New treatments for hormone positive breast cancer - Hormone therapy for ER/PR stage 4 breast cancer

Identifying hormone-positive breast cancer, or ER+ PR+ breast cancer, which has cancer cells with estrogen (ER) and progesterone (PR) receptors, is important to guide treatment. Symptoms like lump in the breast, change in shape, and discharge from the nipple raise suspicion of cancer. Accurate diagnosis requires tests such as immunohistochemistry (IHC). In Delhi, India, treatment depends on the stage (Stage 1 to Stage 4). Treatment for this cancer includes drugs such as hormone therapy (tamoxifen, letrozole, anastrozole and fulvestrant), in addition to surgery, chemotherapy, immunotherapy and radiotherapy. Newer treatments include targeted therapies (capivasertib, everolimus, alpelisib, palbociclib or Palbace, ribociclib or Kryxana, abemaciclib or Ramiven), which are particularly important for the treatment of metastases that have spread to the bone, lung, or brain.
Mammography is important, with an emphasis on early detection. Awareness of the side effects of treatment is extremely important. This is a special cancer in which even in stage 4, survival is 5-8 years or more. The video also covers the latest developments in cancer research and clinical trials, which provide hope and potential for the development of new treatments. Learn from Delhi's renowned Cancer Specialist Medical Oncologist Dr. Vineet Govinda Gupta MBBS (AIIMS) , MD (AIIMS), DM (AIIMS), Gold Medalist.
If you have any question other than this video contact us on whatsapp, phone, or email. Subscribe to our channel.
Phone: [phone]
Website: drvineetgovinda.com
E-Mail: [e-mail]
Facebook: @drvineetgovindagupta
Twitter: @drvineetgovinda
00:00 Introduction परिचय
01:26 What is hormone positive Breast cancer हॉर्मोन पॉजिटिव स्तन कैंसर क्या होता है
02:31 Diagnosis of hormone positive breast cancer हॉर्मोन पॉजिटिव स्तन कैंसर कैसे पता करते है
03:24 Features of hormone positive breast cancer हॉर्मोन पॉजिटिव स्तन कैंसर में क्या होता है
04:56 What is hormone therapy हॉर्मोन थेरेपी क्या होती है
09:31 Treatment options for ER+ breast cancer ई आर पॉजिटिव ब्रैस्ट कैंसर में इलाज कैसे करते है
11:59 Treatment and survival of ER+ breast cancer by stage ई आर पॉजिटिव स्तन कैंसर के हर स्टेज में इलाज और सर्वाइवल
16:27 Contact information संपर्क

[@jyotsnatiwari6209]

Such a positive information video this is 🙏

[@amritkaur6441]

Thank you Sir, very good information

[@smshoaib3329]

Thank U very much sir.May Allah bless you😊

[@sangeetabansal8175]

आप की vlog se सब ladies main Possitiv vibes आय gi. Again Thank u so much

[@asmaasif3077]

Useful information

[@shakeelchowdhary9329]

Simplified, YOUR MANNER OF PROVIDING INFORMATION JUSTIFIES THE SAYING, "" DOCTORS ARE EXTENSION OF GOD."" MAY U LIVE LONG WITH PEACE.

[@uurvashi23]

Thanks sir Apki bato se himmat milti he

[@nageenakhan2367]

Excellent sir

[@soniachugh6121]

Thanks sir aap buat badiya se samjati ho

[@GeetaPatel-qj3ly]

Very informative.

[@KiranSingh-dv3zy]

Thanku sir for this video I m mcb patient in er pr postive

[@NehaKumari-hr6yj]

Thankyou sir,will connect Asap

[@namratashrestha8973]

Thank you so much Dr. Sahab. It is really very informative

[@gyanendrabhandari7856]

Great Sir

[@achint7622]

Thankyou sir for the detailed explanation

[@preetigulia1387]

Ur way of explaining is so gud sir

[@ManishRawat-lr2ih]

Thankyou sir for information

[@jeetendrapathak8371]

Very informative and easy to understand

[@laxmikumari-ln6ee]

Thank you sir itni acchi jankari ke liye

[@mukeshmallik7160]

Good suggestion dr

[@avinichlani3710]

Thank you Doctor. You explain no well and decrease anxiety. God bless.

[@hemantsharma4182]

Vineet Sir treated my 23 year old sister stage 4 lung cancer for around 2 years..... Vineet sir is a gem & very knowledgeable & kind. He is going to be the best oncologist in India.

[@ashutoshvyas885]

Konsa ca tha aapki sister ko bhai mari wife ko squamous cell carcinoma alk positive h stege 4th h tab.alectinib 600mg bd le rhi h

[@hemantsharma4182]

​@@ashutoshvyas885EGFR positive

[@harshitaagarwal8131]

​​@@hemantsharma4182 sir meri mom k bhi treatment sir se hi chal raha 2022 se ..egfr positive hi h meri mom k bhi . Abhi Kasi h apki sister?

[@priyanka...sharma]

What were symptoms for your sister? Please tell me .

[@user-bj5nn4md7f]

Thank u sir ur information about breast cancer means alot for me mujhe same yahi hua hai aap ki baateon se mujhe mere answer mil gaye hai.

[@mohammadraheemuddin502]

Thank you sir.. It was very informative..

[@sangeetabansal8175]

Thanks a lot for very good information. You r doing great job. Because so many women's doesn't have knowledge. I m beautician nd I have my own beauty parlour in Mumbai. I have seen so many my clients those having Brest cancer... I have seen their sadness

[@cool_boys_short]

thanks a lot dr you are such a great doctor, very informative video ❤

[@zareekhan7313]

Very nice 🎉

[@shahibhim1874]

thanks Drsab

[@rajeevkumar-ny9zk]

Thanx doctor ❤

[@bheruram3833]

Dr veenit sb G your experience with this subject is very very nice 👍👍👍👍👍👍

[@drvineetgovindagupta]

Thanks and welcome

[@engineersera4829]

Thanks sir

[@kushaldas5323]

Nice information

[@hasibulislam5191]

Thank you sir

[@GayathriS-x9n]

Thanks a lot Doctor, gained lot of courage from your detailed explanation. God bless you, doing very good job .

[@bidyutparnalourembamcarter3757]

Very helpful video, thank you for explaining elaborately.

[@bidyutparnalourembamcarter3757]

Doctor I really need your help. 2 months ago my sister was diagnosed lymphoma in breast and lymph nodes in armpit. In 2020 she's diagnosed calcification on same breast and operation was done. In the same year again she's diagnosed bowel cancer, operated and removed 8 inches. At the moment she's taking targeted therapy and immune therapy. She really wants to remove her breast.She should or shouldn't remove her breast. please give your valuable advice. Thank you.

[@parveensultanamazumder3550]

Tnks sir

[@ilaanand264]

Thx sir

[@AnandSingh-jx3ml]

Thank you sir you r next to god

[@mukeshgovindani866]

Sirji❤❤

[@BishnuGurung-qr2er]

brautiful explained sir👍Thank you🙏🏻it really helped us.

[@drvineetgovindagupta]

It's my pleasure

[@tamajeetsinha9013]

Sir make e video on gastric MALT lymphoma and it's effective treatments and further management.

[@bijendersharma1378]

Thanks a lot Sir, You a serving the nation in this way of awareness.Pl let me what are tests required for healthy person to know that he is not in grip of cancer

[@qaisarsbiology5267]

Very nice explanation sir. I am doing research on molecular subtypes of BC. Please also make a video on molecular subtypes (based on gene expression) with respect to their medicine 💊

[@farhanas3922]

We cannot find this kind of detailed information anywhere else. It’s easy to understand and very helpful. Thank you very much 🌷

[@ANITAKUMARI-xe3cg]

Thank you Dr. Gupta sir is jankari kay liye mujhe bhi 4th stage Cancer ho gayi hai

[@sakshampathak9019]

Kha tk spread h apko

[@SmartiBhati-de3uv]

Dear sir plz bataye ki temoxifine lene ke baad bahoot thkan lgti ese na le to eski jagah kya le

[@user-fm5oy6bp5i]

Hi sir ., my mother is suffer from breast cancer . Can you pls sugges..step And how she can recover. Your reply is very helpful for me.

[@arunkash8702]

Hello sir, I find your videos highly informative. I have a query regarding post-treatment for hormone-positive breast cancer with letrozole. Is it advisable to consume giloy juice (Tinospora cordifolia) in the morning?

[@sunandashinde1965]

Thank❤🌹🙏 you sir aapke videos se bahot madat milti hai 🌹🙏stage 3 breast cancer hua tha 🙏🙏yesterday ko stool me se blood aa raha tha 🙏🙏ye konsa indication hai🌹🙏🌹🙏

[@farharahamath3948]

Aapne doctor ko consult Kiya?

[@ashimamohapatra8242]

Sir after breast cancer treatment ke baad 3 months check up mei Dr ne bola tha ki ultrasound aur blood test karne ke liye report me thoda sa bone week Aya kya kuch problem hai

[@ramanagudluru]

My mother she is 76 and she was harmonal +ve what kind of treatment she sutable plz answer my question recently she was diagonised cancer

[@ArunSharma-sx4ej]

ER -ve PR -ve HER 2neu -ve Kya line of treatment hoga sir.

[@aizarsriddlesfuntime1462]

How long Harmon therpy need after stage 2 surgery.Its all informative. Thanks for details.

[@drvineetgovindagupta]

7-10 years

[@farharahamath3948]

Sir her 2 positive may 17 chemos karani hai?

[@sayyedrahematali1623]

Brest Cancer brain me chala Gaya hai. To tretment kya honga pls reply

[@barshabar6246]

Sir need your online consultation.

[@AnkushAggarwal-zi1jz]

Sir Stage 4 Her2 positive breast cancer main clinical trial chal raha hain kya ??

[@user-on2ln3ou8i]

Name of hospital please 😊

[@jyotiraj2271]

Sir mera husband ko limphoma censar huo h kya hm baby plane kr sakte h

[@jrshorts6223]

Sir advance tnbc curable hota h kya?? (With lung metastasis)

[@drvineetgovindagupta]

Depends on genetics of the tumor. Connect via number in video description

[@user-rf8qv2ys3e]

Sir ek short video on Oligomestatic breast cancer please?

[@drvineetgovindagupta]

It is a complex topic. Get in touch via number in video description

[@opbatra1487]

Sir In case pr is positive in core Needle biopsy and negative in surgical specimen. Which report is reliable and what will be treatment plan. Please make one video on this topic Thanks and regards

[@drvineetgovindagupta]

Usually PR won't lead to change in therapy

[@Mukesk971]

Scrape Cytology Report - * Mature Squamous Cells * Sprace Inflammatory Cells * No Dysplastic Cells Or Fungal Elements Seen Sir Please Bataya Report Main Kya He 🙏🙏

[@AshishKumar-jt4xs]

But sir ek bhod bda confusion h esa kahte h ki chemotherepy cencer cell ko body me kahi bhi ho kill krta h to only harmone therepy kese effective hogi please help me sir bhot bada confusion h mujhe😢🙏

[@isha9831]

Doctor Brest cancer ki kounshi janch karwaani par ye pata chale ga ki cancer hai

[@sandeepsinghluckey9739]

Bhut achi video sir please myeloma patient ke liya koi new treatment aya hai mein aap ke paas aya tha rply

[@drvineetgovindagupta]

Watch our multiple myeloma video from channel page

[@sandeepsingh-yk2gz]

Informative video sir Sir meri mom ko CA Breast metastatic hai 12weekly Paclitaxel inj done last cycle 3august 2023 with monthly zoldronic acid continue after chemo palbociclib and letrozole continue but at present new petcity report 20march 2024 cancer shows in 0.2 in liver Dr.. suggested stopped palbociclib or letrozole and started injection fulventrast 500mg quartely with combination of tab capecitabine 500 ....plz Suggested sir which one is better chemo /palbociclib+letrozole /injection fulventrast+capecitabine plz sir reply or any no.. for query

[@drvineetgovindagupta]

Difficult to answer this question without seeing all reports... Contact via number in video description

[@sabithats6835]

Very informative vedio doctor.. even my doctor couldn't explain .. about my treatment so deep.. ur a god sent angel.. im a stage 4 ER PR positive with skeletal metastasis .. its been 2 years now.. my last 3 pet scan shows no tumor. complete metabolic response and im on letrozole and ribociclib.. Doctor is therr any chance of stopping these drugs because my quality of life is becoming horrible due to this drug.. im into a clean diet exercise yoga and other alternative therapy im jus 36 and wish to have a second baby..kindly respond. . Im awaiting for your response. . God bless you doctor 🙏 ❤

[@drvineetgovindagupta]

Hi... You need to take this drug indefinitely. Do not stop it. Pregnancy might not be possible for you right now but research is going on, maybe it might become possible in future. Currently survival is more important than second child

[@drvineetgovindagupta]

Drug doses can be adjusted if side effects are troublesome. Talk to your oncologist or connect to us via number in video descripiton

[@sabithats6835]

Thank you so much doctor for your time.. indeed ur an angel because I never seen any doctor taking time to explain patient concerns.. God bless you doctor 🙏

[@sakshampathak9019]

​@@sabithats6835hey hope you doing well.. can I contact you my mom diagnosed with same ?

[@sakshampathak9019]

​@@sabithats6835what signa you saw after taking these my doctor has prescribed letrozole and palbociclib

[@talhamohammed8679]

“My mother (57) has been diagnosed with metastatic stage 4 Breast cancer (ER+,PR-,Her2- score1)which has spread to her (Brain, Lung, Liver and Bone) as of 8/2/24. She’s getting Paclitaxel Chemo 9times once a week(3 are done” She started getting radiation in November and December 2023 ( radiation to back bone,breast, and brain)at that time spread of Ca was limited, Then later she was on target therapy(Palbociclib) &hormone therapy(Letrozole) taking this accelerated the disease then got a PET CT and got to know it has spread to Liver also. Please suggest if treatment is right or wrong

[@drvineetgovindagupta]

It is a complicated case. Repeat biopsy with genetic testing should help. Connect via number in video description

[@lily258]

❤❤❤❤of u sir meri sister 4th stage he dna effective nehi hue redio Or opration nehi kie to chalega😢

[@drvineetgovindagupta]

Stage 4 mein surgery compulsory nahi hai. Video description mein number se sampark karo

[@bijucvcv268]

Doctor, can high SGPT elevate CEA observed value.

[@drvineetgovindagupta]

It is possible

[@bimaleshdutta624]

leiomyosarcoma, it had been spread to the liver from gastro intestine. Is it curable? How much risk of life is involved in this? Sir, Please reply....

[@surindersingla1620]

Sir I am impressed to see your video n wants to know whether target therapy can be discountinued if pet scan is normal since last18months I am patient of hormone breast cancer since2006 Please guide me

[@drvineetgovindagupta]

It depends on the type and stage of cancer

[@sakshampathak9019]

Where did it spreaded in 2006?

[@sakshampathak9019]

How are you now ..my mom diagnosed with same skeletal metastatis and breast cancer can this medicine work to shrink the tumor even in years

[@user-rf8qv2ys3e]

Sir, when you talking about survival rate? It is again relapse rate?

[@drvineetgovindagupta]

Both are important

[@sopanverulkar3365]

Please i need second opinion from you. Could you please share your details with us for cancer case cure from you. Because i am from Maharashtra.

[@drvineetgovindagupta]

Use number in video description

[@manojkumarsahu4295]

Sir nuroindocrine tumor patient father aur mother Ban sakte han. Baby ko hone me risk hai kya.

[@drvineetgovindagupta]

Usually no. But need to discuss with your oncologist

[@manishjoshi8497]

Dr Vineet, very nice and kind of you. However, why is it that for a young lady below 40, who has high PR & ER Positivity and negative HER, who is in Stage 2, is being recommended Chemotherapy first ? Is it because she is young ? Why Medical & Surgical Oncologist have different views on it ?

[@drvineetgovindagupta]

Younger patients with breast cancer have more aggressive cancers. Even they can avoid chemo if genetics of the cancer are favourable

[@krishnakumaripokhrel6075]

Dr sab mera er pr positive n ihc 2 negitive hee 2nd stage heee avi chemo chal rahahee

[@drvineetgovindagupta]

95% cure rate

[@nikunjsharma2239]

Sir triple negative breast cancer par banae video please

[@drvineetgovindagupta]

Jald hi

[@sanatnandan1864]

सर पुरुषो के breast कैंसर में जिनका er, pr पॉजिटिव और her two नेगेटिव है उनको tamoxifen दिया जा रहा है. इनको और क्या करना चाहिए.

[@user-rf8qv2ys3e]

Sir, this video is very informative, my wife 44 years old, had breast cancer 3 years back, relapsed with spread to bone on july 2023z After palbace and letrozole along with SBRT and last PET WAS CLEAR. Now so we need every 6 months PET SCAN? Or once in a year?

[@drvineetgovindagupta]

There is no fixed guideline in this, it depends on patient health and disease biology. Your doctor will decide

[@sakshampathak9019]

Hey .my mum has same how was your wife now hope she is doing great,i hope for fast recovery.. can you let me know how these medicines affect the overall health and how much tumor shrink we can expect it from .

[@sakshampathak9019]

How are you now ..my mom diagnosed with same skeletal metastatis and breast cancer can this medicine work to shrink the tumor even in years

[@user-rf8qv2ys3e]

@@sakshampathak9019 she is doing good, howz your mom now?

[@sakshampathak9019]

@@user-rf8qv2ys3e we started medicine about a month ago

[@upendrasharma4408]

Hello sir, Meri mother ko 5 sak pahle 4th stage cancer diagnose hua tha. Unko palbace and letrozole diya 5 sal tak. Uske bad August 23 se everolimus and exmestans de rahe the. January 24 se everolimus side effects ki wazh se bnd kr di keval exmestane chal Rahi hai. Kya koi or ilaj h kya? Unko bones me bhi spread h.

[@nirmalmishra7873]

Dear Let me know which organ was involved in stage 4 breast cancer in your Mother

[@nirmalmishra7873]

Dear Pls share stage 4 me disease kaha kaha gayi thi

[@upendrasharma4408]

Sir, I can share all pet ct reports. Could you please share your email id? Sbse phle left breast and lungs me tha. Vocal cord bhi paralysed ho gye the. Palbace lene k bad lungs me se to remove ho gya. By the time bones me bhi ho gya h. Paabace had stopped working then doctor recommended everolimous and exmestane. But everolimous was stopped after 4 months due to the severe side effects. Now she is taking only exmestane.

[@ravi.315.]

Sir mai 19 years ki hu mere left breast ka size thoda bada hai or pain bhi hota hai or meri neck se arm Tak pain rahta hai kya mujhe censer hai please sir bataiye 😢

[@AreeshaShaikh-km9tc]

I'm not a doctor dear but my sister is also a BC survivor ...I suggest you to go and do petscan .stage bahot tezi se badhti hai iski.

[@AreeshaShaikh-km9tc]

Unhe bhi starting symptom yhi thi then bone .

[@oxytocin.8847]

Sir my mother has stage 4. Dr.adviced us to go for hormontherapy including ribociclib** . But RIBOCICLIB COST around 60k per month.which is not affordable for us for a long time is there any alternative of this tablet.or i can get help from any government associations.pls let me know as soon as possible.

[@nirmalmishra7873]

Yes you can aplly CM fund Pm fund

[@ravisharma3987]

Sir mera rectal Cancer permanent colostomy bag lega h kya hyhe hut skta h kya ji please batana ji aapki badi meherbani hogi

[@drvineetgovindagupta]

Depend karta hai. Sabmein nahi

[@awanijain]

Can grade 3 invasive breast cancer ( modified Bloom richardson grade ) T3 N0 M0 . ER + , PR + , her 2 negative. Bcs done Can be treated without chemotherapy

[@choudhary07776]

From where bcs done ?

[@detsunam6108]

My mother jas been given 3 chemo than after debulking surgery another 3 chemo is now being given olaparib.

[@drvineetgovindagupta]

Yes this is recommended in ovarian cancer

[@globaldesirasoi]

सर, मुझे हारमोन पॉजिटिव ब्रेस्ट कैंसर है 2 स्टेज का 15 दिन हुए सर्जरी हुई है , 5 लिम्फ नोड रिमूव हुए हैं क्या मुझे कीमो थेरेपी की जरूरत है

[@nagendranavik7959]

Kha par karye ho

[@ManjeetKumar-uj5wt]

Sir meri mother ko breast cancer h ER-PR positive h aur sir heart ka ejection fraction 30-35% h doctor bol rahe h aise me surgery aur chemo nahi kar sakte kya ye sahi h sir Please guide 🙏🙏

[@ManjeetKumar-uj5wt]

Sir please reply

[@drvineetgovindagupta]

Hi. For ER PR + Hormone therapy can be done with good outcome even with heart failure. Connect via number in video description

[@asmitaadhav9375]

Thanks 🙏🏻 Iam worried about my sister metastatic Brest cancer spread in bone diagnosed in last fifteen days back kindly advise

[@drvineetgovindagupta]

Connect via number in video description

[@detsunam6108]

Sir, why olaparib is given

[@drvineetgovindagupta]

Watch our olaparib video. It improves cure rates and survival

[@anitapatel5119]

ER PR h e r Tina negative hai sar ji marij hit mein hai ki nahin

[@drvineetgovindagupta]

Stage par depend karega

[@simranrk6282]

Sir kya hum chemotherapy beech mein stop kar sakte hai

[@drvineetgovindagupta]

Course poora karna chahiye. Apne oncologist se discuss kare bina kabhi treatment band mat karna

[@meghachauhan5503]

Sir meri ma ko stage 4 cancer h breast me kya kru

[@nima7484]

Sir aapse treatment ke liye kaha aana padega?

[@drvineetgovindagupta]

Call number in video description

[@kushagrasingh518]

Sir. My mother is stage 4 BC (left breast, LN, Bone, lung) patient. Harmone positive. 1st line Letrozole + palbace. 2nd line Fulvestrant + piqray 3rd line Everolimus + exemestane. Then Chemo paclitaxel single agent 10 cycles. And today pet CT show decrease with inactive metabolic activity in bones. Now suggested to take tamoxifen And have chemo break. Please suggest if taking tamoxifen right now is valid And suggested? Or should continue paclitaxel??

[@sakshampathak9019]

How much time interval this treatment worked for her cancer you pls tell me ! my mom is one same 1st line of treatment as your and always terrified and worried .....I hope for speed recovery of your mom🕉️❤️

[@kushagrasingh518]

@@sakshampathak9019 she was diagnosed on Feb 2021. I wish for your mother's good health. God bless brother.

[@sakshampathak9019]

@@kushagrasingh518 thank you bro ..take care of yourself and your mother too...❤️❤️

[@rakhibisht719]

Sir, you talked about hormonal therapy, so for how long do these medicines have to be taken in stage 2 breast cancer

[@drvineetgovindagupta]

5-7 years

[@rakhibisht719]

@@drvineetgovindagupta ok sir thanks

[@ushamorwal2771]

हेलो डॉक्टर मेरे को ट्रिपल नेगेटिव ब्रेस्ट कैंसरहै क्या मैं आपसे बात कर सकती हूं कीमोथेरेपी हो गई ऑपरेशन हो गया अब रेडिएशन हो गई हो ग

[@drvineetgovindagupta]

Video description mein phone number hai

[@codingdevchannel1390]

Do onco vaccines cure cancer?

[@drvineetgovindagupta]

At present onco vaccines that cure cancer are still in research stage

[@SunitaBidve-gz5fx]

ErPr positive hai HER2NEGATIVE hai aur hat aur pair me crams zanznahat hai

[@ImissmyShree]

Lekin meri to nehi ki doctor ne