Neutropenic Sepsis

Neutropenic sepsis is a medical emergency and complication of cancer treatment, usually chemotherapy.
It is thought to be brought about through a combination of the effect of chemotherapy in supressing the bone marrow, and in turn the production of white blood cells, as well as the breakdown of the lining of the gastrointestinal tract, allowing for bacteria to enter the blood stream.
It is a medical emergency, and patients with suspected neutropenic sepsis should receive broad spectrum, empirical antibiotics no later than 1 hour after arriving at hospital.

[@lindastockley6907]

I’m an EMT and encountered this situation only a couple of weeks ago. Chemo patient clearly had sepsis so I called for a Paramedic to administer antibiotics. However we were close to hospital so she made the call to delay broad spectrum ABs to allow the hospital to take blood prior to giving ABs. This video explains it perfectly.

[@LukeA1293]

Thanks a lot for making this - currently revising for finals and this was a big help!

[@elliottedwards9699]

Great vid, helpful for a student nurse. Many thanks.

[@jessyvarghese222]

Beautifully explained!! Thank you

[@paulinemcleggan7585]

Great video with very useful images thank you

[@ziarahman1993]

great video with full detail;

[@sysamanthahope9033]

this is amazing i learned a lot and the graphics make listening more enjoyable

[@nazirusamahabdullahi2582]

Interesting video. I also learnt in school that these patients should be isolated (reverse isolation), given neutropenic diet, multivitamins and sometimes granulocyte stimulating factor. Thank you.

[@himanshujindal6314]

Great content. Thank you. I am a medical student trying to write something on acute oncology. Thanks so much for the video.

[@ghofranhamza698]

Thanks for your great explanation,I was guinely busy about searching about this topic until I found this vedio,so really thankssss😢👏👏👏

[@rufaidataleb6871]

very helpful...thanks a lot

[@lore691]

awesome introduction, concise and to the point ;)

[@Chaudharys1]

This is excellent

[@24Crossdale]

Excellent

[@haroldschummer6163]

that was great! thanks!

[@anugraharajan5250]

Thanks Very much Sir

[@MuhammadAhmad-ek8mt]

Loved it..❤

[@rebeccachace7816]

What causes neutropenia if that person isn't taking chemotherapy?

[@retajalarbab7577]

Did anyone write down the videos of oncological emergencies ? My exam is soon and I can’t go back to watch the videos😭

[@IndigoOptimist]

This was very useful, thanks. What it the name of the study in which they found that infections were being caused by breakdown of gut mucousa?

[@oncologyformedicalstudents6877]

Thanks for the comment! I don't think there is a specific study - I think the theory came about because it was known that chemotherapy damaged the gut mucosa, and other studies had shown that when organisms are successfully cultured from blood samples in patients with neutropenic sepsis, they are frequently found to be bacteria that are also normal gut flora. This review explains it in more detail and might have some helpful references: onlinelibrary.wiley.com/doi/10.1111/bjh.13113/full#bjh13113-bib-0012

[@IndigoOptimist]

Thank you very much, I will check out the link. Im currently writing a case on a cancer patient and thought that it would be an interesting point to add in!