it like this.... thank you

[@jacobjamescabrera431]

God Bless you Doc! I find this topic to be particularly taxing since I don't have that much strong background in undergrad but now I totally got it!

[@traceyodonnell1988]

Currently getting me through Integrated Anatomy and Physiology. THANK YOU!!

[@peterm92]

I just became a member on your website! Can't wait to dig in !

[@albarraaabdulla3753]

Yo deserve more and more than thanks

[@janvichakra607]

how come you are so damn good at explaining! its so damn clear and its just prints in my brain!

[@wolfie5470]

These myosin heads are like: Ooooh man! :DDDDD Zach, you are the best !!!! Studying with you is BIG fun and I manage to concentrate the whole time. Wish you were my teacher :'( :(

[@riyanbabar8416]

Phenomenal lecture 👌 👏 🙌 Thank you so much ❤

[@Bryyo121]

Amazing Presentation

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Really excellent teaching I was literally stopped listening physiology classes in our after listening this classes 👏👏⚕

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Sweet Deal! Thank You Zach! Shout Out Rob and Kristen!

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This course is legen..wait for it DARY Legendary bro keep it up !!

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:D

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as always you end up hitting the nail right on point. concise and brilliant. thank you thank you soo much!!!!!!

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Amazing!

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Amazing mechanism and explanation

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Such an amazing way of teaching 👍👍👍👍

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You are an amazing teacher. I so appreciate you!

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Underrated video. Thank you very much!

[@hendheikal7101]

Thank you so much that helped me a lot to understand such complicated topic

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this man is a teaching god

[@Snowdep]

really mindblowing explaination.

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Bruh.. I really love your explanations.. ❤Tysm

[@arkanshsharma850]

Ninja nerd has certain red marks all over the body in his previous one i saw 2 in back of his neck and now one on the forearm in this video god bless him with long and healthy life

[@a30s]

zach murphy sir....best explanation!!

[@yanjnus]

Thank you so much for the fantastic lecture! I have a few questions, if you don't mind. First, how many sarcomere units are present in a single myofibril? I'm wondering because each sarcomere contains a thick filament, and if I were to cut a myofibril, how many thick filaments would I find in the cross section? Additionally, each myofiber contains many myofibrils. How are these myofibrils connected to each other within the myofiber? Finally, is each myofibril connected to the sarcolemma through dystrophin? If so, can the myofibrils in the center of the myofiber also reach the sarcolemma?

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you saved my life ughh I can't thank you enough

[@sharonnolen2154]

Very in depth, great teaching! Would love to hear why troponin is elevated in a cardiac event, or pulmonary embolism.

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You are the best 👌 👍

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Best teacher ever. Thank you!

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Really fantastic sir 😊

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before i see the video , i am sure that it will be great , thank you

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Legendary bro. NO words to say how much beautiful is it!. Its very much helpful in veterinary medicine.

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best A&P video on the web!!!

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I love u Zach ❤

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Loved the video ,great concept🤗🤗thank u very much sir

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next time please start a series on microbiology for medical students...:)...please ...so that we r gonna get benefitted ...:)...please my dear ninja nerd...thnx ..:)

[@blackyrocky7438]

That’s great video but you didn’t mention voltage gated sodium channel in the first lecture. You mentioned voltage gated calcium channel blast open when inside the cell becomes more positions due to influx of normal sodium channel

[@hihih29]

The mature nicotinic acetylcholine receptor at the postsynaptic (muscular) membrane is composed of 5 subunits (two α, and one each of β, δ, and ε subunits).

[@MarkBurghouwt]

How can the titin stretch and the I band decrease at the same time? Aren't they linked?

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[@jmc9597]

The nicotinic acetylcholine receptor is structurally alpha2, beta, *epsilon*, delta. Gamma is only present in infantile membranes and in denervation states

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this is amazing

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Thank you teacher

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I like your videos, keep up the great work 🩵

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awesome lecture, thank you :)

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Great. Marvellous.superb

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Best explanation ever! Gracias

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Great explanation

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Thank You

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Very nice explanation 💯 % accepted

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Best in the world. Love you.

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great explanations ever

[@waliullahnaderi7141]

Thanks for the video but Ihave got a question, hope you answer Q:The z disk is common between two actin filaments I mean that the actins are bound to the z disc from both side , now at the moment of the contraction both actins are trying to slide one another in both sides of z disc, then z disk is going to which actin filaments side

[@sarfrazahmed5333]

Can anyone plz explain

[@dr.muhammadkamran5847]

nice lecture

[@FrontierThesis]

19:30 - Muscle Contraction 34:57 - Sarcomere