NAC or Glutathione? They Aren't the Same

Wrongfully, many think by taking NAC, they are getting glutathione.
What they are getting is cysteine.
Cysteine is the KEY ingredient of Glutathione - but it is NOT glutathione.
Glutathione is made up of cysteine, glycine and glutamate.
In order to make glutathione from those components, magnesium, ATP and two healthy genes are required.
There are some individuals, such as myself, that do not make glutathione well.
Why?
A genetic mutation found in the GCLC gene, helps make glutathione, is not very functional. It's slow in making glutathione when the body needs it.
Where to buy NAC and Glutathione:
www.seekinghealth.com/collect...
Where to buy the StrateGene genetic test and pathways:
www.seekinghealth.com/collect...
Research:
pubmed.ncbi.nlm.nih.gov/28711...
pubmed.ncbi.nlm.nih.gov/22361...
clinicaltrials.gov/ct2/show/N...

[@nichole_1111]

That’s such a sad reality. That most of us are walking around with constant brain fog and not even aware of it.

[@jacquelineeng3575]

This explanation of making glutathione is amazing! I know someone who was told to take NAC by a doctor for brain health, but they experienced the opposite effect. They felt terribly irritable and also unwell. They tried twice to take NAC then said never again! They take glutathione successfully. Thank you Dr. Lynch. The more you teach us the more we can help each other!

[@PureExistence1]

I took NAC and all I did was make me super tired! Not exactly what I had planned on dealing with considering I was told it would be good to use before a workout..

[@kellyjohnson4836]

It’s comforting to know I’m not alone regarding this type of reaction. So many people praise NAC and I’m happy to hear it helps them, but it triggered anhedonia, exhaustion, and severe depression in me…been taking liposomal glutathione plus for a couple weeks now and I wish I started this sooner! Really thankful for people like Dr. Lynch. His advice and research have greatly improved my quality of life.

[@kr23777]

NAC helped me with Covid. When I start feeling a cold coming on, it knocks it out quickly. I wouldn't be without it.

[@TheRealRealOK]

@@kellyjohnson4836. What dose of NAC did you take?

[@lonewolf5969]

For much older people, i wouldn’t recommend NAC as its only a precursor, you would need to combine it with glutathione to actually supply the depleted amounts as you age, and NAC to help recycle it. Sometimes the amount precursors provide isn’t enough to actually supply the glutathione levels the body needs, specially for much older people or with low glutathione levels in the body already. its good to combine both as they function differently as NAC isn’t solely about being a glutathione precursor.

[@timelessfreedom1410]

Dr Lynch, you’re wondering about carnivore diet and iron. I’ve been carnivore for 14 months. Recent labs showed two scores out of range. Homocysteine 13.7, RDW 16.2. Everything else was in normal range. These scores are what led me to your work. I now have a StrateGene consult in two days with Chris Bramich. A few major gene mutations/variants do leap out me. As for the Glutathione cycle, I have GST family and GGT1. I’m confident that Chris can help me coordinate a plan to move forward with all of my SNPs. I’m profoundly grateful for your groundbreaking work!

[@mshvydka]

Thank God for this amazing doctor! You literally saved my health! Best wishes to you and your beautiful family!

[@rebekasilver1]

thank you so much for your fantastic content Dr Ben. You are amazing.

[@dinomiles7999]

Thank you , simplicity is king . ❤ Eyes mind heart and soul wide open. NO FEAR !

[@kathleentrinity7367]

This is the most thorough explanation for me on youtube.

[@DrBenLynch]

awesome - thank you

[@fibromyalgianational]

Taking liposomal glutathione was a game changer! I also don't make glutathione very well. Your videos and book on the topic helped so much. Thank you!

[@DrBenLynch]

Thanks for sharing!!

[@cherylwilliams4245]

Can I ask what you take it to help with?

[@MasterArmedforces]

@@DrBenLynch Im already taking liposomal glutathione, but I also want to help my cells produce it's own reduced-glutathione by taking glutamine, glycine, and cysteine supplementation. So, what's the best supplemental combination available to get these 3 aminos? Thanks

[@nsudatta-roy8154]

FYI! Liposomal glutathione cannot even enter the cell to produce endogenous glutathione. If your supplements cannot deliver cysteine directly into the cell, you're wasting your money, and practically none of the therapeutic benefits will never be fully realized, ie: intracellular detoxification, heavy metal chelation, or to even make those lymphocytes responsible for ensuring optimal immune response.

[@Padraigp]

Hmm I thought the reason people. Took nac was so they didn't overdose on glutathione which can't be eliminated but gets absorbed whether you need it or not whether your body wants to make it or not.

[@DebbieJoyCabanela]

Hi Dr. Ben! This is Debbie watching from Philippines! Hope to meet u in person 😊

[@katedimmernutritionandhypno]

Thanks. Very helpful

[@FrostyBud777]

Did this liquid just 5-10 drops, and man, i have less brain fog from the sibo die off than this morning. Thank you God for Dr Ben and all the naturopaths helping to heal us.

[@lonewolf5969]

You forgot sulforaphane as another precursor to glutathione and also detoxing

[@DrBenLynch]

yep - that's a great one

[@potluckcrow]

good to know thank you. Dr. Axe has some pretty good articles about NAC. This video is very informative

[@lyd6874]

Thank you !!!

[@maniac577]

Hi Ben. What is your thoughts on S acetyl glutathione? Supposedly The best form of supplememtal glutathione

[@noeldavis6346]

I love the taste , is this usual ?

[@dinomiles7999]

Thank you Dr. Lynch ❤. Please keep swinging . Our spices is in trouble . ❤ Eyes mind heart and soul wide open. NO FEAR ❤ Don't die .

[@walkworthy1541]

Thank you for breaking all these issues down so the ordinary "non-science" person can understand.

[@ralicewells4186]

I still don't understand.

[@jarooty2]

Do you offer any genetic testing based on 23 and me data? I saw the Stratagene product, but I really don't want to pay again or give my DNA again ;) LMK

[@eatpraylove59]

tell us about the yellow glasses Dr Ben

[@barbaras3206]

He may be reducing blue lights AFTER DUSK. Before dusk blue light is somewhat necessary. Reminds me of Easy Rider. Got a Captain America bike, doc? Sold for $1.5 million awhile back.

[@rdance3]

It seems to me that the Homocysteine issue should be looked at as a usage issue and not a supply issue. As prevalent as Methionine is in the human diet, it stands to reason that lower Homocysteine is likely due to an increased draw off they system.

[@versewriter8123]

Please could you tell us which SNP would tell us if there is an anomaly in the glutathione pathway?

[@dumuzidstore3126]

Would be possible to talk about Endometriosis, please?many thanks

[@joannemonavie]

Infection 6 years how bad

[@silviepaskova7311]

PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk.

[@GutsAndGall]

I just reviewed the sample report and reached out to the seeking health team and it appears GCLC results are no longer part of the report. :(

[@kelliebeck5872]

Thank you so much for all this valuable info! I was taking your glutathione but stopped when I got pregnant. (24 weeks pregnant now) Should I hold off until I’m done with pregnancy and breastfeeding? I have been reading that it can support my thyroid issues as well so I’d like to start taking it again as soon as possible. Thank you!

[@FrostyBud777]

would this help clear SIBO biofilms due to the mucolytic factor in theory? Chronic sibo, chronic mucus and many thigns dont work, makes me think of biofilm formation by Citrobacter Freundii and low glutathione.

[@rdance3]

Doesn't having a higher substrate to product ratio encourage specific enzymatic upregulation to promote a higher product count?

[@aaroneley2125]

new study: NAC with glycine as cofactors (see High Intensity Health podcast)

[@davidevans1420]

Dr. do you know where I can obtain a secret decoder ring. These videos are not for beginners, but I would say there is a lot of other information from other sites that glosses over nutrients, which is a big waste of time. Your videos get down to the Nitty Gritty. From now on, I won"t waste my time on the others. Thanks!

[@dinomiles7999]

How is it going for you today ?

[@lindav1189]

I have G6PD deficiency, severe, I am in chronic low-level hemolysis. Would taking NAC and or glutathione help me make reduced glutathione?

[@mariesundholm398]

Im a long hauler since 1,9years now and I wonder if you think that glutathione plus could help me out? My sympthoms are brain fog/tiredness/dizziness / aching and burning legs also pain in my feet:/ before I got sick I had two births and was breastfeeding them for totally 3years in a row! I think maybe my body is empty in glutathion and thats why may react on histamine food/ aldehydes etc But I couldnt order it from you to Sweden …

[@gailrocafort9112]

Dr Ben, can you take a blood test and test for all these necessary nutrients or minerals or vitamins, I have problems with detoxing, so I just had my labs done and my Vitamin B12 is super high , I was having incredible problems the last 2 months with every bone and joint was hurting and making all kinds of noises like crunching and cracking and it felt like my ribs were having subluxations .

[@DrBenLynch]

super high B12 doesn't mean that much without looking at other factors. It could mean you're taking a lot of B12, it could mean you're low in methyl folate, low in glutathione, high in oxidative stress, high in heavy metals, SIBO and others. Sounds like inflammation is hitting you for some reason - look for infections or environmental chemical exposures or both. Plus physical and mental stressors. Working with an integrative doctor is key here. There are many labs you can use - consider working with Dr. Bernarda Zenker via telemedicine.

[@michelesterr6048]

What do you suggest for someone battling mycotoxins in the blood? Is NAC or Glutathione better? Can too much NAC, PQQ or NADH+ cause increased ferritin in the blood? Thanks for responding to my questions!

[@PureExistence1]

@21:30 he begins to explain it..he says to supplement directly w glutathione if you have mold exposure..

[@coleramus561]

What about glutathione IM injections? Tempted to try the IV for my mold...I know what you said but I feel like I'm dying..

[@user-il1nx9bl9z]

Need both

[@rachelestabaya7581]

Dr Lynch can you expand on glutathione should not be taken if one has amalgam fillings. On your FB post people brought up that it moves the mercury to resettle in your body. I’m hesitant I take what I ordered Sunday now. I see you commented nonsense on people’s claims or links but can you expound on it please?

[@snowps1]

Oh no, I wish he had answered this.

[@ValerieZimmer]

How do you know if you have an infection or the presence of mold? Is there a best test for each?

[@blindandlearning9379]

Is L‘serine affected by the same enzyme?

[@vannamiller796]

Your glutathione pulled me out of a health hole. Thank you for that. Something I'm confused about is I tested homocysteine. It was low (makes sense why glutathione was so useful). But I also have the mthfr mutation. Should I stop taking my multi that has the methylated b vitamins?

[@pamelastgeorge4304]

If it mentholated I believe it’s ok But I’m not the dr

[@Padraigp]

​@@pamelastgeorge4304lol menthol is mint ...why would they mentholate b vitmins? 🤔

[@NYGuy2000]

​@@pamelastgeorge4304 You meant menstruated.

[@tendr247]

I take methylated b complex vitamins but not a multivitamin,

[@Padraigp]

@@tendr247 i keep mine in a cupboard.

[@g.s.5868]

you have some Seeking health products on Iherb... but not the liposomal glutathione ?

[@dinomiles7999]

What ?

[@WarIsOver-ifyouwantit]

Dr lynch, I listened to your talk with Dr. Holly Lucille, in which you have mentioned how taking Glutathione orally and letting it pass through the gut could induce\worsen SIBO. Is this a concern for someone not suffering from SIBO? I wish you could discuss how different forms of glutathione perform in that angel, for example s-acetyl l-glutathione or glutathione reduced? Also, you said the acetyl group detaches in the stomach, is there research pointing to that? if not, what makes you think that? I wonder what do you think happens further down the gut when you take something like s-acetyl l-glutathione orally? do you think it is being broken apart by the liver and then rebuilt from its building blocks? or do you think it is already broken down in the gut? or does it stay whole and gets to the bloodstream and broken in cell (another claim I heard). and do you think it might worsen SIBO? be really happy to hear you discuss this.

[@TheChefLady4JC]

Your comment has me intrigued. I'd love to hear Dr. Lynch's take on this.

[@dinomiles7999]

Did he e erer get back to you ?

[@WarIsOver-ifyouwantit]

@@dinomiles7999 no.

[@gratituderanch9406]

Can we still use the strategene test or only add the raw data from things like 23andme…

[@djcontech]

What about NACET?

[@ollymounara605]

My guess is that taking glutathione is preserving methylation because homocysteine is not broken down or less. So the methylation cycle is able to produce more energy.

[@wigglywrigglydoo]

Does glutathione help with cancer? Seeing that glutamate is part of glutathione. I want to recommend NAC or glutathione to a family member who has high risk tumor. But this stopped me and I can't find a more I depth reliable answers than maybe it'll worsen it or make it better.

[@jddavisism]

Ben's had a hair transplant?

[@peterbalazs5983]

I tryed NAC: The day after I took it I woke up with motavation, calmness amazing focus, it felt like it "cured" my lifelong ADHD. The next day I was barely able to leave my bed, felt depressed. It is very confusing: in one hand the benefits were amazing, but on the other hand that depressed feeling was scary. Anyone can explain what is going on?(I am probably having poor methylation. Didn't tested it yet but methyl B12 and folate calms my hyperactivity big time) Thank you !

[@Qqqq-gf9ow]

What are the GST/GPX rs codes on 23andMe. I bought your book but have never herd you mention how to actually see if you have the genes.

[@DrBenLynch]

I don't know the exact variants off hand. We do evaluate them with StrateGene if you like to see what variants you have - along with many others. www.seekinghealth.com/products/strategene-report

[@danielapineros5091]

Can you do a video about glutathione Vs nad ? Ty

[@DrBenLynch]

Apples and oranges - very different. What specifically are you looking for?

[@kenshey3912]

If you supply all the building blocks. Broad based amino acids. Glycine is another major precursor of glutathione production In my case… once I was consistently taking all the precursors… win win. For me

[@DrBenLynch]

perfect!

[@alvidrez7956]

Will we get all day relief from glutathione ?

[@ValerieZimmer]

What would cause sensitivity to glutathione?

[@dinomiles7999]

Brocomax radish with crused mustard seed . ❤.

[@theresacarroll6497]

OK, THANKS FOR INFO. IM NOT SURE OF MY MENTAL HEALTH TERM WAS MISDIGONISED STO TAKENING MEDICAL MEDICATION. IM GOING TO GET PRESCITION FOR LEGAL MARJANIA. I HAVE ORGANIC HERBS AND FOODS. I'LL GET SUPLIMENTS NEXT MONTH.

[@jeanetteschauerman908]

Does this correlate in any way with psychiatric theory that Schizophrenia is caused by too much dopamine in the brain?

[@zazenchuch]

How to lower your homocysteine levels ?

[@luvyou-baby]

what should we do if we need glutathione plus but we have mold in the environment and infection in the body that we can’t get rid off and heal from? also does PQQ help as well with mood neurotransmitters issues and toxic chemicals exposure the same way?

[@dinomiles7999]

Research pine . Yes pine oil . ❤ Eyes mind heart and soul wide open. NO FEAR ❤ !

[@gabrielgabriel8908]

Is it possible to book a consultation with you ? Paid off course ? Please let me know

[@DrBenLynch]

I'm not doing consults anymore. I will be making more videos though. I also have a book which is excellent for getting you on the right track - amzn.to/49oFcK3

[@bogrunberger]

My right ear felt left out! :(

[@DrBenLynch]

I think we're good now with stereo. Check my latest videos :)

[@sblb9852]

I have MTHFR mutation and homocysteine was at 14 (normal for conventional doctors), using homocysteine product, I've gotten it down to 8.5. Do I need to worry about glutathione levels or are they fine because I have high homocyteine? Should I confirm I don't have GCLC mutation also?

[@nsudatta-roy8154]

MTHFR presents an issue for making intracellular glutathione. NAC has a short half-life and therefore must be taken throughout the day. Cysteine must be deposited directly into the cell to make glutathione. Don't waste money on GMO glutathione. Yes! ALL manufactured glutathione is gmo. The science is NOT supportive of oral glutathione. There are more than 170K studies on glutathione, yo will not find one on oral glutathione or injectable glutathione that works.

[@awakenow711]

How do you know if you are one who CAN convert NAC to glutathione?

[@gnic1717]

Checking genes

[@Amor-Fati.]

I was looking for this very exact info. I take NAC, because I want my body to make its own Glu. However ,I know I need to activate it. The research I've done, has lede to believe, unnatural Glu can actually cause cancer.

[@jackics6540]

Where did you see it?.. about cancer. Point to research or sources?..

[@joemchenry6569]

Really nothing to do what what we're talking about glutathione or urolithin A what is the better for anti-aging trying to find this out on the internet but couldn't find it.

[@joannemonavie]

Hello🎉

[@4tun8nanette]

I want to do Stratagene testing. However, I want to know where and with whom are my data being shared?

[@sandywinterfield4240]

4tun8-Excellent question. As I want to test with Stratagene as it seems most complete. I would never go with 23and me as the owner is married to the Google guy. So you know they are sharing information. Who sees my data is my concern also. And what if he sells the company?

[@stephanieann1859]

Great question! I have thought about this too!

[@sandywinterfield4240]

@@barbaras3206 It’s much deeper than just China.

[@alvidrez7956]

Why does Nac dry me out ?

[@paulettestancil5986]

Is there a Glutathione topical or dermal patch

[@SLC429]

Livewave has one.

[@gloryshouse5198]

I need your Help. I just found you and I need to know if you can see my husband as a patient to give Him advice on what to take. They think he has a spot of cancer on a lung and we need to strengthen His immune system. Please let me know if you see clients.

[@dinomiles7999]

Hello, did he get back to you folks ? ❤

[@loriegreen8840]

So my dr told me to take nac 2x day because it's"good for me" & I've been very irritable & moody lately...but never made the connection - just know it's not typical for me. My glutathione was low on my last bloodwork, so I started glutathione & I'm switching over to your optimal one... should I stop talking the nac?

[@lonewolf5969]

NAC is an anti-oxidant its good to recycle the glutathione they have different functions. Having only one anti-oxidant isn’t benefitial.

[@willprice8696]

You wouldn't happen to be a Rh - Negative blood type?

[@micaonyx5301]

I'm rh negative, just wondering why did you ask that question ❓

[@hypnoticleslie]

I have not been able to have a fever over 100 in 8 years, after a horrible reaction to a booster (I'll never do that again, for me or my family). Early in the video, you mentioned not being able to have a fever if you're deficient in glutathione. I've spent years of my life with mediocre fever - often every day. What level of glutathione would you suggest I take to get a real 102, 104 fever?

[@sabahkhan2850]

My question too. Mine doesn’t exceed 99 on my sickest days. The last time I got a proper fever was 7 years ago with H1N1 flu. Stopped getting fevers after that. Two years ago I found out about my mold illness.

[@ralicewells4186]

I am old and I had 102.4 with covid and it was horrible. Believe me you do not want 102 fever.

[@samajosells]

Are you related to Dr Jim Lynch?

[@DrBenLynch]

nope

[@21nitya]

Is vitamin A bad ? I see in the chart how it negatively influences glutathione production

[@ralicewells4186]

I would sure like to know this as a friend with CFS said that we should take vitamin A.

[@gnic1717]

Too much vitamin A is bad

[@TS-iv9ml]

​@@gnic1717too much of any fat soluble vit is bad

[@tcook202]

I read that oral glutathione is destroyed in the stomach and is not absorbed.?

[@dinomiles7999]

Put it up your but . I'm NOt kidding . ❤ . Eyes mind heart and soul wide open. NO FEAR ! ❤

[@lenetteblackman6283]

Hi, I have many symptoms that point to low glutathione and My GI map results showed very low glutathione levels. I supplemented with L-glutathione from ortho molecular and it gave me really bad chest pain. I stopped and the side effect went away within 2 days. Would your glutathione plus likely give me the same side effect? Is there anything I can take to help my body tolerate the glutathione? NAC gives me terrible insomnia and its very stimulating for me. . Any help would be appreciated!

[@DrBenLynch]

Glutathione is touchy. I'll do a video on this soon. Couple things will help you tolerate glutathione better. 1) PQQ Lozenge. Why? Having healthy levels of oxidative stress before taking glutathione protects the glutathione from getting damaged. Damaged glutathione makes one have side effects. 2) Cofactors. Yes, the Plus version should be more tolerated and was designed for people experiencing side effects from glutathione. I highly recommend using Optimal Liposomal Glutathione Plus - and just a few drops to start - but only after you've been on PQQ Lozenge for a week. www.seekinghealth.com/products/optimal-liposomal-glutathione-plus-30-servings Glutathione is best used more frequently throughout the day in smaller amounts than higher amounts once. The bad chest pain likely came from high levels of hydrogen sulfide and sulfites. SulfiteX is helpful to process sulfites and thus support your healthy breathing. www.seekinghealth.com/products/sulfitex-600-servings Use SulfiteX Drops IF you experience the same chest tightness from the Optimal Liposomal Glutathione Plus. Do note though that this glutathione formulation has the molybdenum in it to support the hydrogen sulfide breakdown.

[@dannyc8851]

Why would you take NAC when you can just take glutathione once you find your optimal level personally ?

[@kimklampe3134]

Because it’s cheaper to buy much cheaper

[@sigaleyni1948]

Can toddlers take glutathione? If yes, which one and how much should they take? Thanks!

[@crissaxb]

I was adding the optimal liposomal glutathione plus to my smoothies and sharing sips with my 3 year old and he loved it! I have since stopped doing the smoothies after experiencing some of the “side effects” and after learning more from these videos but I have autoimmune stuff going on. My son was fine and his mood and Energy was improved. As far as dosing I use refer to Young’s rule. You can also look up Cowling’s rule. What helped me in deciding is realizing that the vitamins/supplements are naturally occurring as part of processes of the body. Of course you don’t want to over do it but start with one thing and notice the changes. Kids respond really quickly and can often tell you whether something is working by their behavior :)

[@gif24gt60]

What about injectable glutathione?😮

[@DrBenLynch]

I prefer regulating it personally vs an all at once amount. Plus the cost of injectable glutathione is very high - not to mention not pleasant and time consuming. I designed a glutathione lozenge which I take every day usually in the morning immediately upon waking. I take 1/2. www.seekinghealth.com/products/optimal-glutathione-plus-lozenges

[@nichole_1111]

I’m thinking I need a dump truck worth of Glutathione after bleaching and dying my hair for decades 🙄

[@luvyou-baby]

26:00

[@luvyou-baby]

24/2/23

[@LordViktor]

what is iv gluthatione ? intravenous ?

[@LT-mz5yc]

Yes 🙂

[@lraewintercorn1516]

If you add citric acid and it is corn based, so many people can not have this 😢

[@wigglywrigglydoo]

Why?

[@lraewintercorn1516]

@@wigglywrigglydoo I do iv’s, I stopped doing corn based iv vitamin c. So many people can not have corn because it caused high inflammation, raises blood sugar to very high levels. I have switched to non-corn. I also stopped giving glutathione in iv after several had side effects, probably due to the sulfur content or maybe they didn’t need it

[@TS-iv9ml]

​@@wigglywrigglydoocorn sensitivity/allergy and highly inflammatory

[@TheShumoby]

GlyNac

[@francescaelischer6177]

Why not just take ‘Continual G’? It’s scientifically proven to increase glutathione within cells.

[@joannemonavie]

16

[@micaonyx5301]

What is that

[@ethimself5064]

Selenium is known for increasing glutathione

[@DrBenLynch]

Selenium helps your body USE glutathione - not make it. Selenium is the cofactor for Glutathione Peroxidase enzyme which neutralizes hydrogen peroxide.

[@ethimself5064]

@@DrBenLynch Thanks for clarifying.

[@sgtaneja]

I love Ben Lynch !! Do take few seeking health supp incl P5P & niacin. Just like having supp. NAC does not guarantee intracellular GSH synthesis, likewise having supp. GSH does Not guarantee that 1) your cells will be able to efficiently absorb & utilize GSH 2) or this will boost your intracellular GSH levels endogenously I think Methionine is even better than NAC, if you take it with a methylated active B complex. This would give you the benefits of methionine, along with endogenous synthesis of cysteine & SAMe both of which are critically required. You cannot make cysteine endogenously without reasonable methionine intake!! Neither can you have healthy SAMe (universal methylator) levels without methionine !! I pair free form methionine with methylated B complex , and occasionally top up P5P. Further if you want to boost GSH synthesis, add free form Glycine (not NAC) to above regimen. Over the years, I've found Taurine far more therapeutic compared to NAC. Glycine & Taurine are unique & have immense non-protein functions (100s of then). And Taurine is also an antioxidant that assists GSH redox cycle just like vit C. Hence, my stack includes Methionine, Glycine, Taurine & methylated B complex without any NAC whatsoever. Note : For those who still want to have supplemental NAC - make sure you are also having B6, molybdenum, selenium, magnesium, B2 & Glycine along with NAC else you will develop "NAC intolerance" and would not get endogenous synthesis of GSH ! To me, endogenous SAMe, cysteine, taurine & GSH synthesis has following key modulators : 1. Methionine 2. P5P 3. Folate, B12 4. Glycine (Serine, TMG, Heme) 5. Molybdenum, Selenium 6. Magnesium, B2 7. Vit C (GSH redox) 8. Zinc, Copper (Heme, Iron)