Neurobiologic Insights into Major Depressive Disorder: Emerging Therapies with Novel MOAs

Earn CME for related activities: hmpeducation.com/
With a focus on emerging therapies with novel mechanisms of action, this on-demand webcast features a presentation by Dr. Michael E. Thase examining how these novel pharmacotherapies may expand options for evidence-based management of major depressive disorder (MDD).

[@glassangel0000]

Ive been diagnosed with major depression since I was 12 years old. Im 40 now and it doesnt get easier. What is weird is that my feelings are numb but my body is tired. Im just a shell of myself and dead inside.

[@onetwothree3578]

That's so tough! Big hugs 💖

[@damion298]

Same

[@dJOH445-33]

Decades or time can pass where the brain just can’t comprehend nor process - it will function enough to sustain, but the physical pain on top of injuries and pain diseases makes living with this and pain the most hellish Disorders on the planet. We look normal on the outside but we are in pure agony… it’s a crap shoot - I do pray science communicates diligently to doctors when things they test work! Ptsd is awful as well

[@MightyMick88]

I have lived with major depression for over 20 years, everyday is a struggle, I have knocked on deaths door a few times im tired I've had enough but for whatever reason I push on.

[@theadance7282]

I can so relate to how you feel!!

[@damion298]

I can relate my kids keep me going

[@lsoonontop8499]

Idk if I’m depressed but I feel like I just can’t be happy and I just wake up and put my mind off things and try and take away the voice inside my head and the things that tells me no one loves me

[@pophangtime88]

That hit home😪

[@apparently2]

That sounds like depression to me, my friend.

[@Purpleshade29]

To depressed to live while to scared to die

[@kreep182]

No no no. Its to live and die at the same time.

[@Purpleshade29]

Stfu

[@rodhonelynbuendia1800]

I'm not scared to die i just don't know how to suicide

[@Youcandrinkcoffee]

You nailed it

[@cliffkonkle3467]

EXACTLY

[@DanielSRosehill]

Excellent presentation!

[@moka_dotz2857]

I feel so low in life and when I smile I don’t feel anything I just smile I don’t feel it I don’t feel happy I feel nothing I feel pain I can’t ask for help or else I might be called attention seeker or I’m just faking it but it’s been. Almost 2 months and I’m getting worse I’ve bee having fantasies about killing my self and how I’ll be free if I do kill my self my mom and dad already have enough problems I don’t wanna add to it plus they already ignored me

[@davidparkinson6372]

Your never an attention seeker I hate when people say that I have scars from cutting they didn't get there by asking for attention I do the same fake smile to please everyone they don't see what's in my head I know your not faking it because I feel the same way you do family are the worst that's why I don't talk how I'm feeling to them talk to me anytime and when your having them thouts I'll always be here for you💕

[@platiquebarbie]

Nezuko Kamado same.

[@user-jl1sb4jm8g]

I hate myself a lot, I never want to do things I love , I distance myself from people, I sleep all day, I feel lonely and sad. Is that depression? It sounds dumb I know

[@mosspea]

Peep :9 Yes, it sounds you have depression. I know this also sounds dumb, but you’re not alone. I experience the same symptoms and it sucks, but it’s worth trying to feel better. Wishing the best for you.

[@jhoannrabadon1300]

Yes.

[@sunset33533]

The book "30 Days to Reduce Depression" by Harper Daniels uses a mindfulness approach. Share it! It can really help someone. Mindfulness is like a personal trainer for the mind.

[@MrYareyare]

I hate those people who dont have depression acting like they have it

[@lennybarowski3676]

How do u spot them?

[@BambiOnIce19]

i don't know if i want to do cognitive neuroscience as my post grad, or abnormal psych.. so fascinating.

[@theresekirkpatrick3337]

The largest contributor to mental health is lack of parenting and diet. Dairy is a huge contribution im allergic to dairy casein to be specific and i was moody, short tempered, sad, anxious just felt awful. Quit it for a year. Added back in here and there as it’s difficult to avoid eating out. Ive found plant-based alternatives that don’t affect my moods. Take 0 medications for it anymore and i was on benzodiazepines and two heavy anti psychotics and sleep meds at 48 was taking an Obscene amount of prescriptions I fired all of those doctors I didn’t have any of those mood disorders if they would’ve looked at my diet also majority of the children that are on ADD 80 HD and other mood drugs as kids because I can’t sit still and act out there eating lucky charms for breakfast which is full of red dye number 40 and I’ll kinds of other poisonous crap and they push it off as part of a nutritious breakfast. Should he criminal. Eat real food avoid fast food like the big md it’s poison. Grow your own food in containers if thats all you can do. Prices aren’t going down in price anytime soon.

[@woolfy02]

I have had TRD for a long time and possibly, some for of Bipolar. Not sure exactly what form the bipolar is but, seems like "SSRI induced bipolar". (Don't have obvious manic/hypomanic problems when not on medications) Have mentioned the symptoms many times but Psych doctors have refused to try me on A SSRI + Mood stabilizer when there is obviously something going on. Since telling the truth doesn't seem to work, Feels like I'm going to have to lie just to be treated the correct way. Just wish psychiatrists were more open minded about just 'Trying' a medication if a bipolar diagnosis isn't 100% clear. Sick of feeling like crap allll the time.

[@TURK_182]

Have you tried micro dosing psyclobin?

[@carrietoponce-moore2698]

T U R K - 1 8 2 See a Psychiatrist with a background in Neurology! I found mine in an office that offers TMS aka Transcranial Magnetic Stimulation. She offered me a Gene Test from GenoMind. You know what I discovered? I’d been prescribed the wrong Class of Antidepressants for thirty years!! My body can’t metabolize the one I’ve been taking. I’m now on a SNRI and two critical supplements, Methylfolate 15 mg once a day, and two Ace-L-Carnitine 500 mg. capsules once a day that are completely depleted in people with TRMD, and am feeling better, but am still pursuing TMS Treatments next month which my Medical Insurance is covering. This is the latest cutting edge treatment for TRMD. Good luck!

[@BrazilcarnivalSamba]

GO FOR MAOIS

[@FROFilmsIRE]

It makes me angry that this wonder drug Ketamine has been hidden from depressed people who need it for 50 years, certainly here in Ireland. I want to campaign to have it replace the useless SRis we are stuffed with instead.

[@trexbattle]

I do mdma and psylocivin

[@dJOH445-33]

Do you make your work known to ALL through targeted prescribers currently?

[@prosperouseye]

Routinely do not sleep well at night and wake up feeling depressed. Ate 2 hamburgers and a banana right before bed last night. Slept better and woke up feeling amazingly better. More energy, more eager to get up and virtually no depressed feeling. Any clue as to why?

[@bobsnittle3793]

Improper nutrition can fuck with your sleep and mood which will worsen depression. Eat a whole foods balanced, and exercise regularly.

[@TheOn3LeftBehind]

At the basic level, eating those is a combination of protein, carbs, and potassium. Potassium is used to help people with restless leg syndrome and leg cramping at bed time. Carbs increase mood naturally, and protein provides energy. Providing energy and nutrients leads to better function of the brain. Also, if you have GI issues with a lot of looser stools, potassium helps there as well. If you’re low on potassium, because potassium is used to regulate the sodium-potassium pump, your body tries to contain it, resulting in containment of more sodium. The sodium-potassium pump is how neurons communicate with one another at the basic biochemistry level.

[@PyonDude]

some of depression can be just a symptom of synucleinopathies. both are very resembe from point view of supplements. depression is just early an non-movement symptom of synucleinopathies.

[@FoxinTaiwan]

Do you have any references for that?

[@thomassilvestreotero9059]

WELL MY DIASNOSTIC ARE DEPRETION ANSAITY BIPOLARRITY AND ISSUES TO SLEEP AND IN MASSACHUSETT THE DMH AND THE ELDER SERVICES IN WORCESTER MA BOTH PLANT TO PUT ME IN ONE MENTAL HOSPITAL THE SAME MOBILE RESPITE IS OTHER SERVICE IN THIS AREA

[@satanfather5406]

I'm cri

[@zandilendzungu3906]

Interestingly, talking to someone will be your first move to freeeedom, enjoy the journey, He will never leave nor forsake and judge you

[@sivasankarnallapati]

Ok

[@barbaramatthews4735]

Isn't Ketamine the "date rape drug?" Is it also used as an animal tranquilizer for dogs and cats? What about addiction like opioids?

[@barbaramatthews4735]

@560172 thank you for the clarification

[@barbaramatthews4735]

@UwowU thank you for the clarification

[@nickjamesb2051]

10:30 you said it, doc. Get the rodent out of that circumstance... but lets not talk about that. Lets talk about the drug you made that you want to sell me.

[@ponygirlusa]

That just made me SICK. Those greedy, miserable f*c ks torturing animals so they can then give them drugs till they find the one that works. I refuse to take the meds. And people like him are exactly why life isn't worth anything. This guy just reaffirmed for me what continues to be the truth about humanity.

[@unitys1]

Spiritual emptiness! Connect to the spirit of life, there is a river flowing just there inside each one of us.

[@filipmitrovic4103]

You have a manual for that smart guy?