What is Kratom? A Pharmacologist's Perspective

Kratom use is widespread in the United States, as it is available as a herbal supplement. In this video, I will give pharmacologists perspective of what it is and what kind of effects it produces, while briefly discussing the pharmacology of mitragynine/7-hydroxymitragynine.
I'd be happy to hear your thoughts on kratom and continue the discussion down below in the comments section.
For more in-depth videos related to neuropharmacology, subscribe to my channel!
IG: @neuropharmacist
Twitter: @samuelkohtala
www.neuropharmacist.com
References:
Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
D A Todd, J J Kellogg, E D Wallace, M Khin, L Flores-Bocanegra, R S Tanna, S McIntosh, H A Raja, T N Graf, S E Hemby, M F Paine, N H Oberlies, N B Cech
PMID: 33154449 DOI: 10.1038/s41598-020-76119-w
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias
Graciela Pineyro, Karim Nagi
PMID: 33383156 DOI: 10.1016/j.cellsig.2020.109906
Kratom Use and Toxicities in the United States
William Eggleston , Robert Stoppacher, Kyle Suen, Jeanna M Marraffa, Lewis S Nelson
PMID: 31099038 DOI: 10.1002/phar.2280
#kratom #whatiskratom

[@Neuropharmacist]

1k subs broken! Thank you so much for watching and subbing! Gives me great motivation to keep on pushing new stuff!

[@LouiesLog]

Congrats on 1k! :)

[@Neuropharmacist]

@@LouiesLog Thank you! Reaching 1k was my goal when I started, can't believe we're there already!

[@Guidus125]

​@@Neuropharmacist My degree was in neuropharmacology and I've been wondering for a while why there weren't any neuropharm youtubers out there. Your videos are great and these topics are definitely gaining more attention from the general public, so I think there's real potential to grow this! (especially cause you have sort of first-mover advantage)

[@Neuropharmacist]

@@Guidus125 Nice! Thanks for the feedback. This is just a new hobby for me, but I must admit I've been very happy with the numbers, really motivates to continue making more content!

[@genericx2347]

can corydalis extract really mitigate morphine withdrawl?

[@bobapruginic]

10 years on heroin 7 on subotex hell in life, 6 months I use kratom red type 4 times 5 grams each, I'm living life to the fullest again with my children and wife greetings from Serbia

[@josephfarrier3978]

Same i wish i would of found it years ago...im from southdakota usa did prison for pills ect..... im 37 i just found it a year ago when i was desperate comming off meth n booze.... i never did another drug or drank a drop since i love it

[@Ned88Man]

All the best to you. Is it fully legal in Serbia? if so, I hope it remains so

[@coreymonday1375]

Same 10 years of hell then found kratom

[@CreatorsExpress]

Kratom will also be hell. Get off before it’s too late. Unless you can do it responsibly. But eventually you need more and more

[@Ned88Man]

@@CreatorsExpress some people are able to be responsible. Don't blame the drug because you take way too much and have an issue.

[@sarahshanahan2222]

I take kratom to help me manage my chronic pain. It helps so much to live my life. I can cook... clean... play with my children.. and work. I make sure I take tolerance breaks

[@jarredmarques9660]

tolerance breaks are a great way to refresh. As someone who takes it for depression, I find myself needing to take two day breaks from it to reset. with my bi polar depression it comes every-time I get bored of the mundane. By taking breaks from Kratom it allows me to appreciate life without sweating the fact i rely on a plant to get by. it gives me time to evaluate my self and after my break ends I am always much more enthusiastic and glad to have access. its the one plant besides marijuana that allows for me to be content with life no matter how good or bad.

[@moonlightreveries1459]

Are you concerned of any liver damage? How do I get over the fear of trying it/ getting “addicted to it” (I’m quite confident and don’t get addicted to anything and I’ve tried most hard drugs. Quit tobacco use of 14 years on a whim, like it was nothing. I’m strong mentally) :) Thanks any advice will help 😊

[@TheFruitingChamber]

@@moonlightreveries1459 addiction is all in the mind. If you have an addictive personality, you might get hooked on the stuff but if you can tell yourself you don’t need it then you’ll be fine I can take it two or three days in a row and then take two or three day break before I go back to it I would stop completely if I didn’t have back pain and depression whenever I have weed I don’t touch the stuff but as soon as I run out I dose kratom 4-5g to alleviate the stress of being out of weed it’s not addictive in my opinion, but everyone’s dif more then 5g u can get nauseous but it will feel more like a opiode

[@corneliusthecrowtamer1937]

@@TheFruitingChamber It's not all in the mind, chemical dependency is real and kratom can cause withdrawals and side-effects that are indeed dangerous to your health.

[@ricosuavey4930]

If you can take breaks of a few days a time you'll find kratom to be as successful if not more than any pharmacy ducal product made. But if it gets to a daily use multiple times a day it's trouble. Bad trouble.

[@Tuxedosandhandgrenades]

I am a decade long kratom user, I started taking it to kick a Vicodin habit, which works wonders, that being said in high dose long term use (I take about 35g daily, 7g 5 times daily) it has the exact same withdrawal symptoms, not nearly as intense but very similar in symptoms such as constant yawning, runny nose, sneezing, foggy thinking, restless legs and severe lethargy. Let me reiterate, the symptoms are not as intense as opiates but very similar in effects, kratom is definitely a life saver when it comes to kicking opiates of any kind but it is definitely a double edged sword because if left unchecked kratom abuse and addiction is a very real thing especially in long term high dose use so be careful because exchanging one addiction for another is a definite possibility with kratom if you're not careful.

[@linagarcia4822]

Hello I’ve been taking for about 3 years and I was wondering if I could talk to you about your use and share some of my concerns and questions

[@Tuxedosandhandgrenades]

@@linagarcia4822 sure, what's on your mind?

[@greenmanalishi6086]

yeah 35 grams a day ?? Is a STUPID high dose ... it's like drinking a Fifth of Vodka per day... Gallon of Coffee a day ? just dumb. 😏

[@Tuxedosandhandgrenades]

@@greenmanalishi6086 u would be surprised how easily a habit gets out of control when your missing your left foot and work 70hrs a week to support a wife and 4 children, don't judge unless u been there buddy!

[@linagarcia4822]

@@Tuxedosandhandgrenades exactly

[@jarredmarques9660]

i subscribed because of your unbiased opinion on the matter. you really looked at both sides thoroughly and represented both sides equally. Great work this is what were missing in the world.

[@Neuropharmacist]

Thanks! Appreciate it :)

[@The88Cheat]

Same-sees

[@bekeneel]

Indeed, that's what I like too, cuz if you search on google it's pathetic some things they are suggesting.. I think I should be dead by now if all those things were true 😂😂 lol. It's just typical, how they can't look at the substance objectively, cuz it's unknown or new. I've personally felt that kratom has lots of medical & therapeutical potential.. Imo it is a wonderdrug, which doesn't mean that it doesn't have "side effects" tho and that it can still be dangerous if you don't use it wisely.

[@eddiemedusa1]

I have taken lots of kratom daily for years and I have no problem with it. But quitting is no fun. I feel really bad for like 10 days, but that is it.

[@Dothwa]

Do you taper off of it slowly? Or do you go cold turkey? I tried quitting and had the worst night of my life, I couldn’t get to sleep and my legs wouldn’t stop feeling restless.

[@devilslettucehorticultural5292]

Getting off opiods is difficult without psilocybin mushrooms or some other psychedelics to help with the withdrawal. However if you're dealing with someone who's trying to get off heroin or Suboxone, Kratom could be the safe herb that keeps them from using and knocks out there withdrawal symptoms long enough to get some peace. Anybody who's ever gotten off any drug knows that it's not fun to stop taking a substance but Kratom could be a huge factor in helping people off opioids.

[@Man-u-flex]

Yea that sounds like a withdrawal problem lol

[@mattweber5242]

Ive taken handfuls of the shit and nothing.

[@mattweber5242]

I'm not bragging either. I have had a few back surgeries and was in a lot of pain and thought I could try Kratom and it didn't help one bit. I was very disappointed as others have had great experiences.

[@OuterHeaven210]

I fricked up my brain chemistry with heroin. Kratom helps me do stuff like play with my daughter and go to work.

[@maxturner653]

Same my brain is literally fried from fentany I'm only 5 days clean and kratom helping stabilize it I can just feel it

[@OuterHeaven210]

@Max Turner yuh. It's literally a gift from God. I take 8g of white indo twice daily. Pretty much as maintenance for me. I'd rather eat a bunch of leaves than a real deal chemical like suboxone or methadone.

[@Ned88Man]

@@OuterHeaven210 yup. Plus its been used for centuries in Southeast Asia.

[@catbakkorrel]

From personal experience: it can be pretty addictive and if you're prone to addiction think twice if and how you use it.

[@jarredmarques9660]

im an addict an i can say your statement is true! I have a love hate relationship with Kratom. But being an ex opioid addict i can say its was like a cake walk sobering up from kratom compared to the heavy opioids I was on after surgery.

[@thehandliesthandle]

i have been addicted to a few different things in the past. the difference between kratom and drugs of abuse like for example amphetamine or morphine or alcohol, is that kratom cannot really be used recreationally, since higher doses feel bad, and lower doses feel good, and kratom is not a lethal drug, but people need to know they cant just stop using it suddenly. i even tapered and had pretty bad withdrawl from only 6 grams a day. i thought i could suddenly stop 6 grams a day. apparently not, but i found it quite easy to quit using something like 3 grams a day. at 3 grams a day it was comparable to caffeine withdrawl. i cannot promote the use of kratom with a clear conscience without also warning about withdrawl every time i claim that kratom is good for pain or depression or anxiety and is safer than most pharmaceuticals. thats all true but so are the negative aspects

[@catbakkorrel]

@@jarredmarques9660 I do feel pretty bad withdrawals from it, I pushed it too much and use it as an alternative to overeating. I don't wanna find out how much worse the addiction is with real opiates, atleast I don't have to deal with that :)

[@Jacob_Overby]

WITHDRAWALS ARE A BITCH

[@nightone9720]

Yes. I am currently addicted to Kratom. I have went through withdrawal twice now. And I have relapsed both times. Very difficult to completely quit. I suppose it's due to the fact that I have an addictive personality. My family deals with addiction and i believe the addiction potential is very high in my family line. Quite sad. Although I do think I have the strength to quit. I just haven't found that strength yet. Maybe I have the strength but just haven't held myself accountable. I hope everyone is having a great day.

[@kellythesequel]

This is just what I need for a presentation in my Pharmacology of Psychoactive Drugs class! Thank you for breaking down the two main alkaloids and their interaction with the mu-, delta- and kappa- receptors. I feel like I have a better understanding beyond trying to decipher studies.

[@Shadow-bouncer]

What would you suggest for someone who has the opposite effect of sleeping medicine and antihistamine

[@aeon--]

Thorough video, wasn't aware that metabolism likely played such a large role in the subjective effects of kratom. Learned a bunch of new things. Thanks! I'm looking forward to seeing more research on it - I hope kratom can prove valuable for the development of better pain medications.

[@kirbyroad7222]

Prescribed Hydrocodone for the past 18 years. Im finding that kratom relieves my constant pain much better and lasts longer than the opiates. I take 2 capsulesin the morning and I'm absolutely pain free for 6 hours of construction work. Before kratom I took 2 hydrocodone pills a day one in the morning and one in the afternoon. The kratom has so far been much better at pain management. I'm going to treat it as an opiate and not raise the dosage.

[@coog9]

What strain, brand, and dosage do you take? I've been taking Bali Red, 3 each 1gram capsule 2 times a day, and I don't get the hip pain relief I need. Nothing

[@enigmaticglo]

@@coog9the dose you’re taking is just enough to feel relaxed stimulant effects. since red kratom is considered the “indica” of kratom it wont necessarily “stimulate” you like a white vein would at low doses. but take at LEAST 5-6 grams and the painkiller effects should work. the dose you’re taking of the red is usually known to uplift your mood while relaxing you, not necessarily ease pain. you need to take a greater dose (dont overdo it) to get those desired effects. and who knows, maybe you’ll react better with a different strain like white or green. everybody reacts differently to drugs and to herbal medicines alike. try upping the dose to 5 grams, and if you’re gonna do more, i highly suggest doing it at home. if you work, taking over 7 grams could sedate you and obviously make you sluggish at work. doses that high usually put kratom users to sleep. thats what it does for me anyways. hope this helps!

[@dustinwhitesell4860]

I’ve been using Kratom for a little over a year and a half now, if you can even put a time frame on it. I only take it for pain, and really bad pain that Tylenol couldn’t help. However sometimes I have taken it just to lighten my mood when I don’t want to smoke marijuana and be high around people who would be uncomfortable with that. I’ve never abused it, I’ve always done the research and have been wise with it, I also make sure not to use it every day, and only on days when I am in severe pain. So I agree with your video, I love the information and the way you have it put out, But I hope they’re able to study it in clinical trials before it’s outlawed. But realistically, I think it really comes down to moderation, and being able to have the willpower to say I’m only going to take this when I need it. And then making that necessity only as a last resort

[@corneliusthecrowtamer1937]

Make sure you keep your electrolytes up, specifically Potassium and Magnesium. Agmatine is interesting too, it's supposed to potentiate the effects and prevent tolerance a little bit.

[@EWats-gz6mk]

Very well explained! Thank you for the perfect level of medical / “non professional” person explanation!

[@RedSkúmi]

I've sadly seen what this does to my dad. Yes it does give him energy but when he doesn't have it he's all depressed. So yeah it's very addicting.

[@jerryburns1258]

The amino acid L-Tyrosine promotes energy without addictive potential or depression when going without. Amino acid must be taken on an empty stomach (nothing by mouth for two hours prior to taking it, though water n black coffee are okay) and nothing by mouth for one hour after taking it. Tilray Corp bought the healthiest energy drink on Earth, Hi*Ball, from Anheuser-Busch in July 2023, so hopefully it will reappear on local store shelves soon. One 16 oz can provides 5-6 hours of energy with no jack, nor crash. My favorites are their Blackberry n Wildberry flavors. Himalaya brand Organic Ashwagandha is a powerful anti-depressant n mild anti-anxiety agent, which slashes stress, thus mildly boosting energy levels.

[@coltenmatthues2716]

It's not addictive in the same sense as true opiates are. It's much more light hearted in regards to being addictive. Plus it takes longer to get addicted to kratom than traditional opiates

[@jamesa6080]

Tell your dad to stop being a little girl

[@RogerRandolph-or2cq]

I've taken it on and off for many years and never experienced any issues with becoming addicted. I guess everyone reacts differently.

[@debbiewasshername]

i subed because your voice is about as professional as it can get and the accent isnt at all distracting.

[@Neuropharmacist]

That's great to hear!

[@GrantusM]

Thank you for the informative post. The drug is very popular in my city and I was curious about it, but wanted a Pharmacologist's perspective.

[@stellarshriner]

My experience was Kratom was very addictive, but I agree with his advice, great job on the video.

[@wewalkedonthemoon]

Helpful, and well presented. Just gained a new subscriber.

[@alexc7857]

I use a plant called Damiana which eradicates cravings for nicotine, cannabis, kratom and I'd love to know how it does this. I also use Damiana for mild depression and stress relief. It has been used by man for 1000's of years but now it's not so known so would be interesting to hear a pharmacologists view on this. Love this kratom video!

[@Neuropharmacist]

Interesting idea! Not sure if there's enough literature on Damiana though.

[@aaroncathey627]

never heard of damiana. I've had some withdrawl symptoms from kratom and would like to stop. How long have you been taking it? Feel like it's a safe alternative?

[@elimuro3173]

@alex7857-how many cups of damiana tea do you take a day?

[@jerryburns1258]

Very interesting; Damiana is primarily known for it's aphrodisiac properties...

[@leomajor7435]

Why did you wanted to stop kratom? What undesirable side affect did you experienced? Thanks in advance for your response!

[@nitro913]

I’m a paramedic. I had to RSI a 24yom who was taking this poison. I’ve never heard of it before until that day. Now, I’m on a mission to learn all I can about this toxin.

[@Slip0824]

I've been using kratom for exactly a year this month. I take a heaping spoonful 3-4 times a day. Kratom let me kick my alcohol addiction. The moment i started kratom i didn't think of alcohol again. I didn't even realize I hadn't had alcohol until two weeks after. I've had no adverse effects so far and my quality of life has only improved. I do find myself wanting more and more kratom but I do not up my usage. It's all about self control!

[@theHert1965]

Its a miracle. Crazy that the FDA is doing a witch hunt on it. Moon Kratom saved me years ago and im never looking back.

[@Punchmemommy]

Kratom definitely has the potential for abuse & addiction. But so do Nicotine & Morphine. Treat Kratom like s drug. Kratom doesn’t cause respiratory depression, so unlike Percocet its hard to OD on Kratom even when mixing with other drugs (Don’t do it. Be safe). Kratom helps me stay off opiate drugs for back pain, and antidepressant drugs,

[@OuterHeaven210]

Finally a video about the pharmacology of kratom

[@tyjandrews]

I appreciate your objective approach to this video.

[@Neuropharmacist]

Thank you! I try to maintain as objective and science based perspective as possible.

[@collinstanton]

Very informative, and shared on my social media FB & Twitter. Thank you.

[@Neuropharmacist]

Thank you! Appreciate it.

[@dustinmoritz6634]

Kratom has gotten me off opiates completely. Have a fractured spine with torn and 4 buldged disk. It is a thing from the heavens. I don't do weekends but while at work I take capsules and has kept me from disability

[@jobeheath9794]

Can you please do a video on amyl nitrite and nitrites alike. I am unable to find reliable information on their psychotropic mechanism of action. In Australia their recreational use is common place.

[@seth4035]

Really great video!

[@MrBlakeleyden]

The Red kind is for relaxation, the white kind is for energy, and the green kind is somewhere in between. Having tried both red and green, the red SO nice for getting a great night sleep and waking up feeling refreshed, EVEN after a night of drinking. Just make sure you have a minimum of 6 hours to sleep, but more ideally, at least 8 hours. The green kind for me does give some energy, but it is a very fine line between taking enough to feel much of anything, to then overdoing and starting to feel uneasy and anxious (much like taking too much caffeine). If you stick with the red kind and watch your tolerance so you don't start taking excessive amounts of it, it can be a great tool for getting some much needed rest and recovery from a hard day of work. I work a very physical job, and my muscles actually feel really good when I wake up in the morning. The sleep is so deep and comfortable that I think the body recovers better. That's been my experience anyways.

[@JohnQueSacc]

It's all the same. Effects vary from person to person

[@garycon25]

@@JohnQueSacc No it is not, but yes

[@AppleOfThineEye]

I take kratom once or twice a day, typically taking between 2 and 4 grams in a single sitting. It helps me manage my back pain and my sociability (I have Asperger's). It has been a welcome addition to my life. It makes me feel all warm, fuzzy, and motivated!

[@jerryburns1258]

Gut Reg may benefit you. The amino acid, L-Carnosine, improves social functioning in those with Autism Spectrum disorders like Asperger's by 30%. Gut Reg contains ZincCarnosine. This formula enhanced the effects of L-Carnosine. Amino acid need to be taken on an empty stomach in order to have therapeutic effects (no food for two hours prior to taking them n only plain water or black coffee before n for 1 hour after taking them.

[@dandyfi4076]

Have been taking low to moderate doses 2-3 times a week for years to great affect in help with mood and energy. Very little if any side effects at theses doses.

[@allancrow134]

This was very informative. Thanks. :)

[@Neuropharmacist]

Great! Thanks for watching!

[@torreydunn2170]

Great channel! So glad I found it!!

[@Neuropharmacist]

Thanks!

[@kongkratom9417]

Thanks for all the info!

[@Berley_1234]

creepy

[@robbiemurda2213]

Kratom forsure helps me stay off the harder drugs especially when mixed with cannabis or delta 8 🤘 sometimes phenibut once in a blue moon to add an extra kick when at a social event/gathering lol

[@neinlives9424]

I really appreciate you taking the time to give a nuanced take on this subject. There are millions of people benefiting from this plant.

[@TheAseer2020]

What academic papers about Kratom do your recommend people to read ?

[@JDqs-kg5sp]

Kratom helps with anxiety and pain for me. Started about 2 months ago and after finding a dosage that works it’s been good for me.

[@rudytorres26]

Ive been on opioids for 19 years lost them due to others but kratom saved me alot of problems with severe ddd and cervical ddd kratom stopped alot of pain been using for 1 year and a half.ive taken thousands of capsules and no overdose

[@rickybelmontes5364]

Just the video I needed on kratom

[@longbow6416]

My neighbor: you really like poppies! Me: yup, I really like poppies!

[@LeonNikkidude]

How does it effect thyroid?

[@c0nsci0usness]

What do think about ATAI pursuing deuterated mitragynine for treatment of Opioid Use Disorder in clinical trials?

[@Neuropharmacist]

While there may be some potential advantages, I think it is more of a gimmick. Like the CEO said in some interview: "it also gives you intellectual property." But I have nothing against new therapeutics that are effective, of course.

[@berman2198]

I think you offer an excellent breakdown of the active ingredients , but as another commented, I am curious as to the refined 7-OHMZ tablets compare to raw crushed dried leaf. (¿)

[@LouiesLog]

Oh fantastic, glad you made this! I am very interested in Kratom and take it daily. It helps me greatly with a.d.h.d & anxiety and even some hypertension pain. It definitely does cause constipation lol Little worried about all these side effects though. I haven't take some in three days, not noticing any withdrawal symptoms yet. Of course I'm going to say this but I think Kratom is great, just keep the doses low Grats on 1k :)

[@Neuropharmacist]

Thanks you! Indeed, I believe kratom is (and many other drugs are) relatively safe, when consumed in low doses, but then again there's limited evidence and I want to maintain a critically honest opinion for the safety of people who are not accustomed to these drugs.

[@berternie6181]

Watch out for hormonal suppression

[@Ryry-ig6sn]

I started taking kratom for anxiety and depression and because I loved the effects from kratom and they helped until it startrd giving me full on panic attacks taking it and did the opposite of everything it helped me with on this first time but 10x. Be careful and be responsible. The withdrawls are horrible to and I've withdrawled through heroin and a lot of other stuff and kratom is up there. If you plan on being on it rest of your life, no worries then but shit feels like coming off of opiates and Xanax at the same time. Not fun at all

[@getoutsidenow420]

Makes me crap, never constipated, i live off fiber though but still as soon as i take it, i crap 5 times some days effortlessly sorry for sharing lol wtf

[@getoutsidenow420]

Stay hydrated and dont drink the treated water, ive been slacking on my hydration felt better at least drinking a gallon a day

[@HRCISASKNK]

What can using large doses chronically of alcohol daily do to you?

[@suzysurgent62]

whats the best kratoom for sleep? where can i buyh the cheapest kratom???

[@khaoticgrumpy]

What’s ur thoughts on high purity 7 hydroxymitrgynine, such as 7OHMZ that’s 14mg 7OH to 1 mg mitragynine

[@Yabani-Ra]

Kratom helped me stop drinking alcohol. It immediately stopped the cravings. To me, it was a blessing.😊

[@romanone]

I tried it for the first time a few weeks ago, I felt like I was reborn, I was so happy, and hyped up. MUCH better than cannabis for me, I don’t like pot at all. Makes me dizzy & spaced out, Kratom is way better for some people that don’t want a strong psychoactive effect

[@misscogito]

wonderful video :))) well explained

[@ryanblaschik1254]

Wow, thank you for the information. And the very pleasant speaking voice. I've recently started using kratom for sleep and pain and my curiosity is around what drives the stimulating and energizing effects. Because even using Red Bali, the least stimulating and energizing strain I see with the greatest amount of sedation ( based on one chart I found) it still keeps me awake at night. So I've been trying to find out what in it is stimulating/energizing so I might find a way to counteract it. I've heard kratom is related to coffee but from what I read does not contain caffeine. I've tried different doses with the same effect. Any insight would be greatly appreciated and thanks again for the video.

[@WaterShowsProd]

I tried Kratom once, chewing on a fresh leaf that was given to me by some Akha friends when they saw how exhausted I was from overwork. The Akha are an ethnic mountain people who live in Southeast Asia. They explained that it picked you up similar to a strong cup of coffee but without the buzz of caffeine. It did the trick; I found it to be similar to chewing betel nut, but it doesn't turn your teeth black.

[@lukefarnham2119]

It's entirely based on dosage. Even a low dosage of a red strain will have energizing effects, on the flip side high doses of white or green can cause sedation. In order to get the most sedation, higher doses of red strains should do the trick. Be careful though, daily use over uninterrupted long periods of time will cause a physical dependence. I.e. withdrawals. Best wishes.

[@ourgrassisblue2153]

’ve Recently Had to Have my Appendix removed From a blockage Caused by Kratom. After 7 years of daily use. I still firmly believe that it is a Very helpful Thing I’ve never had opioid problems with any drugs. I’ve recently spoke to my Dr and now I’m using it in Concentrated form.! Just be careful appendicitis sucks.!!I’ve allways gotten my kratom straight from Bali as my best friend lives there! May not be the same for anyone else but that’s what it did to me!

[@GeorgeCoggins]

i've found the remarkable herbs bali to be my favorite.but it is definitely dependency forming and if my dose wears off im in worse physical hell but less mental hell than i was coming off of various opioids in the past. i only get about 4-6hrs of sleep before needing to redose. im hoping to be rid of this with the help of iboga soon tho working with a protocol that isnt the same as those typically used for opioid WD.

[@benjammin2L8]

I reduced my dosage by half over a period of a few weeks and am trying to taper off further. I work 12-16hrs a day so I need to be on my a game. What is iboga and could I use it to help me do this?

[@Normipedia]

I've found through myself and with others a massive spike in blood pressure with kratom use. Sadly, i have not been able to find much info on this, but something to be conscious of.

[@Neuropharmacist]

Interesting. Acute or chronic?

[@garycon25]

Kratom purity can vary wildly be careful to get stuff with plenty good reviews and seller of good repute

[@Normipedia]

@Neuropharmacist so for some context: I'm 26 years old and active, but due to my genetics I have chronically elevated blood pressure(avg 160/80 without medication) But when I take kratom I see my systolic increase between 5 and 15 points. My grandma took some for pain and she also noticed a significant increase in systolic bp. I have been using kratom from canopy botanicals.

[@Normipedia]

@Neuropharmacist so the increase from kratom is acute and comes back to "normal" when the kratom wears off

[@lewisyoung8362]

I take Kratom and It lowers my BP . Everyone’s chemistry is different . ☮️

[@TreadTalk247]

What brand has the highest quality Kratom? I’m looking at suggesting Kratom to a loved one who has been on pain meds for decades and would like them to get off their RX dependency! Any recommendations would be appreciated….. TY!

[@tinypoolmodelshipyard]

Opms Silver is there regular kratom in capsules. Gold and black are extracts, capsules and shots. If your on pain meds these will be more up your alley. There is a new thing 7 oh, a isolation of 7 hydromitrgynine but its showing tolerance and shorter duration in its isolated form. The extracts still have some other alkoloids from the plant that aid in its effects. And when u want to stop the extracts, go down to regular kratom, and slowly taper. It help me get of percs 6 years ago. I used it everyday for 2 years. Stopped but now still take it 2 times a week. If you have decent self control, and dont keep upping your dose, you can find kratom can help at almost every dose, and can have a sweet spot. That element is ehat lacks in the 7 oh isolation.

[@Morgan-pf8nu]

Very interesting. Thank you for sharing

[@Neuropharmacist]

Thanks!

[@jp-gs9qp]

I got insanely addicted to kratom a few years back (10-15g/day) until the side effects forced me to stop. Withdrawals were awful. I couldn’t function for a week and I was insanely depressed for months after. I stopped when I started to feel pain in my liver area + growing stomach problems.

[@lustalgia...]

comes with the miracle. I willfully am aware and i see no better alternative but of course wd are bad

[@Guidus125]

I'm sorry to hear that, that sounds awful. It's strange how some people have been taking kratom for 20+ years and don't have any side effects, while others have experience more similar to you. May I ask where this kratom was bought? (country and type of vendor). I'm asking because there have been plenty of reports of kratom being contaminated with stronger opioids or other pollutants.

[@longbow6416]

Seems everyone is different. I do 5mg 3 to 4 times a day. I don't feel 'high' from it, I just dont feel like crap :)

[@Beans-great]

Same with me. 4 to 5 grams 4 to 5 times a day. I use it before a workout. I work in sales and find it keeps me focused, motivated, and in a great frame of mine to do really well. I do take some small breaks and switch strains. Prefer the red.

[@Tracey..H]

I got stomach issues w it-/- never again!

[@pattreadwell6149]

Thank you sir

[@susanhalkin2614]

THANK YOU FOR THAT. IT SOUNDS AS THOUGH REPLACING TRAMADOLE WITH KRATOM WOULD STILL LEAVE ME WITH WITHDRAWAL CHALLENGES. HAVE YOU RESEARCHED FURTHER INTO DAMIANA ? WOULD DAMIANA EVEN HELP WITH CHRONIC PAIN ?

[@davidshafer6388]

thank you

[@HRCISASKNK]

How many people a year directly or indirectly does alcohol kill?

[@mosler302]

I can't answer that question but I can report that Tylenol kills about 2500 Americans per year. I believe there's less than 10 cases of Americans dying from kratom without any other drugs in their systems, primarily from tachycardia.

[@neuroticnation144]

I have fibromyalgia and it really helps with fatigue, pain and depression. It’s safer than the prescription meds I take.

[@jerryburns1258]

Terry Naturally Andrographis EP-80, NOW Boswellia extract, Seabuck Wonders Omega-7 Complete in conjunction with Horny Goat Weed with Maca, Nutrigold Ubiquinol Gold, Jarrow's PQQ 20 mg, Barlean's Liquid Strawberry Shake Vitamin D-3

[@MsAdventure531]

I feel like I’ve developed fibromyalgia upon withdrawal from Kratom. Scary shit.

[@forgottenmemory5735]

I used to take two ounces a day of gold bali. Then when I quit I dropped down to 128lbs and I'm usually 185. After that, who could go back to it?

[@SamBambi-wy3op]

I have a friend who used Kratom and I saw his life turn around. I will literally say he became more alive than ever. recently I have been feeling mild anxiety and stress. I am wondering if any one knows where I could get Kratom in the united states

[@chuckesavage8383]

Nice!

[@aivy-aigeneratedmusic6370]

Love kratom. However it is definitely addictive. But after months of daily use quitting is uncomfortable for a few days, but not that hard to quit. I love the effects and would probably use it daily, but I feel like it has negative effects on my libido. Not sure however if this is just my mental expectation and maybe just occurs if I take a higher dose

[@TDghf]

Yeah opiates and opiods 100 percent do that too most men I'm sure . Does to me

[@bronson9253]

Thanks

[@user-wy5fo9mu5t]

I have a fractured c6 vertebrae that is refractured but I was on painkillers,physical therapy,chiropractor,massage therapy,alcohol and cocaine,stopped 8/1/15 started using kratom 4/5 years ago

[@kaffirfromgod5162]

Ok I also have spinal injuries, and cocaine,speed, would cause me way way more pain.

[@zachgillen6549]

I have been getting off of Kratom the last five days but recommended that stem and vein will help drastically but I need to know am I just setting myself back by doing a scoop of day of this would actually is stem in vain is it just basically the stem in vain and it’s still kratom. I need to speak with someone about this if possible.

[@jerryburns1258]

Wtf

[@sarahmayer8539]

Tianeptin as a substance would be neat, I use it as an AD since a few years

[@Neuropharmacist]

Tianeptine is an interesting compound indeed, will consider that!

[@sarahmayer8539]

@@Neuropharmacist thanks! I feel like it's really underrated and it's abuse hinders it's use as an AD in many countries. It's the only one that worked so far out of at least 12 different ones and had no side-effects besides slight constipation. Have a nice day!

[@sarahmayer8539]

@@nomorenames5568 it's not awful if you need it for depression and use it as a medication, per doctors order. Of course a shitty batch of cheapo-tianeptine is trash, but it's godsend if nothing else helps. Obviousy if you abuse it, it's trash and there are better options.

[@sarahmayer8539]

@@nomorenames5568 I bet! haha

[@TheRawvila]

I appreciate the information, however, most of the information you provide in the video does not answer any questions i have about Kratom due to the fact one has to study pharmacology to understand how this all reacts on our bodies. You are using scientific terms that most of us do not understand, I would be happy to listen to a longer video on the subject if you were to define the scientific terms for someone like me who is an end user. For example I a long-term daily user of Kratom due to having Lyme's disease. How does kratom effect the endocrine system , my adrenals, thyroid, or liver in long-term use. Have their been any studies on this, if not what is your best guess. You know maybe dumb down your video's or please give more detailed explanations for people who have not studied pharmacology. That would be really nice to be able to listen, Check out Andrew Hubberman, Neurobiologist, neurochemistry. He really does a good job transmuting the science into a more palatable verbiage for the common person seeking information. He has his own podcast Humberman Labs.

[@Cheesesticks7451]

Just my experience I have cancer pancreatic kidney spinal ...the list goes on ..I was on high does of 120 mil of Methadone for long acting and 4 15mg perc for over 20 years. I went threw hell..I needed a reset to see if I should risk the 18 hr surgery of spinal tumor I needed to know my true pain so I stopped taking pills and started the kratom.. as far as suppressing chronic intractable pain . Nope not even touching pain but withdrawal was manageable and I've survived still pushing threw. This might be a great option for weening off opiates but pain can physically and mentally cripple one. God knows I've been grasping at straws so I had to change the plan .. Why keep taking meds that don't work I knew it could have turned bad..I'm so thankful I have self control and did not fall to my own demise and give up... I'm not saying this is a good thing for People who are terminal and severe pain. Quality of life seemed more manageable on medication but they say pain let's you know your alive and I'm feeling extreamly alive yet not withdrawal..

[@jokcoustou]

Kratom user 2009 to present .. use about half a heaping tsp 5x / day (green vein). Labwork kidney & liver function good after all these years . Constipation / hydration is the thing to watch out for. Pain relief is good / mental clarity does suffer. Youll be tired and no energy if you quit cold turkey . 10 days or so and things return to normal.. Good stuff otherwise.

[@killtime351]

NIce video

[@garycon25]

Love this guy's accent , will we all learn to speak nicely on drugs ( ;

[@Neuropharmacist]

Haha

[@SwiftzRushV1]

Watch at 1.5x speed

[@carolinemurphy8872]

Very interesting. I had no idea that neuropharmacists are a vocation.

[@Neuropharmacist]

In some countries, pharmacists can specialize in neuropharmacy, but to be honest, I'm not one of those "neuropharmacists". I took the nick because I'm a pharmacist turned into a neuroscientist, working mostly on neuropharmacological questions. So I think neuropharmacist is a pretty descriptive word.

[@kylejohnson7777]

Ive done alot of drugs kratom is second only to pot for pain

[@brianweakley3150]

You are a smart dude!

[@Neuropharmacist]

Not smart enough!

[@hankaul6256]

❤

[@LtGregoryStevens]

You should do one on Phenibut next.

[@Neuropharmacist]

Thanks for the suggestion, is phenibut freely available in the US?

[@LtGregoryStevens]

@@Neuropharmacist Yes, most people purchase it online though. Sometimes it's sold in gas stations.

[@ImChrisHansen.]

@@LtGregoryStevens that stuff will mess you up. Id stick with kratom.

[@Guidus125]

I second this. Phenibut is commonly prescribed in Russia, and it was already given to astronauts back in the soviet days. The substance was synthesized in an attempt to create a gaba derivative that would cross the BBB. Also, it's a GABA-B agonist which is pretty rare pharmacologically speaking. I also think phenibut exemplifies that the field of medicine has a subjective side, since it is basically the benzodiazepine of the east yet the west has never even heard of it. So, lots of interesting stuff to talk about when it comes to phenibut

[@shanemillott5229]

How many times did you say the word Opiod? I thought it was not an Opiod..I am certainly getting conflicting info?? I am confused is it or isn't it??

[@Neuropharmacist]

Opioids are drugs that activate opioid receptors. Several alkaloids in kratom activate opioid receptors, thus they can be classified as opioids.

[@skateorbri]

Either you are Dracula or his younger brother.

[@Neuropharmacist]

Mwahaha!

[@pob2527]

From a regular user I recommend trying it from the leaf itself if you're visiting Thailand or other SEA countries. Taste like shit but it's an experience.

[@cannibalwarlord1884]

Interesting, is it much different than the powder??

[@Spectre2434]

❤❤❤

[@mmingle57]

I’m sure when you go through 5 failed spinal fusion surgeries along with cancer you might endorse Kratom with a little more support? Thought your info was quite interesting. I hope you never have to go through and experience the daily severe debilitating spinal pain like I go through on a daily basis! You along with the government would understand the need for something like Kratom!

[@Neuropharmacist]

I understand your point, but I try to avoid endorsing anything. I only hope to provide some neutral information on drug pharmacology.

[@jerryburns1258]

Terry Naturally Andrographis EP-80, NOW Boswellia Extract, Seabuck Wonders Omega-7 Complete in conjunction with Horny Goat Weed with Maca, Barlean's Liquid Strawberry Shake Vitamin D-3, Zhou Black Seed Oil or Peak Golden Oil, Zentopis beverages with 50 mg of CBD isolate.

[@fancyincubus]

The stuff in your bottle on the thumbnail looks like the oral morphine I use to buy in highschool

[@Cozumel22]

I close my eyes and I hear Sean Connery waxing poetic about Kratom.

[@Neuropharmacist]

😄

[@MsAdventure531]

Not even close

[@danielholmes8714]

its crazy the world has chosen fentanyl over kratom

[@scrapbandicoot]

Lets get healthy everyone, reroute into natural alternatives though use responsibly.

[@anthonyromayo9255]

Huh ???

[@vtogvblog]

Considering in the USA the only options are Kratom or some laced fentanyl made by a cartel. I'd rather take the kratom.

[@TexasRain45]

Facts I agree

[@EDD519]

it is in the coffee tree family , nothing to do with pot !

[@diptipman]

I'm interested in ADD medication. Pleeease make one on Ritalin, modafinal, dex etc..

[@Neuropharmacist]

I'd love to make in depth videos about all of those. I have a long list of already suggested ideas, but I will add these there!

[@jnewmark41]

@@Neuropharmacist Modafinil is a great idea! It is very helpful..

[@jerryburns1258]

Evening Primrose Oil reduced ADD symptoms by 50%. Then eliminate all artificial colors, flavors, msg, aspartame, n preservatives from your food plan and, viola, no more ADD!

[@hankaul6256]

I take five grams 3 times a day for half a year now, I still have plenty of po

[@ronnie5329]

Its very low level, yes like a weaker codeine pill, so it is very weak

[@TDghf]

Yeah but take 40g at once and u will know about it

[@ronnie5329]

@@TDghf I have no idea how ppl are able to get 40 g of that down.

[@garycon25]

Kraytommm ! Cool shirt also ?

[@SwampWaterBud]

Kratom blocks the kappa receptor..

[@Neuropharmacist]

Not sure if it's completely clear if mitragynine is an agonist or an antagonist at kappa.

[@thedomestead3546]

Good video, you got yourself a new subscriber. Brother, what are the chances of all the millions of plants that exist,or have existed, that this plant contains chemicals that function, just so, within the human body? Great luck? Wonderfully fortunate coincidence? Can you "reverse work" this allignment with the human biology to gain insight and understanding? Thanks for your time.

[@Neuropharmacist]

We have coevolved with plants for millions of years! Many plant substances act as insectisides and thus promote survival, some are byproducts of plant metabolism and happen to share key chemical structures with mammalian receptors. Some might particularly be there to promote consumption and the spreading of e.g. seeds. In many cases, we will never know why, but I think it makes sense as fundamentally all living things share ancestry.

[@thedomestead3546]

@@Neuropharmacist how did it concieve this ?