Tumour Lysis Syndrome

Tumour Lysis syndrome is an oncological emergency whereby the lysis (or breakdown) of vast numbers of cells leads to the release of their contents, which can have catastrophic consequences for the function of the kidneys, heart and central nervous system.
This video describes the pathophysiology of TLS, risk factors, clinical definition and diagnosis, prevention and management.
References
Larson, R., & Piu, C. (2016). Tumor lysis syndrome: Definition, pathogenesis, clinical manifestations, etiology and risk factors. In D. Savarese (Ed.), UpToDate. Retrieved December 10, 2017, from www.uptodate.com/contents/tum...
Larson, R., & Piu, C. (2016). Tumor lysis syndrome: Prevention and treatment. In D. Savarese (Ed.), UpToDate. Retrieved December 10, 2017, from www.uptodate.com/contents/tum...

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[@EclipsaRosa]

So if you were going through chemotherapy and taking acyclovir and allopurinol, what are the chances of acute kidney injury, and are there other causes for high levels of protein in urine? Could it be caused by iflex? And if so would that resolve once chemotherapy treatments are ended?

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