New Antipsychotic Drug Cobenfy: The Miracle Cure for Schizophrenia?

[@DrMizanMD]

What are your thoughts on Cobenfy, the new antipsychotic drug for adult schizophrenia? Like, subscribe, and comment below! For business inquiries, 1-on-1 medical life coaching, and if you are interested in seeking an alternative MD/DO career such as medicolegal consulting, our email can be found in our profile!

[@CellitOfficial]

Is the high BP worse than zyprexa?

[@DrMizanMD]

@@CellitOfficial We'll have to wait and see unfortunately since Cobenfy has very recently obtained approval to be prescribed. Since it has a totally different mechanism of action, it's probable it won't have similar side effects, e.g. hypertension, tardive dyskinesia, indigestion, but we'll see in the next coming months. Thanks for watching and for the insightful question!

[@CellitOfficial]

@@DrMizanMD also do you know when this will come to canada?

[@DrMizanMD]

@@CellitOfficial Not sure. Canada has its own version of the USA's FDA (Health Canada) so it'll have to be approved by them. It could be soon since drugs approved by the US FDA tend to get approved by Health Canada and vice versa quickly.

[@fabistar2000]

I’m excited. My brother has schizophrenia. All meds he tried had severe side effects while not helping as much as hoped for. I hope this will lead to a lot of people being able to live their lifes with dignity

[@DrMizanMD]

The research on Cobenfy does indeed look promising. I sincerely hope so as well. Thanks for watching and I wish the best for your brother and your family

[@Dbl_OG_13]

I'm excited to see where this goes. I've tried every medication out there just about and none have worked for me. 🤞 Hoping this lives up to the hype.

[@DrMizanMD]

Same here brother, if this is effective then it will change the world of psychiatry as we know it and help tons of people!

[@barbaramartinetti]

@@DrMizanMD Look up Metabolic Mind and the Baszucki Group for Ketogenic Diet interventions...so far, very impressive.

[@Roberto11231]

I read that Cobenfy constantly activates acetylcholine, which will cause agitation and anxiety in people. And it is not known if it will be good for the negative symptoms yet. I'd say we remain cautious.

[@DrMizanMD]

Excellent points Roberto. Indeed this is brand new so we should remain cautious and not get too excited. We have a couple videos on the side effects of Ozempic that illustrate this. The whole world seems to be blindly optimistic about it but there are so many significant side effects. I'd highly recommend watching those videos. Thanks for the insightful comment!

[@barbaramartinetti]

I have myasthenia gravis, caused by problems with the acetycholine and cholinesterase receptors. Since Cobevny deals with acetycholine mechanisms, is there a link between treatments for Schiz and MG? I'm a lay person with a son with Schiz.

[@DrMizanMD]

That's an excellent question Barbara and since it's so new to the market we'll have to wait and see. I'll provide an update video in the future

[@SmashDaBlade456]

Hello doctor, does cobenfy help relieve negative symptoms like anhedonia and lack of motivation ?

[@DrMizanMD]

Thanks for the question! Indeed, because it works on acetylcholine receptors instead of dopamine receptors, it's reported to NOT have the same side effects (including negative symptoms of schizophrenia). They do however report significant nausea, vomiting, and constipation (GI issues). However, because this medication is so new, we'll have to wait and see for its full profile.

[@SmashDaBlade456]

@@DrMizanMD thank you for the detailed reply 🙏🏾

[@DrMizanMD]

@@SmashDaBlade456 Of course, brother!

[@abdirizaksaid7957]

I don't think this is better than Invega and the side effects are still same

[@aethylwulfeiii6502]

Have you looked at the drug NyX 2925 an Nmda receptor agonist.

[@DrMizanMD]

Never heard of it and will look into it, thank you!

[@Skoda130]

There will likely never be "miracle drugs" without side effects. That's like energy without entropy.

[@DrMizanMD]

Love the analogy! I personally don't believe any drug is a panacea or "miracle drug."

[@lucalodirizzini]

When will it be available in italy please sir?

[@DrMizanMD]

Hi Luca, unfortunately there isn't any news of it being available anywhere in Europe yet. We'll post an update video once it gains global approval!

[@bmjjjhnm]

Dr pls can i have it in Cyprus?

[@DrMizanMD]

Hopefully it will be available globally!

[@bmjjjhnm]

Dr is urgent to bring Cobenfy for my son. All the others antipsychotics didnt help him includind clozapine. How can we bring Cobenfy now to Cyprus?

[@kelllefae3026]

​@bmjjjhnm I'm in same situation with my son in uk ... its not released here yet .. our countries will have to approve its use .

[@AnneSklavos]

Will it be approved in Australia?

[@kelllefae3026]

@@AnneSklavos eventually....

[@winstonblue457]

So my question is this: will we be able to take the new medicine and at the same time we taking the old one, let's say for a while, until we are stable and safe?. or is it monotherapy?? 1 Reply

[@DrMizanMD]

Excellent question; it's likely there will be a weening off/tapering period for the old one and then a gradual increase to maintenance of the new drug but we'll have to wait and see once this hits the market fully

[@winstonblue457]

@@DrMizanMD so you are not sure?

[@DrMizanMD]

@@winstonblue457 Correct, there isn't any clinical data yet on this but we'll make an update video in the future

[@jeanpaultongeren125]

Id put more hope in a Ketogenic diet. If you haven't tried it. It fixes mitchondrial function

[@DrMizanMD]

Keto has a ton of benefits! Combined with intermittent fasting, it's a great tool to fix many health issues. Thanks for the comment Jean!

[@Skoda130]

@@DrMizanMD exceot for things like colon cancer.

[@kaurpreetilonghair7714]

Please tell me is it in India my brother have please I request you

[@DrMizanMD]

Unfortunately no news on when it will be available in India yet, but we'll keep you posted!

[@Rosiesunnyday]

Hi, Can you take cobenfy if you have NAFLD or high ALT and AST?

[@DrMizanMD]

That's an excellent Question Rosie. Since it's brand new to the market, we'll have to wait at least a year for clinical trials to details its list of contraindications and side effect profile.

[@venkatelumalai1207]

When will come India sir please tell me

[@DrMizanMD]

Unfortunately there's no news of approval in India yet but hopefully very soon. Thanks for watching Venkat!

[@usharengarajan3288]

Waiting to be given to my son/

[@DrMizanMD]

You're a good parent 😊 Hope it helps your son!

[@shannon-daygrant8754]

"Our current theory of mental illness is that there's an imbalance of serotonin, dopamine, acetylcholine, all the neurotransmitters..." Yes, emphasis on theory. To steal an analogy from Andrew Scull, if someone's social anxiety was reduced by drinking wine that doesn't mean their brain had a deficit of alcohol that needed correcting. Thanks for the video :)

[@DrMizanMD]

Excellent analogy 😂 And I entirely agree. Allopathic/Western Medicine has reduced the beauty, complexity, and spirituality of the human being into little more than a material machine. Also, what's hilarious about medical guidelines is that they literally seem to change overnight so we're constantly having to learn, apply, replace, and repeat. I'm certain this current theory will be replaced soon with something different once AI, biotech, and nanotech enter the psychiatry world. Thanks for the insightful comment Shannon :)