Immunology in the skin

The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the skin sense and respond to infection or various barrier breaches to activate an immune response and eventually, return to homeostasis. However, deregulated immune responses can also cause skin disorders, such as psoriasis.
This Nature Video introduces the environment and key participants in skin immunity during steady-state and disease.
Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors.
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[@harshavardhan2162]

The quality of the work they have done from the point of research to the animation is mind blowing never seen such beautifully explained or animated video...

[@calebhaines3794]

It needs to have quantum detail.

[@hibiscusdandelionlove7804]

Hey our ancestors been on this!

[@warrenarnold]

@@calebhaines3794 bt am always confused when their videos say 'mature videos'💀 at the start😅

[@kedikidailiam9889]

@@calebhaines3794 8

[@interactive1178]

💯

[@sincityfire]

The music makes this so interesting, like I'm in a drama but for immunology

[@marioianniello5578]

There are many factors in reducing eczema at home . One resource I discovered which successfully combines these is the Takiras magic method (google it if you're interested) it's the no.1 plan that I've heard of. look at the super info.

[@viraligtrends7908]

Hey beautiful 🥰I've just created a new channel and uploaded a video on how to layer skincare like a pro? .. If u don't mind plz check it out 😊kzbin.info/www/bejne/fajOkHlnoqZ7bLM and don't take me wrong, I'm not self promoting.. It's jst cuz my channel is new so it's difficult for people to reach a new channel 😇 God bless u.. Thank u

[@mehtazmahzabin1943]

🤣🤣🤣🤣🤣🤣🤣

[@NightcorEDM]

Fun fact: If you go to Endia 🇮🇳 you'll see lots of dirty disgusting stinky slums

[@khandelwal_chilly]

@@NightcorEDM its India 🇮🇳

[@sumadhuchakrabarty193]

Thank you, Nature! Having a master degree on Microbiology, I still find it more effective than numerous ponderous textbooks.

[@imthecoolest50]

So do you recommend not reading textbooks? I don’t know which one I should study from, videos or reading textbooks. At the same time, I feel like if I referred to only videos, I might miss some details that are only in the textbook. Should I do both? But it’s not like a semester lasts that long, so much to study but so little time 😢

[@DB-gl3jx]

@@imthecoolest50 I would recommend watching videos first to get the general idea & a visual representation of how something works, as textbooks typically describe these topics in further detail. So both. :) I would also recommend reading some research articles as they can provide a different perspective that can not be explained in videos or textbooks. You can do it! The hardest part is staying motivated and being productive.

[@TopMusicChartsChannel]

do you have a phd tho?

[@rankawatsourbh8926]

150 pages sums up less then 8 minute speechless 🤐

[@Pjhchase]

Are you studying in med school?

[@concept_of_BiologyAS]

Ya you are right this is absolutely nice and wow ❤️☺️

[@saumitrashaligram4076]

Because this is a generalised video and doesnt have lot of details which might be present in those 150 pages.

[@concept_of_BiologyAS]

@@saumitrashaligram4076 some thing that is learn only conceptual not lot of..

[@saumitrashaligram4076]

@@concept_of_BiologyAS I apologise but I couldn't understand what you were trying to say. Can you please elaborate?

[@TheJoker9772]

Biomedical Science student here, from Brazil. It's kinda hopeless but also intriguing to study an immune disorder that you have yourself such as Psoarisis. Luckly, mine isn't that difficult to take care but it do has a stressful routine trying to maintain the inflammation at low knowing that is lifelong. After finishing the graduate degree, probably I'll focus on genetic research; but later, I'll try my best to come up with good results on the immune research/field specially on skin disorders to end this stressful and harsh condition that millions of people suffer off.

[@---jx4vh]

I wish you best. Btw there are researches about importance of vitamin D in psoriasis.

[@securelyincloud]

Did you do your research and found something about autoimmune like psoriasis

[@ossikossi1]

A bit more effective that sitting on a lecture

[@GuillermoValleCosmos]

yesyesyes

[@philidor9657]

Sadly you can’t get a degree in KZbin video watching :/

[@darrenmarchant1720]

this type of video needs to be put into the KZbin kids mix.

[@darrenmarchant1720]

@@philidor9657 a degree does not imply ability. a lack of a degree does not imply inability.

[@woofcaptain8212]

@@darrenmarchant1720 nope but a degree does suggest ability.

[@RamiElRefai]

This is one incredibly captivating and immersive video. The animations really brought out an entire dimension of life there.

[@whatrtheodds]

Yes

[@darrenmarchant1720]

this should be shown to young children while they are so receptive to foundational learning.

[@misovejasescuchanmivoz]

@@darrenmarchant1720 More incredible is the one who created everything perfect. Jesus.

[@npm1811]

@@misovejasescuchanmivoz sigh

[@misovejasescuchanmivoz]

@@npm1811 What?

[@ali09gaming58]

I did Masters and Bachelors in Molecular Biology and Drug Design and now when i look at this after 10 years from my graduation, now I realize how sophisticated all this is, its mind blowing, when I was in uni I did not think of it as much.

[@sayedelghairb8640]

Glory be to Allah 🙏🤲🏻❤️❤️❤️❤️❤️❤️❤️ Creator of everything

[@TopMusicChartsChannel]

drug design? contact me

[@ChristopherHarris]

That is some really beautiful science communication. Very well done.

[@whatrtheodds]

This seems to me as though my body is like some sort of planet and I'm watching another civilization. Very weird how all this is going on in me and you we have such basic awareness of it and just how detailed it actually is.

[@jsaggu23]

Crystal sikhism tells "what is in universe , That is in human ".

[@MGrey-qb5xz]

@Ancient Link yeah just keep digging yourself in to a deeper hole why don't yeah.Also watch your mouth,in an instant your entire body could fail you and then you will be crying no God could be this cruel like some ignorant buffoon.

[@joniarali4630]

ALLAH SUBHANA WATALA is the greatest owner of the universe read the Holi book (QURAN ) this is the book reveal all the matters of life cell and all science. All of the information about anything had been told by the messenger of ALLAH ( SUBHANA WATALA). Read the book and realized how true that is.

[@hemangvyas830]

In Indian granths book says already our body is also small model of brhamand means univers because human body and unviers made Up of 5 elements . But today's science knows only 3 matter solid liquid & gas but ancient rishis of India say 5..eliments are there .1 water..(jal) means liquid..2(vayu)means air gas 3(aakash) means sky or space it's related to blankness empty . 4(prithavi) means..🌍 earth Related to solids.. Substance & last is 5 (aagani) 🔥 mens fire. The all univers made by this 5 eliment 😏😏🤔🐳🐳🐳🐳🐳🐳☺☺

[@karlakarl3715]

@@joniarali4630 There is nothing about the cell in quran because mohammed didnt know about the cell. A university with only the quran would not get any nobel prizes :D

[@johndorian4074]

love how the cells move, frickin beautiful

[@abhishekshah11]

This was just the skin. Nature is truly beautiful

[@chrisvinu]

Thank you Nature for this video, WE WANT MORE!!

[@sakarregmi8784]

There are several factors in remedies for psoriasis. One plan I found which successfully combines these is the Myracs glear guide (google it if you're interested) it's the most helpful plan i've seen. Check out all the awesome info.

[@ibrahafishbagaskara2601]

Agree

[@omarborn]

Nature? How? Are you blind? There is an intelligent creator behind all this advanced mechanisms. Look in your self enough lies. Why you hate the truth?

[@taidanahito1862]

@@omarborn He meant the channel name calm down 😂

[@rudrapratap3294]

@@omarborn broooo😂😂😂

[@zack_120]

A stunning animation explains a divine defense system of Homo sapiens' body, very impressive in both science and art ! Thank you for sharing !

[@Slicerizerer]

The vocabulary needed to describe this complex organ is crazy, reflecting on a small scale the super genius designer behind all this. Glory to God!

[@broccolihart1]

The human body truly is amazing and a work of art.

[@ghostassassin2818]

All glory to god

[@ghostassassin2818]

PUMA 118 wrong all glory to god you heathen fuck

[@N0URii]

@@ghostassassin2818 chill, if you acting like that non religious people will hate religion just because of someone like you

[@daughterofzion14]

@@ghostassassin2818 exactly

[@daughterofzion14]

@@N0URii if you think science did this you are fucked.

[@momerathe]

this is a great video - I'd love to see more of these.

[@olivermfluni4973]

A layman who watches this will 1-2 times will understand this complex beautiful micro-world and its relevance better than a med school student who has read a textbook 10000 times. Bravo c'est magnifique!

[@am.Shub2770]

As a med school student, I find whatever you said absolutely ridiculous

[@jackyjack9660]

Whatever you say is ridiculous... Do you how they target cells? Or what is CDK? Why and how it originates and why it function in such way?... This is very basic video...

[@lidiajamal6365]

I've been having psoriasis since I was a child. It used to be very mild but now it evolved to be more severe for the past years. It's a pleasant surprise to hear how it actually works eventhough I only understand few points.

[@annadiciero]

I wish I had such detailed video when I was in University!

[@johnsontan345]

It's like there's an entire ecosystem of creatures living just under our skin, amazing.

[@christinamay6596]

What a beautiful made video. All-be-it a bit of a short film, it was incredibly informative. The #3DSkin #anatomy view threw the tissue was wonderfully represented. I can't wait to dive into your other videos.

[@Starbat88]

This is an incredible amount of information packed into 7.5 minutes...

[@goldentattoo9660]

This is such a BEAUTIFUL ANIMATION AND EXPLANATION, I LOVED IT.

[@lucasnakata7146]

Muito obrigado @nature video, vocês me ajudaram muito nas minhas provas aqui no Brasil.

[@pusatpendidikananak8252]

The world inside our body

[@honestabe1940]

Visual: the way all education should be! Good job.

[@GuidetteExpert]

This is amazing video on how you teach what actually is going on in our body!

[@Southernburrito]

Wow, that was amazing! Definitely worth a repeat viewing :) It's like cruising the cosmos.

[@shaikhfarhan340]

Such a wonderful explaination about immune system in form of animation i haven't seen ever!!! Great great salute to your hard work and skill in teaching.wonderfull ! keep making this type of videos 🙏

[@leinekuotsu4080]

The human body is just so complex and amazing!

[@ahamedimthikab5779]

I love Nature..awesome video

[@leeoconnor123]

great info, i would love to see more about the mast cells specifically in allergic reactions, cytokine storms but also how IgE reactions take place on the skin to the blood by touching an allergen. i am also interested in histamine reactions too.

[@emi432emi]

Did you find this??? Can you share

A picture worth a thousand words. With videos like this we can all keep up. Thank you for sharing!

[@arlenecrespo4316]

Well, done. It takes you inside the complexes of the immune system and the skin. I now have a better understanding of the skin immunology,

[@denisale1]

Amazing human body, very nice video

[@mariainesharris3719]

Thank you!!

[@MollyTequila]

Muito legal.

[@TritiumCupcakes]

These are all amazing, just discovering them, thank you nature

[@Tenorgeiger]

I couldn’t understand 50% of the words, but still found this fascinating!

[@user-um2uf9zq4c]

Such great quality. I wish my university was up to this standard.

[@mikaelfalk6720]

I love these videos so much. I only wish they were a couple of hours each and went into more detail

[@auxesis303]

Haha it seems uploaded today

[@OperationAllOut]

Body is a battlefield..

[@CarolineWirthle]

Really cool animations. Especially the T cells going in and out of the blood vessel, a bit creepy, but probably exactly what’s happening

[@user-nl8cw2sj8b]

perfect work thanks ALOT

[@el-hp1lj]

would love to see how the skin cancers develop and how the immune system failed to stop it

[@samanthagonah8243]

EXACTLY WHAT I NEEDED!!! Thank you :)

[@eloimumford5247]

30 trillions cells orchestrated by a genius : harmonie. Thanks for this magnifique vidéo.

[@ChaosAddiction]

Thank you masterful King of Nature

[@Nexus2Eden]

Yes Seriously...more of this please!

[@viraligtrends7908]

Hey beautiful 🥰I've just created a new channel and uploaded a video on how to layer skincare like a pro? .. If u don't mind plz check it out 😊kzbin.info/www/bejne/fajOkHlnoqZ7bLM and don't take me wrong, I'm not self promoting.. It's jst cuz my channel is new so it's difficult for people to reach a new channel 😇 God bless u.. Thank u

[@z4k4z]

That'll do for my fix of Kerri Smith talking some serious science. Mmmm, nice :) Now, to listen to the Nature podcast.

[@viraligtrends7908]

Hey beautiful 🥰I've just created a new channel and uploaded a video on how to layer skincare like a pro? .. If u don't mind plz check it out 😊kzbin.info/www/bejne/fajOkHlnoqZ7bLM and don't take me wrong, I'm not self promoting.. It's jst cuz my channel is new so it's difficult for people to reach a new channel 😇 God bless u.. Thank u

[@pharmaceuti]

It is absolutely necessary point of medical sciences

[@vijayakrishna07]

Great production of quality content.

[@cuishannon7850]

This Video is great, WE WANT MORE!!

[@lbcufal7323]

Wonderful!!! Please post more from immunology, thymus, lymphocytes, migration Thanks! (I don't think music is bad, i liked it... Gives emmotion to watching experience)

[@cristinatyler967]

have you ever tried Bovine Colostrum?

[@jyotikumari-vc4ep]

More of such videos would be very helpful

[@sameenathokan9980]

Thank you!

[@ankitmahato6986]

Support who don't understand anything

[@doomoftruth9953]

Wow god is great

[@burningcandle2098]

Even though I'm not going to remember everything you said here but after watching this video it makes me realize how far scientists have come through studying and technology.

[@sharooz1122]

And still not willing to accept these all are God's signs.

[@bastiatintheandes4958]

Great contribution to science outreach.

[@pradeepstha4735]

oh there are hell lot of a name to remember . But I liked the video

[@ripme6616]

I made it to 5 minutes 44 seconds ...now my skin is crawling like mad

[@chikaznze3414]

Right

[@giaselma9281]

Skin is the barrier against physical insults... i like that ~

[@brainstormingsharing1309]

Absolutely well done and definitely keep it up!!! 👍👍👍👍👍

[@tiagoveit3243]

I'm an Immunology lecturer from a public university in Brazil. I´ve added a Brazilian Portuguese translation to this and other Nature videos. Could you please publish them so that Portuguese speaking people could understand them? Thanks in advance.

[@misovejasescuchanmivoz]

nao eles nao podem, eles podem aprender falar ingles, seria otimo.

[@ismailmohd9790]

Really informative.. godbless u all putting lot of effort making such a superb video... I was feeling watching missing impossible 1 movie..

[@eunicemwicigi8104]

The way my heart just sinks when I see the credits...

[@shaimaasanhoop406]

Such a great info thank you 🙏🏻❤️

[@chrystinamurray8949]

This is amazing, first time I've seen this. You guys should try to make a visual of the skin/ mucous membranes and immune system trying to combat COVID. There are some weird connections I made. I think it would be amazing

[@arkitekscientific4536]

Thank you, Chrystina, we're working on it.

[@jakekarreofficial]

1:32 that looked like a worm going through my skin lol

[@PauloRLustosa]

Interessantíssimo, muito obrigado.

[@donross7820]

Great graphics! It is much more fun to learn when the graphics are this beautiful.

[@RVCCVR]

🤟Very cool❣️

[@auxesis303]

Hahaha meditate bro🥰💓🌌😬😭😭👌🤔😁😂💪😡🙏💪🙏

[@RVCCVR]

Bhumgu Brahma. ☺️I do🙏

[@FredSlocombe]

04:30 What happens in the case of Psoriasis, where over-production of cells in the epidermis occur?

[@leeoconnor123]

the dead skin cells don't shed, do they? and then there is a massive build up of dead skin cells upon dead skin cells that create a thick layer that crusts and breaks craters deep, such as bends in the elbows etc..but the new skin cells speed up in creation furthering the issue..?

[@rajeshkarmakar5923]

Very nice video and information

[@rahulpippal2426]

Really appreciate this video. Please make more informative video like this.

[@mohamedsameer3044]

Glory to The One Great Creator

[@petitio_principii]

I can't fathom how such a great video can have so much garbage in the comment section. Why aren't these people commenting on voodoo and astrology channels?

[@lilsmolcrow]

Some people are really weird and incoherent. This is scary

[@kathymyers7279]

Omgg fb. The thumbnail. ART!

[@DanieI1]

Es increíble como la célula inclusive sin vida tiene una función fundamental en el organismo como lo son los queratinocitos de la epidermis 😊

[@meriemhousni7449]

لا إله إلا الله محمد رسول الله يقول الله تعالي فاعلم أنه لا إله إلا الله قال الله تعالي (فإنهم لا يكذبنك ولكن الظالمين بآيات الله يجحدون ) (ثم قست قلوبكم من بعد ذلك فهي الحجارة أ و أشد قسوة.................)سورة البقرة قال الله تعالي (والله مخرج ما كنتم تكتمون.........)البقرة (لنجعلها تذكرة.........)

[@hadiaafzal1072]

SubhanAllah

[@heikg]

I couldn't agree more! But you have a typo, you used ... instead of a special symbol again.

[@misovejasescuchanmivoz]

@@heikg The bible was finished hundreds of years before coran so why do you believe on it?

[@heikg]

@@misovejasescuchanmivoz and the vedas are even older, so why don't you believe in them? Also I never said what I believe in

[@misovejasescuchanmivoz]

@@heikg c. 1500-1200 BCE (Rig Veda c. 1200-900 BCE (Yajur Veda, Sama Veda, Atharva Veda) Moses books already existed at that time

[@lilywong7661]

God’s creation is so amazing!👍👍👍🤩🤩🤩💖💖💖😄😄😄

[@Alicii._.]

Actually this really helps me as I'm studying Immunology rn in college Also this video quality is amazing to be 8 years old

[@Triknow-Acedemy]

Best ever video thanks alot

[@abubakrtarig2122]

سبحان الله

[@duvanviafara3547]

I don't know what are you saying, but I give you like 😅

[@ANONYMOUS-sx2np]

@@duvanviafara3547 he said " Subhan Allah

[@saraimtiazuddin]

It means Glory be to God

[@hadiaafzal1072]

SubhanAllah indeed

[@beezmanit2683]

Sry I don't speak noodles

[@RobinCawthorne]

How on earth do we know these things? I mean how are we seeing what's going on at such a minuscule level. I'm sorry if this seems like a naive question, I sincerely am asking.

[@agent475816]

microscopes

[@liamobrien4317]

+Robin Cawthorne and inserting 'Green fluorescent protein' into the DNA of particular cells so they light up and we can see what those cells are doing

[@GuillermoValleCosmos]

and lots of patience

[@lucasnakata7146]

lots of testing drugs on little rats, experiments, years of dedication to discover a single molecule, inserting isotopes in molecules to track them...and a fuck lot of patience i guess

[@pluvia13]

making such a video is fusing together so many aspects of science. structual biology, physiology, immunology.. thats the big puzzle science is made up of. you have to test and interpret your result so you can say: ".. well i am pretty sure it works like that. " :) the most important principle in science is not to proof, but trying to disproof your hypothesis. after all it needs great scientists to put together the bigger picture

[@theshezasfamily2524]

Thank you for your video

[@yogeshpanchal6311]

Beautifully consize the whole topic

[@Paulo-zr5zo]

*Video uploaded 2014 2014-2019:..... Wuhan Coronavirus:..... KZbin: It's time to get views old friend.

[@robinuchia7855]

alhamdulillah

[@LIAQUATALIKHANMEER-bz5ns]

Thank you very much

[@habtamutedila2974]

Really these is amazing and interesting video

[@ferdyz6029]

Ada yang nonton karena tugas sekolah?

[@timothyamadeus762]

sekolah mana ya

[@reginaldulysses2001]

sekolah mana yg kasi video bahasa inggris? susah ya sekolah nya:(

[@jackiechan3299]

And they say such an advance system came on its own smh

[@mpoweron]

Yeah, shallow thinkers.

[@jackiechan3299]

PUMA 118 when u nod your head yes but u wanna say no :/

[@jackiechan3299]

PUMA 118 I don’t know maybe u were the creators of yourselves

[@jackiechan3299]

PUMA 118 sum force beyond our imagination/God

[@jackiechan3299]

PUMA 118 u can’t even create a fly, why think of comparing yourself with God

[@riyakt8428]

Its so helpful to understand the concept very well.. Thank you

[@GlynWilliams1950]

Very Informative video.

[@ayumiallouch70]

Thank you Jesus for your amazing creation. I am in awe of the creator of the universe.

[@roidroid]

This animation was partially funded by Johnson & Johnson, a lot of the products they sell are profitable solely because of general public ignorance about biology, and their industry routinely purpetuates and encourages this public ignorance. Given the funding, i thus worry that this animation may not have scientific accuracy and public education as it's primary endevour. I know it's rude to bring it up, but i think you'll agree it's important. We've ALL seen the appalling misrepresentations cosmetics companies give in their advertisements, we are right to be wary. So, given the possible conflict of interest involved in the funding, can we please have some sort of editorial assurance regarding the accuracy of this video? And please include such editorial assurances in future videos that also have possible conflicts of interest with funding. Thankyou. This video was quite nice.

[@NatureVideoChannel]

Thank you for pointing out that we could be more clear about the provenance of our content; as always, Nature has full responsibility for all editorial content, including the Immunology in the Skin animation, and we will try to be more explicit about this.

[@gianlucadantonio7924]

+roidroid True that my friend But its especially evident now that the immune system plays a double edged sword effect with tissue repair and immunity on one hand with persistent pro inflammatory signals and lack of immune resolution on the other I think Johnson and Johnson is looking to aid current research while indirectly advertising their company name. Its good business modeling. It is true that many products are redundant and useless- especially when you look at the antimicrobial industry...kinda makes you suspicious

[@IHLWonk]

+roidroid It would help if you knew anything about Immunology, the accuracy is spot-on in this video, and in others.

[@lucasnakata7146]

it does have cientifical base, at least with my knowledge, and this video is helping me with my exams. If you are in this area of study you should that it is spot-on. This video is certainly not destinated to an ignorant general public.

[@roidroid]

+MMArtist141 +SpiderPig- Man i didn't say i saw any inaccuracies. I'm saying that the Johnson & Johnson company contains a COSMETICS products branch which makes ridiculous non-scientific claims about it's cosmetic products, this taints the overall J&J company name, and thus warrants extra editorial assurances for anything associating itself with that name. ie: does this animation come from the company's ridiculous cosmetics branch, or from it's trustworthy medical branch? It's a very important distinction.

[@blancosanmartin]

Speechless I am.

[@wilkensbrito2879]

Holy Moly! We went from Atari to PS5! Excellent video and Explanation! Thank you for the better understanding.